DK2748182T3 - Peptide nanoparticles and their applications - Google Patents

Peptide nanoparticles and their applications Download PDF

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Publication number
DK2748182T3
DK2748182T3 DK12756593.5T DK12756593T DK2748182T3 DK 2748182 T3 DK2748182 T3 DK 2748182T3 DK 12756593 T DK12756593 T DK 12756593T DK 2748182 T3 DK2748182 T3 DK 2748182T3
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DK
Denmark
Prior art keywords
peptide
trp
leu
amphiphilic
lys
Prior art date
Application number
DK12756593.5T
Other languages
Danish (da)
English (en)
Inventor
Christian Dittrich
Gaudenz Danuser
Original Assignee
Harvard College
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Application granted granted Critical
Publication of DK2748182T3 publication Critical patent/DK2748182T3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK12756593.5T 2011-08-23 2012-08-23 Peptide nanoparticles and their applications DK2748182T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161526526P 2011-08-23 2011-08-23
PCT/US2012/052027 WO2013028843A1 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and uses thereof

Publications (1)

Publication Number Publication Date
DK2748182T3 true DK2748182T3 (en) 2017-02-06

Family

ID=46826904

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12756593.5T DK2748182T3 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and their applications

Country Status (19)

Country Link
US (1) US8828928B2 (https=)
EP (1) EP2748182B1 (https=)
JP (1) JP2014524477A (https=)
KR (1) KR20140068087A (https=)
CN (1) CN104011065B (https=)
AU (1) AU2012298824B2 (https=)
BR (1) BR112014004014A2 (https=)
CA (1) CA2845886A1 (https=)
CL (1) CL2014000418A1 (https=)
DK (1) DK2748182T3 (https=)
ES (1) ES2610779T3 (https=)
HU (1) HUE031511T2 (https=)
IL (1) IL231005A0 (https=)
MX (1) MX2014002062A (https=)
PT (1) PT2748182T (https=)
RU (1) RU2014110901A (https=)
SG (1) SG11201400073SA (https=)
WO (1) WO2013028843A1 (https=)
ZA (1) ZA201401210B (https=)

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* Cited by examiner, † Cited by third party
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US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US11286489B2 (en) * 2016-02-11 2022-03-29 The Curators Of The University Of Missouri POSH inhibitor complex biomolecules and amphiphile micelles
CA3018561A1 (en) 2016-03-21 2017-09-28 Rhode Island Council On Postsecondary Education Ph-sensitive peptides
CN116908452A (zh) * 2016-12-16 2023-10-20 布里格姆及妇女医院股份有限公司 用于疾病的早期检测的蛋白质冠传感器阵列的系统和方法
CN106832003B (zh) * 2017-02-15 2021-01-05 中国药科大学 一种酸敏性多肽及其应用
CN119185557A (zh) 2018-04-06 2024-12-27 阿玛治疗公司 用于控释治疗剂的组合物
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
US12509552B2 (en) * 2021-04-08 2025-12-30 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures
CN114516819B (zh) * 2022-02-25 2024-02-27 顺毅宜昌化工有限公司 一种n,n’-二乙酰基肼的制备方法
US20250360158A1 (en) * 2022-06-13 2025-11-27 Neubase Therapeutics, Inc. Oligonucleotide analogue formulations
CN116004221B (zh) * 2022-12-15 2023-12-19 湖南卓润生物科技有限公司 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒

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US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3872925A (en) 1973-04-24 1975-03-25 Gearhart Owen Industries Through-tubing bridge plug
US3842067A (en) 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (https=) 1974-03-08 1982-06-04
US4105603A (en) 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4511390A (en) 1983-06-10 1985-04-16 E. I. Du Pont De Nemours And Company Aralkylcarbamoyl peptide alcohols
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
FR2736642B1 (fr) 1995-07-10 1997-09-12 Pasteur Institut Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
IL147031A0 (en) 1999-08-02 2002-08-14 Synt Em Sa Computational design methods for making molecular mimetics
JP4215512B2 (ja) 2001-02-26 2009-01-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非オリゴマー化タンデム蛍光性タンパク質
JP5255274B2 (ja) 2004-07-06 2013-08-07 スリーディー マトリックス, インコーポレイテッド 精製両親媒性ペプチド組成物およびその使用
CA2713879C (en) * 2008-02-01 2020-01-07 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
JP2011523353A (ja) * 2008-04-28 2011-08-11 プレジデント アンド フェロウズ オブ ハーバード カレッジ 細胞透過のための過剰に荷電されたタンパク質

Also Published As

Publication number Publication date
EP2748182B1 (en) 2016-10-19
ZA201401210B (en) 2015-12-23
WO2013028843A1 (en) 2013-02-28
AU2012298824B2 (en) 2017-06-01
PT2748182T (pt) 2017-01-20
BR112014004014A2 (pt) 2020-10-27
RU2014110901A (ru) 2015-09-27
IL231005A0 (en) 2014-03-31
KR20140068087A (ko) 2014-06-05
EP2748182A1 (en) 2014-07-02
SG11201400073SA (en) 2014-03-28
HUE031511T2 (en) 2017-07-28
CL2014000418A1 (es) 2014-07-25
JP2014524477A (ja) 2014-09-22
NZ622045A (en) 2016-02-26
MX2014002062A (es) 2014-05-28
ES2610779T3 (es) 2017-05-03
CA2845886A1 (en) 2013-02-28
AU2012298824A1 (en) 2014-03-20
US8828928B2 (en) 2014-09-09
US20130064895A1 (en) 2013-03-14
CN104011065A (zh) 2014-08-27
CN104011065B (zh) 2017-06-30

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