CN104011065B - 肽纳米粒子及其用途 - Google Patents

肽纳米粒子及其用途 Download PDF

Info

Publication number
CN104011065B
CN104011065B CN201280052123.9A CN201280052123A CN104011065B CN 104011065 B CN104011065 B CN 104011065B CN 201280052123 A CN201280052123 A CN 201280052123A CN 104011065 B CN104011065 B CN 104011065B
Authority
CN
China
Prior art keywords
peptide
trp
leu
amphiphilic
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280052123.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN104011065A (zh
Inventor
克里斯蒂安·迪特里希
高登茨·达努斯尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of CN104011065A publication Critical patent/CN104011065A/zh
Application granted granted Critical
Publication of CN104011065B publication Critical patent/CN104011065B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280052123.9A 2011-08-23 2012-08-23 肽纳米粒子及其用途 Expired - Fee Related CN104011065B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161526526P 2011-08-23 2011-08-23
US61/526,526 2011-08-23
PCT/US2012/052027 WO2013028843A1 (en) 2011-08-23 2012-08-23 Peptide nanoparticles and uses thereof

Publications (2)

Publication Number Publication Date
CN104011065A CN104011065A (zh) 2014-08-27
CN104011065B true CN104011065B (zh) 2017-06-30

Family

ID=46826904

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280052123.9A Expired - Fee Related CN104011065B (zh) 2011-08-23 2012-08-23 肽纳米粒子及其用途

Country Status (19)

Country Link
US (1) US8828928B2 (https=)
EP (1) EP2748182B1 (https=)
JP (1) JP2014524477A (https=)
KR (1) KR20140068087A (https=)
CN (1) CN104011065B (https=)
AU (1) AU2012298824B2 (https=)
BR (1) BR112014004014A2 (https=)
CA (1) CA2845886A1 (https=)
CL (1) CL2014000418A1 (https=)
DK (1) DK2748182T3 (https=)
ES (1) ES2610779T3 (https=)
HU (1) HUE031511T2 (https=)
IL (1) IL231005A0 (https=)
MX (1) MX2014002062A (https=)
PT (1) PT2748182T (https=)
RU (1) RU2014110901A (https=)
SG (1) SG11201400073SA (https=)
WO (1) WO2013028843A1 (https=)
ZA (1) ZA201401210B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US11286489B2 (en) * 2016-02-11 2022-03-29 The Curators Of The University Of Missouri POSH inhibitor complex biomolecules and amphiphile micelles
CA3018561A1 (en) 2016-03-21 2017-09-28 Rhode Island Council On Postsecondary Education Ph-sensitive peptides
CN116908452A (zh) * 2016-12-16 2023-10-20 布里格姆及妇女医院股份有限公司 用于疾病的早期检测的蛋白质冠传感器阵列的系统和方法
CN106832003B (zh) * 2017-02-15 2021-01-05 中国药科大学 一种酸敏性多肽及其应用
CN119185557A (zh) 2018-04-06 2024-12-27 阿玛治疗公司 用于控释治疗剂的组合物
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
US12509552B2 (en) * 2021-04-08 2025-12-30 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures
CN114516819B (zh) * 2022-02-25 2024-02-27 顺毅宜昌化工有限公司 一种n,n’-二乙酰基肼的制备方法
US20250360158A1 (en) * 2022-06-13 2025-11-27 Neubase Therapeutics, Inc. Oligonucleotide analogue formulations
CN116004221B (zh) * 2022-12-15 2023-12-19 湖南卓润生物科技有限公司 环肽的新应用、吖啶标记复合物与制备方法、检测试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101932594A (zh) * 2008-02-01 2010-12-29 阿尔法-O肽股份公司 可用作疫苗的自装配肽纳米颗粒
CN102066405A (zh) * 2008-04-28 2011-05-18 哈佛大学校长及研究员协会 用于细胞穿透的超荷电蛋白

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3872925A (en) 1973-04-24 1975-03-25 Gearhart Owen Industries Through-tubing bridge plug
US3842067A (en) 1973-07-27 1974-10-15 American Home Prod Synthesis of(des-asn5)-srif and intermediates
JPS5726506B2 (https=) 1974-03-08 1982-06-04
US4105603A (en) 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4511390A (en) 1983-06-10 1985-04-16 E. I. Du Pont De Nemours And Company Aralkylcarbamoyl peptide alcohols
US5643873A (en) 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5654276A (en) 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
FR2736642B1 (fr) 1995-07-10 1997-09-12 Pasteur Institut Immunovecteurs, notamment anticorps et fragments d'anticorps utilisables pour le transport intracellulaire et intranucleaire de principes biologiquement actifs notamment d'haptenes, de proteines et d'acides nucleiques
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
IL147031A0 (en) 1999-08-02 2002-08-14 Synt Em Sa Computational design methods for making molecular mimetics
JP4215512B2 (ja) 2001-02-26 2009-01-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 非オリゴマー化タンデム蛍光性タンパク質
JP5255274B2 (ja) 2004-07-06 2013-08-07 スリーディー マトリックス， インコーポレイテッド 精製両親媒性ペプチド組成物およびその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101932594A (zh) * 2008-02-01 2010-12-29 阿尔法-O肽股份公司 可用作疫苗的自装配肽纳米颗粒
CN102066405A (zh) * 2008-04-28 2011-05-18 哈佛大学校长及研究员协会 用于细胞穿透的超荷电蛋白

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Peptide and protein drug delivery to and into tumors: challenges and solutions;Vladimir P. Torchilin等;《Drug Discovery Today》;20030331;第8卷(第6期);第262页、摘要 *
Solid Peptide Nanoparticles – Structural Characterization and Quantification of Cargo Encapsulation;Christian Dittrich等;《Macromolecular Bioscience》;20101231;第10卷(第12期);摘要，第1407页左栏最后一段至右栏第二段、第1411页左栏第2段、表3 *

Also Published As

Publication number Publication date
EP2748182B1 (en) 2016-10-19
ZA201401210B (en) 2015-12-23
WO2013028843A1 (en) 2013-02-28
AU2012298824B2 (en) 2017-06-01
PT2748182T (pt) 2017-01-20
BR112014004014A2 (pt) 2020-10-27
RU2014110901A (ru) 2015-09-27
IL231005A0 (en) 2014-03-31
KR20140068087A (ko) 2014-06-05
DK2748182T3 (en) 2017-02-06
EP2748182A1 (en) 2014-07-02
SG11201400073SA (en) 2014-03-28
HUE031511T2 (en) 2017-07-28
CL2014000418A1 (es) 2014-07-25
JP2014524477A (ja) 2014-09-22
NZ622045A (en) 2016-02-26
MX2014002062A (es) 2014-05-28
ES2610779T3 (es) 2017-05-03
CA2845886A1 (en) 2013-02-28
AU2012298824A1 (en) 2014-03-20
US8828928B2 (en) 2014-09-09
US20130064895A1 (en) 2013-03-14
CN104011065A (zh) 2014-08-27

Similar Documents

Publication Publication Date Title
CN104011065B (zh) 肽纳米粒子及其用途
US20150218252A1 (en) Self-assembling peptides, peptide nanostructures and uses thereof
KR101475447B1 (ko) 자기-조립 블록 코폴리머의 베시클 그리고 그것의 제조 및 사용 방법
WO2021167107A1 (ja) ヒトトランスフェリンレセプター結合ペプチド
EP3405429B1 (en) Formation of functionalized nanoparticles by supramolecular co-assembly
US20090238886A1 (en) Retro-Inversion Peptides That Target GIT Transport Receptors and Related Methods
US8603966B2 (en) Amino acid-based compounds, their methods of use, and methods of screening
US20100098748A1 (en) Arg-Gly-Asp (RGD) Sequence Containing Cyclic Peptide and Its Active Targeting Liposomes
CN102516395B (zh) 提高药物/基因的靶向性和转染效率的多肽载体及用途
US20240336655A1 (en) Amphiphilic peptides for nucleic acid and protein delivery
HK1193115B (en) Peptide nanoparticles and uses thereof
HK1193115A (en) Peptide nanoparticles and uses thereof
CA3228449A1 (en) Human transferrin receptor binding peptide
Dittrich et al. Solid peptide nanoparticles–Structural characterization and quantification of cargo encapsulation
NZ622045B2 (en) Peptide nanoparticles and uses thereof
JP7068711B2 (ja) 細胞質送達ペプチド
TWI362270B (https=)
JP7610308B2 (ja) ペプチド及び該ペプチドを含む会合体又は組成物
Navarro Barreda Macro-and nanoscale self-assembled amino acid derivatives as reduction-sensitive and photoactive materials
HK40090445A (zh) 靶组织特异性递送型药物递送系统用胶囊的用途
Huang Adaptive Bioinspired Nanovesicles: Stimuli-Responsive Elastin-Collagen Peptides for Drug Delivery Approaches
JP2018534317A (ja) 結腸がんの処置および検出のための組成物および方法
Ruenraroengsak Studies of diffusion in cells using a self-fluorescent dendrimer
CN115232195A (zh) 寡肽二维纳米材料及其应用
EP3952912A1 (en) Cell-penetrating conjugate systems

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170630

Termination date: 20190823