DK2602623T3 - Fremgangsmåde til detekteringen af intracellulært trunkerede receptorer - Google Patents
Fremgangsmåde til detekteringen af intracellulært trunkerede receptorer Download PDFInfo
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- DK2602623T3 DK2602623T3 DK12183659.7T DK12183659T DK2602623T3 DK 2602623 T3 DK2602623 T3 DK 2602623T3 DK 12183659 T DK12183659 T DK 12183659T DK 2602623 T3 DK2602623 T3 DK 2602623T3
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
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- Biomedical Technology (AREA)
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (13)
1. Fremgangsmåde til detektering af tilstedeværelsen af en trunkeret receptor p95ErbB2, under anvendelse af et array, hvilken fremgangsmåde omfatter: (a) inkubering af en celleekstrakt med en flerhed af perler der er specifikke for en ekstracellulær domæne (ECD) bindingsregion af en fuld-længde receptor ErbB2 (HER-2) og inkubere celleekstrakten med en flerhed af fangst-antistoffer, hvor flerheden af fangst-antistoffer er specifik for en intracellulær domæne (ICD) bindingsregion af den trunkerede receptor og hvor flerheden af fangst-antistoffer er fastholdt på en fast støtte i arrayet for at danne en flerhed af fangede trunkerede receptorer; (b) inkubere flerheden af indfangne trunkerede receptorer med detektionsantistoffer der er specifikke for de tilsvarende trunkerede receptorer for at danne en flerhed af detekterbare indfangne trunkerede receptorer; (c) inkubere flerheden af detekterbare indfangne trunkerede receptorer med første og anden medlemmer af et signal-amplifikationspar for at generere et amplificeret signal; og (d) detektere et amplificeret signal genereret fra de første og anden medlemmer af signalamplifi kationsparret.
2. Fremgangsmåden ifølge krav 1, hvor detektionsantistofferne der er specifikke for de tilsvarende trunkerede receptorer omfatter en flerhed af aktiverings-tilstandsuafhængige antistoffer og en flerhed af aktiverings-tilstands-afhængige antistoffer.
3. Fremgangsmåden ifølge krav 2, hvor de aktiverings-tilstandsuafhængige antistoffer er mærket med et faciliterende fragment, de aktiverings-tilstands-afhængige antistoffer er mærket med et første medlem af et signalamplifikationspar, og det faciliterende fragment genererer et oxidationsmiddel der kanaliserer til og omsættes med det første medlem af signalamplifi kationsparret.
4. Fremgangsmåden ifølge krav 3, hvor flerheden af detekterbare indfangne trunkerede receptorer inkuberes med et andet medlem af signalamplifikationsparret for at generere et amplificeret signal.
5. Fremgangsmåden ifølge et hvilket som helst af kravene 1-2, hvor flerheden af perler der er specifikke for et ekstracellulært domæne (ECD) bindingsregion af en fuld-længde receptor ErbB2 (HER-2) omfatter et streptavidin-biotinpar, hvor streptavidinet hæfter til perlerne og biotinet hæfter til et antistof.
6. Fremgangsmåden ifølge et hvilket som helst af kravene 1-5, hvor celleekstrakten fremstilling ved lysering af cirkulerende celler af en brysttumor eller ved lysering af celler isoleret fra tumorvæv.
7. Fremgangsmåden ifølge krav 6, hvor tumorvævet er primær tumorvæv eller metastatisk tumorvæv.
8. Fremgangsmåden ifølge krav 6, hvor cellerne er isoleret fra tumorvæv som en fin nål-aspiratprøve.
9. Fremgangsmåden ifølge kravene 1 eller 2-4, hvor en aktiveringstilstand af flerheden af detekterbare indfangne trunkerede receptorer er interrogeret.
10. Fremgangsmåden ifølge krav 9, hvor aktiveringstilstanden er valgt fra gruppen bestående af en phosphoryleringstilstand, ubiquitineringstilstand, kompleksationstilstand, og kombinationer deraf.
11. Fremgangsmåden ifølge krav 3, hvor det faciliterende fragment er glucoseoxidase.
12. Fremgangsmåden ifølge krav 11, hvor glucoseoxidasen og de aktiveringstilstandsuafhængige antistoffer konjugeres til et sulfhydryl-aktiveret dextranmolekyle.
13. Fremgangsmåden ifølge krav 12, hvor det sulfhydryl-aktiverede dextranmolekyle har en molekylvægt på 500kDa.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3131908P | 2008-02-25 | 2008-02-25 | |
US10640408P | 2008-10-17 | 2008-10-17 | |
US10838408P | 2008-10-24 | 2008-10-24 | |
US11790808P | 2008-11-25 | 2008-11-25 | |
US14055808P | 2008-12-23 | 2008-12-23 | |
EP09715619A EP2250498B1 (en) | 2008-02-25 | 2009-02-24 | Drug selection for breast cancer therapy using antibody-based arrays |
Publications (1)
Publication Number | Publication Date |
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DK2602623T3 true DK2602623T3 (da) | 2015-11-09 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09715619.4T DK2250498T3 (da) | 2008-02-25 | 2009-02-24 | Lægemiddelvalg til brystcancerterapi under anvendelse af antistof-baserede arrays |
DK12183659.7T DK2602623T3 (da) | 2008-02-25 | 2009-02-24 | Fremgangsmåde til detekteringen af intracellulært trunkerede receptorer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09715619.4T DK2250498T3 (da) | 2008-02-25 | 2009-02-24 | Lægemiddelvalg til brystcancerterapi under anvendelse af antistof-baserede arrays |
Country Status (13)
Country | Link |
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US (4) | US8163499B2 (da) |
EP (3) | EP2602623B1 (da) |
JP (2) | JP5414701B2 (da) |
CN (2) | CN103399144B (da) |
AU (1) | AU2009219437B2 (da) |
CA (2) | CA2716826C (da) |
DK (2) | DK2250498T3 (da) |
ES (3) | ES2398618T3 (da) |
HK (2) | HK1182441A1 (da) |
IL (3) | IL207637A (da) |
MX (1) | MX2010009140A (da) |
NZ (3) | NZ617520A (da) |
WO (1) | WO2009108637A1 (da) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2517939C (en) * | 2003-03-03 | 2015-11-24 | Dyax Corp. | Peptides that specifically bind hgf receptor (cmet) and uses thereof |
CN108421044A (zh) | 2005-02-03 | 2018-08-21 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
WO2007056118A1 (en) | 2005-11-04 | 2007-05-18 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
NZ582618A (en) | 2007-07-13 | 2012-07-27 | Prometheus Lab Inc | Drug selection for lung cancer therapy using antibody-based arrays |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
NZ617520A (en) | 2008-02-25 | 2015-05-29 | Nestec Sa | Drug selection for breast cancer therapy using antibody-based arrays |
EP2310011B1 (en) | 2008-06-17 | 2013-07-24 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
AU2009279771B2 (en) | 2008-08-04 | 2015-05-14 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
GB2467691A (en) | 2008-09-05 | 2010-08-11 | Aueon Inc | Methods for stratifying and annotating cancer drug treatment options |
WO2010085845A1 (en) * | 2009-01-28 | 2010-08-05 | The University Of Queensland | Cancer therapy and/or diagnosis |
KR20220143154A (ko) | 2009-04-06 | 2022-10-24 | 와이어쓰 엘엘씨 | 네라티닙을 이용한 유방암의 치료법 |
CA2761777A1 (en) | 2009-05-14 | 2010-11-18 | Prometheus Laboratories Inc. | Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy |
EP2473854B1 (en) * | 2009-06-23 | 2017-08-23 | Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud | Systems and methods for treating, diagnosing and predicting the response to therapy of breast cancer |
JP5795311B2 (ja) | 2009-07-15 | 2015-10-14 | ネステク ソシエテ アノニム | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
WO2011015921A1 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | A highly efficient process of purification and production of recombinant cetuximab |
WO2011015920A2 (en) * | 2009-08-03 | 2011-02-10 | Avesthagen Limited | A highly efficient process of purification and production of recombinant trastuzumab |
WO2011034919A2 (en) * | 2009-09-15 | 2011-03-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Sh2 domain profiling to characterize tyrosine phosphorylation signaling in cancer |
DK2491385T3 (da) * | 2009-10-20 | 2017-08-28 | Diatech Holdings Inc | Proximitetsmedierede assays til detektering af oncogene fusionsproteiner |
WO2011088149A2 (en) * | 2010-01-12 | 2011-07-21 | Prometheus Laboratories Inc. | Methods for predicting response of triple-negative breast cancer to therapy |
CA2787048C (en) * | 2010-01-13 | 2021-06-22 | Wyeth Llc | A cut-point in pten protein expression that accurately identifies tumors and is predictive of drug response to a pan-erbb inhibitor |
CN103109187B (zh) | 2010-07-07 | 2015-03-25 | 密执安大学评议会 | 乳腺癌的诊断和治疗 |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
IN2013MN00522A (da) | 2010-09-24 | 2015-05-29 | Univ Leland Stanford Junior | |
CA2822283A1 (en) | 2010-12-23 | 2012-06-28 | Nestec S.A. | Drug selection for malignant cancer therapy using antibody-based arrays |
US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
BR112013020992A2 (pt) | 2011-02-17 | 2016-10-11 | Nestec Sa | aparelho e método para isolamento de leucócitos e células tumorosas por meio de filtração |
KR20140008397A (ko) | 2011-02-17 | 2014-01-21 | 네스텍 소시에테아노님 | 항-TNFα 약물에 대한 자가항체 검출을 위한 검정법 |
EP2908132B8 (en) | 2011-03-02 | 2019-06-12 | Nestec S.A. | Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures |
CN103597354B (zh) | 2011-04-04 | 2016-04-20 | 雀巢产品技术援助有限公司 | 用于预测和改善胃癌患者存活的方法 |
EP2670866A4 (en) * | 2011-04-05 | 2015-09-02 | Translational Genomics Res Inst | BIOMARKERS AND METHODS OF USE |
CA2839792A1 (en) | 2011-05-10 | 2012-11-15 | Nestec S.A. | Methods of disease activity profiling for personalized therapy management |
KR20140057343A (ko) | 2011-08-18 | 2014-05-12 | 네스텍 소시에테아노님 | 대립형질 변이 검출을 위한 조성물 및 방법 |
KR101851425B1 (ko) | 2011-09-02 | 2018-04-23 | 네스텍 소시에테아노님 | 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링 |
US20140296198A1 (en) * | 2011-11-04 | 2014-10-02 | Invivis SAS a corporation | Assay For Predictive Biomarkers Of Anti-Estrogen Efficacy |
WO2013086031A1 (en) * | 2011-12-05 | 2013-06-13 | Nestec S.A. | Method of therapy selection for patients with cancer |
CN107929732A (zh) * | 2011-12-12 | 2018-04-20 | 中国科学院生物物理研究所 | Cd146及其抗体诊断和治疗三阴性乳腺癌的应用 |
EP2797603B1 (en) * | 2011-12-30 | 2019-02-20 | Somalogic, Inc. | Aptamers and diagnostic methods for detecting the egf receptor |
US20130330761A1 (en) | 2012-06-12 | 2013-12-12 | Celcuity, LLC | Whole cell assays and methods |
US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
EP2877853A1 (en) * | 2012-07-27 | 2015-06-03 | Centre Léon Bérard | Detection of the er /src/pi3k complex as predictive marker in breast cancer |
WO2014054013A1 (en) | 2012-10-05 | 2014-04-10 | Nestec S.A. | Methods for predicting and monitoring mucosal healing |
CA3215087A1 (en) * | 2013-01-03 | 2014-07-10 | Meso Scale Technologies, Llc | Assay panels |
WO2014122582A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Drug selection for non-small cell lung cancer therapy |
EP2954329A1 (en) | 2013-02-05 | 2015-12-16 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
WO2014122599A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
KR102378388B1 (ko) | 2013-03-13 | 2022-03-25 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
CN105308186A (zh) * | 2013-03-15 | 2016-02-03 | 詹森药业有限公司 | 预测性生物标记的测定法 |
CA2909310A1 (en) | 2013-04-12 | 2014-10-16 | Asana Biosciences, Llc | Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways |
EP2999966B1 (en) | 2013-05-21 | 2018-04-25 | Pierian Holdings, Inc. | Methods for predicting and improving the survival of colorectal cancer patients |
KR20160026909A (ko) | 2013-07-09 | 2016-03-09 | 네스텍 소시에테아노님 | 미세유체 협동 효소 증강 반응성(ceer) 면역검정 |
EP3039429B1 (en) | 2013-08-30 | 2018-10-10 | Nestec S.A. | Polyp recurrence |
AU2014333815B2 (en) * | 2013-10-11 | 2020-07-09 | Nihon University School Of Medicine | Multiplex HER2 and estrogen receptor co-staining assays for detecting tumor heterogeneity |
AU2014339977A1 (en) * | 2013-10-23 | 2016-05-19 | Oregon Health & Science University | Methods of determining breast cancer prognosis |
WO2015083085A1 (en) | 2013-12-03 | 2015-06-11 | Nestec S.A. | Signaling pathways in tissues from inflammatory bowel disease patients |
WO2015089380A2 (en) | 2013-12-12 | 2015-06-18 | Celcuity Llc | Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent |
US9730935B2 (en) * | 2013-12-13 | 2017-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting a non-canonical notch signaling pathway for cancer treatment |
WO2015108342A1 (ko) * | 2014-01-14 | 2015-07-23 | 최원철 | 루테리알의 형태특성을 이용한 암 예방제 또는 항암제의 스크리닝 방법 |
WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
WO2015166461A1 (en) | 2014-05-01 | 2015-11-05 | Nestec S.A. | Methods of selecting treatment regimen using tnf alpha and anti-tnf alpha drug levels |
CA2948547A1 (en) | 2014-05-15 | 2015-11-19 | Meso Scale Technologies, Llc. | Assay methods and kits for detecting an analyte of interest |
CN104083762A (zh) * | 2014-06-27 | 2014-10-08 | 中国科学院生物物理研究所 | 用于阻断Netrin-1与CD146之间的相互作用的试剂及其肿瘤治疗用途 |
CA2964857A1 (en) | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
CA2969326A1 (en) | 2014-12-02 | 2016-06-09 | Nestec S.A. | Methods for establishing a vedolizumab dosing regimen to treat patients with irritable bowel disease |
CA2969471C (en) * | 2014-12-12 | 2024-02-20 | Celcuity Llc | Methods of measuring signaling pathway activity to diagnose and treat patients |
JP6720138B2 (ja) * | 2015-03-13 | 2020-07-08 | シスメックス株式会社 | 被検物質の検出方法およびその方法に用いられる試薬キット |
US10724071B2 (en) | 2015-10-14 | 2020-07-28 | Nitto Boseki Co., Ltd. | Method for determining drug-sensitive human cell lines by analysis method in which measurement of activity of two types of protein kinase is used |
KR20190015360A (ko) * | 2016-05-31 | 2019-02-13 | 네스텍 소시에테아노님 | Her2 및 her3 경로 아형 분류를 기반으로 한, 유방암 환자에 대한 약물 치료법의 선택 방법 |
CN107727752B (zh) * | 2016-08-12 | 2019-11-08 | 北大方正集团有限公司 | 免疫抑制剂依维莫司的分析方法 |
JP6779483B2 (ja) | 2016-09-29 | 2020-11-04 | 住友ゴム工業株式会社 | 医療用検査装置及び細胞検査方法 |
JP6518985B2 (ja) | 2016-09-29 | 2019-05-29 | 住友ゴム工業株式会社 | がん細胞捕捉方法 |
CN106645728A (zh) * | 2016-11-09 | 2017-05-10 | 百奥森(江苏)食品安全科技有限公司 | 一种食品中氟喹诺酮类药物的检测试剂盒 |
JP7377713B2 (ja) * | 2016-12-07 | 2023-11-10 | ファンダシオ プリバーダ インスティトゥト ディンベスティガシオ オンコロジカ デ バル デブロン | 細胞毒性治療を行わない二重her2遮断に対する反応の予測因子としてのher2 |
WO2018175251A1 (en) | 2017-03-20 | 2018-09-27 | Celcuity Llc | Methods of measuring signaling pathway activity for selection of therapeutic agents |
CA3060564A1 (en) | 2017-04-18 | 2018-10-25 | Eli Lilly And Company | Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds |
JP2020523560A (ja) | 2017-05-31 | 2020-08-06 | プロメテウス バイオサイエンシーズ インコーポレイテッド | クローン病患者の粘膜治癒を評価する方法 |
WO2019073391A1 (en) | 2017-10-10 | 2019-04-18 | Nestec S.A. | METHODS OF MONITORING VEDOLIZUMAB TREATMENT |
JP7158671B2 (ja) | 2018-02-14 | 2022-10-24 | 住友ゴム工業株式会社 | 特定細胞捕捉方法 |
JP7109719B2 (ja) | 2018-02-14 | 2022-08-01 | 住友ゴム工業株式会社 | 特定細胞捕捉方法 |
BR112020019023A2 (pt) * | 2018-03-26 | 2020-12-29 | Icahn School Of Medicine At Mount Sinai | Métodos de tratamento do câncer residual mínimo |
US10871485B2 (en) | 2018-04-13 | 2020-12-22 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
US11614440B2 (en) | 2019-01-24 | 2023-03-28 | Sumitomo Rubber Industries, Ltd. | Specific cell fractionating and capturing methods |
JP6886667B2 (ja) * | 2019-03-27 | 2021-06-16 | 住友ゴム工業株式会社 | がん細胞捕捉方法 |
AR123306A1 (es) | 2020-08-21 | 2022-11-16 | Genzyme Corp | Anticuerpos fgfr3 y métodos de uso |
CN113929764B (zh) * | 2021-10-15 | 2023-12-29 | 中山大学孙逸仙纪念医院 | 一种乳腺叶状肿瘤分子标志物cd146及其应用 |
Family Cites Families (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
US5516931A (en) * | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4690890A (en) | 1984-04-04 | 1987-09-01 | Cetus Corporation | Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay |
SE8500817D0 (sv) | 1985-02-20 | 1985-02-20 | Lars Jonsson | Halvoppet anestesisystem |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
US4959306A (en) * | 1986-11-28 | 1990-09-25 | Sclavo, Inc. | Labeling design for a binding assay reagent |
US4975532A (en) | 1986-11-28 | 1990-12-04 | Sclavo, Inc. | Method to derivatize dextran |
JPH01163661A (ja) | 1987-10-02 | 1989-06-27 | E I Du Pont De Nemours & Co | IgG捕捉抗体および多重単クローン性抗体検出系を用いたイムノアツセイ |
US4855241A (en) * | 1988-05-26 | 1989-08-08 | Washington University | Tumor diagnostic method |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5192660A (en) | 1989-04-24 | 1993-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | ELISA methods for the determination of human platelet derived growth factor (PDGF) dimer forms present in human tissues and fluids |
US5089419A (en) | 1989-08-07 | 1992-02-18 | International Canine Genetics | Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals |
US5120660A (en) | 1989-12-05 | 1992-06-09 | International Canine Genetics, Inc. | Method for canine fertility detection |
US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
US5532138A (en) | 1990-04-26 | 1996-07-02 | Behringwerke Ag | Method and kits for determining peroxidatively active catalysts |
FR2672128B1 (fr) | 1991-01-28 | 1995-08-18 | Cis Bio Int | Procede de mesure de la luminescence emise dans un dosage par luminescence. |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
US6251581B1 (en) | 1991-05-22 | 2001-06-26 | Dade Behring Marburg Gmbh | Assay method utilizing induced luminescence |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
CA2129663C (en) | 1992-02-06 | 2005-07-05 | James S. Huston | Biosynthetic binding protein for cancer marker |
ATE244763T1 (de) | 1992-02-11 | 2003-07-15 | Cell Genesys Inc | Erzielen von homozygotem durch zielgerichtete genetische ereignisse |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5332662A (en) | 1992-07-31 | 1994-07-26 | Syntex (U.S.A.) Inc. | Methods for determining peroxidatively active substances |
JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク,インコーポレイテッド | 二特異的免疫アドヘジン |
JPH06109734A (ja) | 1992-09-30 | 1994-04-22 | S R L:Kk | 抗原の測定方法 |
US6201109B1 (en) | 1993-01-13 | 2001-03-13 | Dade Behring Marburg Gmbh | Assay for bone alkaline phosphatase |
WO1995006877A1 (en) | 1993-09-03 | 1995-03-09 | Behringwerke Ag | Fluorescent oxygen channeling immunoassays |
JP3825815B2 (ja) | 1994-01-31 | 2006-09-27 | 信義 清水 | 上皮細胞増殖因子レセプターに対するモノクローナル抗体の結合体ならびにその複合体およびその細胞への嵌入方法 |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
FI98961C (fi) | 1994-08-26 | 1997-09-10 | Medix Biochemica Ab Oy | Menetelmät ja määritysvälineet parodontaalisairauden aktiivisuuden ja/tai peri-implantiitin ja/tai niiden kohonneen riskin diagnosoimiseksi |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5876944A (en) | 1996-06-10 | 1999-03-02 | Bayer Corporation | Method for amplification of the response signal in a sandwich immunoassay |
US20040023375A1 (en) | 2002-07-30 | 2004-02-05 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays |
US5728541A (en) | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
US6416967B2 (en) | 1996-07-12 | 2002-07-09 | Precision Therapeutics, Inc. | Method of using multicellular particulates to analyze malignant or hyperproliferative tissue |
US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
US6780582B1 (en) | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6897073B2 (en) | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
US6197599B1 (en) | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
US6541214B1 (en) | 1998-11-13 | 2003-04-01 | Oregon Heath Science University | N-terminally truncated HER-2/neu protein as a cancer prognostic indicator |
RU2165081C2 (ru) | 1999-01-05 | 2001-04-10 | Ставропольский научно-исследовательский противочумный институт | Способ индикации микроорганизмов |
US6335173B1 (en) | 1999-01-12 | 2002-01-01 | Verve, Ltd. C/O James Bell | Methods for detecting an analyte of interest using tyramide coating technology |
GB9901072D0 (en) | 1999-01-19 | 1999-03-10 | Imp Cancer Res Tech | Methods for detecting changes to a macromolecular component of a cell |
US6972198B2 (en) | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using protein binding partners |
RU2149404C1 (ru) | 1999-03-24 | 2000-05-20 | Московский НИИ глазных болезней им. Гельмгольца | Способ прогнозирования клинического течения увеальной меланомы |
US6322980B1 (en) | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
US6627400B1 (en) | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
US6649351B2 (en) | 1999-04-30 | 2003-11-18 | Aclara Biosciences, Inc. | Methods for detecting a plurality of analytes by mass spectrometry |
DE19926010C2 (de) | 1999-06-08 | 2003-01-30 | Bundesdruckerei Gmbh | Wert- und Sicherheitsdokument mit Sicherheitsmerkmal mit Piezo-Effekt-basierten Eigenschaften und dazugehöriges Nachweisverfahren |
US7179638B2 (en) | 1999-07-30 | 2007-02-20 | Large Scale Biology Corporation | Microarrays and their manufacture by slicing |
US7033781B1 (en) * | 1999-09-29 | 2006-04-25 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
AU1630501A (en) * | 1999-10-08 | 2001-04-23 | Superarray, Inc. | Compositions and methods for detecting protein modification and enzymatic activity |
EP1222468B1 (en) | 1999-10-13 | 2004-03-31 | Incyte Corporation | Multiplex cytokine analysis |
US7537938B2 (en) | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
US6511809B2 (en) | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
EP1307285A2 (en) | 2000-08-03 | 2003-05-07 | Massachusetts Institute Of Technology | Microarrays of functional biomolecules, and uses therefor |
WO2002020825A1 (en) * | 2000-09-09 | 2002-03-14 | The Research Foundation Of State University Of New York | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
US6797481B1 (en) | 2000-10-17 | 2004-09-28 | Dade Behring Marburg Gmbh | Simultaneous screening of multiple analytes |
US7635571B2 (en) | 2000-12-07 | 2009-12-22 | Siemens Healthcare Diagnostics Products Gmbh | Amplified signal in binding assays |
DE10064827A1 (de) | 2000-12-22 | 2002-06-27 | Dade Behring Marburg Gmbh | Nachweisverfahren |
US20070111944A1 (en) * | 2001-02-16 | 2007-05-17 | Scrofani Sergio D B | Purification of vascular endothelial growth factor-B |
US20020168641A1 (en) | 2001-03-09 | 2002-11-14 | Bruce Mortensen | Fluorescein-cyanine 5 as a fluorescence resonance energy transfer pair |
US20020142361A1 (en) | 2001-03-27 | 2002-10-03 | Emmert-Buck Michael R. | Biodetection method |
WO2002084252A2 (en) | 2001-04-17 | 2002-10-24 | Xenoport, Inc. | Epitope-captured antibody display |
AU2002305337A1 (en) | 2001-05-03 | 2002-11-18 | Genometrix Genomics, Inc. | Method and apparatus to determine the performance of protein arrays |
EP1409982A4 (en) | 2001-06-14 | 2006-05-24 | Anadys Pharmaceuticals Inc | PROCESS FOR SCREENING ON LIGANDS OF TARGET MOLECULES |
US7695926B2 (en) | 2001-07-10 | 2010-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting receptor-ligand interactions in single cells |
US7381535B2 (en) | 2002-07-10 | 2008-06-03 | The Board Of Trustees Of The Leland Stanford Junior | Methods and compositions for detecting receptor-ligand interactions in single cells |
JP2005500045A (ja) | 2001-07-12 | 2005-01-06 | ルードビッヒ、インスティテュート、フォー、キャンサー、リサーチ | リンパ管内皮細胞材料および方法 |
JP2003028874A (ja) * | 2001-07-12 | 2003-01-29 | Mitsubishi Chemicals Corp | 2段階酵素反応を用いた測定対象物質の測定法 |
US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
US20050069962A1 (en) | 2001-10-12 | 2005-03-31 | Archer Robert M | Antibody complexes and methods for immunolabeling |
WO2003040670A2 (en) | 2001-11-07 | 2003-05-15 | Sensor Technologies Llc | Method of identifying energy transfer sensors for analytes |
US6949347B2 (en) | 2002-03-05 | 2005-09-27 | Aclara Biosciences, Inc. | Multiplex analysis using membrane-bound sensitizers |
US20030190689A1 (en) * | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
WO2003087761A2 (en) * | 2002-04-05 | 2003-10-23 | Cell Signaling Technology, Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
US20040229380A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
HUP0600340A3 (en) | 2002-07-15 | 2011-06-28 | Genentech Inc | Methods for identifying tumors that are responsive to treatment with anti-erbb2 antibodies |
FR2843126B1 (fr) | 2002-08-01 | 2006-01-27 | Cis Bio Int | "methode de determination d'une activite enzymatique endoglycosidase" |
US20040235002A1 (en) | 2002-09-20 | 2004-11-25 | Sangamo Biosciences, Inc. | Multiplex screening assays |
US20030153013A1 (en) | 2002-11-07 | 2003-08-14 | Ruo-Pan Huang | Antibody-based protein array system |
AU2003302821B2 (en) * | 2002-12-11 | 2009-05-07 | Cell Signaling Technology, Inc. | Method for predicting the response to HER2-directed therapy |
CA2515096A1 (en) | 2003-02-06 | 2004-08-26 | Genomic Health, Inc. | Gene expression markers for response to egfr inhibitor drugs |
BRPI0408928A (pt) | 2003-04-01 | 2006-09-12 | Monogram Biosciences Inc | métodos para determinar uma situação de doença em um paciente, uma situação apoptótica de células em uma amostra, e uma situação de um cáncer em um paciente |
US20040265938A1 (en) | 2003-06-25 | 2004-12-30 | Jose Remacle | Method for the determination of cell activation |
US7279286B2 (en) | 2003-09-11 | 2007-10-09 | Sanofi-Aventis Deutschland Gmbh | High-throughput-assay with high sensitivity for measuring of the activity of β-adrenergic receptor kinase and for determining the impact of test substances on such activity |
FI20031370A0 (fi) | 2003-09-23 | 2003-09-23 | Wallac Oy | Automaattinen hemoglobiinin määritysmenetelmä vastasyntyneiden seulontaan |
US7402399B2 (en) | 2003-10-14 | 2008-07-22 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
ES2343840T3 (es) | 2003-11-04 | 2010-08-11 | Bayer Healthcare Llc | Procedimientos inmunohistoquimicos para supervisar los niveles de perk. |
CA2548394A1 (en) * | 2003-12-12 | 2005-06-30 | Bayer Pharmaceuticals Corporation | Methods for prediction and prognosis of cancer, and monitoring cancer therapy |
JP2007526460A (ja) | 2004-03-03 | 2007-09-13 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法 |
ES2553264T3 (es) | 2004-05-27 | 2015-12-07 | The Regents Of The University Of Colorado | Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer |
SV2006002143A (es) | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
US20060263837A1 (en) | 2004-06-17 | 2006-11-23 | Liu George D | Immunoassay system and method for detection of antigens |
EP1778874B1 (en) | 2004-07-30 | 2011-11-23 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for cervical cancer |
WO2006031815A2 (en) | 2004-09-13 | 2006-03-23 | Monogram Biosciences, Inc. | Methods and compositions for proximity assays |
WO2006044748A2 (en) * | 2004-10-15 | 2006-04-27 | Monogram Biosciences, Inc. | RESPONSE PREDICTORS FOR ErbB PATHWAY-SPECIFIC DRUGS |
WO2006045991A1 (en) | 2004-10-25 | 2006-05-04 | Astrazeneca Ab | Method to predict whether a tumor will react to a chemotherapeutic treatment |
WO2006054991A1 (en) | 2004-11-17 | 2006-05-26 | Immunivest Corporation | Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection |
WO2006055739A2 (en) | 2004-11-17 | 2006-05-26 | Robert Sack | Stationary phase antibody arrays for trace protein analysis |
DE102004056794B4 (de) | 2004-11-24 | 2010-08-26 | Protagen Ag | Verwendung einer Anordnung und Verfahren zur Validierung von Bindern |
WO2006105642A1 (en) | 2005-04-05 | 2006-10-12 | British Columbia Cancer Agency | Biomarkers for the detection of lung cancer and uses thereof |
JP4851730B2 (ja) * | 2005-05-09 | 2012-01-11 | 小澤 滿 | 除塵加湿装置 |
AR053272A1 (es) | 2005-05-11 | 2007-04-25 | Hoffmann La Roche | Determinacion de responsivos a la quimioterapia |
US7771955B2 (en) | 2005-06-09 | 2010-08-10 | University Of Maryland | Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule |
JP2007089548A (ja) * | 2005-09-30 | 2007-04-12 | Univ Of Tokushima | シグナル増幅方法 |
CN101008644A (zh) * | 2006-01-27 | 2007-08-01 | 陈云 | 功能性中枢神经损伤诊断检测用蛋白芯片及其制造方法 |
DK2032982T3 (da) * | 2006-05-05 | 2012-11-05 | Univ Yale | Anvendelse af subcellulær lokaliseringsprofiler som prognostiske eller prædiktive indikatorer |
WO2008019375A2 (en) * | 2006-08-07 | 2008-02-14 | The Board Of Regents Of The University Of Texas System | Proteomic patterns of cancer prognostic and predictive signatures |
KR101424304B1 (ko) | 2006-09-21 | 2014-08-06 | 네스텍 소시에테아노님 | 희귀 순환세포 내의 다수의 신호전달인자를 검출하기 위한 항체 기반 분석법 |
BRPI0717416A2 (pt) | 2006-09-21 | 2013-11-12 | Prometheus Lab Inc | Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo |
KR20090093959A (ko) * | 2006-10-23 | 2009-09-02 | 더 유에이비 리서치 파운데이션 | 항암제에 대한 감수성을 나타내는 암에 대한 생체마커 및 이의 용도 |
US20100234417A1 (en) | 2006-11-10 | 2010-09-16 | Dimerix Bioscience Pty Ltd. | Thyrotropin releasing hormone receptor-orexin receptor hetero-dimers/-oligomers |
EP2097754B2 (en) | 2006-11-28 | 2018-01-24 | Daiichi Sankyo Europe GmbH | Activated her3 as a marker for predicting therapeutic efficacy |
WO2008117278A2 (en) | 2007-03-27 | 2008-10-02 | Rosetta Genomics Ltd. | Gene expression signature for classification of cancers |
JP2008292424A (ja) | 2007-05-28 | 2008-12-04 | Nippon Medical School | 腫瘍の検出方法 |
NZ582618A (en) | 2007-07-13 | 2012-07-27 | Prometheus Lab Inc | Drug selection for lung cancer therapy using antibody-based arrays |
EP2065475A1 (en) | 2007-11-30 | 2009-06-03 | Siemens Healthcare Diagnostics GmbH | Method for therapy prediction in tumors having irregularities in the expression of at least one VEGF ligand and/or at least one ErbB-receptor |
NZ617520A (en) | 2008-02-25 | 2015-05-29 | Nestec Sa | Drug selection for breast cancer therapy using antibody-based arrays |
JP5795311B2 (ja) | 2009-07-15 | 2015-10-14 | ネステク ソシエテ アノニム | 抗体ベースのアレイを使用する胃癌療法のための薬物選択 |
US20120270745A1 (en) | 2009-07-15 | 2012-10-25 | Prometheus Laboratories Inc. | Drug selection for cancer therapy by profiling signal transduction proteins in ascites or pleural efflux samples |
WO2012047294A2 (en) | 2010-10-06 | 2012-04-12 | Ludwig Institute For Cancer Research Ltd | Antibodies directed against hla-b27 homodimers and methods and uses thereof in diagnosis and therapy |
US20120231965A1 (en) | 2011-02-03 | 2012-09-13 | Prometheus Laboratories Inc. | Drug selection for colorectal cancer therapy using antibody-based arrays |
US9719995B2 (en) | 2011-02-03 | 2017-08-01 | Pierian Holdings, Inc. | Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling |
US20130216523A1 (en) | 2011-03-31 | 2013-08-22 | Laboratory Corporation Of America Holdings | Methods for Facilitating Diagnosis, Prognosis and Treatment of Cancer by Detecting HER1 Expression |
KR101851425B1 (ko) | 2011-09-02 | 2018-04-23 | 네스텍 소시에테아노님 | 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링 |
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