DK2366405T3 - Antagonistic IL-17 antibodies - Google Patents

Antagonistic IL-17 antibodies Download PDF

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Publication number
DK2366405T3
DK2366405T3 DK10174725.1T DK10174725T DK2366405T3 DK 2366405 T3 DK2366405 T3 DK 2366405T3 DK 10174725 T DK10174725 T DK 10174725T DK 2366405 T3 DK2366405 T3 DK 2366405T3
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DK
Denmark
Prior art keywords
amino acid
seq
antibody
acid sequence
fragment
Prior art date
Application number
DK10174725.1T
Other languages
Danish (da)
English (en)
Inventor
Padova Franco E Di
Hermann Gram
Hans Hofstetter
Margit Jeschke
Jean-Michel Rondeau
Den Berg Wim Van
Original Assignee
Novartis Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32982602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2366405(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of DK2366405T3 publication Critical patent/DK2366405T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK10174725.1T 2004-08-05 2005-08-04 Antagonistic IL-17 antibodies DK2366405T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417487.6A GB0417487D0 (en) 2004-08-05 2004-08-05 Organic compound
EP05770286.2A EP1776142B9 (en) 2004-08-05 2005-08-04 Il-17 antagonistic antibodies

Publications (1)

Publication Number Publication Date
DK2366405T3 true DK2366405T3 (en) 2015-05-11

Family

ID=32982602

Family Applications (4)

Application Number Title Priority Date Filing Date
DK10174725.1T DK2366405T3 (en) 2004-08-05 2005-08-04 Antagonistic IL-17 antibodies
DK05770286.2T DK1776142T6 (en) 2004-08-05 2005-08-04 Antagonistic antibodies against IL-17th
DK15156029.9T DK2902039T3 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies
DK10175150.1T DK2364729T6 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK05770286.2T DK1776142T6 (en) 2004-08-05 2005-08-04 Antagonistic antibodies against IL-17th
DK15156029.9T DK2902039T3 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies
DK10175150.1T DK2364729T6 (en) 2004-08-05 2005-08-04 IL-17 antagonistic antibodies

Country Status (40)

Country Link
US (9) US7807155B2 (https=)
EP (5) EP2364729B3 (https=)
JP (1) JP4682200B2 (https=)
KR (2) KR100852523B1 (https=)
CN (1) CN101001645B (https=)
AR (1) AR050200A1 (https=)
AT (1) ATE517924T1 (https=)
AU (2) AU2005268857C1 (https=)
BE (1) BE2015C041I2 (https=)
BR (3) BR122017009404B1 (https=)
CA (1) CA2573586C (https=)
CY (6) CY1111963T1 (https=)
DK (4) DK2366405T3 (https=)
EC (1) ECSP077198A (https=)
ES (4) ES2677245T3 (https=)
FR (1) FR15C0048I2 (https=)
GB (1) GB0417487D0 (https=)
HK (1) HK1256639A1 (https=)
HR (3) HRP20110758T4 (https=)
HU (4) HUE038187T2 (https=)
IL (1) IL180717A (https=)
LT (3) LT2902039T (https=)
LU (2) LU92768I2 (https=)
MA (1) MA28982B1 (https=)
MX (1) MX2007001338A (https=)
MY (1) MY144925A (https=)
NL (1) NL300749I2 (https=)
NO (9) NO336279B1 (https=)
NZ (1) NZ552658A (https=)
PE (1) PE20060418A1 (https=)
PL (4) PL2902039T3 (https=)
PT (4) PT1776142E (https=)
RU (2) RU2426741C3 (https=)
SG (1) SG155186A1 (https=)
SI (4) SI1776142T1 (https=)
TN (1) TNSN07034A1 (https=)
TR (1) TR201808057T4 (https=)
TW (1) TWI359153B (https=)
WO (1) WO2006013107A1 (https=)
ZA (1) ZA200700242B (https=)

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KR20070036166A (ko) 2007-04-02
CN101001645A (zh) 2007-07-18
HRP20110758T1 (en) 2011-11-30
DK1776142T3 (da) 2011-10-31
MX2007001338A (es) 2008-03-11
DK2902039T3 (en) 2018-07-16
EP1776142A1 (en) 2007-04-25
LTPA2015029I1 (lt) 2022-07-11
CY2018027I1 (el) 2020-05-29
EP2902039A1 (en) 2015-08-05
NO348010B1 (no) 2024-06-17
PL2364729T6 (pl) 2016-06-30
FR15C0048I2 (fr) 2015-11-20
CY1115444T1 (el) 2017-01-04
HUE038187T2 (hu) 2018-10-29
NO20150064L (no) 2007-03-30
HUS1800040I1 (hu) 2018-11-28
NO2015023I2 (no) 2015-10-26
EP2366405A2 (en) 2011-09-21
US20150152178A1 (en) 2015-06-04
JP4682200B2 (ja) 2011-05-11
SI2902039T1 (en) 2018-07-31
PL1776142T4 (pl) 2018-04-30
LTPA2018515I1 (lt) 2018-10-25
CY2015030I2 (el) 2017-11-14
US8617552B2 (en) 2013-12-31
TWI359153B (en) 2012-03-01
HK1207559A1 (en) 2016-02-05
SI2366405T1 (sl) 2015-07-31
ES2367440T7 (es) 2015-07-14
AU2005268857A1 (en) 2006-02-09
US20120107325A1 (en) 2012-05-03
CA2573586C (en) 2013-06-25

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