DK2341142T3 - HLA-A*1101-begrænset-WT1-peptid og farmaceutisk sammensætning omfattende dette - Google Patents
HLA-A*1101-begrænset-WT1-peptid og farmaceutisk sammensætning omfattende dette Download PDFInfo
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- DK2341142T3 DK2341142T3 DK10191234.3T DK10191234T DK2341142T3 DK 2341142 T3 DK2341142 T3 DK 2341142T3 DK 10191234 T DK10191234 T DK 10191234T DK 2341142 T3 DK2341142 T3 DK 2341142T3
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- peptide
- amino acid
- hla
- seq
- cancer
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Classifications
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- C—CHEMISTRY; METALLURGY
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464452—Transcription factors, e.g. SOX or c-MYC
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A—HUMAN NECESSITIES
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Claims (13)
1 3atentkrav L. Peptid bestående af en aminosyresekvens (1) eller (2): (1) en aminosyresekvens af Thr Gly Val Lys Pro Phe Gin Cys Lys (SEQ ID NO: 7), (2) en aminosyresekvens ifølge SEQ ID NO:7, i hvilket en aminosyre er substitueret med en anden aminosyre, hvor peptidet bestående af en aminosyresekvens of (2) har en evne til at binde til et HLA-A*1101-molekyle, og har en evne til at inducere CTL.
2. Peptiddimer bestående af peptidmonomerer af (1) og (2) der er bundet sammen gennem en disulfidbinding: (1) (1) peptidmonomer bestående af en aminosyresekvens: Thr Gly Val Lys Pro Phe Gin Cys Lys (SEQ ID NO: 7), eller (ii) peptidmonomer bestående af en aminosyresekvens of SEQ ID NO:7, i hvilket en aminosyre er substitueret med en anden aminosyre, (2) (i) peptidmonomer bestående af en aminosyresekvens valgt fra: Thr Gly Val Lys Pro Phe Gin Cys Lys (SEQ ID No: 7), Pro Ile Leu Cys Gly Ala Gin Tyr Arg (SEQ ID No: 3), Lys Thr Cys Gin Arg Lys Phe Ser Arg (SEQ ID No: 8) og Ser Cys Arg Trp Pro Ser Cys Gin Lys (SEQ ID No: 9), eller (ii) peptidmonomer bestående afen aminosyresekvens ifølge SEQ ID NO: 3, SEQ ID NO:7, SEQ ID NO:8 og SEQ ID NO:9, i hvilket en aminosyre er substitueret med en anden aminosyre, 2 hvor peptiddimeren har en evne til at binde til et HLA-A*1101-molekyle og har en evne til at inducere CTL.
3. Farmaceutisk sammensætning til behandlingen eller forebyggelse af en cancer, ! omfattende et peptid ifølge krav 1 og/eller peptiddimeren ifølge krav 2.
4. Anvendelse af et peptid ifølge krav 1 og/eller peptiddimeren ifølge krav 2 til fremstilling af et medikament til behandlingen eller forebyggelse af en cancer i et HLA-A*1101-positivet individ. I
5. Polynukleotid der koder for peptidet ifølge krav 1.
6. Ekspressionsvektor omfattende polynukleotidet ifølge krav 5. ! 7. Farmaceutisk sammensætning til anvendelse i behandlingen eller forebyggelsen af en cancer i et FILA-A*1101-positivt individ, omfattende et polynukleotid der koder for et peptid ifølge krav 1, eller en vektor omfattende polynukleotidet.
8. Anvendelse af et polynukleotid der koder for et peptid ifølge krav 1, eller en vektor omfattende polynukleotidet, til fremstilling af et medikament til behandlingen eller forebyggelse afen cancer i et HLA-A*1101-positivt individ.
9. WTl-specifik CTL, der induceres af et peptid ifølge krav 1 og/eller en peptiddimer ifølge krav 2.
10. Fremgangsmåde til induktionen af en WTl-specifik CTL, omfattende dyrkning af en perifer blod-mononukleær celle opnået fra et HLA-A*1101-positivt individ i tilstedeværelse af et peptid ifølge krav 1 og/eller peptiddimer ifølge krav 2 til at inducere den WT1-specifikke CTL fra den perifere blod-mononukleære celle. i
11. Antigen-præsenterende celle der præsenterer et WTl-peptid, der er induceret in vitro af et peptid ifølge krav 1 og/eller peptiddimer ifølge krav 2.
12. Fremgangsmåde til induktionen af antigen-præsenterende celle der præsenterer et WT1 peptid, omfattende dyrkning af en umoden antigen-præsenterende celle opnået fra et FILA-A*1101-positivt individ i tilstedeværelse af et peptid ifølge krav 1 og/eller en peptiddimer ifølge krav 2 til at inducere den antigen-præsenterende celle der præsenterer et WTl-peptid fra den umodne antigen-præsenterende celle. 3
13. Kit til induktionen af en WTl-specifik CTL eller til induktionen af en antigenpræsenterende celle der præsenterer et WTl-peptid, omfattende peptidet ifølge krav 1 og/eller peptiddimeren ifølge krav 2 som en essentiel komponent.
14. Fremgangsmåde til diagnosen af en cancer i et HLA-A*1101-positivt individ, omfattende inkubering af CTL'en ifølge krav 9 eller den antigen-præsenterende celle ifølge krav 11 med en prøve fra et HLA-A*1101-positivt individ, og bestemme mængden deraf.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006355356 | 2006-12-28 | ||
| EP07850650A EP2098595A4 (en) | 2006-12-28 | 2007-12-14 | HLA-A * 1101 RESTRICTED WT1 PEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2341142T3 true DK2341142T3 (da) | 2014-12-08 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10191234.3T DK2341142T3 (da) | 2006-12-28 | 2007-12-14 | HLA-A*1101-begrænset-WT1-peptid og farmaceutisk sammensætning omfattende dette |
| DK12164855.4T DK2479275T3 (da) | 2006-12-28 | 2007-12-14 | HLA-A*1101-begrænset WT1-peptid og farmaceutisk sammensætning omfattende dette |
| DK12164856.2T DK2479276T3 (da) | 2006-12-28 | 2007-12-14 | HLA-A*-1101-begrænset WT1-peptid og farmaceutisk sammensætning omfattende dette |
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Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2378264T3 (es) | 2003-11-05 | 2012-04-10 | International Institute Of Cancer Immunology, Inc. | Péptido antigénico de unión a HLA-DR derivado de WT1 |
| EP1951281B1 (en) | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| EP3117836A1 (en) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and uses thereof |
| CN103103246B (zh) | 2007-02-27 | 2018-05-01 | 株式会社癌免疫研究所 | 活化辅助t细胞的方法以及用于该方法的组合物 |
| WO2012046730A1 (ja) * | 2010-10-05 | 2012-04-12 | 国立大学法人大阪大学 | ヘルパーｔ細胞の活性化方法 |
| MY160662A (en) * | 2011-04-01 | 2017-03-15 | Memorial Sloan Kettering Cancer Center | T cell receptor-like antibodies specific for a wt1 peptide presented by hla-a2 |
| BR112014002747A2 (pt) * | 2011-09-14 | 2020-10-27 | International Institute Of Cancer Immunology, Inc | método para medir um anticorpo anti-wt1 |
| CN104684577B (zh) | 2012-01-13 | 2018-05-08 | 纪念斯隆凯特林癌症中心 | 免疫原性wt-1肽及其使用方法 |
| KR20150046346A (ko) | 2012-09-12 | 2015-04-29 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 항원 특이적 헬퍼 t 세포 리셉터 유전자 |
| KR102208505B1 (ko) | 2012-12-11 | 2021-01-27 | 앨버트 아인슈타인 컬리지 오브 메디신 | 고처리량 수용체:리간드 확인을 위한 방법 |
| EP2933261B1 (en) * | 2012-12-17 | 2020-06-10 | Otsuka Pharmaceutical Co., Ltd. | Method for activating helper t cell |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| PT2945647T (pt) | 2013-01-15 | 2020-11-26 | Memorial Sloan Kettering Cancer Center | Péptidos imunogénicos wt-1 e métodos de uso dos mesmos |
| KR20140100419A (ko) | 2013-02-05 | 2014-08-14 | 닛토덴코 가부시키가이샤 | 경피 투여용 ｗｔ1 펩티드 암 백신 조성물 |
| CA2840988A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for mucosal administration |
| EP2762157A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Vaccine composition for transdermal or mucosal administration |
| RU2685933C2 (ru) | 2013-02-05 | 2019-04-23 | Нитто Денко Корпорейшн | Композиция противораковой вакцины, содержащая пептид wt1, для трансдермального введения |
| RU2014102945A (ru) | 2013-02-05 | 2015-08-10 | Нитто Денко Корпорейшн | Вакцинная композиция |
| JP6512569B2 (ja) | 2013-02-05 | 2019-05-15 | 日東電工株式会社 | 経皮投与用ｗｔ１ペプチド癌ワクチンテープ剤 |
| CA2840974A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Vaccine composition for mucosal administration |
| CN103961306A (zh) | 2013-02-05 | 2014-08-06 | 日东电工株式会社 | 经皮给予用疫苗组合物 |
| MX364459B (es) * | 2013-03-29 | 2019-04-26 | Sumitomo Dainippon Pharma Co Ltd | Vacuna de conjugado de péptido-antígeno de wt1. |
| JP6671956B2 (ja) * | 2013-03-29 | 2020-03-25 | 大日本住友製薬株式会社 | Ｅｒａｐ１によるトリミング機能をきっかけとしたコンジュゲートワクチン |
| US10525096B2 (en) | 2014-12-11 | 2020-01-07 | International Institute Of Cancer Immunology, Inc. | Immunotherapy for angiogenic disease |
| US11339201B2 (en) | 2016-05-18 | 2022-05-24 | Albert Einstein College Of Medicine | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
| WO2017201210A1 (en) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| AU2017379900A1 (en) | 2016-12-22 | 2019-06-13 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3565829A4 (en) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| US20200368338A1 (en) * | 2017-12-27 | 2020-11-26 | Sumitomo Dainippon Pharma Co., Ltd. | Conjugate of wt1-derived peptides and composition comprising the same |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| WO2021230247A1 (ja) * | 2020-05-12 | 2021-11-18 | 大日本住友製薬株式会社 | 癌を処置するための医薬組成物 |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575374A (en) * | 1983-02-16 | 1986-03-11 | Anis Aziz Y | Flexible anterior chamber lens |
| US5763209A (en) * | 1988-09-26 | 1998-06-09 | Arch Development Corporation | Methods and materials relating to the functional domains of DNA binding proteins |
| US5584304A (en) * | 1993-11-18 | 1996-12-17 | Allergan, Inc. | Method of inserting an IOL using a forceps inside a folding tube |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5984962A (en) * | 1996-01-22 | 1999-11-16 | Quantum Vision, Inc. | Adjustable intraocular lens |
| US6207375B1 (en) * | 1996-12-11 | 2001-03-27 | Mayo Foundation For Medical Educational & Research | TGF-β inducible early factor-1 (TIEF-1) and a method to detect breast cancer |
| US7655249B2 (en) | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030039635A1 (en) | 1998-09-30 | 2003-02-27 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7144581B2 (en) * | 2000-10-09 | 2006-12-05 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| MY139226A (en) * | 1998-09-30 | 2009-08-28 | Corixa Corp | Compositions and methods for wt1 specific immunotherapy |
| US7063854B1 (en) * | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
| US7115272B1 (en) | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20030072767A1 (en) * | 1998-09-30 | 2003-04-17 | Alexander Gaiger | Compositions and methods for WT1 specific immunotherapy |
| CZ20013527A3 (cs) * | 1999-04-02 | 2002-10-16 | Corixa Corporation | Sloučeniny a způsoby pro terapii a diagnostiku karcinomu plic |
| AU7859900A (en) * | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| AU2001247220A1 (en) | 2000-02-22 | 2001-09-03 | Corixa Corporation | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| US20030082194A1 (en) | 2000-02-22 | 2003-05-01 | Alexander Gaiger | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| TWI318630B (en) * | 2001-03-22 | 2009-12-21 | Int Inst Cancer Immunology Inc | Wt1 modified peptide |
| IL145015A0 (en) * | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
| US7553494B2 (en) * | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| CN101113163B (zh) | 2002-06-12 | 2010-10-06 | 株式会社国际癌症免疫研究所 | Hla-a24限制性癌抗原肽 |
| KR20050010515A (ko) | 2002-06-14 | 2005-01-27 | 머크 앤드 캄파니 인코포레이티드 | 유사분열 키네신 억제제 |
| SE0201863D0 (en) * | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| US20060217297A1 (en) * | 2003-01-15 | 2006-09-28 | Haruo Sugiyama | Dimerized peptide |
| US7976520B2 (en) * | 2004-01-12 | 2011-07-12 | Nulens Ltd. | Eye wall anchored fixtures |
| ATE462003T1 (de) | 2004-03-31 | 2010-04-15 | Int Inst Cancer Immunology Inc | Aus wt1 stammende krebsantigenpeptide |
| JP2006045287A (ja) | 2004-08-02 | 2006-02-16 | Inax Corp | 弾性接着剤及びタイル張り壁面 |
| JP4719876B2 (ja) * | 2005-04-04 | 2011-07-06 | 国立大学法人愛媛大学 | Ｈｌａクラスｉｉ拘束性ｗｔ１抗原ペプチド |
| EP2337795A2 (en) * | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
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