RU2014102945A - Вакцинная композиция - Google Patents
Вакцинная композиция Download PDFInfo
- Publication number
- RU2014102945A RU2014102945A RU2014102945/10A RU2014102945A RU2014102945A RU 2014102945 A RU2014102945 A RU 2014102945A RU 2014102945/10 A RU2014102945/10 A RU 2014102945/10A RU 2014102945 A RU2014102945 A RU 2014102945A RU 2014102945 A RU2014102945 A RU 2014102945A
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- Prior art keywords
- agonist
- receptor agonist
- receptor
- vaccine composition
- composition according
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract 25
- 229960005486 vaccine Drugs 0.000 title claims abstract 14
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- 239000000018 receptor agonist Substances 0.000 claims abstract 6
- 239000000556 agonist Substances 0.000 claims abstract 5
- 230000007969 cellular immunity Effects 0.000 claims abstract 5
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- 125000004122 cyclic group Chemical group 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
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- Peptides Or Proteins (AREA)
Abstract
1. Вакцинная композиция, для применения в стимуляции клеточного иммунитета, содержащаяантиген ипо меньшей мере один первый промотор стимуляции клеточного иммунитета, выбранный из группы, состоящей из ингибитора циклооксигеназы, антагониста простагландинового рецептора, агониста простагландинового рецептора, ингибитора продукции TSLP, ингибитора аденилатциклазы, омега-3 жирной кислоты, агониста PPAR, антагониста дофаминового рецептора, агониста дофаминового рецептора, агониста гистаминового рецептора, антагониста гистаминового рецептора, агониста серотонинового рецептора, антагониста серотонинового рецептора, антагониста рецептора вазопрессина, агониста рецептора вазопрессина, антагониста мускаринового рецептора, агониста мускаринового рецептора, антагониста адренергического рецептора, агониста адренергического рецептора, агониста рецептора ангиотензина, агониста GABA-рецептора, антагониста рецептора тромбина, агониста рецептора тромбина, агониста опиоидного рецептора, агониста рецептора ADP, антагониста лейкотриенового рецептора, агониста лейкотриенового рецептора, агониста рецептора мелатонина, агониста рецептора соматостатина, агониста каннабиноидного рецептора, агониста рецептора сфингозин-1-фосфата, агониста метаботропного глутаматного рецептора, ингибитора фосфолипазы А2, ингибитора продукции TGF-β и ингибитора цитокинов Th2.2. Вакцинная композиция по п.1, где композиция предназначена для применения в лечении рака.3. Вакцинная композиция по п.1, где композиция предназначена для применения в лечении вирусного заболевания.4. Вакцинная композиция по п.1, где композиция дополнительно содержит по
Claims (9)
1. Вакцинная композиция, для применения в стимуляции клеточного иммунитета, содержащая
антиген и
по меньшей мере один первый промотор стимуляции клеточного иммунитета, выбранный из группы, состоящей из ингибитора циклооксигеназы, антагониста простагландинового рецептора, агониста простагландинового рецептора, ингибитора продукции TSLP, ингибитора аденилатциклазы, омега-3 жирной кислоты, агониста PPAR, антагониста дофаминового рецептора, агониста дофаминового рецептора, агониста гистаминового рецептора, антагониста гистаминового рецептора, агониста серотонинового рецептора, антагониста серотонинового рецептора, антагониста рецептора вазопрессина, агониста рецептора вазопрессина, антагониста мускаринового рецептора, агониста мускаринового рецептора, антагониста адренергического рецептора, агониста адренергического рецептора, агониста рецептора ангиотензина, агониста GABA-рецептора, антагониста рецептора тромбина, агониста рецептора тромбина, агониста опиоидного рецептора, агониста рецептора ADP, антагониста лейкотриенового рецептора, агониста лейкотриенового рецептора, агониста рецептора мелатонина, агониста рецептора соматостатина, агониста каннабиноидного рецептора, агониста рецептора сфингозин-1-фосфата, агониста метаботропного глутаматного рецептора, ингибитора фосфолипазы А2, ингибитора продукции TGF-β и ингибитора цитокинов Th2.
2. Вакцинная композиция по п.1, где композиция предназначена для применения в лечении рака.
3. Вакцинная композиция по п.1, где композиция предназначена для применения в лечении вирусного заболевания.
4. Вакцинная композиция по п.1, где композиция дополнительно содержит по меньшей мере один второй промотор стимуляции клеточного иммунитета, выбранный из группы, состоящей из лиганда TLR, циклического динуклеотида, низкомолекулярного иммуномодулирующего препарата и/или хелперного пептида.
5. Вакцинная композиция по п.1, где композицию вводят на кожу и/или слизистую оболочку.
6. Вакцинная композиция по п.5, где композицию вводят на кожу, находящуюся в состоянии умеренного раздражения.
7. Вакцинная композиция по п.6, где состояние умеренного раздражения представляет собой состояние, при котором трансэпидермальная потеря воды (TEWL) на модельных животных, используемых для оценки раздражения кожи, перед введением композиции составляет 50 г/ч·м2 или ниже.
8. Вакцинная композиция по п.5, где состояние умеренного раздражения представляет собой состояние, при котором уровень кожного TEWL на модельных животных, используемых для оценки раздражения кожи, после окончания введения композиции составляет 10000 пг/мг белка или ниже.
9. Вакцинная композиция по п.1, где композицию вводят внутрикожной инъекцией, подкожной инъекцией или внутримышечной инъекцией.
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JP2016074654A (ja) * | 2014-10-02 | 2016-05-12 | 日東電工株式会社 | 経皮投与用ワクチン医薬組成物 |
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CN103961701B (zh) | 2018-09-14 |
JP6473292B2 (ja) | 2019-02-20 |
EP3662927A2 (en) | 2020-06-10 |
EP3662927A3 (en) | 2020-10-21 |
KR20140100422A (ko) | 2014-08-14 |
US10076491B2 (en) | 2018-09-18 |
CA2840959A1 (en) | 2014-08-05 |
IN2014CH00396A (ru) | 2015-04-03 |
EP2762155A3 (en) | 2015-11-04 |
EP2762155A2 (en) | 2014-08-06 |
US20140220063A1 (en) | 2014-08-07 |
JP2014169281A (ja) | 2014-09-18 |
CN103961701A (zh) | 2014-08-06 |
EP2762155B1 (en) | 2020-03-11 |
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