DK2170952T3 - Rsv-specifikke bindingsmolekyler og middel til fremstilling deraf - Google Patents
Rsv-specifikke bindingsmolekyler og middel til fremstilling deraf Download PDFInfo
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- DK2170952T3 DK2170952T3 DK08766756.4T DK08766756T DK2170952T3 DK 2170952 T3 DK2170952 T3 DK 2170952T3 DK 08766756 T DK08766756 T DK 08766756T DK 2170952 T3 DK2170952 T3 DK 2170952T3
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- Peptides Or Proteins (AREA)
Claims (11)
1. Isoleret antistof eller funktionsdygtig del deraf, som er i stand til specifikt at binde respiratorisk syncytialvirus (RSV)-F-antigen, og hvor antistoffet eller den funktionsdygtige del deraf omfatter: a. en tungkæde-komplementaritetsbestemmende region (CDR) 1, som omfatter aminosyresekvensen NYIIN (SEQ ID NO: 1), en tungkæde-CDR2, som omfatter aminosyresekvensen GIIPVLGTVHYAPKFQG (SEQ ID NO: 2), en tungkæde-CDR3, som omfatter aminosyresekvensen ETALVVSTTYLPHYFDN (SEQ ID NO: 3), en letkæde-CDRl, som omfatter aminosyresekvensen QASQDIVNYLN (SEQ ID NO: 4), en letkæde-CDR2, som omfatter aminosyresekvensen VASNLET (SEQ ID NO: 5), og en letkæde-CDR3, som omfatter aminosyresekvensen QQYDNLP (SEQ ID NO: 6); eller b. en tungkæde-CDR1, som omfatter aminosyresekvensen GFSFSHYA (SEQ ID NO: 73), en tungkæde-CDR2-sekvens, som omfatter aminosyresekvensen ISYDGENT (SEQ ID NO: 74), en tungkæde-CDR3-sekvens, som omfatter aminosyresekvensen ARDRIVDDYYYYGMDV (SEQ ID NO: 75), en letkæde-CDRl, som omfatter aminosyresekvensen QDIKKY (SEQ ID NO: 76), en letkæde-CDR2, som omfatter aminosyresekvensen DAS, og en letkæde-CDR3, som omfatter aminosyresekvensen QQYDNLPPLT (SEQ ID NO: 77); eller c. en tungkæde-CDRl, som omfatter aminosyresekvensen GFTFSSYN (SEQ ID NO: 80), en tungkæde-CDR2-sekvens, som omfatter aminosyresekvensen ISAGSSYI (SEQ ID NO: 81), en tungkæde-CDR3-sekvens, som omfatter aminosyresekvensen AREDYGPGNYYSPNWFDP (SEQ ID NO: 82), en letkæde-CDRl, som omfatter aminosyresekvensen SSNIGAGYD (SEQ ID NO: 83), en letkæde-CDR2, som omfatter aminosyresekvensen GNT, og en letkæde-CDR3, som omfatter aminosyresekvensen HSYDRSLSG (SEQ ID NO: 84); eller d. en tungkæde-CDRl, som omfatter aminosyresekvensen GFNFHNYG (SEQ ID NO: 87), en tungkæde-CDR2-sekvens, som omfatter aminosyresekvensen VWYDGSKK (SEQ ID NO: 88), en tungkæde-CDR3-sekvens, som omfatter aminosyresekvensen VRDKVGPTPYFDS (SEQ ID NO: 89), en letkæde-CDRl, som omfatter aminosyresekvensen NIGSET (SEQ ID NO: 90), en letkæde-CDR2, som omfatter aminosyresekvensen DDD, og en letkæde-CDR3, som omfatter aminosyresekvensen QVWDRSNYHQV (SEQ ID NO: 91).
2. Antistof eller funktionsdygtig del deraf ifølge krav 1, hvor antistoffet omfatter en variabel tungkæde-sekvens, som omfatter aminosyresekvensen QVQLVQSGAEVKKPGSSVMVSCQASGGPLRNYIINWLRQAPGQGPEWMG-GIIPVLG TVHYAPKFQGRVTITADESTDTAYIHLISLRSEDTAMYYCATETA LVVSTTYLPHYFDN WGQGTLVTVSS (SEQ ID NO: 7), og/eller en variabel letkæde- sekvens, som omfatter aminosyresekvensen DIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYV-ASNLETG VPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGT KVEIKRTV (SEQ ID NO: 8).
3. Antistof eller funktionsdygtig del deraf ifølge krav 1, hvor den funktionsdygtige del deraf er et enkelt domæneantistof, et enkeltkædet antistof, et enkeltkædet variabelt fragment (scFv), et Fab-fragment eller et F(ab')2-fragment.
4. Isoleret nukleinsyre, som koder for antistoffet eller den funktionsdygtige del deraf ifølge et hvilket som helst af kravene 1-3.
5. Isoleret nukleinsyresekvens ifølge krav 4, hvor nukleinsyresekvensen omfatter tung- og letkæde- nukleotidsekvenser valgt fra gruppen bestående af: (i) SEQ ID NO: 9 og SEQ ID NO: 10; (ii) SEQ ID NO: 139 og SEQ ID NO: 141; og (iii) SEQ ID NO: 140 og SEQ ID NO: 142.
6. Celle, som udtrykker nukleinsyresekvensen ifølge krav 4 eller 5.
7. Fremgangsmåde til fremstilling af et antistof eller en funktionsdygtig del deraf ifølge et hvilket som helst af kravene 1-3, hvilken fremgangsmåde omfatter dyrkning af cellen ifølge krav 6 in vitro og opnåelse af antistoffer eller funktionsdygtige dele deraf, som er fremstillet af cellerne.
8. Sammensætning, som omfatter antistoffet af (of) funktionsdygtig del deraf ifølge et hvilket som helst af kravene 1-6 og en farmaceutisk acceptabel bærer, et farmaceutisk acceptabelt fortyndingsmiddel og/eller en farmaceutisk acceptabel excipiens.
9. Antistof eller funktionsdygtig del deraf ifølge et hvilket som helst af kravene 1-3 eller sammensætning ifølge krav 8 eller nukleinsyresekvens ifølge krav 4 eller 5 til anvendelse til behandling eller forebyggelse af en RSV-relateret lidelse eller forebyggelse eller modvirkning af bivirkningerne af en RSV-infektion hos et menneske.
10. Anvendelse af antistoffet eller en funktionsdygtig del deraf ifølge et hvilket som helst af kravene 1-3 eller sammensætningen ifølge krav 8 eller nukleinsyresekvensen ifølge krav 4 eller 5 til fremstilling af et lægemiddel til behandling eller forebyggelse af en RSV-relateret lidelse eller forebyggelse eller modvirkning af bivirkninger af en RSV-infektion hos et menneske.
11. Antistof eller funktionsdygtig del deraf, sammensætning eller nukleinsyresekvens ifølge krav 9 til anvendelse ifølge krav 9, eller anvendelse ifølge krav 10, hvor mennesket har en kronisk lungesygdom, medfødt hjertesygdom eller kompromitteret immunitet, eller mennesket er et barn, som er under 6 uger gammelt, eller et ældre menneske, eventuelt hvor antistoffet eller den funktionsdygtige del deraf er formuleret til administration i en dosering på 0,1 til 10 mg/kg af menneskets kropsvægt.
Applications Claiming Priority (2)
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EP07109472A EP1997830A1 (en) | 2007-06-01 | 2007-06-01 | RSV specific binding molecules and means for producing them |
PCT/NL2008/050333 WO2008147196A2 (en) | 2007-06-01 | 2008-05-30 | Rsv-specific binding molecules and means for producing them |
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DK08766756.4T DK2170952T3 (da) | 2007-06-01 | 2008-05-30 | Rsv-specifikke bindingsmolekyler og middel til fremstilling deraf |
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