DK2105164T3 - Nye P2X7R-antagonister og deres anvendelse - Google Patents

Nye P2X7R-antagonister og deres anvendelse

Info

Publication number
DK2105164T3
DK2105164T3 DK09004301.9T DK09004301T DK2105164T3 DK 2105164 T3 DK2105164 T3 DK 2105164T3 DK 09004301 T DK09004301 T DK 09004301T DK 2105164 T3 DK2105164 T3 DK 2105164T3
Authority
DK
Denmark
Prior art keywords
new
p2x7r
antagonists
p2x7r antagonists
carboxamide
Prior art date
Application number
DK09004301.9T
Other languages
Danish (da)
English (en)
Inventor
Michael Boes
Original Assignee
Affectis Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affectis Pharmaceuticals Ag filed Critical Affectis Pharmaceuticals Ag
Application granted granted Critical
Publication of DK2105164T3 publication Critical patent/DK2105164T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK09004301.9T 2008-03-25 2009-03-25 Nye P2X7R-antagonister og deres anvendelse DK2105164T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08005532 2008-03-25
US4105008P 2008-03-31 2008-03-31

Publications (1)

Publication Number Publication Date
DK2105164T3 true DK2105164T3 (da) 2011-03-21

Family

ID=41010874

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09004301.9T DK2105164T3 (da) 2008-03-25 2009-03-25 Nye P2X7R-antagonister og deres anvendelse

Country Status (18)

Country Link
US (2) US8232290B2 (fr)
EP (1) EP2105164B1 (fr)
JP (1) JP5506776B2 (fr)
CN (1) CN102046240B (fr)
AT (1) ATE494926T1 (fr)
AU (1) AU2009228649B2 (fr)
BR (1) BRPI0910034B1 (fr)
CA (1) CA2719745C (fr)
DE (1) DE602009000550D1 (fr)
DK (1) DK2105164T3 (fr)
EA (1) EA022505B1 (fr)
ES (1) ES2357682T3 (fr)
IL (1) IL207976A0 (fr)
NZ (1) NZ587799A (fr)
PL (1) PL2105164T3 (fr)
PT (1) PT2105164E (fr)
WO (1) WO2009118175A1 (fr)
ZA (1) ZA201006782B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8815892B2 (en) * 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
WO2010075449A1 (fr) 2008-12-24 2010-07-01 Quest Diagnostics Investments Incorporated Analyse par spectrométrie de masse pour l'hyperplasie surrénale congénitale
CN102395562A (zh) * 2009-04-14 2012-03-28 阿费克蒂斯制药股份公司 新的p2x7r拮抗剂及其用途
WO2012110190A1 (fr) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Nouveaux antagonistes p2x7r et leur utilisation
WO2012163792A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
WO2012163456A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
BR112014001454A2 (pt) 2011-07-22 2017-06-27 Actelion Pharmaceuticals Ltd derivados de amidas heterocíclicas como antagonistas do receptor de p2x7
JP6111268B2 (ja) * 2012-01-20 2017-04-05 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
EP2931717B1 (fr) 2012-12-12 2016-12-07 Actelion Pharmaceuticals Ltd. Dérivés d'indole carboxamide utilisés en tant qu'antagonistes du récepteur p2x7
US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
EP2956457B1 (fr) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7
EP2956135B1 (fr) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7
US10071167B2 (en) 2013-05-08 2018-09-11 Children's Medical Center Corporation Method of preventing and treating type 1 diabetes, allograft rejection and lung fibrosis (by targeting the ATP/P2X7R axis)
WO2016100281A1 (fr) * 2014-12-15 2016-06-23 Merck Patent Gmbh Dérivés indoliques et azaindoliques et leur utilisation dans le traitement de maladies neurodégénératives
CN109879790B (zh) * 2017-12-06 2022-09-20 华东师范大学 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法
CN110668992B (zh) * 2018-07-02 2023-06-09 华东师范大学 Ido/hdac双靶点化合物及其合成方法和应用

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
WO1998038179A1 (fr) 1997-02-26 1998-09-03 Glaxo Group Limited Derives d'hydroxamate utilises comme inhibiteurs de metalloprotease
ZA988967B (en) 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
SE9704544D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704546D0 (sv) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
EP1087937A1 (fr) 1998-06-17 2001-04-04 Du Pont Pharmaceuticals Company Acides hydroxamiques cycliques utilises en tant qu'inhibiteurs de metalloproteases
US6239151B1 (en) 1998-06-26 2001-05-29 Hoffmann-La Roche Inc. Compounds as inhibitor of tumor necrosis factor alpha release
UA59453C2 (uk) 1998-08-12 2003-09-15 Пфайзер Продактс Інк. Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ
US20040122011A1 (en) 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6225311B1 (en) 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
BR0009651A (pt) 1999-04-09 2002-01-08 Astrazeneca Ab Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, e, método para tratar artrite reumatóide e uma doença obstrutiva das vias aéreas
SE9901875D0 (sv) 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
SE9904738D0 (sv) 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
JP2004502642A (ja) * 2000-02-11 2004-01-29 ブリストル−マイヤーズ　スクイブ　カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用
GB0013737D0 (en) 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
EP1314721A1 (fr) 2000-08-31 2003-05-28 Wakunaga Pharmaceutical Co., Ltd. Nouveaux derives d'acide propenohydroxamique
WO2002096426A1 (fr) 2001-05-25 2002-12-05 Bristol-Myers Squibb Company Derives d'hydantoine utilises comme inhibiteurs des metalloproteinases matricielles
FR2825926A1 (fr) * 2001-06-14 2002-12-20 Sod Conseils Rech Applic Derives d'imidazoles modulant les canaux sodiques
WO2003016248A2 (fr) 2001-08-17 2003-02-27 Bristol-Myers Squibb Company Patent Department Hydroxamates bicycliques utilises comme inhibiteurs de metalloproteinases matricielles et/ou enzyme de conversion du tnf-$g(a) (tace)
WO2003024899A2 (fr) 2001-09-17 2003-03-27 Bristol-Myers Squibb Company Acides hydroxamiques cycliques utilises comme inhibiteurs de metalloproteinases matricielles et/ou d'enzyme de conversion du tnf-$g(a) (tace)
WO2003031431A1 (fr) 2001-10-09 2003-04-17 Bristol-Myers Squibb Company Derives de sulfone cycliques utilises comme inhibiteurs de metalloproteinases matricielles et/ou d'enzyme de conversion du tnf-$g(a) (tace)
AU2002365132A1 (en) 2001-10-17 2003-07-15 Bristol-Myers Squibb Company BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-Alpha CONVERTING ENZYME (TACE)
US20030212056A1 (en) 2001-11-02 2003-11-13 Jingwu Duan Beta-sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
WO2003042190A1 (fr) 2001-11-12 2003-05-22 Pfizer Products Inc. Derives de n-adamantylalkyle benzamide en tant qu'antagonistes du recepteur p2x7
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
SE0103836D0 (sv) 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
AU2002359524A1 (en) 2001-11-30 2003-06-17 The Government Of The United States Of America, Represented By The Secretary, Department Of Health A P2x7 receptor antagonists
AU2002357312A1 (en) 2001-12-20 2003-07-09 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-alpha converting enzyme (tace) and/or matrix metalloproteinases
NZ533649A (en) 2001-12-21 2006-01-27 King Pharmaceuticals Res & Dev Tyrosyl derivatives and their use as P2X7 receptor modulators
WO2003079986A2 (fr) 2002-03-18 2003-10-02 Bristol-Myers Squibb Company Derives d'uracile utilises en tant qu'inhibiteurs de l'enzyme tnf-alpha convertase (tace) et metalloproteases matricielles
SE0200920D0 (sv) 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
GB0216379D0 (en) 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
WO2004012663A2 (fr) 2002-08-01 2004-02-12 Bristol-Myers Squibb Company Derives d'yhydantoine utilises comme inhibiteurs de metalloproteases maticielles et/ou d'enzyme de conversion de tnf-alpha
EP1546109A4 (fr) 2002-10-04 2005-11-09 Bristol Myers Squibb Co Derives d'hydantoine en tant qu'inhibiteurs de metalloproteinases matricielles et/ou de l'enzyme de conversion de tnf-alpha (tace)
EP1558581A4 (fr) 2002-10-07 2007-07-25 Bristol Myers Squibb Co Derives de la triazolone et de la triazolethione
WO2004043349A2 (fr) 2002-11-06 2004-05-27 Bristol-Myers Squibb Company Derives d'isoxazoline comme inhibiteurs de metalloproteases matricielles et/ou d'enzyme de conversion de tnf-$g(a)
AU2003288640A1 (en) 2002-12-31 2004-07-22 Pfizer Products Inc. Benzamide inhibitors of the p2x7 receptor
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
ITMI20030287A1 (it) * 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
SE0300480D0 (sv) 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP4731468B2 (ja) 2003-05-12 2011-07-27 ファイザー・プロダクツ・インク Ｐ２ｘ７受容体のベンズアミド阻害剤
GB0312609D0 (en) 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
US7132432B2 (en) 2003-06-05 2006-11-07 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
SE0302139D0 (sv) 2003-07-28 2003-07-28 Astrazeneca Ab Novel compounds
SE0302192D0 (sv) 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
WO2005019182A1 (fr) 2003-08-20 2005-03-03 Bayer Healthcare Ag Derives de pyrazolylmethylbenzamide utilises comme antagonistes du recepteur p2xt
JP2007509180A (ja) 2003-10-21 2007-04-12 インスパイアー ファーマシューティカルズ，インコーポレイティド 疼痛を治療するための、非ヌクレオチド組成物および方法
WO2005111003A1 (fr) 2004-04-29 2005-11-24 Abbott Laboratories Analogues d’amino-tétrazoles et méthodes d’utilisation
AU2005258911A1 (en) 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3H`1,2,4!triazin-2-YL!-benzamide derivatives by deprotecting the hydroxyl-protected precursers
WO2006003513A1 (fr) 2004-06-29 2006-01-12 Pfizer Products Inc. Procede de preparation de derives de 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4-triazin-2-yl-benzamide aant une activite inhibant p2x7 par reaction du derive non substitue en position 4 de triazine avec un oxyrane en presence d'un acide de lewis
US7241776B2 (en) 2004-08-02 2007-07-10 Abbott Laboratories Cyanoamidine P2X7 antagonists for the treatment of pain
SA05260265A (ar) 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
SE0402925D0 (sv) 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
NZ555768A (en) 2004-12-24 2009-12-24 Astrazeneca Ab Benzamide derivatives as inhibitors of cytokine mediated disease
JP2008528580A (ja) 2005-01-27 2008-07-31 アストラゼネカ・アクチエボラーグ Ｐ２ｘ７受容体の阻害剤である新規二環式芳香族化合物
US20060211739A1 (en) 2005-02-08 2006-09-21 Arturo Perez-Medrano Use of selective P2X7 receptor antagonists
US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
WO2006110516A1 (fr) 2005-04-11 2006-10-19 Abbott Laboratories Antagonistes de l'acylhydrazide p2x7 et leurs utilisations
EP1885376A1 (fr) 2005-05-05 2008-02-13 Medicure International Inc. Inhibition des voies dependantes de p2x7 mediees par l'atp au moyen de pyridoxal-5-phosphate et de composes associes a la vitamine b6
WO2007016597A2 (fr) 2005-07-29 2007-02-08 The Regents Of The University Of California Ciblage de secretion de facteur de croissance dependant d'enzyme de conversion de tnf-alpha (tace) dans une therapie anticancereuse
US20090124555A1 (en) 2005-08-29 2009-05-14 Irma Bernatchez-Lemaire Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents
US20100022531A1 (en) 2005-09-01 2010-01-28 Renovis, Inc. Novel compounds as p2x7 modulators and uses thereof
JP2009514864A (ja) 2005-11-07 2009-04-09 アボット・ラボラトリーズ Ｐ２ｘ７受容体拮抗薬および使用方法
CA2628260A1 (fr) 2005-11-09 2007-05-18 Abbott Laboratories Antagonistes des recepteurs p2x7 et utilisations associees
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
EP1937643B1 (fr) 2006-03-16 2016-07-13 Second Genome, Inc. Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 et leurs utilisations
CA2645652A1 (fr) 2006-03-16 2007-09-27 Renovis, Inc. Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations
DK2001474T3 (en) 2006-03-16 2016-05-09 Second Genome Inc BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND APPLICATIONS THEREOF
WO2007109201A2 (fr) 2006-03-16 2007-09-27 Renovis, Inc. Composés de bicyclohétéroaryle en tant que modulateur de p2x7 et leurs utilisations
WO2007109182A2 (fr) 2006-03-16 2007-09-27 Renovis, Inc. Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 et leurs utilisations
US20090149524A1 (en) 2006-06-06 2009-06-11 Paul John Beswick N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration
GB0611154D0 (en) 2006-06-06 2006-07-19 Glaxo Group Ltd Novel receptor antagonists and their methods of use
US20080076924A1 (en) 2006-06-30 2008-03-27 Patrick Betschmann Piperazines as P2X7 antagonists
EA016076B1 (ru) 2006-07-06 2012-01-30 Глэксо Груп Лимитед Замещенные n-фенилметил-5-оксопролин-2-амиды в качестве антагонистов р2х7-рецептора и способы их применения
CA2714573A1 (fr) * 2008-02-29 2009-09-03 Pfizer Inc. Derives d'indazole
CN102395562A (zh) * 2009-04-14 2012-03-28 阿费克蒂斯制药股份公司 新的p2x7r拮抗剂及其用途

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JP5506776B2 (ja) 2014-05-28
NZ587799A (en) 2012-06-29
JP2011515432A (ja) 2011-05-19
PL2105164T3 (pl) 2011-05-31
US20090312366A1 (en) 2009-12-17
CN102046240A (zh) 2011-05-04
CA2719745A1 (fr) 2009-10-01
CN102046240B (zh) 2014-06-25
WO2009118175A1 (fr) 2009-10-01
CA2719745C (fr) 2016-07-05
ZA201006782B (en) 2011-05-25
ES2357682T3 (es) 2011-04-28
US8232290B2 (en) 2012-07-31
US20120302597A1 (en) 2012-11-29
EA022505B1 (ru) 2016-01-29
AU2009228649B2 (en) 2014-05-22
EP2105164B1 (fr) 2011-01-12
BRPI0910034A2 (pt) 2021-03-30
AU2009228649A1 (en) 2009-10-01
ATE494926T1 (de) 2011-01-15
IL207976A0 (en) 2010-12-30
BRPI0910034B1 (pt) 2022-02-08
EP2105164A1 (fr) 2009-09-30
DE602009000550D1 (de) 2011-02-24
US8569334B2 (en) 2013-10-29
EA201001522A1 (ru) 2011-06-30

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