CA2645652A1 - Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations - Google Patents
Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations Download PDFInfo
- Publication number
- CA2645652A1 CA2645652A1 CA002645652A CA2645652A CA2645652A1 CA 2645652 A1 CA2645652 A1 CA 2645652A1 CA 002645652 A CA002645652 A CA 002645652A CA 2645652 A CA2645652 A CA 2645652A CA 2645652 A1 CA2645652 A1 CA 2645652A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- unsubstituted
- compound according
- alkyl
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78330406P | 2006-03-16 | 2006-03-16 | |
US78374806P | 2006-03-16 | 2006-03-16 | |
US78297306P | 2006-03-16 | 2006-03-16 | |
US78277506P | 2006-03-16 | 2006-03-16 | |
US78277606P | 2006-03-16 | 2006-03-16 | |
US78292206P | 2006-03-16 | 2006-03-16 | |
US78278206P | 2006-03-16 | 2006-03-16 | |
US78359006P | 2006-03-16 | 2006-03-16 | |
US78312106P | 2006-03-16 | 2006-03-16 | |
US60/782,922 | 2006-03-16 | ||
US60/782,776 | 2006-03-16 | ||
US60/782,973 | 2006-03-16 | ||
US60/782,782 | 2006-03-16 | ||
US60/783,121 | 2006-03-16 | ||
US60/782,923 | 2006-03-16 | ||
US60/782,775 | 2006-03-16 | ||
US60/783,590 | 2006-03-16 | ||
US60/783,748 | 2006-03-16 | ||
US60/783,304 | 2006-03-16 | ||
US83141606P | 2006-07-17 | 2006-07-17 | |
US60/831,416 | 2006-07-17 | ||
US84699306P | 2006-09-25 | 2006-09-25 | |
US60/846,993 | 2006-09-25 | ||
US91812307P | 2007-03-15 | 2007-03-15 | |
US60/918,123 | 2007-03-15 | ||
US78292307P | 2007-03-16 | 2007-03-16 | |
PCT/US2007/006676 WO2007109154A2 (fr) | 2006-03-16 | 2007-03-16 | Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2645652A1 true CA2645652A1 (fr) | 2007-09-27 |
Family
ID=38522986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002645652A Abandoned CA2645652A1 (fr) | 2006-03-16 | 2007-03-16 | Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2645652A1 (fr) |
WO (1) | WO2007109154A2 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2576643T3 (es) * | 2007-03-09 | 2016-07-08 | Second Genome, Inc. | Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos |
KR20100084516A (ko) * | 2007-10-31 | 2010-07-26 | 닛산 가가쿠 고교 가부시키 가이샤 | 피리다지논 유도체 및 이의 p2x7 수용체 억제제로서의 용도 |
CA2719745C (fr) | 2008-03-25 | 2016-07-05 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes de p2x7r et leur utilisation |
CA2747158A1 (fr) * | 2008-12-16 | 2010-07-08 | Sirtris Pharmaceuticals, Inc. | Phtalazinone et analogues apparentes en tant que modulateurs de la sirtuine |
GB0906274D0 (en) | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
ATE541832T1 (de) | 2009-04-14 | 2012-02-15 | Affectis Pharmaceuticals Ag | Neuartige p2x7r-antagonisten und ihre verwendung |
EP2386541A1 (fr) | 2010-05-14 | 2011-11-16 | Affectis Pharmaceuticals AG | Nouveaux procédés de préparation d'antagonistes de P2X7R |
WO2012110190A1 (fr) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes p2x7r et leur utilisation |
WO2012163456A1 (fr) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes de p2x7r et leur utilisation |
WO2012163792A1 (fr) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes de p2x7r et leur utilisation |
CA2838640C (fr) | 2011-07-22 | 2019-06-11 | Actelion Pharmaceuticals Ltd | Derives d'amides heterocycliques utilises comme antagonistes du recepteur p2x7 |
EP2804865B1 (fr) | 2012-01-20 | 2015-12-23 | Actelion Pharmaceuticals Ltd. | Dérivés d'amide hétérocyclique comme antagonistes du récepteur p2x7 |
MX368044B (es) | 2012-12-12 | 2019-09-17 | Idorsia Pharmaceuticals Ltd | Derivados de indol carboxamida como antagonistas del receptor p2x7. |
EP2935211B1 (fr) | 2012-12-18 | 2016-11-09 | Actelion Pharmaceuticals Ltd. | Dérivés d'indole carboxamide utilisés en tant qu'antagonistes du récepteur p2x7 |
KR102222220B1 (ko) | 2013-01-22 | 2021-03-03 | 이도르시아 파마슈티컬스 리미티드 | P2x7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
KR102220847B1 (ko) | 2013-01-22 | 2021-02-26 | 이도르시아 파마슈티컬스 리미티드 | P2x7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
AU2015237050B2 (en) * | 2014-03-24 | 2019-05-09 | Guangdong Zhongsheng Pharmaceutical Co., Ltd | Quinoline derivatives as SMO inhibitors |
JP6771023B2 (ja) | 2015-05-06 | 2020-10-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | K−ras調節物質 |
SG11201909570PA (en) | 2017-04-20 | 2019-11-28 | Univ California | K-ras modulators |
TWI825637B (zh) | 2021-03-31 | 2023-12-11 | 美商輝瑞股份有限公司 | 啶-1,6(2h,7h)-二酮 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1566099A (zh) * | 2003-06-13 | 2005-01-19 | 中国科学院上海药物研究所 | 异喹啉-1,3,4-三酮类化合物、制备方法及其用途 |
-
2007
- 2007-03-16 CA CA002645652A patent/CA2645652A1/fr not_active Abandoned
- 2007-03-16 WO PCT/US2007/006676 patent/WO2007109154A2/fr active Search and Examination
Also Published As
Publication number | Publication date |
---|---|
WO2007109154A3 (fr) | 2008-05-02 |
WO2007109154A2 (fr) | 2007-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2645652A1 (fr) | Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations | |
CA2645556C (fr) | Composes de bicycloheteroaryle en tant que modulateurs de p2x7 et leurs utilisations | |
DK1933622T3 (en) | Bicycloheteroarylforbindelser som P2X7-modulatorer og anvendelser deraf | |
CA2645551C (fr) | Composes de bicycloheteroaryle en tant que modulateurs de p2x7 et leurs utilisations | |
DK2124562T3 (en) | BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof | |
US20070197565A1 (en) | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | |
WO2007109182A2 (fr) | Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 et leurs utilisations | |
US20100184802A1 (en) | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | |
US20090298825A1 (en) | Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |