WO2007109154A3 - Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations - Google Patents

Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations Download PDF

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Publication number
WO2007109154A3
WO2007109154A3 PCT/US2007/006676 US2007006676W WO2007109154A3 WO 2007109154 A3 WO2007109154 A3 WO 2007109154A3 US 2007006676 W US2007006676 W US 2007006676W WO 2007109154 A3 WO2007109154 A3 WO 2007109154A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
compounds
bicycloheteroaryl compounds
bicycloheteroaryl
formula
Prior art date
Application number
PCT/US2007/006676
Other languages
English (en)
Other versions
WO2007109154A2 (fr
Inventor
Michael G Kelly
John Kincaid
Yunfeng Fang
Yeyu Cao
Carl Kaub
Sumithra Gowlugari
Zhan Wang
Original Assignee
Renovis Inc
Michael G Kelly
John Kincaid
Yunfeng Fang
Yeyu Cao
Carl Kaub
Sumithra Gowlugari
Zhan Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renovis Inc, Michael G Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang filed Critical Renovis Inc
Priority to US12/225,276 priority Critical patent/US20090298825A1/en
Priority to JP2009500513A priority patent/JP2009541205A/ja
Priority to EP07753312A priority patent/EP1996585A4/fr
Priority to CA002645652A priority patent/CA2645652A1/fr
Publication of WO2007109154A2 publication Critical patent/WO2007109154A2/fr
Publication of WO2007109154A3 publication Critical patent/WO2007109154A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés de bicyclohétéroaryle de formule (I). Ces composés peuvent être préparés sous la forme de compositions pharmaceutiques et peuvent être utilisés pour prévenir et traiter chez des mammifères, y compris chez l'homme, un certain nombre d'états pathologiques comprenant, entre autres, la douleur, l'inflammation, les blessures traumatiques, etc.
PCT/US2007/006676 2006-03-16 2007-03-16 Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations WO2007109154A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/225,276 US20090298825A1 (en) 2006-03-16 2007-03-16 Bicycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof
JP2009500513A JP2009541205A (ja) 2006-03-16 2007-03-16 Ｐ２ｘ７調節因子としてのビシクロへテロアリール化合物およびその使用
EP07753312A EP1996585A4 (fr) 2006-03-16 2007-03-16 Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations
CA002645652A CA2645652A1 (fr) 2006-03-16 2007-03-16 Composes de bicycloheteroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
US78330406P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US78374806P 2006-03-16 2006-03-16
US78277606P 2006-03-16 2006-03-16
US78277506P 2006-03-16 2006-03-16
US78292206P 2006-03-16 2006-03-16
US78359006P 2006-03-16 2006-03-16
US78297306P 2006-03-16 2006-03-16
US78278206P 2006-03-16 2006-03-16
US60/782,922 2006-03-16
US60/782,782 2006-03-16
US60/783,121 2006-03-16
US60/782,775 2006-03-16
US60/783,304 2006-03-16
US60/782,923 2006-03-16
US60/783,748 2006-03-16
US60/782,973 2006-03-16
US60/783,590 2006-03-16
US60/782,776 2006-03-16
US83141606P 2006-07-17 2006-07-17
US60/831,416 2006-07-17
US84699306P 2006-09-25 2006-09-25
US60/846,993 2006-09-25
US91812307P 2007-03-15 2007-03-15
US60/918,123 2007-03-15
US78292307P 2007-03-16 2007-03-16

Publications (2)

Publication Number Publication Date
WO2007109154A2 WO2007109154A2 (fr) 2007-09-27
WO2007109154A3 true WO2007109154A3 (fr) 2008-05-02

Family

ID=38522986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/006676 WO2007109154A2 (fr) 2006-03-16 2007-03-16 Composés de bicyclohétéroaryle en tant que modulateurs de p2x7 modulators et leurs utilisations

Country Status (2)

Country Link
CA (1) CA2645652A1 (fr)
WO (1) WO2007109154A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101686680B (zh) * 2007-03-09 2015-12-09 伊沃泰克美国股份有限公司 作为p2x7调节剂的双环杂芳基化合物及其用途
WO2009057827A1 (fr) 2007-10-31 2009-05-07 Nissan Chemical Industries, Ltd. Dérivés de pyridazinone et leur utilisation comme inhibiteurs du récepteur p2x7
EA022505B1 (ru) 2008-03-25 2016-01-29 Эффектис Фармасьютиклз Аг Новые p2x7r антагонисты и их применение
JP2012512254A (ja) * 2008-12-16 2012-05-31 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュインモジュレーターとしてのフタラジノンおよび関連するアナログ
GB0906274D0 (en) 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
PT2243772E (pt) 2009-04-14 2012-03-28 Affectis Pharmaceuticals Ag Novos antagonistas de p2x7r e sua utilização
JP2013526496A (ja) 2010-05-14 2013-06-24 アフェクティス ファーマシューティカルズ アーゲー Ｐ２ｘ７ｒ拮抗剤の新規調製方法
WO2012110190A1 (fr) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Nouveaux antagonistes p2x7r et leur utilisation
WO2012163456A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
WO2012163792A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
KR101995088B1 (ko) 2011-07-22 2019-07-02 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
JP6111268B2 (ja) 2012-01-20 2017-04-05 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
BR112015013463B1 (pt) 2012-12-12 2022-06-14 Idorsia Pharmaceuticals Ltd Derivados de carboxamida indol como antagonistas do receptor de p2x7
ES2614495T3 (es) 2012-12-18 2017-05-31 Actelion Pharmaceuticals Ltd. Derivados de indol carboxamida como antagonistas del receptor P2X7
ES2616114T3 (es) 2013-01-22 2017-06-09 Actelion Pharmaceuticals Ltd. Derivados de amida heterocíclica como antagonistas del receptor P2X7
KR102220847B1 (ko) 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
PE20170331A1 (es) * 2014-03-24 2017-04-28 Guangdong Zhongsheng Pharmaceutical Co Ltd Derivados quinolina como inhibidores smo
CN107847495A (zh) 2015-05-06 2018-03-27 加利福尼亚大学董事会 K‑Ras调节剂
WO2018195439A2 (fr) 2017-04-20 2018-10-25 The Regents Of The University Of California Modulateurs de k-ras
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060135557A1 (en) * 2003-06-13 2006-06-22 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060135557A1 (en) * 2003-06-13 2006-06-22 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1996585A4 *

Also Published As

Publication number Publication date
CA2645652A1 (fr) 2007-09-27
WO2007109154A2 (fr) 2007-09-27

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