DK2094690T3 - 2-aza-bicyclo[3.1.0]hexanderivater som orexinreceptorantagonister - Google Patents

2-aza-bicyclo[3.1.0]hexanderivater som orexinreceptorantagonister

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Publication number
DK2094690T3
DK2094690T3 DK07859531.1T DK07859531T DK2094690T3 DK 2094690 T3 DK2094690 T3 DK 2094690T3 DK 07859531 T DK07859531 T DK 07859531T DK 2094690 T3 DK2094690 T3 DK 2094690T3
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DK
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Prior art keywords
aza
bicyclo
receptor antagonists
orexin receptor
hexane derivatives
Prior art date
Application number
DK07859531.1T
Other languages
Danish (da)
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Daniel Trachsel
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK2094690T3 publication Critical patent/DK2094690T3/da

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
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DK07859531.1T 2006-12-28 2007-12-28 2-aza-bicyclo[3.1.0]hexanderivater som orexinreceptorantagonister DK2094690T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055042 2006-12-28
PCT/IB2007/055326 WO2008081399A2 (en) 2006-12-28 2007-12-28 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists

Publications (1)

Publication Number Publication Date
DK2094690T3 true DK2094690T3 (da) 2011-07-18

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Application Number Title Priority Date Filing Date
DK07859531.1T DK2094690T3 (da) 2006-12-28 2007-12-28 2-aza-bicyclo[3.1.0]hexanderivater som orexinreceptorantagonister

Country Status (28)

Country Link
US (1) US8288435B2 (enExample)
EP (1) EP2094690B1 (enExample)
JP (1) JP2010514751A (enExample)
KR (1) KR20090094168A (enExample)
CN (1) CN101568536B (enExample)
AR (1) AR064561A1 (enExample)
AT (1) ATE505467T1 (enExample)
AU (1) AU2007340944B2 (enExample)
BR (1) BRPI0720876A2 (enExample)
CA (1) CA2669821A1 (enExample)
CL (1) CL2007003827A1 (enExample)
CY (1) CY1111705T1 (enExample)
DE (1) DE602007013937D1 (enExample)
DK (1) DK2094690T3 (enExample)
ES (1) ES2364297T3 (enExample)
HR (1) HRP20110509T1 (enExample)
MA (1) MA31000B1 (enExample)
MX (1) MX2009006860A (enExample)
MY (1) MY157344A (enExample)
NO (1) NO20092762L (enExample)
NZ (1) NZ578642A (enExample)
PL (1) PL2094690T3 (enExample)
PT (1) PT2094690E (enExample)
RU (1) RU2460732C2 (enExample)
SI (1) SI2094690T1 (enExample)
TW (1) TW200833328A (enExample)
WO (1) WO2008081399A2 (enExample)
ZA (1) ZA200905229B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US20100016401A1 (en) * 2006-09-29 2010-01-21 Actelion Phamaceuticals Ltd. 3-aza-bicyclo[3.1.0]hexane derivatives
CN101568533A (zh) 2006-12-01 2009-10-28 埃科特莱茵药品有限公司 3-异芳基(氨基或酰胺基)-1-(联苯或苯基噻唑基)羰基哌啶衍生物食欲素受体抑制剂
CL2008000836A1 (es) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
WO2008150364A1 (en) 2007-05-23 2008-12-11 Merck & Co., Inc. Cyclopropyl pyrrolidine orexin receptor antagonists
CN101874030B (zh) * 2007-09-24 2012-11-14 埃科特莱茵药品有限公司 用作食欲素受体拮抗剂的吡咯烷和哌啶
JP2011512400A (ja) * 2008-02-21 2011-04-21 アクテリオン ファーマシューティカルズ リミテッド ２−アザ−ビシクロ［２．２．１］ヘプタン誘導体
EP2318367B1 (en) * 2008-04-30 2013-03-20 Actelion Pharmaceuticals Ltd. Piperidine and pyrrolidine compounds
JP2012505263A (ja) * 2008-10-14 2012-03-01 アクテリオン ファーマシューティカルズ リミテッド フェネチルアミド誘導体及びそれらのヘテロシクリル類似体
EP2275421A1 (en) * 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
KR101410903B1 (ko) * 2009-12-29 2014-06-23 수벤 라이프 사이언시스 리미티드 α４β２ 신경 니코틴성 아세틸콜린 수용체 리간드
PT2626350E (pt) * 2010-09-22 2015-08-03 Eisai R&D Man Co Ltd Composto de ciclopropano
US9012489B2 (en) * 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
ITMI20112329A1 (it) * 2011-12-21 2013-06-22 Rottapharm Spa Nuovi derivati spiro amminici
SG11201404738QA (en) 2012-02-07 2014-10-30 Eolas Therapeutics Inc Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ITMI20120424A1 (it) * 2012-03-19 2013-09-20 Rottapharm Spa Composti chimici
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