KR20090094168A - 오렉신 수용체 길항제로서 2-아자-바이시클로[3.1.0]헥산 유도체 - Google Patents

오렉신 수용체 길항제로서 2-아자-바이시클로[3.1.0]헥산 유도체

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Publication number
KR20090094168A
KR20090094168A KR1020097015732A KR20097015732A KR20090094168A KR 20090094168 A KR20090094168 A KR 20090094168A KR 1020097015732 A KR1020097015732 A KR 1020097015732A KR 20097015732 A KR20097015732 A KR 20097015732A KR 20090094168 A KR20090094168 A KR 20090094168A
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KR
South Korea
Prior art keywords
thiazole
methyl
aza
hex
bicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097015732A
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English (en)
Korean (ko)
Inventor
아메드 애자위
크리슈토프 보쓰
마르쿠스 구데
랄프 코베르슈타인
띠에리 시페랑
다니엘 트라흐젤
Original Assignee
액테리온 파마슈티칼 리미티드
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Application filed by 액테리온 파마슈티칼 리미티드 filed Critical 액테리온 파마슈티칼 리미티드
Publication of KR20090094168A publication Critical patent/KR20090094168A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
KR1020097015732A 2006-12-28 2007-12-28 오렉신 수용체 길항제로서 2-아자-바이시클로[3.1.0]헥산 유도체 Ceased KR20090094168A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WOPCT/IB2006/055042 2006-12-28
IB2006055042 2006-12-28

Publications (1)

Publication Number Publication Date
KR20090094168A true KR20090094168A (ko) 2009-09-03

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KR1020097015732A Ceased KR20090094168A (ko) 2006-12-28 2007-12-28 오렉신 수용체 길항제로서 2-아자-바이시클로[3.1.0]헥산 유도체

Country Status (28)

Country Link
US (1) US8288435B2 (enExample)
EP (1) EP2094690B1 (enExample)
JP (1) JP2010514751A (enExample)
KR (1) KR20090094168A (enExample)
CN (1) CN101568536B (enExample)
AR (1) AR064561A1 (enExample)
AT (1) ATE505467T1 (enExample)
AU (1) AU2007340944B2 (enExample)
BR (1) BRPI0720876A2 (enExample)
CA (1) CA2669821A1 (enExample)
CL (1) CL2007003827A1 (enExample)
CY (1) CY1111705T1 (enExample)
DE (1) DE602007013937D1 (enExample)
DK (1) DK2094690T3 (enExample)
ES (1) ES2364297T3 (enExample)
HR (1) HRP20110509T1 (enExample)
MA (1) MA31000B1 (enExample)
MX (1) MX2009006860A (enExample)
MY (1) MY157344A (enExample)
NO (1) NO20092762L (enExample)
NZ (1) NZ578642A (enExample)
PL (1) PL2094690T3 (enExample)
PT (1) PT2094690E (enExample)
RU (1) RU2460732C2 (enExample)
SI (1) SI2094690T1 (enExample)
TW (1) TW200833328A (enExample)
WO (1) WO2008081399A2 (enExample)
ZA (1) ZA200905229B (enExample)

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CL2008000836A1 (es) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
WO2009040730A2 (en) * 2007-09-24 2009-04-02 Actelion Pharmaceuticals Ltd Pyrrolidines and piperidines as orexin receptor antagonists
EP2247586B1 (en) * 2008-02-21 2012-04-25 Actelion Pharmaceuticals Ltd. 2-aza-bicyclo[2.2.1]heptane derivatives
EP2318367B1 (en) * 2008-04-30 2013-03-20 Actelion Pharmaceuticals Ltd. Piperidine and pyrrolidine compounds
KR20110071004A (ko) * 2008-10-14 2011-06-27 액테리온 파마슈티칼 리미티드 페네틸아미드 유도체 및 이의 헤테로시클릭 유사체
EP2275421A1 (en) * 2009-07-15 2011-01-19 Rottapharm S.p.A. Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
EP2519514B1 (en) * 2009-12-29 2015-08-26 Suven Life Sciences Limited Alpha4beta2 neuronal nicotinic acetylcholine receptor ligands
SI2626350T1 (sl) * 2010-09-22 2015-09-30 Eisai R&D Management Co., Ltd. Spojina ciklopropana
US9012489B2 (en) * 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
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