DK1955102T3 - Fremgangsmåde og indretning til konfokal billedbehandling - Google Patents

Fremgangsmåde og indretning til konfokal billedbehandling

Info

Publication number
DK1955102T3
DK1955102T3 DK06838184.7T DK06838184T DK1955102T3 DK 1955102 T3 DK1955102 T3 DK 1955102T3 DK 06838184 T DK06838184 T DK 06838184T DK 1955102 T3 DK1955102 T3 DK 1955102T3
Authority
DK
Denmark
Prior art keywords
confocal imaging
confocal
imaging
Prior art date
Application number
DK06838184.7T
Other languages
English (en)
Inventor
Theofilos Kotseroglou
Mark Wang
Alexander Triener
Diping Che
Robert Kain
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37808340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1955102(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of DK1955102T3 publication Critical patent/DK1955102T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036Scanning details, e.g. scanning stages
    • G02B21/004Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • G01N2021/6421Measuring at two or more wavelengths

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
DK06838184.7T 2005-11-23 2006-11-21 Fremgangsmåde og indretning til konfokal billedbehandling DK1955102T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/286,309 US7329860B2 (en) 2005-11-23 2005-11-23 Confocal imaging methods and apparatus
PCT/US2006/045058 WO2007062039A2 (en) 2005-11-23 2006-11-21 Confocal imaging methods and apparatus

Publications (1)

Publication Number Publication Date
DK1955102T3 true DK1955102T3 (da) 2013-05-13

Family

ID=37808340

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06838184.7T DK1955102T3 (da) 2005-11-23 2006-11-21 Fremgangsmåde og indretning til konfokal billedbehandling
DK13155085.7T DK2594981T3 (da) 2005-11-23 2006-11-21 Fremgangsmåder og indretning til konfokal billedbehandling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK13155085.7T DK2594981T3 (da) 2005-11-23 2006-11-21 Fremgangsmåder og indretning til konfokal billedbehandling

Country Status (9)

Country Link
US (6) US7329860B2 (da)
EP (2) EP1955102B1 (da)
JP (1) JP5055292B2 (da)
CN (1) CN101361015B (da)
CA (1) CA2632221C (da)
DK (2) DK1955102T3 (da)
ES (2) ES2635094T3 (da)
PL (1) PL2594981T3 (da)
WO (1) WO2007062039A2 (da)

Families Citing this family (276)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082863A1 (en) * 2002-03-15 2004-04-29 Mcgreevy James Device and method for the photodynamic diagnosis of tumor tissue
EP1889111A2 (en) 2005-05-25 2008-02-20 Massachusetts Institute of Technology Multifocal imaging systems and methods
US7329860B2 (en) * 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
US8725425B2 (en) * 2007-01-26 2014-05-13 Illumina, Inc. Image data efficient genetic sequencing method and system
US7687776B2 (en) * 2007-04-11 2010-03-30 General Monitors, Inc. Gas and/or flame imaging system with explosion proof housing
EP2201352B2 (en) 2007-09-28 2018-08-29 Illumina, Inc. Fluorescence excitation and detection system and method
JP5072688B2 (ja) * 2008-04-02 2012-11-14 キヤノン株式会社 走査型撮像装置
CN102084003A (zh) * 2008-04-04 2011-06-01 生命科技公司 用于成像和测序的扫描系统和方法
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
EP2291533B2 (en) 2008-07-02 2020-09-30 Illumina Cambridge Limited Using populations of beads for the fabrication of arrays on surfaces
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
EP2335111A4 (en) * 2008-10-09 2013-12-25 Ge Healthcare Bio Sciences SYSTEM AND METHOD FOR ADJUSTING A BEAM DILATOR IN AN IMAGING SYSTEM
US7675045B1 (en) * 2008-10-09 2010-03-09 Los Alamos National Security, Llc 3-dimensional imaging at nanometer resolutions
EP2340314B8 (en) 2008-10-22 2015-02-18 Illumina, Inc. Preservation of information related to genomic dna methylation
KR101061004B1 (ko) * 2008-12-10 2011-09-01 한국전기연구원 광역학 치료 및 광 검출을 위한 장치
US20100157086A1 (en) 2008-12-15 2010-06-24 Illumina, Inc Dynamic autofocus method and system for assay imager
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS
US8222589B2 (en) * 2009-05-29 2012-07-17 General Electric Company Solid-state photomultiplier module with improved signal-to-noise ratio
JP5568912B2 (ja) * 2009-07-22 2014-08-13 富士ゼロックス株式会社 発光素子ヘッドの特性計測装置および発光素子ヘッドの光量補正方法
US20110017915A1 (en) * 2009-07-23 2011-01-27 Palo Alto Research Center Incorporated Drift scanner for rare cell detection
DK2456892T3 (da) 2009-07-24 2014-12-08 Illumina Inc Fremgangsmåde til sekventering af en polynukleotidskabelon
EP2293032A1 (en) * 2009-09-04 2011-03-09 Radisens Diagnostic Limited An Integrated Cytometric Sensor System and Method
KR101075155B1 (ko) 2009-10-07 2011-10-19 한국과학기술원 선주사 방식을 이용한 공초점 레이저 주사 현미경 시스템에 적용하기 위한 영상처리 장치 및 방법
FI20096067A0 (fi) * 2009-10-15 2009-10-15 Valtion Teknillinen Raman-säteilyn mittaus
DE102009057304A1 (de) * 2009-12-07 2011-06-09 Leica Microsystems Cms Gmbh Vorrichtung zum Untersuchen einer Probe umfassend ein Mikroskop
DE102009058295A1 (de) * 2009-12-10 2011-06-16 Biostep Gmbh Transilluminator
US8470733B2 (en) * 2009-12-22 2013-06-25 Zih Corp. Direct thermal media and registration sensor system and method for use in a color thermal printer
DK2531880T3 (da) * 2010-02-01 2016-11-07 Illumina Inc Fokuseringsmetoder og optiske systemer samt anordninger dermed
US8481903B2 (en) 2010-03-06 2013-07-09 Alexander Triener Systems, methods, and apparatuses including a moveable optical component for detecting optical signals from a sample
US8532398B2 (en) 2010-03-26 2013-09-10 General Electric Company Methods and apparatus for optical segmentation of biological samples
ITRM20100286A1 (it) 2010-05-28 2011-11-29 Consiglio Nazionale Ricerche Microscopio confocale spettrale in riflettanza a larga banda.
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
US8575071B2 (en) 2010-11-03 2013-11-05 Illumina, Inc. Reducing adapter dimer formation
US8773526B2 (en) 2010-12-17 2014-07-08 Mitutoyo Corporation Edge detection using structured illumination
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US10908403B2 (en) * 2011-02-14 2021-02-02 European Molecular Biology Laboratory (Embl) Light-pad microscope for high-resolution 3D fluorescence imaging and 2D fluctuation spectroscopy
US9291802B2 (en) * 2011-04-29 2016-03-22 Corning Incorporated Compact label free imaging system
US20120306998A1 (en) * 2011-06-01 2012-12-06 Merrill Ii Dennis E Macro Area Camera for an Infrared (IR) Microscope
US10378051B2 (en) 2011-09-29 2019-08-13 Illumina Cambridge Limited Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
WO2013063382A2 (en) 2011-10-28 2013-05-02 Illumina, Inc. Microarray fabrication system and method
KR101302162B1 (ko) * 2011-11-04 2013-09-10 광주과학기술원 3차원 공초점 전계발광 분광 현미경 장치
EP2776165A2 (en) 2011-11-07 2014-09-17 Illumina, Inc. Integrated sequencing apparatuses and methods of use
EP2753967B1 (en) * 2011-11-14 2023-04-12 Koninklijke Philips N.V. Optical microscopy probe for scanning microscopy of an associated object
DK2788499T3 (da) 2011-12-09 2016-03-21 Illumina Inc Udvidet rod for polymer-tags
WO2013117595A2 (en) 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
CN104220919B (zh) * 2012-02-15 2016-10-05 奥林巴斯株式会社 激光扫描型观察装置
US20130250088A1 (en) * 2012-03-22 2013-09-26 Molecular Devices, Llc Multi-color confocal microscope and imaging methods
CN102638659B (zh) * 2012-03-28 2014-05-14 西安电子科技大学 基于cmos-tdi模式的高分辨率成像系统及方法
CA3138752C (en) 2012-04-03 2024-02-06 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
RU2616653C2 (ru) * 2012-06-05 2017-04-18 Хайпермед Имэджинг, Инк. Способы и устройство для соосного формирования изображения с множеством длин волн
NL2017959B1 (en) 2016-12-08 2018-06-19 Illumina Inc Cartridge assembly
CA2881823C (en) 2012-08-20 2019-06-11 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
US9116139B2 (en) 2012-11-05 2015-08-25 Illumina, Inc. Sequence scheduling and sample distribution techniques
WO2014074611A1 (en) 2012-11-07 2014-05-15 Good Start Genetics, Inc. Methods and systems for identifying contamination in samples
JP5388078B1 (ja) 2012-11-14 2014-01-15 レーザーテック株式会社 解析装置及び解析方法
US9426400B2 (en) * 2012-12-10 2016-08-23 Kla-Tencor Corporation Method and apparatus for high speed acquisition of moving images using pulsed illumination
US20140168402A1 (en) * 2012-12-13 2014-06-19 Vala Sciences, Inc. Continuous-Scanning Image Acquisition in Automated Microscopy Using Reflective Autofocus
CN103018911B (zh) * 2012-12-14 2015-06-24 清华大学 基于波分复用的光纤激光合成装置
US9805407B2 (en) 2013-01-25 2017-10-31 Illumina, Inc. Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data
US8842273B2 (en) 2013-02-14 2014-09-23 United Sciences, Llc Optical measurement of drilled holes
EP2971159B1 (en) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Methods for analyzing nucleic acids
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
CN103257438B (zh) * 2013-05-29 2015-02-18 哈尔滨工业大学 一种基于自动控制电动平移台的平面二维矩形扫描装置及其扫描方法
EP3005200A2 (en) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Methods and systems for storing sequence read data
EP3241913B1 (en) 2013-07-03 2019-02-20 Illumina, Inc. System for sequencing by orthogonal synthesis
US9324900B2 (en) * 2013-08-01 2016-04-26 Teledyne Scientific & Imaging, Llc Method of fabricating a superlattice structure
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
CN206281782U (zh) 2013-08-28 2017-06-27 伊鲁米那股份有限公司 检查设备及光学检测装置
US9188775B2 (en) * 2013-08-28 2015-11-17 United Sciences, Llc Optical scanning and measurement
EP3038834B1 (en) 2013-08-30 2018-12-12 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
SG11201603039PA (en) 2013-10-18 2016-05-30 Seven Bridges Genomics Inc Methods and systems for identifying disease-induced mutations
WO2015058120A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
WO2015058095A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for quantifying sequence alignment
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
SG11201602903XA (en) 2013-10-18 2016-05-30 Seven Bridges Genomics Inc Methods and systems for genotyping genetic samples
EP3058096A1 (en) 2013-10-18 2016-08-24 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
US9092402B2 (en) 2013-10-21 2015-07-28 Seven Bridges Genomics Inc. Systems and methods for using paired-end data in directed acyclic structure
US10540783B2 (en) * 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
WO2015100421A1 (en) * 2013-12-24 2015-07-02 Tissuevision, Inc. Multi-foci multiphoton imaging systems and methods
WO2015103225A1 (en) 2013-12-31 2015-07-09 Illumina, Inc. Addressable flow cell using patterned electrodes
JP2017510871A (ja) 2014-01-10 2017-04-13 セブン ブリッジズ ジェノミクス インコーポレイテッド リードマッピングにおける公知の対立遺伝子の使用のためのシステム及び方法
US9817944B2 (en) 2014-02-11 2017-11-14 Seven Bridges Genomics Inc. Systems and methods for analyzing sequence data
WO2015138648A1 (en) 2014-03-11 2015-09-17 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making and using same
KR101476820B1 (ko) * 2014-04-07 2014-12-29 주식회사 썸텍 3d 비디오 현미경 장치
FR3019901B1 (fr) 2014-04-09 2020-10-30 Bio Rad Innovations Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
CA2951118C (en) 2014-05-16 2024-01-09 Illumina, Inc. Nucleic acid synthesis techniques
US10427155B2 (en) 2014-05-27 2019-10-01 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
GB201409777D0 (en) 2014-06-02 2014-07-16 Illumina Cambridge Ltd Methods of reducing density-dependent GC bias in isothermal amplification
JP6408796B2 (ja) * 2014-06-11 2018-10-17 オリンパス株式会社 レーザ顕微鏡装置
US9439568B2 (en) 2014-07-03 2016-09-13 Align Technology, Inc. Apparatus and method for measuring surface topography optically
US9261358B2 (en) 2014-07-03 2016-02-16 Align Technology, Inc. Chromatic confocal system
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
ES2803079T3 (es) 2014-09-12 2021-01-22 Illumina Inc Métodos para detectar la presencia de subunidades de polímeros usando quimioluminiscencia
EP3224595A4 (en) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
WO2016057950A1 (en) 2014-10-09 2016-04-14 Illumina, Inc. Method and device for separating immiscible liquids to effectively isolate at least one of the liquids
CN107408043A (zh) 2014-10-14 2017-11-28 七桥基因公司 用于序列流水线中的智能工具的系统和方法
US9897791B2 (en) 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
EP3835429A1 (en) 2014-10-17 2021-06-16 Good Start Genetics, Inc. Pre-implantation genetic screening and aneuploidy detection
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
TWI569912B (zh) * 2014-12-08 2017-02-11 國立高雄應用科技大學 雷射聚焦光學模組及雷射聚焦方法
CA3010579A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
CN104568710B (zh) * 2015-01-22 2017-03-08 福建师范大学 一种高时空分辨光学检测与显微成像方法与装置
WO2016121946A1 (ja) * 2015-01-30 2016-08-04 国立研究開発法人科学技術振興機構 多焦点分光計測装置、及び多焦点分光計測装置用光学系
JP6375239B2 (ja) 2015-02-05 2018-08-15 オリンパス株式会社 レーザ顕微鏡装置
US10192026B2 (en) 2015-03-05 2019-01-29 Seven Bridges Genomics Inc. Systems and methods for genomic pattern analysis
EP3268715A1 (en) 2015-03-11 2018-01-17 Timothy Ragan System and methods for serial staining and imaging
WO2016154038A1 (en) 2015-03-20 2016-09-29 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
EP3274692B1 (en) 2015-03-24 2022-08-10 Illumina, Inc. Methods for imaging samples for biological or chemical analysis
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
US10519493B2 (en) 2015-06-22 2019-12-31 Fluxergy, Llc Apparatus and method for image analysis of a fluid sample undergoing a polymerase chain reaction (PCR)
WO2016209731A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Test card for assay and method of manufacturing same
US11371091B2 (en) 2015-06-22 2022-06-28 Fluxergy, Inc. Device for analyzing a fluid sample and use of test card with same
ES2966968T3 (es) * 2015-06-22 2024-04-25 Fluxergy Inc Dispositivo para analizar una muestra de fluido y uso de tarjeta de ensayo con el mismo
WO2017007757A1 (en) 2015-07-06 2017-01-12 Illumina, Inc. Balanced ac modulation for driving droplet operations electrodes
CA2992578A1 (en) 2015-07-14 2017-01-19 Victor Velculescu Neoantigen analysis
US10465245B2 (en) 2015-07-29 2019-11-05 Progenity, Inc. Nucleic acids and methods for detecting chromosomal abnormalities
DK3329007T3 (da) 2015-07-30 2021-04-26 Illumina Inc Ortogonal afblokering af nukleotider
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
CN106541132B (zh) * 2015-09-18 2018-09-25 广东汉邦激光科技有限公司 激光3d打印机及其调焦系统及方法
DE102015116598A1 (de) 2015-09-30 2017-03-30 Carl Zeiss Microscopy Gmbh Verfahren und Mikroskop zur hochauflösenden Abbildung mittels SIM
US10577643B2 (en) 2015-10-07 2020-03-03 Illumina, Inc. Off-target capture reduction in sequencing techniques
ES2796501T3 (es) 2015-10-10 2020-11-27 Guardant Health Inc Métodos y aplicaciones de la detección de fusión de genes en el análisis de ADN sin células
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
CA3005101A1 (en) * 2015-11-16 2017-05-26 Progenity, Inc. Nucleic acids and methods for detecting methylation status
CN108602066B (zh) 2015-12-01 2021-08-17 亿明达股份有限公司 液体存储输送机构以及方法
AU2016364722B2 (en) 2015-12-01 2020-10-22 Illumina, Inc. Digital microfluidic system for single-cell isolation and characterization of analytes
EP3390668A4 (en) 2015-12-17 2020-04-01 Guardant Health, Inc. METHODS OF DETERMINING THE NUMBER OF TUMOR GENE COPIES BY ACELLULAR DNA ANALYSIS
US20170199960A1 (en) 2016-01-07 2017-07-13 Seven Bridges Genomics Inc. Systems and methods for adaptive local alignment for graph genomes
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
US10460829B2 (en) 2016-01-26 2019-10-29 Seven Bridges Genomics Inc. Systems and methods for encoding genetic variation for a population
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
US11021742B2 (en) 2016-03-28 2021-06-01 Boreal Genomics, Inc. Linked-fragment sequencing
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
SG11201805665UA (en) 2016-03-28 2018-10-30 Illumina Inc Multi-plane microarrays
ES2786974T3 (es) 2016-04-07 2020-10-14 Illumina Inc Métodos y sistemas para la construcción de bibliotecas de ácidos nucleicos normalizadas
CN108885260B (zh) * 2016-04-08 2022-06-03 苹果公司 具有单轴扫描的渡越时间探测器
EP3465157B1 (en) * 2016-05-27 2021-12-08 Verily Life Sciences LLC Systems and methods for 4-d hyperspectral imaging
CN109477956B (zh) * 2016-05-30 2022-01-14 纽约市哥伦比亚大学理事会 使用扫掠、共焦对准的平面激发的三维成像
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
CA3213915A1 (en) 2016-09-22 2018-03-29 Illumina, Inc. Somatic copy number variation detection
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
US10955652B2 (en) 2016-09-30 2021-03-23 The Trustees Of Columbia University In The City Of New York Three-dimensional imaging using swept, confocally aligned planar excitation with a Powell lens and/or deliberate misalignment
DE102016119268B3 (de) * 2016-10-10 2017-12-21 Leica Microsystems Cms Gmbh Schiefebenenmikroskop
CN111781139B (zh) 2016-10-14 2023-09-12 亿明达股份有限公司 夹盒组件
CN110023509A (zh) 2016-11-15 2019-07-16 私人基因诊断公司 基因型分型测定中的非独特条形码
KR101936120B1 (ko) * 2016-11-30 2019-01-08 부경대학교 산학협력단 광음향 단층촬영을 위한 프로브 및 실시간 광음향 단층촬영 장치
CA3048420A1 (en) 2016-12-09 2018-06-14 Boreal Genomics, Inc. Linked ligation
GB201704771D0 (en) 2017-01-05 2017-05-10 Illumina Inc Modular optical analytic systems and methods
TWI773721B (zh) * 2017-01-20 2022-08-11 日商東京威力科創股份有限公司 異物檢測裝置、異物檢測方法及記憶媒體
CN110214268A (zh) * 2017-01-26 2019-09-06 蔚蓝生物系统有限公司 用于成像生物分子的装置和方法
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
CN109414673B (zh) 2017-02-01 2021-09-07 伊鲁米那股份有限公司 具有响应于多个激发频率的基准的系统和方法
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
GB201701691D0 (en) 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
WO2018183745A1 (en) 2017-03-30 2018-10-04 Illumina, Inc. Genomic data analysis system and method
EP3607087A4 (en) 2017-04-04 2020-12-30 Omniome, Inc. FLUIDIC APPARATUS AND USEFUL METHODS FOR CHEMICAL AND BIOLOGICAL REACTIONS
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
JP2021500531A (ja) 2017-08-15 2021-01-07 オムニオム インコーポレイテッドOmniome, Inc. 化学的および生物学的検体の検出に有用なスキャン装置および方法
CA3202587A1 (en) 2017-11-06 2019-05-09 Illumina, Inc Nucleic acid indexing techniques
US11740255B2 (en) 2017-11-14 2023-08-29 Illumina, Inc. Droplet dispensing
US20190156922A1 (en) 2017-11-16 2019-05-23 Illumina, Inc. Systems and methods for determining microsatellite instability
CN110870016A (zh) 2017-11-30 2020-03-06 伊鲁米那股份有限公司 用于序列变体呼出的验证方法和系统
CN108519329B (zh) * 2018-03-26 2021-01-15 华中科技大学 一种多路扫描与探测的线共聚焦成像装置
US20190338352A1 (en) 2018-04-19 2019-11-07 Omniome, Inc. Accuracy of base calls in nucleic acid sequencing methods
CN112567047A (zh) 2018-04-26 2021-03-26 欧姆尼欧美公司 用于稳定核酸-核苷酸-聚合酶复合物的方法和组合物
EP3802874A1 (en) 2018-05-31 2021-04-14 Omniome, Inc. Increased signal to noise in nucleic acid sequencing
US10753734B2 (en) 2018-06-08 2020-08-25 Dentsply Sirona Inc. Device, method and system for generating dynamic projection patterns in a confocal camera
CA3107165A1 (en) 2018-07-24 2020-01-30 Omniome, Inc. Serial formation of ternary complex species
WO2020072030A1 (en) * 2018-10-01 2020-04-09 Hewlett-Packard Development Company, L.P. Microscopy systems
CN211311477U (zh) 2018-12-04 2020-08-21 欧姆尼欧美公司 测序系统
EP3894598B1 (en) 2018-12-14 2024-01-03 Illumina Cambridge Limited Decreasing phasing with unlabeled nucleotides during sequencing
CN112639125A (zh) 2018-12-17 2021-04-09 伊卢米纳剑桥有限公司 用于多核苷酸测序的组合物
SG11202012758WA (en) 2018-12-17 2021-01-28 Illumina Cambridge Ltd Primer oligonucleotide for sequencing
WO2020132350A2 (en) 2018-12-20 2020-06-25 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
US11473136B2 (en) 2019-01-03 2022-10-18 Ncan Genomics, Inc. Linked target capture
EP3908823A4 (en) 2019-01-10 2022-10-12 Travera LLC CALIBRATION OF A FUNCTIONAL BIOMARKER INSTRUMENT
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
CN113613787B (zh) 2019-02-20 2023-06-13 加利福尼亚太平洋生物科学股份有限公司 用于检测化学和生物分析物的扫描装置和方法
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
WO2020191390A2 (en) 2019-03-21 2020-09-24 Illumina, Inc. Artificial intelligence-based quality scoring
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
WO2020223713A1 (en) * 2019-05-02 2020-11-05 Duke University Devices and methods for imaging microarray chips
US11644406B2 (en) 2019-06-11 2023-05-09 Pacific Biosciences Of California, Inc. Calibrated focus sensing
EP3987274A1 (en) 2019-06-19 2022-04-27 Life Technologies Holdings Pte Limited Biological analysis devices and systems
DE102019004870B4 (de) * 2019-07-11 2023-03-09 Particle Metrix Gmbh Vorrichtung und Verfahren zur Reduzierung der Intensitätsminderung des Fluoreszenzfarbstoffes durch Laserlicht bei der Bestimmung der Fluoreszenz und der Anzahl von Antikörpern auf Exosomen.
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
CN114728996B (zh) 2019-09-10 2022-11-29 加利福尼亚太平洋生物科学股份有限公司 核苷酸的可逆修饰
EP4045683A1 (en) 2019-10-18 2022-08-24 Omniome, Inc. Methods and compositions for capping nucleic acids
EP3990891A4 (en) * 2019-12-31 2023-07-26 Illumina, Inc. AUTO FOCUS FEATURE IN OPTICAL SAMPLE ANALYSIS
CN115698282A (zh) 2020-01-13 2023-02-03 福路伦特生物科学公司 单细胞测序
WO2021158511A1 (en) 2020-02-04 2021-08-12 Omniome, Inc. Flow cells and methods for their manufacture and use
US20210265018A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Knowledge Distillation and Gradient Pruning-Based Compression of Artificial Intelligence-Based Base Caller
WO2021178467A1 (en) 2020-03-03 2021-09-10 Omniome, Inc. Methods and compositions for sequencing double stranded nucleic acids
CA3175931A1 (en) 2020-03-16 2021-09-23 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
US20230203592A1 (en) 2020-05-05 2023-06-29 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US20230183798A1 (en) 2020-05-05 2023-06-15 Pacific Biosciences Of California, Inc. Compositions and methods for modifying polymerase-nucleic acid complexes
BR112022020101A2 (pt) 2020-05-08 2022-11-29 Illumina Inc Técnicas de sequenciamento e detecção de genoma
EP4165549A1 (en) 2020-06-11 2023-04-19 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
WO2021262285A1 (en) 2020-06-26 2021-12-30 Becton, Dickinson And Company Dual excitation beams for irradiating a sample in a flow stream and methods for using same
US20220042108A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of assessing breast cancer
US20220042107A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of scoring risk and residual disease from passenger mutations
WO2022029484A1 (en) 2020-08-06 2022-02-10 Agendia NV Methods of assessing breast cancer using circulating hormone receptor transcripts
US20220042106A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of using cell-free nucleic acids to tailor cancer treatment
JP2023541449A (ja) 2020-09-14 2023-10-02 シンギュラー・ゲノミクス・システムズ・インコーポレイテッド 多次元撮像のための方法およびシステム
AU2021378290A1 (en) 2020-11-11 2023-06-29 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
CA3179883A1 (en) 2020-12-02 2022-06-09 Illumina Software, Inc. System and method for detection of genetic alterations
CN116507963A (zh) * 2020-12-08 2023-07-28 深圳华大智造科技股份有限公司 超分辨检测系统及超分辨检测方法
CN116601469A (zh) 2020-12-21 2023-08-15 奇异基因组学系统公司 用于多色成像的系统和方法
US12009442B2 (en) 2021-01-14 2024-06-11 Kabushiki Kaisha Toshiba Light detector, light detection system, lidar device, and moving body
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
IL305336A (en) 2021-03-11 2023-10-01 Nautilus Subsidiary Inc Systems and methods for the preservation of biomolecules
KR20230165273A (ko) 2021-03-31 2023-12-05 일루미나 케임브리지 리미티드 어댑터 이량체 검출을 갖는 핵산 라이브러리 서열분석 기술
WO2022232425A2 (en) 2021-04-29 2022-11-03 Illumina, Inc. Amplification techniques for nucleic acid characterization
WO2022240764A1 (en) 2021-05-10 2022-11-17 Pacific Biosciences Of California, Inc. Single-molecule seeding and amplification on a surface
CN117858959A (zh) 2021-05-10 2024-04-09 加利福尼亚太平洋生物科学股份有限公司 滚环扩增期间的dna扩增缓冲液补充
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
US20220414853A1 (en) 2021-06-25 2022-12-29 Illumina, Inc. Fiducials for use in registration of a patterned surface
WO2022269033A1 (en) 2021-06-25 2022-12-29 Illumina Cambridge Limited Linear fourier fiducial
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023003757A1 (en) 2021-07-19 2023-01-26 Illumina Software, Inc. Intensity extraction with interpolation and adaptation for base calling
CN113780521B (zh) * 2021-08-24 2022-03-04 中国人民解放军93114部队 一种基于深度学习的辐射源个体识别方法
KR20240049214A (ko) 2021-09-01 2024-04-16 일루미나, 인코포레이티드 가속 염기 호출을 위한 진폭 변조
US20230070896A1 (en) 2021-09-09 2023-03-09 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
US20230088338A1 (en) 2021-09-10 2023-03-23 Illumina, Inc. Sequencer focus quality metrics and focus tracking for periodically patterned surfaces
WO2023049212A2 (en) 2021-09-22 2023-03-30 Illumina, Inc. State-based base calling
WO2023049073A1 (en) 2021-09-22 2023-03-30 Nautilus Biotechnology, Inc. Methods and systems for determining polypeptide interactions
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
WO2023064181A1 (en) 2021-10-11 2023-04-20 Nautilus Biotechnology, Inc. Highly multiplexable analysis of proteins and proteomes
CN114035199B (zh) * 2021-10-15 2024-04-12 中国人民解放军91977部队 一种基于雪崩二极管成像器件的光电搜索跟踪装置
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023081485A1 (en) 2021-11-08 2023-05-11 Pacific Biosciences Of California, Inc. Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
WO2023107622A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
KR102645654B1 (ko) * 2021-12-22 2024-03-13 (주)얼라인드제네틱스 고효율 다중 스펙트럼 검출을 위한 라인 공초점 세포 계수기
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129764A1 (en) 2021-12-29 2023-07-06 Illumina Software, Inc. Automatically switching variant analysis model versions for genomic analysis applications
US20230296516A1 (en) 2022-02-17 2023-09-21 Illumina, Inc. Ai-driven signal enhancement of sequencing images
WO2023158809A1 (en) 2022-02-17 2023-08-24 Illumina, Inc. Ai-driven enhancement of motion blurred sequencing images
US11639499B1 (en) 2022-03-08 2023-05-02 Watchmaker Genomics, Inc. Reverse transcriptase variants
WO2023175042A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Parallel sample and index sequencing
WO2023183937A1 (en) 2022-03-25 2023-09-28 Illumina, Inc. Sequence-to-sequence base calling
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
AU2023250540A1 (en) 2022-04-08 2024-01-18 Illumina, Inc. Aptamer dynamic range compression and detection techniques
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
US20230407386A1 (en) 2022-06-09 2023-12-21 Illumina, Inc. Dependence of base calling on flow cell tilt
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024025806A1 (en) 2022-07-27 2024-02-01 Illumina, Inc. Motion feedback using patterned flowcells
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024072799A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Flow cell based motion system calibration and control methods
WO2024072866A1 (en) 2022-09-28 2024-04-04 Illumina, Inc. Method for reducing vibration using segmented acceleration
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
WO2024130000A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204230A (en) * 1978-10-25 1980-05-20 Xerox Corporation High resolution input scanner using a two dimensional detector array
US4382267A (en) * 1981-09-24 1983-05-03 Rca Corporation Digital control of number of effective rows of two-dimensional charge-transfer imager array
US4700298A (en) * 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4826299A (en) * 1987-01-30 1989-05-02 Canadian Patents And Development Limited Linear deiverging lens
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US4877326A (en) * 1988-02-19 1989-10-31 Kla Instruments Corporation Method and apparatus for optical inspection of substrates
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5159199A (en) * 1991-08-12 1992-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Integrated filter and detector array for spectral imaging
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix Inc N D Ges D Staat Verfahren zur Herstellung von Polymerarrays
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5173748A (en) * 1991-12-05 1992-12-22 Eastman Kodak Company Scanning multichannel spectrometry using a charge-coupled device (CCD) in time-delay integration (TDI) mode
DE69333650T2 (de) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5583211A (en) 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US6309601B1 (en) * 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US6741344B1 (en) * 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
DE69503126T2 (de) 1994-05-05 1998-11-12 Beckman Instruments Inc Repetitive oligonukleotide matrix
US5782770A (en) * 1994-05-12 1998-07-21 Science Applications International Corporation Hyperspectral imaging methods and apparatus for non-invasive diagnosis of tissue for cancer
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
WO1996018205A1 (en) * 1994-12-08 1996-06-13 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5578818A (en) * 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5528050A (en) * 1995-07-24 1996-06-18 Molecular Dynamics, Inc. Compact scan head with multiple scanning modalities
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5585639A (en) * 1995-07-27 1996-12-17 Hewlett-Packard Company Optical scanning apparatus
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US5629808A (en) * 1995-12-15 1997-05-13 National Research Council Of Canada D-shape laser beam projector
GB9526183D0 (en) * 1995-12-21 1996-02-21 Stc Submarine Systems Ltd Dispersion slope equalisaion for wdm systems wih branches
US5847400A (en) * 1996-02-01 1998-12-08 Molecular Dynamics, Inc. Fluorescence imaging system having reduced background fluorescence
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
WO1997043611A1 (en) * 1996-05-16 1997-11-20 Affymetrix, Inc. Systems and methods for detection of labeled materials
US5754291A (en) * 1996-09-19 1998-05-19 Molecular Dynamics, Inc. Micro-imaging system
ATE234674T1 (de) 1996-11-14 2003-04-15 Affymetrix Inc Chemische amplifizierung zur synthese von musterordnungen
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
JP3438855B2 (ja) 1997-01-23 2003-08-18 横河電機株式会社 共焦点装置
US5837475A (en) * 1997-01-30 1998-11-17 Hewlett-Packard Co. Apparatus and method for scanning a chemical array
DE19707227A1 (de) * 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6008892A (en) * 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
JP2002508664A (ja) 1997-06-25 2002-03-19 オーキッド・バイオサイエンシーズ・インコーポレイテッド 複数の単一ヌクレオチド多型を単一の反応で検出する方法
US6043506A (en) * 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
US6043880A (en) * 1997-09-15 2000-03-28 Becton Dickinson And Company Automated optical reader for nucleic acid assays
US6033860A (en) 1997-10-31 2000-03-07 Affymetrix, Inc. Expression profiles in adult and fetal organs
US5998796A (en) * 1997-12-22 1999-12-07 Spectrumedix Corporation Detector having a transmission grating beam splitter for multi-wavelength sample analysis
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
JP2002502588A (ja) 1998-02-06 2002-01-29 アフィメトリックス インコーポレイテッド 製造プロセスにおける品質管理の方法
JP3944996B2 (ja) 1998-03-05 2007-07-18 株式会社日立製作所 Dnaプローブアレー
IL138496A0 (en) 1998-03-16 2001-10-31 Praelux Inc Confocal microscopy imaging system
US6388788B1 (en) * 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
AU3102699A (en) 1998-03-19 1999-10-11 Board Of Regents, The University Of Texas System Fiber-optic confocal imaging apparatus and methods of use
US6031078A (en) 1998-06-16 2000-02-29 Millennium Pharmaceuticals, Inc. MTbx protein and nucleic acid molecules and uses therefor
US6160618A (en) * 1998-06-19 2000-12-12 Board Of Regents, The University Of Texas System Hyperspectral slide reader
US6678048B1 (en) * 1998-07-20 2004-01-13 Sandia Corporation Information-efficient spectral imaging sensor with TDI
US6245507B1 (en) * 1998-08-18 2001-06-12 Orchid Biosciences, Inc. In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
CA2341359A1 (en) * 1998-08-21 2000-03-02 Ian Walton Novel optical architectures for microvolume laser-scanning cytometers
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
AT410718B (de) * 1998-10-28 2003-07-25 Schindler Hansgeorg Dr Vorrichtung zur visualisierung von molekülen
US6545264B1 (en) * 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6134002A (en) * 1999-01-14 2000-10-17 Duke University Apparatus and method for the rapid spectral resolution of confocal images
US6355934B1 (en) * 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20030207295A1 (en) 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
ATE553219T1 (de) 1999-04-20 2012-04-15 Illumina Inc Erkennung von nukleinsäurereaktionen auf bead- arrays
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
US6371370B2 (en) * 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
US6222664B1 (en) * 1999-07-22 2001-04-24 Agilent Technologies Inc. Background reduction apparatus and method for confocal fluorescence detection systems
AU2421101A (en) * 1999-11-16 2001-05-30 Agilent Technologies Inc. Confocal imaging
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6687000B1 (en) * 2000-06-26 2004-02-03 Wisconsin Alumni Research Foundation Photon-sorting spectroscopic microscope system
US6818907B2 (en) * 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
JP3590765B2 (ja) * 2000-12-21 2004-11-17 Smc株式会社 電磁弁
TW555954B (en) * 2001-02-28 2003-10-01 Olympus Optical Co Confocal microscope, optical height-measurement method, automatic focusing method
GB0106342D0 (en) * 2001-03-15 2001-05-02 Renishaw Plc Spectroscopy apparatus and method
US6650411B2 (en) * 2001-04-26 2003-11-18 Affymetrix, Inc. System, method, and product for pixel clocking in scanning of biological materials
US7105795B2 (en) * 2001-07-06 2006-09-12 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
US7248716B2 (en) * 2001-07-06 2007-07-24 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
JP2003028798A (ja) * 2001-07-11 2003-01-29 Olympus Optical Co Ltd 蛍光取得装置
US20080099667A1 (en) * 2001-08-14 2008-05-01 President And Fellows Of Harvard College Methods and apparatus for sensing a physical substance
JP3616999B2 (ja) 2001-12-04 2005-02-02 レーザーテック株式会社 コンフォーカル顕微鏡
CN1435684A (zh) * 2002-01-30 2003-08-13 无锡市朗珈生物医学工程有限公司 生物芯片荧光检测扫描装置
US6825930B2 (en) * 2002-06-04 2004-11-30 Cambridge Research And Instrumentation, Inc. Multispectral imaging system
US20050227252A1 (en) 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
EP1575707A1 (en) 2002-09-12 2005-09-21 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US6813018B2 (en) * 2002-11-07 2004-11-02 The Boeing Company Hyperspectral imager
US20040140417A1 (en) * 2002-12-27 2004-07-22 Accretech (Israel) Ltd. Image sensor for confocal microscopy
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
JP4235046B2 (ja) * 2003-07-08 2009-03-04 新日本製鐵株式会社 鋼板表面の検査方法、システム、画像処理装置、及びコンピュータプログラム
US7218446B2 (en) 2003-08-27 2007-05-15 Biomedical Photometrics Inc. Imaging system having a fine focus
CA2559801A1 (en) 2003-10-01 2005-04-14 Cyvera Corporation Optical reader for diffraction grating-based encoded optical identification elements
WO2005043197A2 (en) * 2003-10-28 2005-05-12 University Of Maryland, Baltimore Spatial light modulator apparatus and method
US7227113B2 (en) * 2003-11-21 2007-06-05 Olympus Corporation Confocal laser scanning microscope
JP4589101B2 (ja) * 2003-12-25 2010-12-01 昭和電工株式会社 表面検査方法および同装置
JP4635145B2 (ja) 2004-03-17 2011-02-16 レーザーテック株式会社 コンフォーカル顕微鏡及び膜厚測定装置
US20050225849A1 (en) 2004-04-05 2005-10-13 Fujifilm Electronic Imaging Ltd. Slit confocal microscope and method
EP1782172A1 (en) 2004-06-30 2007-05-09 Anoto Ab Data processing in an electronic pen
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7791013B2 (en) * 2006-11-21 2010-09-07 Illumina, Inc. Biological microarray line scanning method and system

Also Published As

Publication number Publication date
CN101361015A (zh) 2009-02-04
US20150069267A1 (en) 2015-03-12
EP1955102B1 (en) 2013-04-24
EP2594981A3 (en) 2013-06-19
PL2594981T3 (pl) 2017-10-31
WO2007062039A3 (en) 2007-07-19
EP2594981A2 (en) 2013-05-22
ES2635094T3 (es) 2017-10-02
DK2594981T3 (da) 2017-08-21
US20070114362A1 (en) 2007-05-24
EP2594981B1 (en) 2017-05-10
JP2009517662A (ja) 2009-04-30
US9816929B2 (en) 2017-11-14
CA2632221A1 (en) 2007-05-31
JP5055292B2 (ja) 2012-10-24
CA2632221C (en) 2013-08-27
US20100012825A1 (en) 2010-01-21
US20080290263A1 (en) 2008-11-27
CN101361015B (zh) 2012-11-21
US8884211B2 (en) 2014-11-11
ES2407968T3 (es) 2013-06-17
WO2007062039A2 (en) 2007-05-31
US7329860B2 (en) 2008-02-12
EP1955102A2 (en) 2008-08-13
US20110204212A1 (en) 2011-08-25
US7589315B2 (en) 2009-09-15
US20120168644A1 (en) 2012-07-05
US8158926B2 (en) 2012-04-17
US7960685B2 (en) 2011-06-14

Similar Documents

Publication Publication Date Title
DK1955102T3 (da) Fremgangsmåde og indretning til konfokal billedbehandling
DE602006009191D1 (de) Bildaufnahmegerät und -verfahren
DK1937137T3 (da) Fremgangsmåde og indretning til optisk billeddannelse via spektral kodning
BRPI0607526A2 (pt) Dispositivo e método para suporte de câmara
DE602006020651D1 (de) Kalibrierverfahren und -vorrichtung
DE602006008682D1 (de) Bildgebungsanordnung und Prüfverfahren
FI20060449A0 (fi) Mammografiamenetelmä ja mammografialaite
DE602006003491D1 (de) Beobachtungsvorrichtung und Beobachtungsverfahren
DK1997291T3 (da) Metode og anordning til sikker godkendelse
DE602006016186D1 (de) Anzeigevorrichtung und Anzeigeverfahren
DE602006020556D1 (de) Bilddecodierungsvorrichtung und bilddecodierungsverfahren
DK2079355T3 (da) Fremgangsmåde og system til brilleordination
DE602006011416D1 (de) Bilderzeugungsvorrichtung
DE602006011600D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
DE602006014957D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
DK1966594T3 (da) Anordning og fremsgangsmåde til påvisning af mykotoxiner
NL1032239A1 (nl) Sequentieel veldweergave-inrichting en werkwijze daarvoor.
DK2131939T3 (da) Filteranordning og fremgangsmåde
DE602005002786D1 (de) Bilderzeugungsvorrichtung
DK1937332T3 (da) Infusionsapparat og aktuator hertil
DE602006000911D1 (de) Bilderzeugungsvorrichtung
DE602005015751D1 (de) Bilderzeugungsvorrichtung
DE602006006130D1 (de) Bildaufnahmevorrichtung
DE602006006244D1 (de) Bildaufzeichnungsgerät und Verfahren
DE602006020989D1 (de) Bildverarbeitungseinrichtung und bildverarbeitungsverfahren