DK1847524T3 - Terphenylderivater til behandling af Alzheimers sygdom - Google Patents

Terphenylderivater til behandling af Alzheimers sygdom

Info

Publication number
DK1847524T3
DK1847524T3 DK06112934T DK06112934T DK1847524T3 DK 1847524 T3 DK1847524 T3 DK 1847524T3 DK 06112934 T DK06112934 T DK 06112934T DK 06112934 T DK06112934 T DK 06112934T DK 1847524 T3 DK1847524 T3 DK 1847524T3
Authority
DK
Denmark
Prior art keywords
alzheimer
disease
treatment
terphenyl derivatives
terphenyl
Prior art date
Application number
DK06112934T
Other languages
Danish (da)
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Adeline Leformal
Svenja Burckhardt
Remedios Hernadez-Perni
Andrew Cansfield
Jess Taylor
Original Assignee
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1847524(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Ltd filed Critical Cellzome Ltd
Application granted granted Critical
Publication of DK1847524T3 publication Critical patent/DK1847524T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK06112934T 2006-04-21 2006-04-21 Terphenylderivater til behandling af Alzheimers sygdom DK1847524T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (en) 2006-04-21 2006-04-21 Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number Publication Date
DK1847524T3 true DK1847524T3 (da) 2010-01-11

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06112934T DK1847524T3 (da) 2006-04-21 2006-04-21 Terphenylderivater til behandling af Alzheimers sygdom

Country Status (35)

Country Link
US (1) US8106236B2 (ru)
EP (2) EP1847524B1 (ru)
JP (1) JP5422827B2 (ru)
KR (1) KR101494906B1 (ru)
CN (1) CN101484410B (ru)
AR (1) AR060621A1 (ru)
AT (1) ATE445586T1 (ru)
AU (1) AU2007240382B2 (ru)
BR (1) BRPI0710632A2 (ru)
CA (1) CA2649845C (ru)
CR (2) CR10376A (ru)
CY (1) CY1109729T1 (ru)
DE (1) DE602006009764D1 (ru)
DK (1) DK1847524T3 (ru)
EA (1) EA016908B1 (ru)
ES (2) ES2333539T3 (ru)
GE (1) GEP20115211B (ru)
HK (1) HK1134923A1 (ru)
IL (2) IL194853A0 (ru)
MA (1) MA30420B1 (ru)
MX (1) MX2008013447A (ru)
MY (1) MY148988A (ru)
NO (1) NO20084516L (ru)
NZ (1) NZ572999A (ru)
PE (1) PE20080267A1 (ru)
PL (1) PL1847524T3 (ru)
PT (1) PT1847524E (ru)
SI (1) SI1847524T1 (ru)
SM (1) SMP200800062B (ru)
TN (1) TNSN08414A1 (ru)
TW (1) TWI435720B (ru)
UA (1) UA95766C2 (ru)
UY (1) UY30300A1 (ru)
WO (1) WO2007124351A1 (ru)
ZA (1) ZA200809857B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE445586T1 (de) 2006-04-21 2009-10-15 Cellzome Ltd Terphenylderivate zur alzheimerbehandlung
MX2010004318A (es) 2007-10-19 2010-04-30 Janssen Pharmaceutica Nv Moduladores de la gamma-secretasa con enlaces de amina.
KR20100081350A (ko) * 2007-10-19 2010-07-14 얀센 파마슈티카 엔.브이. Ｇｓｍ 중간체
MX2010004309A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de piperidinil y piperazinil de gamma-secretasa.
KR101618068B1 (ko) 2007-10-19 2016-05-04 얀센 파마슈티카 엔.브이. γ-세크레타아제의 탄소 결합된 조절제
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
US20110166132A1 (en) * 2007-12-13 2011-07-07 Amgen Inc. Gamma Secretase Modulators
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
KR20100125304A (ko) * 2008-03-11 2010-11-30 뉴로서치 에이/에스 니코틴성 아세틸콜린 수용체의 조절제로서 유용한 신규한 트리아릴 유도체
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
ES2583093T3 (es) * 2011-03-03 2016-09-19 Denovamed Inc. Compuestos antimicrobianos/adyuvantes
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
KR20230113770A9 (ko) * 2020-11-27 2024-03-25 미라이랩 바이오사이언스 인코퍼레이티드 고순도 β 니코틴아미드 모노뉴클레오티드(NMN) 및 그 제조 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
AU4537400A (en) 1999-05-12 2000-12-05 Neurosearch A/S Ion channel modulating agents
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
AU2001254555A1 (en) * 2000-04-24 2001-11-07 Merck Frosst Canada & Co Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore
CN1277872C (zh) * 2001-02-20 2006-10-04 安德鲁斯街大学管理处 含金属的树状物
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
US20060122184A1 (en) * 2002-12-05 2006-06-08 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
JP2006524638A (ja) * 2003-04-30 2006-11-02 メルク フロスト カナダ リミテツド ８−（３−ビアリール）フェニルキノリン系ホスホジエステラーゼ−４阻害薬
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
KR100997549B1 (ko) * 2005-08-15 2010-11-30 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 길항제로서의 피페리딘 및 피페라진 유도체
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物
ATE445586T1 (de) 2006-04-21 2009-10-15 Cellzome Ltd Terphenylderivate zur alzheimerbehandlung

Also Published As

Publication number Publication date
SMAP200800062A (it) 2008-11-19
AU2007240382B2 (en) 2013-05-02
UA95766C2 (ru) 2011-08-25
ES2392352T3 (es) 2012-12-10
KR101494906B1 (ko) 2015-02-24
US20070254957A1 (en) 2007-11-01
TNSN08414A1 (en) 2010-04-14
PL1847524T3 (pl) 2010-03-31
CY1109729T1 (el) 2014-09-10
TWI435720B (zh) 2014-05-01
US8106236B2 (en) 2012-01-31
IL194853A0 (en) 2009-08-03
IL194789A0 (en) 2009-08-03
SI1847524T1 (sl) 2010-01-29
EP1847524B1 (en) 2009-10-14
CA2649845C (en) 2014-09-16
MA30420B1 (fr) 2009-05-04
AR060621A1 (es) 2008-07-02
MX2008013447A (es) 2009-03-10
UY30300A1 (es) 2007-08-31
MY148988A (en) 2013-06-28
JP2009538275A (ja) 2009-11-05
EP2016039B1 (en) 2012-08-01
EP2016039A1 (en) 2009-01-21
ES2333539T3 (es) 2010-02-23
DE602006009764D1 (de) 2009-11-26
TW200810746A (en) 2008-03-01
CN101484410B (zh) 2013-08-21
EA200802173A1 (ru) 2009-06-30
PT1847524E (pt) 2009-12-18
ATE445586T1 (de) 2009-10-15
WO2007124351A1 (en) 2007-11-01
NZ572999A (en) 2012-06-29
CN101484410A (zh) 2009-07-15
EA016908B1 (ru) 2012-08-30
EP1847524A1 (en) 2007-10-24
HK1134923A1 (en) 2010-05-20
CA2649845A1 (en) 2007-11-01
BRPI0710632A2 (pt) 2011-08-23
SMP200800062B (it) 2009-07-14
NO20084516L (no) 2009-01-13
ZA200809857B (en) 2009-08-26
AU2007240382A1 (en) 2007-11-01
GEP20115211B (en) 2011-04-26
JP5422827B2 (ja) 2014-02-19
CR10452A (es) 2009-02-23
CR10376A (es) 2009-02-26
KR20090024678A (ko) 2009-03-09
PE20080267A1 (es) 2008-05-16

Similar Documents

Publication Publication Date Title
DK1847524T3 (da) Terphenylderivater til behandling af Alzheimers sygdom
DK2303330T4 (da) Farmaceutiske sammensætninger til behandling af parkinsons sygdom
DK3456707T3 (da) 4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme
ATE542823T1 (de) 4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen
DK2324126T3 (da) FREMGANGSMÅDE TIL IDENTIFICERING AF Alzheimers SYGDOMSRISIKOFAKTORER
CY2016017I2 (el) Συνθεση για θεραπεια πνευμονικης υπερτασης
BRPI0810646A2 (pt) " compostos farmacêuticos ".
DK1720571T3 (da) Fremgangsmåde til behandling af hæmolytisk sygdom
DK1708992T3 (da) Sulfonamidderivater til behandling af sygdomme
NO20070753L (no) Fremgangsmåte for fremstilling av dihydropteridinoner
DK2504005T3 (da) Anvendelse af 1,3-diphenylprop-2-en-1-on-derivater til behandling af lever-sygdomme
DK1937633T3 (da) Biphenyloxyeddikesyrederivater til behandling af respiratoriske sygdomme
DK1948176T3 (da) Diarylurinstoffer til behandling af pulmonær hypertension
DK1893586T3 (da) Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler
ATE527241T1 (de) Pyridiazinonderivate zur behandlung von tumoren
ZA201006868B (en) Aminodihydrothiazine derivatives as bace inhibitors for the treatment of alzheimer's disease
NO20076030L (no) Fremgangsmåte for fremstilling av hydroklorsilaner
DK1685834T3 (da) Anvendelse af pinolensyre til behandling af obesitet
DK1828151T3 (da) Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdom
CL2007003158A1 (es) Procedimiento de preparacion de compuestos derivados de quinazolina o sus sales farmaceuticamente aceptables; compuestos intermediarios; procedimiento de preparacion.
DK1907374T3 (da) Til behandling af gastrointestinale sygdomme anvendelige benzylpiperazin-derivater
DK2117565T3 (da) Anvendelse af chitosaner til behandlingen af negleinflammatoriske sygdomme
DK1881830T3 (da) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinolin-derivater til behandling af infertilitet
ITRM20050179A1 (it) Composizione impiegabile per il trattamento delle patologie paradontali.
ATE525355T1 (de) 1-ä(4-äbenzoyl(methyl)aminoü-3- (phenyl)butylüazetidinderivate zur behandlung von gastrointestinalen erkrankungen 1