DK1830888T3 - LIPID COMPLEX COATED WITH PEG AND APPLICATION THEREOF - Google Patents
LIPID COMPLEX COATED WITH PEG AND APPLICATION THEREOF Download PDFInfo
- Publication number
- DK1830888T3 DK1830888T3 DK05822677.0T DK05822677T DK1830888T3 DK 1830888 T3 DK1830888 T3 DK 1830888T3 DK 05822677 T DK05822677 T DK 05822677T DK 1830888 T3 DK1830888 T3 DK 1830888T3
- Authority
- DK
- Denmark
- Prior art keywords
- lipid
- composition
- group
- nucleic acid
- helper
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- 239000000203 mixture Substances 0.000 claims description 200
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- 108020004707 nucleic acids Proteins 0.000 claims description 81
- 150000007523 nucleic acids Chemical class 0.000 claims description 81
- 210000004027 cell Anatomy 0.000 claims description 50
- -1 omithyl Chemical group 0.000 claims description 42
- 108020004459 Small interfering RNA Proteins 0.000 claims description 27
- 229940106189 ceramide Drugs 0.000 claims description 27
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 26
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 26
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 26
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 25
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- XLPHMKQBBCKEFO-DHYROEPTSA-N 2-azaniumylethyl [(2r)-2,3-bis(3,7,11,15-tetramethylhexadecanoyloxy)propyl] phosphate Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C XLPHMKQBBCKEFO-DHYROEPTSA-N 0.000 claims description 12
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- BKHMAOXOKNEKHL-NNJYRKLXSA-N (5s)-2,3,5-triamino-8-(diaminomethylideneamino)-n-hexadecyl-n-[(z)-octadec-9-enyl]-4-oxooctanamide;trihydrochloride Chemical compound Cl.Cl.Cl.CCCCCCCCCCCCCCCCN(C(=O)C(N)C(N)C(=O)[C@@H](N)CCCNC(N)=N)CCCCCCCC\C=C/CCCCCCCC BKHMAOXOKNEKHL-NNJYRKLXSA-N 0.000 claims description 6
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- SHCCKWGIFIPGNJ-NSUCVBPYSA-N 2-aminoethyl [(2r)-2,3-bis[(z)-octadec-9-enoxy]propyl] hydrogen phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC[C@H](COP(O)(=O)OCCN)OCCCCCCCC\C=C/CCCCCCCC SHCCKWGIFIPGNJ-NSUCVBPYSA-N 0.000 claims description 4
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- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
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- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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Landscapes
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04030846 | 2004-12-27 | ||
| PCT/EP2005/014074 WO2006069782A2 (en) | 2004-12-27 | 2005-12-27 | Lipid complexes coated with peg and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1830888T3 true DK1830888T3 (en) | 2015-10-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| DK05822677.0T DK1830888T3 (en) | 2004-12-27 | 2005-12-27 | LIPID COMPLEX COATED WITH PEG AND APPLICATION THEREOF |
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|---|---|
| US (2) | US8852472B2 (enExample) |
| EP (2) | EP1830888B1 (enExample) |
| JP (1) | JP5292572B2 (enExample) |
| KR (1) | KR101366482B1 (enExample) |
| CN (1) | CN101287497B (enExample) |
| AU (1) | AU2005321469B2 (enExample) |
| BR (1) | BRPI0519468A2 (enExample) |
| CA (1) | CA2593032C (enExample) |
| DK (1) | DK1830888T3 (enExample) |
| ES (1) | ES2548515T3 (enExample) |
| HK (1) | HK1222541A1 (enExample) |
| IL (1) | IL183775A (enExample) |
| MX (1) | MX2007007913A (enExample) |
| PL (1) | PL1830888T3 (enExample) |
| SG (1) | SG158175A1 (enExample) |
| WO (1) | WO2006069782A2 (enExample) |
| ZA (1) | ZA200704168B (enExample) |
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| ES2280826T5 (es) | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Nuevas formas adicionales de moléculas de ARN de interferencia |
| WO2006069782A2 (en) | 2004-12-27 | 2006-07-06 | Silence Therapeutics Ag. | Lipid complexes coated with peg and their use |
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-
2005
- 2005-12-27 WO PCT/EP2005/014074 patent/WO2006069782A2/en not_active Ceased
- 2005-12-27 US US11/722,948 patent/US8852472B2/en not_active Expired - Fee Related
- 2005-12-27 ES ES05822677.0T patent/ES2548515T3/es active Active
- 2005-12-27 DK DK05822677.0T patent/DK1830888T3/en active
- 2005-12-27 SG SG200908620-8A patent/SG158175A1/en unknown
- 2005-12-27 KR KR1020077014611A patent/KR101366482B1/ko not_active Expired - Fee Related
- 2005-12-27 AU AU2005321469A patent/AU2005321469B2/en not_active Ceased
- 2005-12-27 EP EP05822677.0A patent/EP1830888B1/en not_active Not-in-force
- 2005-12-27 JP JP2007548751A patent/JP5292572B2/ja not_active Expired - Fee Related
- 2005-12-27 MX MX2007007913A patent/MX2007007913A/es active IP Right Grant
- 2005-12-27 PL PL05822677T patent/PL1830888T3/pl unknown
- 2005-12-27 EP EP15179144.9A patent/EP2992902A1/en not_active Withdrawn
- 2005-12-27 CA CA2593032A patent/CA2593032C/en not_active Expired - Fee Related
- 2005-12-27 CN CN2005800450816A patent/CN101287497B/zh not_active Expired - Fee Related
- 2005-12-27 BR BRPI0519468-7A patent/BRPI0519468A2/pt active Search and Examination
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2007
- 2007-05-22 ZA ZA200704168A patent/ZA200704168B/en unknown
- 2007-06-07 IL IL183775A patent/IL183775A/en not_active IP Right Cessation
-
2014
- 2014-10-06 US US14/507,045 patent/US9387262B2/en not_active Expired - Fee Related
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2016
- 2016-09-07 HK HK16110655.7A patent/HK1222541A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2548515T3 (es) | 2015-10-19 |
| PL1830888T3 (pl) | 2015-12-31 |
| CN101287497A (zh) | 2008-10-15 |
| KR20070090956A (ko) | 2007-09-06 |
| AU2005321469B2 (en) | 2012-04-05 |
| KR101366482B1 (ko) | 2014-02-21 |
| IL183775A (en) | 2016-12-29 |
| ZA200704168B (en) | 2008-05-28 |
| BRPI0519468A2 (pt) | 2009-01-27 |
| US8852472B2 (en) | 2014-10-07 |
| WO2006069782A9 (en) | 2009-04-30 |
| EP1830888B1 (en) | 2015-08-05 |
| CA2593032A1 (en) | 2006-07-06 |
| IL183775A0 (en) | 2007-09-20 |
| SG158175A1 (en) | 2010-01-29 |
| WO2006069782A3 (en) | 2007-04-12 |
| EP1830888A2 (en) | 2007-09-12 |
| US20100062967A1 (en) | 2010-03-11 |
| HK1119090A1 (en) | 2009-02-27 |
| JP2008525514A (ja) | 2008-07-17 |
| AU2005321469A1 (en) | 2006-07-06 |
| US20150031752A1 (en) | 2015-01-29 |
| EP2992902A1 (en) | 2016-03-09 |
| CN101287497B (zh) | 2013-03-06 |
| JP5292572B2 (ja) | 2013-09-18 |
| US9387262B2 (en) | 2016-07-12 |
| MX2007007913A (es) | 2007-08-14 |
| HK1222541A1 (en) | 2017-07-07 |
| CA2593032C (en) | 2015-12-22 |
| WO2006069782A2 (en) | 2006-07-06 |
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