DK179886A - Fremgangsmaade til fremstilling af eburnameninderivater eller et syreadditionssalt deraf, forbindelsernes anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling - Google Patents
Fremgangsmaade til fremstilling af eburnameninderivater eller et syreadditionssalt deraf, forbindelsernes anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling Download PDFInfo
- Publication number
- DK179886A DK179886A DK179886A DK179886A DK179886A DK 179886 A DK179886 A DK 179886A DK 179886 A DK179886 A DK 179886A DK 179886 A DK179886 A DK 179886A DK 179886 A DK179886 A DK 179886A
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- eburnamen
- relations
- pharmaceuticals
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compounds Of Unknown Constitution (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
hvor er alkyl, og R er H, alkyl, alkenyl eller eventuelt substitueret acyl, og syreadditionssalte deraf fremstilles ved en kemisk egenartet metode med en række varianter, til dels over dihydroapovinca-minsyreestere med formel (Illa) og (Hib)
(Illa)
(IHb) hvor R' er alkyl.
De trans-stereoisomere af forbindelserne med formel (la), (Ib), (Illa) og (Hib) er hidtil ukendte.
Forbindelserne roed formel (la) og (Ib) er farmaceutisk aktive, idet de har vasodilatatorisk virkning.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU851516A HU198207B (en) | 1985-04-19 | 1985-04-19 | Process for production of derivatives of eburnamenin and medical compositions containing them |
HU151685 | 1985-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK179886D0 DK179886D0 (da) | 1986-04-18 |
DK179886A true DK179886A (da) | 1986-10-20 |
Family
ID=10954833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK179886A DK179886A (da) | 1985-04-19 | 1986-04-18 | Fremgangsmaade til fremstilling af eburnameninderivater eller et syreadditionssalt deraf, forbindelsernes anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling |
Country Status (32)
Country | Link |
---|---|
US (1) | US4839362A (da) |
JP (1) | JPS61249982A (da) |
KR (1) | KR860008175A (da) |
CN (1) | CN1017429B (da) |
AR (1) | AR242386A1 (da) |
AU (1) | AU585973B2 (da) |
BE (1) | BE904619A (da) |
CA (1) | CA1314286C (da) |
CH (1) | CH670449A5 (da) |
CS (1) | CS257791B2 (da) |
DD (1) | DD244555A5 (da) |
DE (1) | DE3613199A1 (da) |
DK (1) | DK179886A (da) |
ES (1) | ES8801259A1 (da) |
FI (1) | FI84352C (da) |
FR (1) | FR2580647B1 (da) |
GB (1) | GB2174092B (da) |
GR (1) | GR861026B (da) |
HU (1) | HU198207B (da) |
IL (1) | IL78534A0 (da) |
IN (1) | IN163020B (da) |
IT (1) | IT1189462B (da) |
NL (1) | NL8600987A (da) |
NO (1) | NO861538L (da) |
NZ (1) | NZ215881A (da) |
PH (1) | PH22427A (da) |
PL (1) | PL149331B1 (da) |
PT (1) | PT82423B (da) |
SE (1) | SE462684B (da) |
SU (1) | SU1443801A3 (da) |
YU (1) | YU46003B (da) |
ZA (1) | ZA862937B (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623501B1 (fr) * | 1987-11-19 | 1990-03-16 | Roussel Uclaf | Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
JPH02167279A (ja) * | 1988-09-30 | 1990-06-27 | Taisho Pharmaceut Co Ltd | アポビンカミン酸誘導体 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2035784A1 (en) * | 1969-03-27 | 1970-12-24 | Olivier Louisette | Vincamine derivs with therapeutic propert- - ies |
FR2211004A5 (da) * | 1972-12-15 | 1974-07-12 | Synthelabo | |
FR2259612B1 (da) * | 1974-01-31 | 1977-09-09 | Synthelabo | |
FR2285390A1 (fr) * | 1974-09-19 | 1976-04-16 | Synthelabo | Nouvelle methode de preparation du desoxyvincaminate d'hydroxy-2 propyle |
HU171163B (hu) * | 1974-09-27 | 1977-11-28 | Richter Gedeon Vegyeszet | Sposob poluchenija proizvodnykh trans eburnamenina |
FR2299033A2 (fr) * | 1975-01-31 | 1976-08-27 | Synthelabo | Esters de |
HU170888B (hu) * | 1975-06-10 | 1977-09-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh, opticheski aktivnykh proizvodnykh eburnameninov |
HU171663B (hu) * | 1975-09-01 | 1978-02-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh proizvodnykh 14-skobka-zamehhennogo metil-skobka zakryta-vinkana |
DE2703920A1 (de) * | 1976-02-05 | 1977-08-11 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
GB1572189A (en) * | 1976-09-03 | 1980-07-23 | Buzas Andre | 14 - alkoxycarbonyl - 3,4 - dehydro - 14,15 - dihydro-14,16 - eburnamenine perchlorates and their use to prepare stereoisomers of dihydro apovincaminic acid esters |
AU532001B2 (en) * | 1978-11-20 | 1983-09-15 | Sumitomo Chemical Company, Limited | Polycyclic indole derivatives |
HU186891B (en) * | 1981-06-12 | 1985-10-28 | Richter Gedeon Vegyeszet | Process for producing esters of apovincaminic acid |
-
1985
- 1985-04-19 HU HU851516A patent/HU198207B/hu not_active IP Right Cessation
-
1986
- 1986-04-04 PH PH33621A patent/PH22427A/en unknown
- 1986-04-14 CH CH1469/86A patent/CH670449A5/de not_active IP Right Cessation
- 1986-04-15 YU YU60386A patent/YU46003B/sh unknown
- 1986-04-17 AR AR86303677A patent/AR242386A1/es active
- 1986-04-18 ZA ZA862937A patent/ZA862937B/xx unknown
- 1986-04-18 PL PL1986259043A patent/PL149331B1/pl unknown
- 1986-04-18 PT PT82423A patent/PT82423B/pt not_active IP Right Cessation
- 1986-04-18 IL IL78534A patent/IL78534A0/xx unknown
- 1986-04-18 GR GR861026A patent/GR861026B/el unknown
- 1986-04-18 NO NO861538A patent/NO861538L/no unknown
- 1986-04-18 JP JP61088395A patent/JPS61249982A/ja active Pending
- 1986-04-18 NL NL8600987A patent/NL8600987A/nl not_active Application Discontinuation
- 1986-04-18 CS CS862862A patent/CS257791B2/cs unknown
- 1986-04-18 DE DE3613199A patent/DE3613199A1/de not_active Withdrawn
- 1986-04-18 US US06/853,844 patent/US4839362A/en not_active Expired - Fee Related
- 1986-04-18 DD DD86289373A patent/DD244555A5/de not_active IP Right Cessation
- 1986-04-18 AU AU56380/86A patent/AU585973B2/en not_active Ceased
- 1986-04-18 BE BE0/216548A patent/BE904619A/fr not_active IP Right Cessation
- 1986-04-18 FI FI861656A patent/FI84352C/fi not_active IP Right Cessation
- 1986-04-18 IT IT20135/86A patent/IT1189462B/it active
- 1986-04-18 NZ NZ215881A patent/NZ215881A/xx unknown
- 1986-04-18 SE SE8601798A patent/SE462684B/sv not_active IP Right Cessation
- 1986-04-18 ES ES554136A patent/ES8801259A1/es not_active Expired
- 1986-04-18 FR FR868605609A patent/FR2580647B1/fr not_active Expired - Fee Related
- 1986-04-18 SU SU864027294A patent/SU1443801A3/ru active
- 1986-04-18 DK DK179886A patent/DK179886A/da not_active Application Discontinuation
- 1986-04-18 IN IN293/MAS/86A patent/IN163020B/en unknown
- 1986-04-18 GB GB8609532A patent/GB2174092B/en not_active Expired
- 1986-04-18 CA CA000507055A patent/CA1314286C/en not_active Expired - Fee Related
- 1986-04-19 KR KR1019860003048A patent/KR860008175A/ko not_active Application Discontinuation
- 1986-04-19 CN CN86102655A patent/CN1017429B/zh not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHS | Application shelved for other reasons than non-payment |