DK175029B1 - 2-(heterocyclylthio)carbapenemderivater, farmaceutiske midler indeholdende dem, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika - Google Patents

2-(heterocyclylthio)carbapenemderivater, farmaceutiske midler indeholdende dem, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika Download PDF

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Publication number
DK175029B1
DK175029B1 DK198901580A DK158089A DK175029B1 DK 175029 B1 DK175029 B1 DK 175029B1 DK 198901580 A DK198901580 A DK 198901580A DK 158089 A DK158089 A DK 158089A DK 175029 B1 DK175029 B1 DK 175029B1
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multiplet
singlet
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methyl
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DK198901580A
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Danish (da)
English (en)
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DK158089D0 (da
DK158089A (da
Inventor
Masayuki Iwata
Teruo Tanaka
Isao Kawamoto
Masao Miyauchi
Rokuro Endo
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Sankyo Co
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Publication date
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Publication of DK158089D0 publication Critical patent/DK158089D0/da
Publication of DK158089A publication Critical patent/DK158089A/da
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Publication of DK175029B1 publication Critical patent/DK175029B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK198901580A 1988-04-01 1989-03-31 2-(heterocyclylthio)carbapenemderivater, farmaceutiske midler indeholdende dem, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika DK175029B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP8097488 1988-04-01
JP8097488 1988-04-01
JP11164088 1988-05-10
JP11164088 1988-05-10

Publications (3)

Publication Number Publication Date
DK158089D0 DK158089D0 (da) 1989-03-31
DK158089A DK158089A (da) 1989-10-02
DK175029B1 true DK175029B1 (da) 2004-05-03

Family

ID=26421941

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198901580A DK175029B1 (da) 1988-04-01 1989-03-31 2-(heterocyclylthio)carbapenemderivater, farmaceutiske midler indeholdende dem, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika
DK199801576A DK199801576A (da) 1988-04-01 1998-11-30 2-(heterocyklylthio)carbapenemderivater, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK199801576A DK199801576A (da) 1988-04-01 1998-11-30 2-(heterocyklylthio)carbapenemderivater, fremgangsmåde til fremstilling deraf samt deres anvendelse som antibiotika

Country Status (16)

Country Link
US (1) US5104867A (de)
EP (2) EP0597821A1 (de)
KR (2) KR0133071B1 (de)
AT (1) ATE114654T1 (de)
AU (1) AU615729B2 (de)
CA (1) CA1336092C (de)
DE (1) DE68919508T2 (de)
DK (2) DK175029B1 (de)
ES (1) ES2067534T3 (de)
FI (1) FI91258C (de)
GR (1) GR3015128T3 (de)
HK (1) HK1005733A1 (de)
HU (2) HU204275B (de)
IE (2) IE950607L (de)
NO (1) NO168304C (de)
NZ (1) NZ228589A (de)

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JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5227376A (en) * 1990-02-14 1993-07-13 Sumitomo Pharmaceuticals Co., Ltd. β-lactam compounds and their production
CA2050255C (en) * 1990-09-07 1997-02-04 Tameo Iwasaki 1-methylcarbapenem derivatives and process for preparation thereof
US5208348A (en) * 1990-09-07 1993-05-04 Tanabe Seiyaku Co., Ltd. Mercaptan compound
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
JPH06508377A (ja) * 1992-04-10 1994-09-22 ゼネカ　リミテッド ヘテロ環式化合物
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5442055A (en) * 1992-11-13 1995-08-15 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
DE69324106T2 (de) * 1992-11-17 1999-12-09 Sankyo Co., Ltd. Krystallines Carbapenemderivat
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
US5495012A (en) * 1992-12-28 1996-02-27 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor
JP2701685B2 (ja) * 1992-12-28 1998-01-21 田辺製薬株式会社 光学活性４−メルカプト−２−ピロリドン誘導体及びその合成中間体の製法
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
JP2969616B2 (ja) 1994-11-24 1999-11-02 田辺製薬株式会社 ４−メルカプトピロリジン化合物の製法
JPH09143156A (ja) * 1995-11-17 1997-06-03 Tanabe Seiyaku Co Ltd アセトキシアゼチジノン誘導体の製法及びその合成中間体
TW420681B (en) * 1995-12-08 2001-02-01 Lederle Japan Ltd Carbapenem-3-carboxylic acid ester derivatives
WO1997041123A1 (fr) * 1996-04-26 1997-11-06 Sankyo Company, Limited Derives de 1-methylcarbapeneme
JPH1077285A (ja) 1996-09-04 1998-03-24 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE69932927D1 (de) 1998-05-01 2006-10-05 Kyoto Pharma Ind Cabapenemderivate, ihre anwendung und ihre zwischenprodukte
EP1076058A4 (de) 1998-05-08 2003-01-02 Sumitomo Pharma $g(b)-LACTAM-DERIVATE UND VERFARHEN ZU IHRER HERSTELLUNG
WO2000042041A1 (fr) * 1999-01-13 2000-07-20 Sankyo Company, Limited Composes a base d'esters de carbapenem
EP1204657A1 (de) * 1999-08-18 2002-05-15 Schering Aktiengesellschaft Piperidine- und pyrrolidinederivate mit neuronaler wirkung
CZ296825B6 (cs) * 2001-05-21 2006-06-14 Kyoto Pharmaceutical Industries, Ltd. Karbapenemový derivát a antibakteriální cinidlo jej obsahující
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2004089954A1 (ja) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
JPWO2006025475A1 (ja) * 2004-09-03 2008-05-08 大日本住友製薬株式会社 新規なカルバペネム化合物
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
FR2508440B1 (fr) * 1981-06-25 1985-11-08 Saint Gobain Isover Procede de preparation d'alcools orthohydroxybenzyliques
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
CA1272719A (en) * 1986-03-06 1990-08-14 Pierre Dextraze Carbapenem antibiotics

Also Published As

Publication number Publication date
NO168304B (no) 1991-10-28
FI891572A0 (fi) 1989-03-31
HU211836A9 (en) 1995-12-28
DK158089D0 (da) 1989-03-31
IE66711B1 (en) 1996-01-24
NO891364L (no) 1990-02-08
HUT50178A (en) 1989-12-28
KR890016045A (ko) 1989-11-28
GR3015128T3 (en) 1995-05-31
AU615729B2 (en) 1991-10-10
FI891572A (fi) 1989-10-02
IE891035L (en) 1989-10-01
HU204275B (en) 1991-12-30
ATE114654T1 (de) 1994-12-15
HK1005733A1 (en) 1999-01-22
DE68919508D1 (de) 1995-01-12
IE950607L (en) 1989-10-01
DK199801576A (da) 1998-11-30
EP0337637B1 (de) 1994-11-30
KR0133071B1 (ko) 1998-04-17
NO891364D0 (no) 1989-03-31
CA1336092C (en) 1995-06-27
FI91258B (fi) 1994-02-28
EP0597821A1 (de) 1994-05-18
ES2067534T3 (es) 1995-04-01
KR0132907B1 (ko) 1998-04-17
FI91258C (fi) 1994-06-10
EP0337637A1 (de) 1989-10-18
AU3238689A (en) 1989-10-05
DK158089A (da) 1989-10-02
NZ228589A (en) 1991-06-25
DE68919508T2 (de) 1995-07-20
NO168304C (no) 1992-02-05
US5104867A (en) 1992-04-14

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