DK174771B1 - Fysiologisk tålelig forbindelse, diagnostisk middel indeholdende denne, anvendelse af forbindelsen til fremstilling af det diagnostiske middel samt en fremgangsmåde til fremstilling af forbindelsen - Google Patents

Fysiologisk tålelig forbindelse, diagnostisk middel indeholdende denne, anvendelse af forbindelsen til fremstilling af det diagnostiske middel samt en fremgangsmåde til fremstilling af forbindelsen Download PDF

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Publication number
DK174771B1
DK174771B1 DK198705003A DK500387A DK174771B1 DK 174771 B1 DK174771 B1 DK 174771B1 DK 198705003 A DK198705003 A DK 198705003A DK 500387 A DK500387 A DK 500387A DK 174771 B1 DK174771 B1 DK 174771B1
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DK
Denmark
Prior art keywords
bis
acid
complex
carboxymethyl
iii
Prior art date
Application number
DK198705003A
Other languages
Danish (da)
English (en)
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DK500387D0 (da
DK500387A (da
Inventor
Bernd Raduechel
Heinz Gries
Ulrich Speck
Wolfgang Muetzel
Hans-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863633245 external-priority patent/DE3633245A1/de
Priority claimed from DE19863633246 external-priority patent/DE3633246A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK500387D0 publication Critical patent/DK500387D0/da
Publication of DK500387A publication Critical patent/DK500387A/da
Application granted granted Critical
Publication of DK174771B1 publication Critical patent/DK174771B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C07D265/33—Two oxygen atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DK198705003A 1986-09-26 1987-09-23 Fysiologisk tålelig forbindelse, diagnostisk middel indeholdende denne, anvendelse af forbindelsen til fremstilling af det diagnostiske middel samt en fremgangsmåde til fremstilling af forbindelsen DK174771B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3633246 1986-09-26
DE19863633245 DE3633245A1 (de) 1986-09-26 1986-09-26 Cyclische amid-komplexe
DE19863633246 DE3633246A1 (de) 1986-09-26 1986-09-26 Amid-komplexe
DE3633245 1986-09-26

Publications (3)

Publication Number Publication Date
DK500387D0 DK500387D0 (da) 1987-09-23
DK500387A DK500387A (da) 1988-03-27
DK174771B1 true DK174771B1 (da) 2003-10-27

Family

ID=25847991

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198705003A DK174771B1 (da) 1986-09-26 1987-09-23 Fysiologisk tålelig forbindelse, diagnostisk middel indeholdende denne, anvendelse af forbindelsen til fremstilling af det diagnostiske middel samt en fremgangsmåde til fremstilling af forbindelsen

Country Status (13)

Country Link
US (1) US5693310A (fi)
EP (1) EP0263059B1 (fi)
JP (1) JP2509247B2 (fi)
AU (1) AU612119B2 (fi)
DE (1) DE3782606D1 (fi)
DK (1) DK174771B1 (fi)
ES (1) ES2044968T3 (fi)
GR (1) GR3006370T3 (fi)
IE (1) IE62181B1 (fi)
IL (1) IL83966A (fi)
NO (1) NO175364C (fi)
NZ (1) NZ221932A (fi)
PT (1) PT85794B (fi)

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AU7899587A (en) 1988-03-31
JP2509247B2 (ja) 1996-06-19
IL83966A0 (en) 1988-02-29
EP0263059A2 (de) 1988-04-06
EP0263059A3 (en) 1989-02-22
GR3006370T3 (fi) 1993-06-21
DK500387D0 (da) 1987-09-23
NZ221932A (en) 1990-07-26
ES2044968T3 (es) 1994-01-16
AU612119B2 (en) 1991-07-04
NO175364B (no) 1994-06-27
NO874031D0 (no) 1987-09-25
IE62181B1 (en) 1994-12-28
JPS6393758A (ja) 1988-04-25
PT85794A (de) 1987-10-01
PT85794B (pt) 1990-08-31
US5693310A (en) 1997-12-02
NO175364C (no) 1994-10-05
DK500387A (da) 1988-03-27
NO874031L (no) 1988-03-28
IE872579L (en) 1988-03-26
IL83966A (en) 1992-03-29
EP0263059B1 (de) 1992-11-11
DE3782606D1 (de) 1992-12-17

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