DK173910B1 - Ikke-glycosylerede polypeptider, som har en intakt lysin-isoleucin-binding i den position, der svarer til aminosyrerne 158-159 i det native prourokinasemolekyle, og som har tilstrækkeligt af den i fig. 4A og 4B viste aminosyresekvens til, ... - Google Patents

Ikke-glycosylerede polypeptider, som har en intakt lysin-isoleucin-binding i den position, der svarer til aminosyrerne 158-159 i det native prourokinasemolekyle, og som har tilstrækkeligt af den i fig. 4A og 4B viste aminosyresekvens til, ... Download PDF

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Publication number
DK173910B1
DK173910B1 DK198301636A DK163683A DK173910B1 DK 173910 B1 DK173910 B1 DK 173910B1 DK 198301636 A DK198301636 A DK 198301636A DK 163683 A DK163683 A DK 163683A DK 173910 B1 DK173910 B1 DK 173910B1
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Prior art keywords
urokinase
polypeptide
dna
amino acid
fragment
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DK198301636A
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Danish (da)
English (en)
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DK163683D0 (da
DK163683A (da
Inventor
Herbert Louis Heyneker
Gordon Alan Vehar
William Evan Holmes
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Genentech Inc
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Publication of DK163683D0 publication Critical patent/DK163683D0/da
Publication of DK163683A publication Critical patent/DK163683A/da
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK198301636A 1982-04-15 1983-04-14 Ikke-glycosylerede polypeptider, som har en intakt lysin-isoleucin-binding i den position, der svarer til aminosyrerne 158-159 i det native prourokinasemolekyle, og som har tilstrækkeligt af den i fig. 4A og 4B viste aminosyresekvens til, ... DK173910B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US36877382 1982-04-15
US47493083A 1983-03-14 1983-03-14
US47493083 1983-03-14

Publications (3)

Publication Number Publication Date
DK163683D0 DK163683D0 (da) 1983-04-14
DK163683A DK163683A (da) 1983-11-28
DK173910B1 true DK173910B1 (da) 2002-02-11

Family

ID=27004326

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198301636A DK173910B1 (da) 1982-04-15 1983-04-14 Ikke-glycosylerede polypeptider, som har en intakt lysin-isoleucin-binding i den position, der svarer til aminosyrerne 158-159 i det native prourokinasemolekyle, og som har tilstrækkeligt af den i fig. 4A og 4B viste aminosyresekvens til, ...

Country Status (20)

Country Link
EP (2) EP0620279B1 (fi)
JP (3) JPH0655145B2 (fi)
AT (2) ATE112802T1 (fi)
AU (1) AU573523B2 (fi)
BR (1) BR8301918A (fi)
CA (1) CA1341301C (fi)
DE (2) DE3382760T2 (fi)
DK (1) DK173910B1 (fi)
ES (3) ES521418A0 (fi)
FI (1) FI88932C (fi)
GR (1) GR78180B (fi)
HK (1) HK38297A (fi)
IE (1) IE64536B1 (fi)
IL (2) IL68366A (fi)
MY (1) MY102472A (fi)
NO (1) NO831317L (fi)
NZ (1) NZ203869A (fi)
PH (4) PH24783A (fi)
PT (1) PT76546B (fi)
YU (1) YU45128B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
EP0139447B1 (en) * 1983-09-13 1992-12-30 The Green Cross Corporation A process for preparing urokinase zymogen
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
EP0154272B1 (en) * 1984-02-27 1992-01-08 Green Cross Corporation Production of human urokinase
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
EP0210279B1 (en) * 1985-01-25 1991-08-14 Sagami Chemical Research Center Stabilized human prourokinase
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
JP2983997B2 (ja) * 1987-01-30 1999-11-29 アメリカン・ホーム・プロダクツ・コーポレイション 脱―表皮細胞成長因子プラスミノーゲンアクチベーター
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
EP0330700B1 (en) * 1987-08-19 1993-12-22 Sagami Chemical Research Center Human prourokinase-like polypeptide
JP2730923B2 (ja) * 1987-10-02 1998-03-25 ザイモジェネティクス，インコーポレイティド Ｂａｒ１分泌シグナル
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
WO1991006658A2 (en) * 1989-10-24 1991-05-16 Cetus Corporation Infective protein delivery system
DE4101736A1 (de) * 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
ATE290600T1 (de) * 1998-06-26 2005-03-15 Croptech Dev Corp Herstellung von urokinase in pflanzlichen expressionssystemen
AU2001269803A1 (en) * 2000-06-20 2002-01-02 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
NZ595193A (en) 2005-10-21 2013-09-27 Catalyst Biosciences Inc Modified Proteases That Inhibit Complement Activation
KR20150033726A (ko) 2006-07-05 2015-04-01 카탈리스트 바이오사이언시즈, 인코포레이티드 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3068549D1 (en) * 1979-11-13 1984-08-16 Syed Shaukat Husain Plasminogen activators useful as therapeutic and diagnostic agents and their isolation
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
PH22337A (en) * 1983-11-21 1988-08-12 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast

Also Published As

Publication number Publication date
AU573523B2 (en) 1988-06-16
DE3382760T2 (de) 1995-03-02
DK163683D0 (da) 1983-04-14
EP0620279A1 (en) 1994-10-19
DK163683A (da) 1983-11-28
FI88932B (fi) 1993-04-15
IE64536B1 (en) 1995-08-09
PH24783A (en) 1990-10-30
JPH0824579B2 (ja) 1996-03-13
EP0092182B1 (en) 1994-10-12
PT76546B (en) 1986-03-20
EP0092182A2 (en) 1983-10-26
ES8506087A1 (es) 1985-07-01
ES533924A0 (es) 1985-07-01
HK38297A (en) 1997-04-04
EP0620279B1 (en) 2003-02-05
YU45128B (en) 1992-03-10
BR8301918A (pt) 1983-12-20
GR78180B (fi) 1984-09-26
FI831228L (fi) 1983-10-16
JPH0530970A (ja) 1993-02-09
IL83236A0 (en) 1987-12-31
PT76546A (en) 1983-05-01
YU86883A (en) 1988-10-31
ES8500325A1 (es) 1984-11-01
ATE232237T1 (de) 2003-02-15
JPH07186A (ja) 1995-01-06
JP2584192B2 (ja) 1997-02-19
MY102472A (en) 1992-06-30
ATE112802T1 (de) 1994-10-15
EP0092182A3 (en) 1984-07-18
IE830850L (en) 1983-10-15
PH22461A (en) 1988-09-12
DE3382760D1 (de) 1994-11-17
ES521418A0 (es) 1984-11-01
NO831317L (no) 1983-10-17
AU1352483A (en) 1983-10-20
FI88932C (fi) 1993-07-26
IL68366A (en) 1990-08-31
DE3382837T2 (de) 2004-01-15
DE3382837D1 (de) 2003-03-13
PH25120A (en) 1991-02-19
NZ203869A (en) 1987-04-30
CA1341301C (en) 2001-10-09
IE950235L (en) 1983-10-15
ES533925A0 (es) 1985-12-01
JPH0655145B2 (ja) 1994-07-27
FI831228A0 (fi) 1983-04-12
PH25312A (en) 1991-04-30
IL68366A0 (en) 1983-07-31
ES8602121A1 (es) 1985-12-01
JPS5951300A (ja) 1984-03-24

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Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired