DK1716119T3 - Analoger af benzoquinonholdige ansamyciner til behandling af cancer - Google Patents
Analoger af benzoquinonholdige ansamyciner til behandling af cancerInfo
- Publication number
- DK1716119T3 DK1716119T3 DK04817048.4T DK04817048T DK1716119T3 DK 1716119 T3 DK1716119 T3 DK 1716119T3 DK 04817048 T DK04817048 T DK 04817048T DK 1716119 T3 DK1716119 T3 DK 1716119T3
- Authority
- DK
- Denmark
- Prior art keywords
- anamicycines
- benzoquinon
- analogs
- cancer
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53208003P | 2003-12-23 | 2003-12-23 | |
| US54014204P | 2004-01-29 | 2004-01-29 | |
| US54738104P | 2004-02-23 | 2004-02-23 | |
| US56171804P | 2004-04-12 | 2004-04-12 | |
| US56756504P | 2004-05-03 | 2004-05-03 | |
| US60628304P | 2004-09-01 | 2004-09-01 | |
| US62628604P | 2004-11-09 | 2004-11-09 | |
| US63285804P | 2004-12-03 | 2004-12-03 | |
| PCT/US2004/043162 WO2005063714A1 (en) | 2003-12-23 | 2004-12-23 | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1716119T3 true DK1716119T3 (da) | 2013-06-10 |
Family
ID=34744040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04817048.4T DK1716119T3 (da) | 2003-12-23 | 2004-12-23 | Analoger af benzoquinonholdige ansamyciner til behandling af cancer |
Country Status (15)
| Country | Link |
|---|---|
| US (13) | US7282493B2 (enExample) |
| EP (2) | EP2492261B1 (enExample) |
| JP (2) | JP4869077B2 (enExample) |
| KR (1) | KR101154351B1 (enExample) |
| CN (1) | CN102643233B (enExample) |
| AU (1) | AU2004309395C1 (enExample) |
| BR (1) | BRPI0418147A (enExample) |
| CA (1) | CA2547343C (enExample) |
| DK (1) | DK1716119T3 (enExample) |
| ES (1) | ES2409351T3 (enExample) |
| IL (2) | IL175911A (enExample) |
| NO (1) | NO337933B1 (enExample) |
| PT (1) | PT1716119E (enExample) |
| RU (1) | RU2484086C9 (enExample) |
| WO (1) | WO2005063714A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090197852A9 (en) * | 2001-08-06 | 2009-08-06 | Johnson Robert G Jr | Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor |
| US20060019941A1 (en) * | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| EP2492261B1 (en) | 2003-12-23 | 2015-02-18 | Infinity Discovery, Inc. | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
| JP2008519031A (ja) * | 2004-11-02 | 2008-06-05 | コンフォーマ・セラピューティクス・コーポレイション | 慢性リンパ球性白血病を治療する方法および組成物 |
| US10252088B2 (en) | 2004-12-02 | 2019-04-09 | Obagi Cosmeceuticals Llc | Topical compositions and methods of manufacturing them in specifically treated steel vessels |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| US11457813B2 (en) | 2005-03-29 | 2022-10-04 | Martin W. Roche | Method for detecting body parameters |
| EP1874296A4 (en) * | 2005-04-29 | 2010-06-30 | Kosan Biosciences Inc | METHOD FOR THE TREATMENT OF SEVERAL MYELOMES USING 17-AAG OR 17-AG OR PRODRUGS OR ALL |
| GB0517886D0 (en) * | 2005-09-02 | 2005-10-12 | Biotica Tech Ltd | Novel compounds |
| US20090042847A1 (en) * | 2005-11-23 | 2009-02-12 | Kosan Biosciences Incorporated | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
| US20070207992A1 (en) * | 2006-02-21 | 2007-09-06 | Board Of Trustees Of Michigan State University | Geldanamycin derivatives and method of use thereof |
| GB0606548D0 (en) * | 2006-03-31 | 2006-05-10 | Biotica Tech Ltd | Novel compounds and methods for their production |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2073803B1 (en) | 2006-10-12 | 2018-09-19 | Astex Therapeutics Limited | Pharmaceutical combinations |
| FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| ES2389740T3 (es) | 2006-11-09 | 2012-10-31 | Bristol-Myers Squibb Company | Nuevos compuestos y procedimientos para su producción |
| PE20081506A1 (es) * | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| EP2121957A4 (en) * | 2007-01-26 | 2010-11-10 | Kosan Biosciences Inc | MACROLACTAMES OBTAINED BY MODIFIED BIOSYNTHESIS |
| CA2684211A1 (en) * | 2007-04-12 | 2008-10-23 | Infinity Discovery, Inc. | Hydroquinone ansamycin formulations |
| CA2687614C (en) * | 2007-06-07 | 2013-04-30 | Joyant Pharmaceuticals, Inc. | Methods for preparing diazonamides |
| US8551964B2 (en) | 2007-08-23 | 2013-10-08 | The Regents Of The University Of Colorado | Hsp90 inhibitors with modified toxicity |
| EP2348845A4 (en) * | 2008-10-15 | 2013-01-23 | Infinity Pharmaceuticals Inc | ANSAMYCIN HYDROQUINONE COMPOSITIONS |
| WO2010124283A2 (en) * | 2009-04-24 | 2010-10-28 | The Jackson Laboratory | Methods and compositions relating to hematologic malignancies |
| US20120108563A1 (en) * | 2009-05-19 | 2012-05-03 | Infinity Pharmaceuticals, Inc. | Methods Of Treating Liposarcoma |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| CA2779843A1 (en) * | 2009-11-13 | 2011-05-19 | Infinity Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| US9603829B2 (en) | 2011-11-14 | 2017-03-28 | The Regents Of The University Of Colorado, A Body Corporate | HSP90 inhibitors with modified toxicity |
| WO2017048911A1 (en) * | 2015-09-19 | 2017-03-23 | Applied Materials, Inc. | Surface-selective atomic layer deposition using hydrosilylation passivation |
| US10052304B2 (en) | 2015-10-12 | 2018-08-21 | University Of Iowa Research Foundation | Compositions and methods for cancer therapy |
| RU2762607C2 (ru) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Стабилизированные небелковые композиции клостридиального токсина |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US123640A (en) | 1872-02-13 | Improvement in tab-plates of buckles | ||
| US120578A (en) | 1871-11-07 | Improvement in letter-boxes | ||
| US745718A (en) * | 1903-04-25 | 1903-12-01 | Owen Thomas Dougherty | Weight-indicating sliding and spring support for vehicle-bodies. |
| GB210611A (en) * | 1923-01-16 | 1924-02-07 | Clarence Hancock | Improved means of heating garden propagating frames, foster mothers and the like |
| US3595955A (en) | 1969-03-26 | 1971-07-27 | Upjohn Co | Geldanamycin and process for producing same |
| JPS5470299A (en) * | 1977-11-14 | 1979-06-05 | Takeda Chem Ind Ltd | Production of maytansine derivative |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| GB2106111B (en) * | 1981-09-17 | 1985-11-06 | Takeda Chemical Industries Ltd | Macbecin derivatives and their production |
| JPS5874651A (ja) * | 1981-09-17 | 1983-05-06 | Takeda Chem Ind Ltd | マクベシン誘導体およびその製造法 |
| US4762857A (en) * | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
| NZ222695A (en) | 1986-11-29 | 1990-03-27 | Ueno Seiyaku Oyo Kenkyujo Kk | Synergistic antiviral compositions |
| BR9207024A (pt) * | 1992-01-06 | 1995-12-05 | Pfizer | Processo e utilizações para 4,5-DI-hidrogeldanamicina e sua hidroquinona |
| US5397584A (en) * | 1992-12-09 | 1995-03-14 | Mccormick & Company, Inc. | Process for preparing stabilized, partially-dehydrated aromatic plant products |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| JP2794342B2 (ja) * | 1993-06-29 | 1998-09-03 | ファイザー・インク. | 抗癌遺伝子剤および抗癌剤としてのアンサマイシン誘導体 |
| US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| EP0833667A4 (en) | 1995-06-07 | 2001-11-21 | Univ California | STABILIZATION OF POLYNUCLEOTIDE COMPLEXES |
| US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| MY120063A (en) | 1997-12-09 | 2005-08-30 | Lilly Co Eli | Stabilized teriparatide solutions |
| WO1999051223A1 (en) | 1998-04-03 | 1999-10-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
| AU764603B2 (en) | 1998-07-17 | 2003-08-21 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Water-soluble drugs and methods for their production |
| US6174875B1 (en) | 1999-04-01 | 2001-01-16 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
| AU2001271567A1 (en) | 2000-06-29 | 2002-01-14 | Trustees Of Boston University | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
| WO2002009696A1 (en) | 2000-07-28 | 2002-02-07 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
| EP1373215B1 (en) * | 2001-03-30 | 2006-07-26 | THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH | Geldanamycin derivatives useful for treating cancer |
| AU2002330998A1 (en) | 2001-08-06 | 2003-02-24 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| CA2456175A1 (en) * | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| DE60225307T2 (de) | 2001-09-24 | 2009-03-19 | Conforma Therapeutics Corp., San Diego | Verfahren zur herstellung von 17-allyl-amino-geldanamycin (17-aag) und anderer ansamycine |
| US20050074457A1 (en) * | 2001-12-12 | 2005-04-07 | Adeela Kamal | Assays and implements for determining and modulating hsp90 binding activity |
| CA2474508A1 (en) * | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| TW200303363A (en) | 2002-02-25 | 2003-09-01 | Upjohn Co | Process to prepare and isolate geldanamycin |
| BRPI0311959B8 (pt) | 2002-06-21 | 2021-05-25 | Novo Nordisk Healthcare Ag | composição, métodos para preparar um polipeptídeo estável do fator vii, e para tratar uma síndrome responsiva do fator vii, e, uso do polipeptídeo do fator vii |
| CN101756961A (zh) | 2003-03-13 | 2010-06-30 | 康福玛医药公司 | 含有长链和中链甘油三酯的药物制剂 |
| US20060019941A1 (en) | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| EP2492261B1 (en) | 2003-12-23 | 2015-02-18 | Infinity Discovery, Inc. | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
| EP1737825A1 (en) | 2004-03-26 | 2007-01-03 | Van Andel Research Institute | Geldanamycin and derivatives inhibit cancer invasion and identify novel targets |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| EP1906950A4 (en) | 2005-06-21 | 2008-09-24 | Infinity Discovery Inc | ANSAMYCIN FORMULATIONS AND METHODS OF USE |
| CA2613632A1 (en) | 2005-06-29 | 2007-01-04 | Shinpei Yamaguchi | Benzenoid ansamycin derivative |
| CN101360492A (zh) | 2005-12-01 | 2009-02-04 | 康福玛医药公司 | 含安莎霉素的组合物 |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| CA2684211A1 (en) | 2007-04-12 | 2008-10-23 | Infinity Discovery, Inc. | Hydroquinone ansamycin formulations |
| US9907242B2 (en) | 2016-02-18 | 2018-03-06 | Seminis Vegetable Seeds, Inc. | Pepper hybrid SV5873HE |
-
2004
- 2004-12-23 EP EP12168729.7A patent/EP2492261B1/en not_active Expired - Lifetime
- 2004-12-23 US US11/022,057 patent/US7282493B2/en not_active Expired - Fee Related
- 2004-12-23 RU RU2006126797/04A patent/RU2484086C9/ru not_active IP Right Cessation
- 2004-12-23 DK DK04817048.4T patent/DK1716119T3/da active
- 2004-12-23 BR BRPI0418147-6A patent/BRPI0418147A/pt active Search and Examination
- 2004-12-23 EP EP04817048A patent/EP1716119B1/en not_active Expired - Lifetime
- 2004-12-23 CN CN201210093005.4A patent/CN102643233B/zh not_active Expired - Fee Related
- 2004-12-23 ES ES04817048T patent/ES2409351T3/es not_active Expired - Lifetime
- 2004-12-23 JP JP2006547323A patent/JP4869077B2/ja not_active Expired - Fee Related
- 2004-12-23 KR KR1020067014822A patent/KR101154351B1/ko not_active Expired - Fee Related
- 2004-12-23 PT PT48170484T patent/PT1716119E/pt unknown
- 2004-12-23 CA CA2547343A patent/CA2547343C/en not_active Expired - Fee Related
- 2004-12-23 AU AU2004309395A patent/AU2004309395C1/en not_active Ceased
- 2004-12-23 WO PCT/US2004/043162 patent/WO2005063714A1/en not_active Ceased
-
2005
- 2005-04-13 US US11/105,203 patent/US7566706B2/en not_active Expired - Fee Related
- 2005-04-14 US US11/108,165 patent/US7375217B2/en not_active Expired - Fee Related
- 2005-04-14 US US11/107,404 patent/US7361647B2/en not_active Expired - Fee Related
-
2006
- 2006-05-25 IL IL175911A patent/IL175911A/en not_active IP Right Cessation
- 2006-06-12 NO NO20062707A patent/NO337933B1/no not_active IP Right Cessation
-
2008
- 2008-08-27 US US12/199,415 patent/US7579337B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/199,211 patent/US7608613B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/199,578 patent/US7833997B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/199,356 patent/US7767662B2/en not_active Expired - Fee Related
-
2009
- 2009-02-11 US US12/369,549 patent/US7691840B2/en not_active Expired - Fee Related
- 2009-02-11 US US12/369,545 patent/US7767663B2/en not_active Expired - Fee Related
-
2010
- 2010-07-14 IL IL206984A patent/IL206984A/en not_active IP Right Cessation
- 2010-10-06 US US12/899,187 patent/US8003634B2/en not_active Expired - Fee Related
-
2011
- 2011-07-27 US US13/191,761 patent/US8252779B2/en not_active Expired - Fee Related
- 2011-08-04 JP JP2011170747A patent/JP5313308B2/ja not_active Expired - Fee Related
-
2012
- 2012-08-20 US US13/589,581 patent/US8703755B2/en not_active Expired - Fee Related
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