BRPI0418147A - análogos de ansamicinas contendo benzoquinona e seus métodos de uso - Google Patents
análogos de ansamicinas contendo benzoquinona e seus métodos de usoInfo
- Publication number
- BRPI0418147A BRPI0418147A BRPI0418147-6A BRPI0418147A BRPI0418147A BR PI0418147 A BRPI0418147 A BR PI0418147A BR PI0418147 A BRPI0418147 A BR PI0418147A BR PI0418147 A BRPI0418147 A BR PI0418147A
- Authority
- BR
- Brazil
- Prior art keywords
- benzoquinone
- analogs
- methods
- ansamycin
- ansamycin analogs
- Prior art date
Links
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 title abstract 5
- ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical class O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 title abstract 3
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53208003P | 2003-12-23 | 2003-12-23 | |
| US54014204P | 2004-01-29 | 2004-01-29 | |
| US54738104P | 2004-02-23 | 2004-02-23 | |
| US56171804P | 2004-04-12 | 2004-04-12 | |
| US56756504P | 2004-05-03 | 2004-05-03 | |
| US60628304P | 2004-09-01 | 2004-09-01 | |
| US62628604P | 2004-11-09 | 2004-11-09 | |
| US63285804P | 2004-12-03 | 2004-12-03 | |
| PCT/US2004/043162 WO2005063714A1 (en) | 2003-12-23 | 2004-12-23 | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0418147A true BRPI0418147A (pt) | 2007-04-17 |
Family
ID=34744040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0418147-6A BRPI0418147A (pt) | 2003-12-23 | 2004-12-23 | análogos de ansamicinas contendo benzoquinona e seus métodos de uso |
Country Status (15)
| Country | Link |
|---|---|
| US (13) | US7282493B2 (enExample) |
| EP (2) | EP2492261B1 (enExample) |
| JP (2) | JP4869077B2 (enExample) |
| KR (1) | KR101154351B1 (enExample) |
| CN (1) | CN102643233B (enExample) |
| AU (1) | AU2004309395C1 (enExample) |
| BR (1) | BRPI0418147A (enExample) |
| CA (1) | CA2547343C (enExample) |
| DK (1) | DK1716119T3 (enExample) |
| ES (1) | ES2409351T3 (enExample) |
| IL (2) | IL175911A (enExample) |
| NO (1) | NO337933B1 (enExample) |
| PT (1) | PT1716119E (enExample) |
| RU (1) | RU2484086C9 (enExample) |
| WO (1) | WO2005063714A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090197852A9 (en) * | 2001-08-06 | 2009-08-06 | Johnson Robert G Jr | Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor |
| CN102643233B (zh) | 2003-12-23 | 2015-11-25 | 无限发现公司 | 用于治疗癌症的包含苯醌的安沙霉素类似物 |
| US20060019941A1 (en) * | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| EP1814392A4 (en) * | 2004-11-02 | 2008-06-11 | Conforma Therapeutics Corp | METHODS AND COMPOSITIONS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA |
| US10252088B2 (en) | 2004-12-02 | 2019-04-09 | Obagi Cosmeceuticals Llc | Topical compositions and methods of manufacturing them in specifically treated steel vessels |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| US11457813B2 (en) | 2005-03-29 | 2022-10-04 | Martin W. Roche | Method for detecting body parameters |
| RU2007144195A (ru) * | 2005-04-29 | 2009-06-10 | Козан Байосайенсиз Инкорпорейтед (Us) | Способ лечения множественной миеломы с использованием 17-aag или 17-ag или пролекарства любого из них |
| GB0517886D0 (en) * | 2005-09-02 | 2005-10-12 | Biotica Tech Ltd | Novel compounds |
| US20090042847A1 (en) * | 2005-11-23 | 2009-02-12 | Kosan Biosciences Incorporated | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
| US20070207992A1 (en) * | 2006-02-21 | 2007-09-06 | Board Of Trustees Of Michigan State University | Geldanamycin derivatives and method of use thereof |
| GB0606548D0 (en) * | 2006-03-31 | 2006-05-10 | Biotica Tech Ltd | Novel compounds and methods for their production |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| US8492370B2 (en) | 2006-11-09 | 2013-07-23 | Bristol-Myers Squibb Company | Compounds and methods for their production |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| CN101688227B (zh) * | 2007-01-26 | 2013-07-24 | 科森生物科学公司 | 通过工程化生物合成制备的大环内酰胺 |
| CN101677991A (zh) * | 2007-04-12 | 2010-03-24 | 英菲尼蒂发现公司 | 氢醌安莎霉素制剂 |
| US7851620B2 (en) * | 2007-06-07 | 2010-12-14 | Board Of Regents, The University Of Texas System | Methods for preparing diazonamides |
| US8551964B2 (en) | 2007-08-23 | 2013-10-08 | The Regents Of The University Of Colorado | Hsp90 inhibitors with modified toxicity |
| WO2010045442A1 (en) * | 2008-10-15 | 2010-04-22 | Infinity Discovery, Inc. | Ansamycin hydroquinone compositions |
| US8669289B2 (en) * | 2009-04-24 | 2014-03-11 | The Jackson Laboratory | Methods and compositions relating to hematologic malignancies |
| WO2010135426A1 (en) * | 2009-05-19 | 2010-11-25 | Infinity Pharmaceuticals, Inc. | Methods of treating liposarcoma |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| JP2013510585A (ja) * | 2009-11-13 | 2013-03-28 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 癌の同定、評価、予防および治療のための組成物、キットおよび方法 |
| WO2013074695A1 (en) | 2011-11-14 | 2013-05-23 | The Regents Of The University Of Colorado, A Body Corporate | Hsp90 inhibitors with modified toxicity |
| WO2017048911A1 (en) * | 2015-09-19 | 2017-03-23 | Applied Materials, Inc. | Surface-selective atomic layer deposition using hydrosilylation passivation |
| US10052304B2 (en) | 2015-10-12 | 2018-08-21 | University Of Iowa Research Foundation | Compositions and methods for cancer therapy |
| HUE046449T2 (hu) | 2016-09-13 | 2020-03-30 | Allergan Inc | Stabilizált, nem fehérje eredetû, clostridiális toxin készítmények |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US120578A (en) | 1871-11-07 | Improvement in letter-boxes | ||
| US123640A (en) | 1872-02-13 | Improvement in tab-plates of buckles | ||
| US745718A (en) * | 1903-04-25 | 1903-12-01 | Owen Thomas Dougherty | Weight-indicating sliding and spring support for vehicle-bodies. |
| GB210611A (en) * | 1923-01-16 | 1924-02-07 | Clarence Hancock | Improved means of heating garden propagating frames, foster mothers and the like |
| US3595955A (en) | 1969-03-26 | 1971-07-27 | Upjohn Co | Geldanamycin and process for producing same |
| JPS5470299A (en) * | 1977-11-14 | 1979-06-05 | Takeda Chem Ind Ltd | Production of maytansine derivative |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| JPS5874651A (ja) * | 1981-09-17 | 1983-05-06 | Takeda Chem Ind Ltd | マクベシン誘導体およびその製造法 |
| GB2106111B (en) * | 1981-09-17 | 1985-11-06 | Takeda Chemical Industries Ltd | Macbecin derivatives and their production |
| US4762857A (en) * | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
| NZ222695A (en) | 1986-11-29 | 1990-03-27 | Ueno Seiyaku Oyo Kenkyujo Kk | Synergistic antiviral compositions |
| CA2127457A1 (en) * | 1992-01-06 | 1993-07-22 | Walter P. Cullen | Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone |
| US5397584A (en) * | 1992-12-09 | 1995-03-14 | Mccormick & Company, Inc. | Process for preparing stabilized, partially-dehydrated aromatic plant products |
| US5387584A (en) | 1993-04-07 | 1995-02-07 | Pfizer Inc. | Bicyclic ansamycins |
| EP0706516A1 (en) * | 1993-06-29 | 1996-04-17 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| US5932566A (en) | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| WO1996040265A1 (en) | 1995-06-07 | 1996-12-19 | The Regents Of The University Of California | Stabilization of polynucleotide complexes |
| US5968921A (en) | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
| ZA9811127B (en) | 1997-12-09 | 2000-07-11 | Lilly Co Eli | Stabilized teriparatide solutions. |
| WO1999051223A1 (en) | 1998-04-03 | 1999-10-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
| WO2000003737A2 (en) | 1998-07-17 | 2000-01-27 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Water-soluble drugs and methods for their production |
| US6174875B1 (en) | 1999-04-01 | 2001-01-16 | University Of Pittsburgh | Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke |
| WO2002002123A1 (en) | 2000-06-29 | 2002-01-10 | Trustees Of Boston University | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
| AU2001292548B2 (en) | 2000-07-28 | 2005-06-16 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
| DE60213386T2 (de) | 2001-03-30 | 2006-11-23 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Geldanamycinderivate zur krebsbehandlung |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| WO2003013430A2 (en) * | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| JP2005515164A (ja) * | 2001-08-06 | 2005-05-26 | コーサン バイオサイエンシーズ, インコーポレイテッド | ベンゾキノンアンサマイシン |
| JP2005504086A (ja) | 2001-09-24 | 2005-02-10 | コンフォーマ セラピューティクス コーポレーション | 17−アリルアミノゲルダナマイシン(17−aag)および他のアンサマイシン類を製造する方法 |
| JP2005520795A (ja) * | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害活性を有するプリン類似体 |
| CA2474508A1 (en) * | 2002-02-08 | 2003-08-14 | Conforma Therapeutics Corporation | Ansamycins having improved pharmacological and biological properties |
| TW200303363A (en) | 2002-02-25 | 2003-09-01 | Upjohn Co | Process to prepare and isolate geldanamycin |
| ES2523655T5 (es) | 2002-06-21 | 2018-04-23 | Novo Nordisk Health Care Ag | Composiciones sólidas estabilizadas de polipéptidos del Factor VIIa |
| JP2006514994A (ja) | 2003-03-13 | 2006-05-18 | コンフォーマ・セラピューティクス・コーポレイション | 長鎖および中鎖トリグリセリドを有する医薬製剤 |
| US20060019941A1 (en) | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| CN102643233B (zh) | 2003-12-23 | 2015-11-25 | 无限发现公司 | 用于治疗癌症的包含苯醌的安沙霉素类似物 |
| EP1737825A1 (en) | 2004-03-26 | 2007-01-03 | Van Andel Research Institute | Geldanamycin and derivatives inhibit cancer invasion and identify novel targets |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| US20100279994A1 (en) | 2005-06-21 | 2010-11-04 | Inifinity Discovery, Inc. | Ansamycin Formulations and Methods of Use Thereof |
| EP1897871A4 (en) | 2005-06-29 | 2009-12-09 | Kyowa Hakko Kirin Co Ltd | ANSAMYCIN BENZENOID DERIVATIVE |
| CN101360492A (zh) | 2005-12-01 | 2009-02-04 | 康福玛医药公司 | 含安莎霉素的组合物 |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| CN101677991A (zh) | 2007-04-12 | 2010-03-24 | 英菲尼蒂发现公司 | 氢醌安莎霉素制剂 |
| US9907242B2 (en) | 2016-02-18 | 2018-03-06 | Seminis Vegetable Seeds, Inc. | Pepper hybrid SV5873HE |
-
2004
- 2004-12-23 CN CN201210093005.4A patent/CN102643233B/zh not_active Expired - Fee Related
- 2004-12-23 CA CA2547343A patent/CA2547343C/en not_active Expired - Fee Related
- 2004-12-23 KR KR1020067014822A patent/KR101154351B1/ko not_active Expired - Fee Related
- 2004-12-23 US US11/022,057 patent/US7282493B2/en not_active Expired - Fee Related
- 2004-12-23 ES ES04817048T patent/ES2409351T3/es not_active Expired - Lifetime
- 2004-12-23 WO PCT/US2004/043162 patent/WO2005063714A1/en not_active Ceased
- 2004-12-23 BR BRPI0418147-6A patent/BRPI0418147A/pt active Search and Examination
- 2004-12-23 JP JP2006547323A patent/JP4869077B2/ja not_active Expired - Fee Related
- 2004-12-23 RU RU2006126797/04A patent/RU2484086C9/ru not_active IP Right Cessation
- 2004-12-23 AU AU2004309395A patent/AU2004309395C1/en not_active Ceased
- 2004-12-23 EP EP12168729.7A patent/EP2492261B1/en not_active Expired - Lifetime
- 2004-12-23 DK DK04817048.4T patent/DK1716119T3/da active
- 2004-12-23 EP EP04817048A patent/EP1716119B1/en not_active Expired - Lifetime
- 2004-12-23 PT PT48170484T patent/PT1716119E/pt unknown
-
2005
- 2005-04-13 US US11/105,203 patent/US7566706B2/en not_active Expired - Fee Related
- 2005-04-14 US US11/107,404 patent/US7361647B2/en not_active Expired - Fee Related
- 2005-04-14 US US11/108,165 patent/US7375217B2/en not_active Expired - Fee Related
-
2006
- 2006-05-25 IL IL175911A patent/IL175911A/en not_active IP Right Cessation
- 2006-06-12 NO NO20062707A patent/NO337933B1/no not_active IP Right Cessation
-
2008
- 2008-08-27 US US12/199,211 patent/US7608613B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/199,415 patent/US7579337B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/199,578 patent/US7833997B2/en not_active Expired - Fee Related
- 2008-08-27 US US12/199,356 patent/US7767662B2/en not_active Expired - Fee Related
-
2009
- 2009-02-11 US US12/369,549 patent/US7691840B2/en not_active Expired - Fee Related
- 2009-02-11 US US12/369,545 patent/US7767663B2/en not_active Expired - Fee Related
-
2010
- 2010-07-14 IL IL206984A patent/IL206984A/en not_active IP Right Cessation
- 2010-10-06 US US12/899,187 patent/US8003634B2/en not_active Expired - Fee Related
-
2011
- 2011-07-27 US US13/191,761 patent/US8252779B2/en not_active Expired - Fee Related
- 2011-08-04 JP JP2011170747A patent/JP5313308B2/ja not_active Expired - Fee Related
-
2012
- 2012-08-20 US US13/589,581 patent/US8703755B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0418147A (pt) | análogos de ansamicinas contendo benzoquinona e seus métodos de uso | |
| IL188355A0 (en) | Methods of treatment using hydroquinone ansamycins | |
| ECSP067043A (es) | Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis | |
| BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
| UY28482A1 (es) | Nuevos compuestos | |
| ECSP034732A (es) | Derivado de fenetanolamina para el tratamiento de enfermedades respiratorias | |
| BR9808953A (pt) | Composto, processo para tratar um distúrbio mediado pela ciclooxigenase-2 em um paciente, e, composição farmacêutica | |
| PA8491901A1 (es) | Procedimientos e intermedios para preparar compuestos anticancerosos. | |
| EP2058317A4 (en) | AMINOOPHOSPHORIC ACID DERTER DERIVATIVE AND THIS ACTIVE MODULATOR OF THE S1P RECEPTOR | |
| UY29919A1 (es) | Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones | |
| TW200716661A (en) | A novel triterpenic acid derivative and the skin external preparation containing the same | |
| BR0204678A (pt) | Inibidor de nf-kb contendo derivado de ácido benzóico substituìdo como ingrediente ativo | |
| ECSP045353A (es) | Derivados de benzoxazinona, su preparación y aplicación como medicamentos | |
| ECSP034518A (es) | Nuevos retinoides para el tratamiento de enfisema | |
| PA8532001A1 (es) | Bifenilcarboxamidas utiles como agentes reductores de lipidos | |
| ES2183180T3 (es) | Nuevos derivados de guanidina, procedimientos para su preparacion y su uso como medicamento. | |
| BR9912179A (pt) | Composição neuroprotetora para a prevenção e/ou tratamento de alterações nervosas e do comportamento devido a estados de ansiedade ou depressão | |
| PA8542601A1 (es) | Bifenilcarboxamidas reductoras de lipidos | |
| GT199900081A (es) | Compuestos de sulfonilbenceno como agentes anti-inflamatorios / analgesicos. | |
| MX9307232A (es) | Arilcicloalquilaminas n,n-disustituidas, sus sales, medicamentos que contiene estos compuestos y su empleo, asi como procedimientos para su preparacion. | |
| MX9303466A (es) | Derivados de bifenilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion. | |
| ES2192668T3 (es) | Compuestos biciclicos-aromaticos. | |
| CO5611124A2 (es) | Derivados de benzofurano substituidos utiles en el tratamiento de desordenes hiper-proliferativos | |
| BR0112337A (pt) | Derivados de fosfolipìdeos de ácido valpróico e suas misturas | |
| ES2187125T3 (es) | Compuestos biciclicos-aromaticos y su utilizacion en medicina humana o veterinaria asi como en cosmetologia. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: INFINITY DISCOVERY, INC. (US) Free format text: NOME ALTERADO DE: INFINITY PHARMACEUTICALS, INC. |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |