KR101154351B1 - 암 치료를 위한 벤조퀴논-함유 안사마이신의 유사체 - Google Patents

암 치료를 위한 벤조퀴논-함유 안사마이신의 유사체 Download PDF

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Publication number
KR101154351B1
KR101154351B1 KR1020067014822A KR20067014822A KR101154351B1 KR 101154351 B1 KR101154351 B1 KR 101154351B1 KR 1020067014822 A KR1020067014822 A KR 1020067014822A KR 20067014822 A KR20067014822 A KR 20067014822A KR 101154351 B1 KR101154351 B1 KR 101154351B1
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South Korea
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alkyl
hydrogen
compound
aryl
formula
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Expired - Fee Related
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Korean (ko)
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KR20060132660A (ko
Inventor
쥴리안 아담스
윤 가오
아시미나 티 조지스 이반젤리노스
루이스 그레니어
로저 에이치 박
제임스 알 포터
제임스 엘 라이트
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인피니티 디스커버리, 인코포레이티드
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Application filed by 인피니티 디스커버리, 인코포레이티드 filed Critical 인피니티 디스커버리, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020067014822A 2003-12-23 2004-12-23 암 치료를 위한 벤조퀴논-함유 안사마이신의 유사체 Expired - Fee Related KR101154351B1 (ko)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US53208003P 2003-12-23 2003-12-23
US60/532,080 2003-12-23
US54014204P 2004-01-29 2004-01-29
US60/540,142 2004-01-29
US54738104P 2004-02-23 2004-02-23
US60/547,381 2004-02-23
US56171804P 2004-04-12 2004-04-12
US60/561,718 2004-04-12
US56756504P 2004-05-03 2004-05-03
US60/567,565 2004-05-03
US60628304P 2004-09-01 2004-09-01
US60/606,283 2004-09-01
US62628604P 2004-11-09 2004-11-09
US60/626,286 2004-11-09
US63285804P 2004-12-03 2004-12-03
US60/632,858 2004-12-03
PCT/US2004/043162 WO2005063714A1 (en) 2003-12-23 2004-12-23 Analogs of benzoquinone-containing ansamycins for the treatment of cancer

Publications (2)

Publication Number Publication Date
KR20060132660A KR20060132660A (ko) 2006-12-21
KR101154351B1 true KR101154351B1 (ko) 2012-06-15

Family

ID=34744040

Family Applications (1)

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KR1020067014822A Expired - Fee Related KR101154351B1 (ko) 2003-12-23 2004-12-23 암 치료를 위한 벤조퀴논-함유 안사마이신의 유사체

Country Status (15)

Country Link
US (13) US7282493B2 (enExample)
EP (2) EP2492261B1 (enExample)
JP (2) JP4869077B2 (enExample)
KR (1) KR101154351B1 (enExample)
CN (1) CN102643233B (enExample)
AU (1) AU2004309395C1 (enExample)
BR (1) BRPI0418147A (enExample)
CA (1) CA2547343C (enExample)
DK (1) DK1716119T3 (enExample)
ES (1) ES2409351T3 (enExample)
IL (2) IL175911A (enExample)
NO (1) NO337933B1 (enExample)
PT (1) PT1716119E (enExample)
RU (1) RU2484086C9 (enExample)
WO (1) WO2005063714A1 (enExample)

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CN102643233B (zh) 2003-12-23 2015-11-25 无限发现公司 用于治疗癌症的包含苯醌的安沙霉素类似物
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
EP1814392A4 (en) * 2004-11-02 2008-06-11 Conforma Therapeutics Corp METHODS AND COMPOSITIONS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA
US10252088B2 (en) 2004-12-02 2019-04-09 Obagi Cosmeceuticals Llc Topical compositions and methods of manufacturing them in specifically treated steel vessels
WO2006098761A2 (en) 2005-03-11 2006-09-21 The Regents Of The University Of Colorado Hsp90 inhibitors, methods of making and uses therefor
US11457813B2 (en) 2005-03-29 2022-10-04 Martin W. Roche Method for detecting body parameters
RU2007144195A (ru) * 2005-04-29 2009-06-10 Козан Байосайенсиз Инкорпорейтед (Us) Способ лечения множественной миеломы с использованием 17-aag или 17-ag или пролекарства любого из них
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US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
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US8492370B2 (en) 2006-11-09 2013-07-23 Bristol-Myers Squibb Company Compounds and methods for their production
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CN101688227B (zh) * 2007-01-26 2013-07-24 科森生物科学公司 通过工程化生物合成制备的大环内酰胺
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US7851620B2 (en) * 2007-06-07 2010-12-14 Board Of Regents, The University Of Texas System Methods for preparing diazonamides
US8551964B2 (en) 2007-08-23 2013-10-08 The Regents Of The University Of Colorado Hsp90 inhibitors with modified toxicity
WO2010045442A1 (en) * 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions
US8669289B2 (en) * 2009-04-24 2014-03-11 The Jackson Laboratory Methods and compositions relating to hematologic malignancies
WO2010135426A1 (en) * 2009-05-19 2010-11-25 Infinity Pharmaceuticals, Inc. Methods of treating liposarcoma
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
JP2013510585A (ja) * 2009-11-13 2013-03-28 インフィニティー ファーマシューティカルズ， インコーポレイテッド 癌の同定、評価、予防および治療のための組成物、キットおよび方法
WO2013074695A1 (en) 2011-11-14 2013-05-23 The Regents Of The University Of Colorado, A Body Corporate Hsp90 inhibitors with modified toxicity
WO2017048911A1 (en) * 2015-09-19 2017-03-23 Applied Materials, Inc. Surface-selective atomic layer deposition using hydrosilylation passivation
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US20090088414A1 (en) 2009-04-02
JP2011225614A (ja) 2011-11-10
US20050227955A1 (en) 2005-10-13
CA2547343A1 (en) 2005-07-14
US20090209549A1 (en) 2009-08-20
EP2492261B1 (en) 2015-02-18
KR20060132660A (ko) 2006-12-21
IL206984A0 (en) 2011-07-31
RU2006126797A (ru) 2008-01-27
US7282493B2 (en) 2007-10-16
ES2409351T3 (es) 2013-06-26
US7608613B2 (en) 2009-10-27
US7833997B2 (en) 2010-11-16
US7566706B2 (en) 2009-07-28
AU2004309395B2 (en) 2011-10-06
US20060014731A1 (en) 2006-01-19
US20090069280A1 (en) 2009-03-12
US7375217B2 (en) 2008-05-20
HK1097410A1 (en) 2007-06-22
RU2484086C2 (ru) 2013-06-10
US7361647B2 (en) 2008-04-22
US8703755B2 (en) 2014-04-22
NO20062707L (no) 2006-09-11
US20090062250A1 (en) 2009-03-05
US20090208590A1 (en) 2009-08-20
US8252779B2 (en) 2012-08-28
BRPI0418147A (pt) 2007-04-17
EP2492261A1 (en) 2012-08-29
AU2004309395C1 (en) 2012-10-04
US7767662B2 (en) 2010-08-03
IL206984A (en) 2015-02-26
US20090253653A1 (en) 2009-10-08
PT1716119E (pt) 2013-06-04
CN102643233A (zh) 2012-08-22
US20120058982A1 (en) 2012-03-08
RU2484086C9 (ru) 2013-08-20
IL175911A (en) 2012-01-31
CN102643233B (zh) 2015-11-25
EP1716119A1 (en) 2006-11-02
NO337933B1 (no) 2016-07-11
US7691840B2 (en) 2010-04-06
JP2007528875A (ja) 2007-10-18
CA2547343C (en) 2013-05-14
DK1716119T3 (da) 2013-06-10
US20050288269A1 (en) 2005-12-29
WO2005063714A1 (en) 2005-07-14
US7579337B2 (en) 2009-08-25
AU2004309395A1 (en) 2005-07-14
US20110086110A1 (en) 2011-04-14
US7767663B2 (en) 2010-08-03
JP4869077B2 (ja) 2012-02-01
JP5313308B2 (ja) 2013-10-09
US20060019939A1 (en) 2006-01-26
IL175911A0 (en) 2006-10-05
US8003634B2 (en) 2011-08-23
EP1716119B1 (en) 2013-03-06
US20130203724A1 (en) 2013-08-08

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