NO337933B1 - Analoger av benzokinon-inneholdende ansamyciner samt fremgangsmåte for fremstilling derav og farmasøytisk sammensetning - Google Patents
Analoger av benzokinon-inneholdende ansamyciner samt fremgangsmåte for fremstilling derav og farmasøytisk sammensetning Download PDFInfo
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- NO337933B1 NO337933B1 NO20062707A NO20062707A NO337933B1 NO 337933 B1 NO337933 B1 NO 337933B1 NO 20062707 A NO20062707 A NO 20062707A NO 20062707 A NO20062707 A NO 20062707A NO 337933 B1 NO337933 B1 NO 337933B1
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- NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
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| US62628604P | 2004-11-09 | 2004-11-09 | |
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| PCT/US2004/043162 WO2005063714A1 (en) | 2003-12-23 | 2004-12-23 | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
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| US20090197852A9 (en) * | 2001-08-06 | 2009-08-06 | Johnson Robert G Jr | Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor |
| CN102643233B (zh) | 2003-12-23 | 2015-11-25 | 无限发现公司 | 用于治疗癌症的包含苯醌的安沙霉素类似物 |
| US20060019941A1 (en) * | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
| EP1814392A4 (en) * | 2004-11-02 | 2008-06-11 | Conforma Therapeutics Corp | METHODS AND COMPOSITIONS FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA |
| US10252088B2 (en) | 2004-12-02 | 2019-04-09 | Obagi Cosmeceuticals Llc | Topical compositions and methods of manufacturing them in specifically treated steel vessels |
| WO2006098761A2 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Colorado | Hsp90 inhibitors, methods of making and uses therefor |
| US11457813B2 (en) | 2005-03-29 | 2022-10-04 | Martin W. Roche | Method for detecting body parameters |
| RU2007144195A (ru) * | 2005-04-29 | 2009-06-10 | Козан Байосайенсиз Инкорпорейтед (Us) | Способ лечения множественной миеломы с использованием 17-aag или 17-ag или пролекарства любого из них |
| GB0517886D0 (en) * | 2005-09-02 | 2005-10-12 | Biotica Tech Ltd | Novel compounds |
| US20090042847A1 (en) * | 2005-11-23 | 2009-02-12 | Kosan Biosciences Incorporated | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
| US20070207992A1 (en) * | 2006-02-21 | 2007-09-06 | Board Of Trustees Of Michigan State University | Geldanamycin derivatives and method of use thereof |
| GB0606548D0 (en) * | 2006-03-31 | 2006-05-10 | Biotica Tech Ltd | Novel compounds and methods for their production |
| US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| US8492370B2 (en) | 2006-11-09 | 2013-07-23 | Bristol-Myers Squibb Company | Compounds and methods for their production |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| CN101688227B (zh) * | 2007-01-26 | 2013-07-24 | 科森生物科学公司 | 通过工程化生物合成制备的大环内酰胺 |
| CN101677991A (zh) * | 2007-04-12 | 2010-03-24 | 英菲尼蒂发现公司 | 氢醌安莎霉素制剂 |
| US7851620B2 (en) * | 2007-06-07 | 2010-12-14 | Board Of Regents, The University Of Texas System | Methods for preparing diazonamides |
| US8551964B2 (en) | 2007-08-23 | 2013-10-08 | The Regents Of The University Of Colorado | Hsp90 inhibitors with modified toxicity |
| WO2010045442A1 (en) * | 2008-10-15 | 2010-04-22 | Infinity Discovery, Inc. | Ansamycin hydroquinone compositions |
| US8669289B2 (en) * | 2009-04-24 | 2014-03-11 | The Jackson Laboratory | Methods and compositions relating to hematologic malignancies |
| WO2010135426A1 (en) * | 2009-05-19 | 2010-11-25 | Infinity Pharmaceuticals, Inc. | Methods of treating liposarcoma |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| JP2013510585A (ja) * | 2009-11-13 | 2013-03-28 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 癌の同定、評価、予防および治療のための組成物、キットおよび方法 |
| WO2013074695A1 (en) | 2011-11-14 | 2013-05-23 | The Regents Of The University Of Colorado, A Body Corporate | Hsp90 inhibitors with modified toxicity |
| WO2017048911A1 (en) * | 2015-09-19 | 2017-03-23 | Applied Materials, Inc. | Surface-selective atomic layer deposition using hydrosilylation passivation |
| US10052304B2 (en) | 2015-10-12 | 2018-08-21 | University Of Iowa Research Foundation | Compositions and methods for cancer therapy |
| HUE046449T2 (hu) | 2016-09-13 | 2020-03-30 | Allergan Inc | Stabilizált, nem fehérje eredetû, clostridiális toxin készítmények |
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| WO1993014215A1 (en) * | 1992-01-06 | 1993-07-22 | Pfizer Inc. | Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone |
| WO1995001342A1 (en) * | 1993-06-29 | 1995-01-12 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| WO2003013430A2 (en) * | 2001-08-06 | 2003-02-20 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
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| US120578A (en) | 1871-11-07 | Improvement in letter-boxes | ||
| US123640A (en) | 1872-02-13 | Improvement in tab-plates of buckles | ||
| US745718A (en) * | 1903-04-25 | 1903-12-01 | Owen Thomas Dougherty | Weight-indicating sliding and spring support for vehicle-bodies. |
| GB210611A (en) * | 1923-01-16 | 1924-02-07 | Clarence Hancock | Improved means of heating garden propagating frames, foster mothers and the like |
| US3595955A (en) | 1969-03-26 | 1971-07-27 | Upjohn Co | Geldanamycin and process for producing same |
| JPS5470299A (en) * | 1977-11-14 | 1979-06-05 | Takeda Chem Ind Ltd | Production of maytansine derivative |
| US4261989A (en) | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
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