DK1781604T3 - Bis(thio-hydrazid-amid)-salte til behandling af cancere - Google Patents
Bis(thio-hydrazid-amid)-salte til behandling af cancereInfo
- Publication number
- DK1781604T3 DK1781604T3 DK05762347.2T DK05762347T DK1781604T3 DK 1781604 T3 DK1781604 T3 DK 1781604T3 DK 05762347 T DK05762347 T DK 05762347T DK 1781604 T3 DK1781604 T3 DK 1781604T3
- Authority
- DK
- Denmark
- Prior art keywords
- amid
- hydrazide
- thio
- cancers
- bis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58259604P | 2004-06-23 | 2004-06-23 | |
US68136805P | 2005-05-16 | 2005-05-16 | |
PCT/US2005/021642 WO2006009940A1 (en) | 2004-06-23 | 2005-06-20 | Bis(thio-hydrazide amide) salts for treatment of cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1781604T3 true DK1781604T3 (da) | 2013-09-16 |
Family
ID=34993190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05762347.2T DK1781604T3 (da) | 2004-06-23 | 2005-06-20 | Bis(thio-hydrazid-amid)-salte til behandling af cancere |
Country Status (22)
Country | Link |
---|---|
US (5) | US7385084B2 (da) |
EP (2) | EP2305642A3 (da) |
JP (1) | JP5362986B2 (da) |
KR (1) | KR101313027B1 (da) |
CN (1) | CN1993318B (da) |
AU (1) | AU2005265202B2 (da) |
BR (1) | BRPI0512526A (da) |
CA (1) | CA2570698C (da) |
DK (1) | DK1781604T3 (da) |
ES (1) | ES2430373T3 (da) |
HK (1) | HK1104526A1 (da) |
HR (1) | HRP20131023T1 (da) |
IL (1) | IL179632A (da) |
ME (1) | ME01644B (da) |
NO (1) | NO20070378L (da) |
NZ (1) | NZ552159A (da) |
PL (1) | PL1781604T3 (da) |
PT (1) | PT1781604E (da) |
RS (1) | RS52999B (da) |
RU (2) | RU2406722C2 (da) |
TW (1) | TWI389684B (da) |
WO (1) | WO2006009940A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI330079B (en) * | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
JP5362986B2 (ja) * | 2004-06-23 | 2013-12-11 | シンタ ファーマスーティカルズ コーポレイション | 癌治療のためのビス(チオ‐ヒドラジドアミド)塩 |
US8148426B2 (en) * | 2004-11-19 | 2012-04-03 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
BRPI0610219A2 (pt) | 2005-04-15 | 2010-06-08 | Synta Pharmaceuticals Corp | métodos de tratamento de um ser humano com cáncer e composição de farmacêutica |
AU2006236534A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
AU2006247470B2 (en) | 2005-05-16 | 2010-04-01 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
JP2009504740A (ja) * | 2005-08-16 | 2009-02-05 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオ−ヒドラジドアミド)製剤 |
US20100310587A1 (en) * | 2005-08-29 | 2010-12-09 | Academia Sinica | Immunomodulatory compositions |
GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
US8609720B2 (en) * | 2006-08-21 | 2013-12-17 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2008024304A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treatment of proliferative disorders |
US20100068174A1 (en) * | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
US20080226588A1 (en) * | 2006-08-21 | 2008-09-18 | Mcleod Matthew | Treating melanoma with bis(thiohydrazide amides) |
WO2008024301A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
WO2008027445A2 (en) | 2006-08-31 | 2008-03-06 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
US7645904B2 (en) | 2006-09-15 | 2010-01-12 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
US8618170B2 (en) * | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
US8581004B2 (en) | 2008-02-21 | 2013-11-12 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
MX2011004276A (es) * | 2008-10-22 | 2011-06-27 | Synta Pharmaceuticals Corp | Complejos de metales de transicion de compuestos bis (tiohidrazida amida). |
US8461199B2 (en) | 2008-10-22 | 2013-06-11 | Synta Pharmaceuticals Corp. | Transition metal complexes of a bis[thio-hydrazide amide] compound |
US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
CA2745065A1 (en) | 2008-12-01 | 2010-06-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2011069159A2 (en) * | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
US20120128580A1 (en) | 2010-11-18 | 2012-05-24 | Synta Pharmaceuticals Corp. | Preselection of subjects for therapeutic treatment with elesclomol based on hypoxic status |
AU2012335105A1 (en) * | 2011-11-10 | 2014-06-19 | Synta Pharmaceuticals Corp. | Administration of a bis(thiohydrazide amide) compound for treating cancers |
US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
WO2013103795A1 (en) | 2012-01-05 | 2013-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
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TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
EA009919B1 (ru) | 2003-02-11 | 2008-04-28 | Вернэлис (Кембридж) Лимитед | Соединения изоксазола |
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US8148426B2 (en) | 2004-11-19 | 2012-04-03 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
BRPI0607688A2 (pt) | 2005-02-17 | 2009-09-22 | Synta Pharmaceuticals Corp | método para inibir a polimerização de tubulina em uma célula; método para tratar ou prevenir um distúrbio proliferativo em um indivìduo; método para bloquear, ocluir ou de outro modo romper o fluxo sangüìneo na neovasculatura; composto; composição farmacêutica e uso do referido método e composto |
WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
AU2006236534A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
BRPI0610219A2 (pt) | 2005-04-15 | 2010-06-08 | Synta Pharmaceuticals Corp | métodos de tratamento de um ser humano com cáncer e composição de farmacêutica |
AU2006247470B2 (en) | 2005-05-16 | 2010-04-01 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
JP2009504740A (ja) | 2005-08-16 | 2009-02-05 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオ−ヒドラジドアミド)製剤 |
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US20100068174A1 (en) | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
WO2008024301A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
US20080226588A1 (en) | 2006-08-21 | 2008-09-18 | Mcleod Matthew | Treating melanoma with bis(thiohydrazide amides) |
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WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
WO2008027445A2 (en) | 2006-08-31 | 2008-03-06 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
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WO2008082579A1 (en) | 2007-01-03 | 2008-07-10 | Synta Pharmaceuticals Corp. | Method for treating cancer |
WO2008136976A2 (en) | 2007-04-30 | 2008-11-13 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
TW200922550A (en) | 2007-08-07 | 2009-06-01 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
US8618170B2 (en) | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
US8637704B2 (en) | 2007-11-28 | 2014-01-28 | Synta Pharmaceuticals Corp. | Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide) |
JP5091056B2 (ja) | 2008-08-28 | 2012-12-05 | 三甲株式会社 | 密閉容器の蓋部シール構造 |
-
2005
- 2005-06-20 JP JP2007518152A patent/JP5362986B2/ja not_active Expired - Fee Related
- 2005-06-20 PT PT57623472T patent/PT1781604E/pt unknown
- 2005-06-20 AU AU2005265202A patent/AU2005265202B2/en not_active Ceased
- 2005-06-20 BR BRPI0512526-0A patent/BRPI0512526A/pt not_active IP Right Cessation
- 2005-06-20 EP EP10009536A patent/EP2305642A3/en not_active Withdrawn
- 2005-06-20 PL PL05762347T patent/PL1781604T3/pl unknown
- 2005-06-20 DK DK05762347.2T patent/DK1781604T3/da active
- 2005-06-20 ME MEP-2013-124A patent/ME01644B/me unknown
- 2005-06-20 CA CA2570698A patent/CA2570698C/en not_active Expired - Fee Related
- 2005-06-20 NZ NZ552159A patent/NZ552159A/en not_active IP Right Cessation
- 2005-06-20 CN CN2005800264456A patent/CN1993318B/zh not_active Expired - Fee Related
- 2005-06-20 ES ES05762347T patent/ES2430373T3/es active Active
- 2005-06-20 WO PCT/US2005/021642 patent/WO2006009940A1/en active Application Filing
- 2005-06-20 EP EP05762347.2A patent/EP1781604B1/en active Active
- 2005-06-20 US US11/157,213 patent/US7385084B2/en not_active Expired - Fee Related
- 2005-06-20 RU RU2007101898/04A patent/RU2406722C2/ru not_active IP Right Cessation
- 2005-06-20 KR KR1020077001513A patent/KR101313027B1/ko not_active IP Right Cessation
- 2005-06-20 RS RS20130458A patent/RS52999B/en unknown
- 2005-06-21 TW TW094120599A patent/TWI389684B/zh not_active IP Right Cessation
-
2006
- 2006-11-27 IL IL179632A patent/IL179632A/en not_active IP Right Cessation
-
2007
- 2007-01-19 NO NO20070378A patent/NO20070378L/no not_active Application Discontinuation
- 2007-11-05 HK HK07112015.9A patent/HK1104526A1/xx not_active IP Right Cessation
-
2008
- 2008-04-18 US US12/148,312 patent/US7579503B2/en not_active Expired - Fee Related
-
2009
- 2009-07-15 US US12/503,661 patent/US7795313B2/en not_active Expired - Fee Related
-
2010
- 2010-08-30 US US12/871,587 patent/US8048925B2/en not_active Expired - Fee Related
- 2010-11-08 RU RU2010145056/04A patent/RU2010145056A/ru not_active Application Discontinuation
-
2011
- 2011-10-14 US US13/273,807 patent/US8461208B2/en not_active Expired - Fee Related
-
2013
- 2013-10-29 HR HRP20131023TT patent/HRP20131023T1/hr unknown
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