NO20070378L - Bis(tio-hydrazidamid)-salter for behandling av kreft - Google Patents
Bis(tio-hydrazidamid)-salter for behandling av kreftInfo
- Publication number
- NO20070378L NO20070378L NO20070378A NO20070378A NO20070378L NO 20070378 L NO20070378 L NO 20070378L NO 20070378 A NO20070378 A NO 20070378A NO 20070378 A NO20070378 A NO 20070378A NO 20070378 L NO20070378 L NO 20070378L
- Authority
- NO
- Norway
- Prior art keywords
- thiohydrazidamide
- bis
- substituted
- cancer
- disalt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Det er beskrevet bis(tio-hydrazidamid)-disalter som er representert ved strukturformel (I): Y er en kovalent binding eller en substituert eller usubstituert, rettkjedet hydrokarbylgruppe. R1-R4 er uavhengig valgt fra -H, en alifatisk gruppe, en substituert, alifatisk gruppe, en arylgruppe eller en substituert arylgruppe, eller R1 og R3, sammen med karbon- og nitrogenatomene de er bundet til, og/eller R2 og R4, sammen med karbon- og nitrogenatomene de er bundet til, danner en ikke-aromatisk, heterocyklisk ring som er eventuelt kondensert til en aromatisk ring. Z er -O eller -S. M+ er et farmasøytisk akseptabelt, monovalent kation og M2+er et farmasøytisk akseptabelt, divalent kation. Det er også beskrevet farmasøytiske preparater som omfatter et bis(tio-hydrazidamid)-disalt som beskrevet ovenfor. Videre er det beskrevet metoder for behandling av en pasient med kreft. Metodene omfatter trinnet å administrere en effektiv mengde av et bis(tio-hydrazidamid)-disalt som beskrevet ovenfor.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58259604P | 2004-06-23 | 2004-06-23 | |
US68136805P | 2005-05-16 | 2005-05-16 | |
PCT/US2005/021642 WO2006009940A1 (en) | 2004-06-23 | 2005-06-20 | Bis(thio-hydrazide amide) salts for treatment of cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20070378L true NO20070378L (no) | 2007-03-16 |
Family
ID=34993190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070378A NO20070378L (no) | 2004-06-23 | 2007-01-19 | Bis(tio-hydrazidamid)-salter for behandling av kreft |
Country Status (22)
Country | Link |
---|---|
US (5) | US7385084B2 (no) |
EP (2) | EP1781604B1 (no) |
JP (1) | JP5362986B2 (no) |
KR (1) | KR101313027B1 (no) |
CN (1) | CN1993318B (no) |
AU (1) | AU2005265202B2 (no) |
BR (1) | BRPI0512526A (no) |
CA (1) | CA2570698C (no) |
DK (1) | DK1781604T3 (no) |
ES (1) | ES2430373T3 (no) |
HK (1) | HK1104526A1 (no) |
HR (1) | HRP20131023T1 (no) |
IL (1) | IL179632A (no) |
ME (1) | ME01644B (no) |
NO (1) | NO20070378L (no) |
NZ (1) | NZ552159A (no) |
PL (1) | PL1781604T3 (no) |
PT (1) | PT1781604E (no) |
RS (1) | RS52999B (no) |
RU (2) | RU2406722C2 (no) |
TW (1) | TWI389684B (no) |
WO (1) | WO2006009940A1 (no) |
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WO2009073148A2 (en) | 2007-11-28 | 2009-06-11 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
JP5091056B2 (ja) | 2008-08-28 | 2012-12-05 | 三甲株式会社 | 密閉容器の蓋部シール構造 |
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