BR0009952A - Composto, pró-droga, processo para produzir um composto, composição farmacêutica, método para antagonizar um receptor de adenosina a3, para inibir a p38 map quinase e a produção de tnf-alfa e para prevenir ou tratar doenças, e uso de um composto - Google Patents

Composto, pró-droga, processo para produzir um composto, composição farmacêutica, método para antagonizar um receptor de adenosina a3, para inibir a p38 map quinase e a produção de tnf-alfa e para prevenir ou tratar doenças, e uso de um composto

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Publication number
BR0009952A
BR0009952A BR0009952-0A BR0009952A BR0009952A BR 0009952 A BR0009952 A BR 0009952A BR 0009952 A BR0009952 A BR 0009952A BR 0009952 A BR0009952 A BR 0009952A
Authority
BR
Brazil
Prior art keywords
compound
tnf
adenosine receptor
antagonizing
inhibit
Prior art date
Application number
BR0009952-0A
Other languages
English (en)
Inventor
Shigenori Ohkawa
Naoyuki Kanzaki
Seiji Miwatashi
Original Assignee
Takeda Chemical Industres Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industres Ltd filed Critical Takeda Chemical Industres Ltd
Publication of BR0009952A publication Critical patent/BR0009952A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

"COMPOSTO, PRó-DROGA PROCESSO PARA PRODUZIR UM COMPOSTO, COMPOSIçãO FARMACêUTICA MéTODO PARA ANTAGONIZAR UM RECEPTOR DE ADENOSINA A3, PARA INIBIR A P38 MAP QUINASE E A PRODUçãO DE TNF-ALFA E PARA PREVENIR OU TRATAR DOENçAS, E USO DE UM COMPOSTO". Os compostos opcionalmente oxidados em N representados pela fórmula geral (I) seus sais que são usáveis como preventivos ou remédios para doenças em associação com o receptor de adenosina A3 porque têm excelente antagonismo ao receptor de adenosina A3 em que R^ 1^ representa hidrogênio, hidrocarbila, um heterociclo, amino ou acila; R^ 2^ representa um grupo aromático; R^ 3^ representa hidrogênio, piridila ou hidrocarbila aromática; X representa oxigênio ou enxofre opcionalmente oxidado; Y representa uma ligação, oxigênio, enxofre opcionalmente oxidado ou NR^ 4^ (em que R^ 4^ representa hidrogênio, hidrocarbila, ou acila); e Z representa uma ligação ou um hidrocarbila de cadeia bivalente. Além disso, os compostos (1) ou seus sais exibem excelentes efeitos de inibir p38MAP quinase e inibir a TNF-<244> e, portanto, também são usáveis como preventivos ou remédios para doenças em associação com a p38MAP quinase ou TNF-<244>.
BR0009952-0A 1999-04-23 2000-04-20 Composto, pró-droga, processo para produzir um composto, composição farmacêutica, método para antagonizar um receptor de adenosina a3, para inibir a p38 map quinase e a produção de tnf-alfa e para prevenir ou tratar doenças, e uso de um composto BR0009952A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11668699 1999-04-23
JP22465099 1999-08-06
PCT/JP2000/002575 WO2000064894A1 (fr) 1999-04-23 2000-04-20 Composes 5-pyridyle-1,3-azole, leur procede de fabrication et leur utilisation

Publications (1)

Publication Number Publication Date
BR0009952A true BR0009952A (pt) 2002-03-26

Family

ID=26454974

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009952-0A BR0009952A (pt) 1999-04-23 2000-04-20 Composto, pró-droga, processo para produzir um composto, composição farmacêutica, método para antagonizar um receptor de adenosina a3, para inibir a p38 map quinase e a produção de tnf-alfa e para prevenir ou tratar doenças, e uso de um composto

Country Status (24)

Country Link
US (3) US7101899B1 (pt)
EP (1) EP1180518B1 (pt)
KR (2) KR100449215B1 (pt)
CN (1) CN1156471C (pt)
AU (1) AU765473B2 (pt)
BR (1) BR0009952A (pt)
CA (1) CA2370264A1 (pt)
CZ (1) CZ300709B6 (pt)
DE (1) DE60033028T2 (pt)
DK (1) DK1180518T3 (pt)
ES (1) ES2275500T3 (pt)
HK (1) HK1044338B (pt)
HU (1) HUP0203766A3 (pt)
IL (1) IL146105A (pt)
MX (1) MXPA01010675A (pt)
MY (1) MY126736A (pt)
NO (1) NO320588B1 (pt)
NZ (1) NZ515215A (pt)
PL (1) PL351148A1 (pt)
PT (1) PT1180518E (pt)
RU (1) RU2237062C2 (pt)
SI (1) SI1180518T1 (pt)
SK (1) SK286666B6 (pt)
WO (1) WO2000064894A1 (pt)

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SK286666B6 (sk) 2009-03-05
KR100449215B1 (ko) 2004-09-18
DE60033028D1 (de) 2007-03-08
US20060135566A1 (en) 2006-06-22
PL351148A1 (en) 2003-03-24
CZ300709B6 (cs) 2009-07-22
NO20015156D0 (no) 2001-10-22
IL146105A0 (en) 2002-07-25
US7276527B2 (en) 2007-10-02
NO320588B1 (no) 2005-12-27
CA2370264A1 (en) 2000-11-02
DE60033028T2 (de) 2007-11-15
KR100558123B1 (ko) 2006-03-07
NZ515215A (en) 2003-07-25
US7101899B1 (en) 2006-09-05
PT1180518E (pt) 2007-02-28
AU3840100A (en) 2000-11-10
HK1044338B (zh) 2007-06-29
US20090048307A1 (en) 2009-02-19
HUP0203766A2 (hu) 2003-03-28
HK1044338A1 (en) 2002-10-18
WO2000064894A1 (fr) 2000-11-02
HUP0203766A3 (en) 2008-01-28
MXPA01010675A (es) 2002-06-04
CZ20013805A3 (cs) 2002-04-17
KR20010111314A (ko) 2001-12-17
DK1180518T3 (da) 2007-05-21
MY126736A (en) 2006-10-31
EP1180518A1 (en) 2002-02-20
ES2275500T3 (es) 2007-06-16
RU2237062C2 (ru) 2004-09-27
IL146105A (en) 2005-09-25
SI1180518T1 (sl) 2007-06-30
SK14952001A3 (sk) 2002-04-04
CN1156471C (zh) 2004-07-07
NO20015156L (no) 2001-12-18
EP1180518B1 (en) 2007-01-17
CN1353710A (zh) 2002-06-12
EP1180518A4 (en) 2004-09-15
KR20020059453A (ko) 2002-07-12
AU765473B2 (en) 2003-09-18

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