DK169686B1 - Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre - Google Patents

Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre Download PDF

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Publication number
DK169686B1
DK169686B1 DK307384A DK307384A DK169686B1 DK 169686 B1 DK169686 B1 DK 169686B1 DK 307384 A DK307384 A DK 307384A DK 307384 A DK307384 A DK 307384A DK 169686 B1 DK169686 B1 DK 169686B1
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DK
Denmark
Prior art keywords
activator
solution
column
arginine
asminogen
Prior art date
Application number
DK307384A
Other languages
Danish (da)
English (en)
Other versions
DK307384D0 (da
DK307384A (da
Inventor
Seishi Takahashi
Kazushi Morimoto
Yoshikazu Fujisawa
Fumiaki Ikeda
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57189067A external-priority patent/JPS5980613A/ja
Priority claimed from JP57189065A external-priority patent/JPH0637398B2/ja
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of DK307384D0 publication Critical patent/DK307384D0/da
Publication of DK307384A publication Critical patent/DK307384A/da
Application granted granted Critical
Publication of DK169686B1 publication Critical patent/DK169686B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK307384A 1982-10-29 1984-06-22 Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre DK169686B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP57189067A JPS5980613A (ja) 1982-10-29 1982-10-29 新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
JP18906582 1982-10-29
JP57189065A JPH0637398B2 (ja) 1982-10-29 1982-10-29 血栓溶解剤
JP18906782 1982-10-29
JP8300386 1983-10-27
PCT/JP1983/000386 WO1984001714A1 (fr) 1982-10-29 1983-10-27 Nouvel activateur de plasminogene, son procede de preparation et medicament thrombolytique le contenant

Publications (3)

Publication Number Publication Date
DK307384D0 DK307384D0 (da) 1984-06-22
DK307384A DK307384A (da) 1984-06-22
DK169686B1 true DK169686B1 (da) 1995-01-09

Family

ID=26505289

Family Applications (1)

Application Number Title Priority Date Filing Date
DK307384A DK169686B1 (da) 1982-10-29 1984-06-22 Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre

Country Status (12)

Country Link
EP (1) EP0124613B1 (fr)
CA (1) CA1221029A (fr)
CH (1) CH660742A5 (fr)
DE (1) DE3390272C2 (fr)
DK (1) DK169686B1 (fr)
FI (1) FI80597C (fr)
GB (1) GB2138824B (fr)
IT (1) IT1169910B (fr)
NL (1) NL191755C (fr)
NO (1) NO166314C (fr)
SE (1) SE8403375L (fr)
WO (1) WO1984001714A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582338D1 (de) * 1984-01-30 1991-05-08 Asahi Chemical Ind Verfahren zur herstellung eines doppelkettigen plasminogenaktivators.
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
NZ216306A (en) * 1985-05-28 1989-10-27 Wellcome Found Pharmaceutical compositions containing tissue plasminogen activator
JPH01500563A (ja) * 1986-07-16 1989-03-01 セルテック　リミテッド 精製方法
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU1668988A (en) * 1987-06-03 1988-12-08 Smithkline Beckman Corporation Purification of tpa
DE3726019A1 (de) * 1987-08-05 1989-02-16 Boehringer Mannheim Gmbh Verfahren zur abtrennung und reinigung von t-pa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
GR79202B (fr) * 1982-05-05 1984-10-22 Genentech Inc
JPS5913732A (ja) * 1982-07-16 1984-01-24 Mitsui Toatsu Chem Inc 血栓溶解剤
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation

Also Published As

Publication number Publication date
IT1169910B (it) 1987-06-03
CA1221029A (fr) 1987-04-28
WO1984001714A1 (fr) 1984-05-10
FI80597B (fi) 1990-03-30
DE3390272T1 (de) 1984-11-29
GB8414992D0 (en) 1984-07-18
NL191755B (nl) 1996-03-01
FI842627A (fi) 1984-06-29
DK307384D0 (da) 1984-06-22
NO166314C (no) 1991-07-03
EP0124613A1 (fr) 1984-11-14
NO842468L (no) 1984-06-19
EP0124613B1 (fr) 1992-12-30
NL191755C (nl) 1996-07-02
FI80597C (fi) 1990-07-10
NO166314B (no) 1991-03-25
CH660742A5 (de) 1987-06-15
EP0124613A4 (fr) 1986-07-29
GB2138824B (en) 1986-12-31
IT8323533A0 (it) 1983-10-28
NL8320346A (nl) 1984-09-03
DE3390272C2 (de) 1987-09-17
DK307384A (da) 1984-06-22
SE8403375D0 (sv) 1984-06-25
GB2138824A (en) 1984-10-31
SE8403375L (sv) 1984-06-25
FI842627A0 (fi) 1984-06-29

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