IT1169910B - Attivatore di plasminogeno, processo di sua preparazione e agente trombolitico che lo contiene - Google Patents

Attivatore di plasminogeno, processo di sua preparazione e agente trombolitico che lo contiene

Info

Publication number
IT1169910B
IT1169910B IT23533/83A IT2353383A IT1169910B IT 1169910 B IT1169910 B IT 1169910B IT 23533/83 A IT23533/83 A IT 23533/83A IT 2353383 A IT2353383 A IT 2353383A IT 1169910 B IT1169910 B IT 1169910B
Authority
IT
Italy
Prior art keywords
preparation
agent containing
plasminogen activator
thrombolytic agent
thrombolytic
Prior art date
Application number
IT23533/83A
Other languages
English (en)
Other versions
IT8323533A0 (it
Inventor
Seishi Takahashi
Kazushi Morimoto
Yoshikazu Fujisawa
Fumiaki Ikeda
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP57189067A external-priority patent/JPS5980613A/ja
Priority claimed from JP57189065A external-priority patent/JPH0637398B2/ja
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of IT8323533A0 publication Critical patent/IT8323533A0/it
Application granted granted Critical
Publication of IT1169910B publication Critical patent/IT1169910B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT23533/83A 1982-10-29 1983-10-28 Attivatore di plasminogeno, processo di sua preparazione e agente trombolitico che lo contiene IT1169910B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57189067A JPS5980613A (ja) 1982-10-29 1982-10-29 新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
JP57189065A JPH0637398B2 (ja) 1982-10-29 1982-10-29 血栓溶解剤

Publications (2)

Publication Number Publication Date
IT8323533A0 IT8323533A0 (it) 1983-10-28
IT1169910B true IT1169910B (it) 1987-06-03

Family

ID=26505289

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23533/83A IT1169910B (it) 1982-10-29 1983-10-28 Attivatore di plasminogeno, processo di sua preparazione e agente trombolitico che lo contiene

Country Status (12)

Country Link
EP (1) EP0124613B1 (it)
CA (1) CA1221029A (it)
CH (1) CH660742A5 (it)
DE (1) DE3390272C2 (it)
DK (1) DK169686B1 (it)
FI (1) FI80597C (it)
GB (1) GB2138824B (it)
IT (1) IT1169910B (it)
NL (1) NL191755C (it)
NO (1) NO166314C (it)
SE (1) SE8403375D0 (it)
WO (1) WO1984001714A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0151996B1 (en) * 1984-01-30 1991-04-03 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a double-chain plasminogen activator
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
NL8601354A (nl) * 1985-05-28 1986-12-16 Wellcome Found Nieuwe samenstelling.
AU7709287A (en) * 1986-07-16 1988-02-10 Celltech Limited Process for purifying a plasminogen activator
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU1668988A (en) * 1987-06-03 1988-12-08 Smithkline Beckman Corporation Purification of tpa
DE3726019A1 (de) * 1987-08-05 1989-02-16 Boehringer Mannheim Gmbh Verfahren zur abtrennung und reinigung von t-pa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
JPS5913732A (ja) * 1982-07-16 1984-01-24 Mitsui Toatsu Chem Inc 血栓溶解剤
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation

Also Published As

Publication number Publication date
SE8403375L (sv) 1984-06-25
NO842468L (no) 1984-06-19
NO166314B (no) 1991-03-25
CH660742A5 (de) 1987-06-15
WO1984001714A1 (en) 1984-05-10
GB2138824B (en) 1986-12-31
GB2138824A (en) 1984-10-31
EP0124613A4 (en) 1986-07-29
FI80597C (fi) 1990-07-10
NL191755C (nl) 1996-07-02
IT8323533A0 (it) 1983-10-28
CA1221029A (en) 1987-04-28
DE3390272T1 (de) 1984-11-29
DE3390272C2 (de) 1987-09-17
EP0124613B1 (en) 1992-12-30
FI842627A (fi) 1984-06-29
FI842627A0 (fi) 1984-06-29
NL191755B (nl) 1996-03-01
DK307384A (da) 1984-06-22
NO166314C (no) 1991-07-03
FI80597B (fi) 1990-03-30
GB8414992D0 (en) 1984-07-18
NL8320346A (nl) 1984-09-03
EP0124613A1 (en) 1984-11-14
DK169686B1 (da) 1995-01-09
DK307384D0 (da) 1984-06-22
SE8403375D0 (sv) 1984-06-25

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971030