DK169686B1 - Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre - Google Patents
Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre Download PDFInfo
- Publication number
- DK169686B1 DK169686B1 DK307384A DK307384A DK169686B1 DK 169686 B1 DK169686 B1 DK 169686B1 DK 307384 A DK307384 A DK 307384A DK 307384 A DK307384 A DK 307384A DK 169686 B1 DK169686 B1 DK 169686B1
- Authority
- DK
- Denmark
- Prior art keywords
- activator
- solution
- column
- arginine
- asminogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18906782 | 1982-10-29 | ||
JP57189067A JPS5980613A (ja) | 1982-10-29 | 1982-10-29 | 新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法 |
JP18906582 | 1982-10-29 | ||
JP57189065A JPH0637398B2 (ja) | 1982-10-29 | 1982-10-29 | 血栓溶解剤 |
PCT/JP1983/000386 WO1984001714A1 (en) | 1982-10-29 | 1983-10-27 | Novel plasminogen activator, process for its preparation, and thrombolytic drug containing the same |
JP8300386 | 1983-10-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK307384A DK307384A (da) | 1984-06-22 |
DK307384D0 DK307384D0 (da) | 1984-06-22 |
DK169686B1 true DK169686B1 (da) | 1995-01-09 |
Family
ID=26505289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK307384A DK169686B1 (da) | 1982-10-29 | 1984-06-22 | Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0124613B1 (fi) |
CA (1) | CA1221029A (fi) |
CH (1) | CH660742A5 (fi) |
DE (1) | DE3390272C2 (fi) |
DK (1) | DK169686B1 (fi) |
FI (1) | FI80597C (fi) |
GB (1) | GB2138824B (fi) |
IT (1) | IT1169910B (fi) |
NL (1) | NL191755C (fi) |
NO (1) | NO166314C (fi) |
SE (1) | SE8403375L (fi) |
WO (1) | WO1984001714A1 (fi) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0151996B1 (en) * | 1984-01-30 | 1991-04-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for the preparation of a double-chain plasminogen activator |
ES8706443A1 (es) * | 1985-05-28 | 1987-07-01 | Wellcome Found | Un procedimiento para preparar una solucion parenteral de activador de plasminogeno de tejido (t-pa) |
US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
JPH01500563A (ja) * | 1986-07-16 | 1989-03-01 | セルテック リミテッド | 精製方法 |
JPS6379591A (ja) * | 1986-09-22 | 1988-04-09 | Mitsui Toatsu Chem Inc | tPAの精製方法 |
AU1668988A (en) * | 1987-06-03 | 1988-12-08 | Smithkline Beckman Corporation | Purification of tpa |
DE3726019A1 (de) * | 1987-08-05 | 1989-02-16 | Boehringer Mannheim Gmbh | Verfahren zur abtrennung und reinigung von t-pa |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
JPS5913732A (ja) * | 1982-07-16 | 1984-01-24 | Mitsui Toatsu Chem Inc | 血栓溶解剤 |
IE81073B1 (en) * | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
-
1983
- 1983-10-27 GB GB08414992A patent/GB2138824B/en not_active Expired
- 1983-10-27 DE DE19833390272 patent/DE3390272C2/de not_active Expired
- 1983-10-27 WO PCT/JP1983/000386 patent/WO1984001714A1/ja active IP Right Grant
- 1983-10-27 NL NL8320346A patent/NL191755C/xx not_active IP Right Cessation
- 1983-10-27 EP EP83903315A patent/EP0124613B1/en not_active Expired - Lifetime
- 1983-10-27 CH CH3063/84A patent/CH660742A5/de not_active IP Right Cessation
- 1983-10-28 CA CA000439941A patent/CA1221029A/en not_active Expired
- 1983-10-28 IT IT23533/83A patent/IT1169910B/it active
-
1984
- 1984-06-19 NO NO84842468A patent/NO166314C/no unknown
- 1984-06-22 DK DK307384A patent/DK169686B1/da active
- 1984-06-25 SE SE8403375A patent/SE8403375L/ unknown
- 1984-06-29 FI FI842627A patent/FI80597C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE8403375D0 (sv) | 1984-06-25 |
DK307384A (da) | 1984-06-22 |
FI842627A0 (fi) | 1984-06-29 |
NO842468L (no) | 1984-06-19 |
FI80597C (fi) | 1990-07-10 |
NL8320346A (nl) | 1984-09-03 |
NL191755B (nl) | 1996-03-01 |
EP0124613A4 (en) | 1986-07-29 |
IT1169910B (it) | 1987-06-03 |
NO166314B (no) | 1991-03-25 |
DE3390272C2 (de) | 1987-09-17 |
CA1221029A (en) | 1987-04-28 |
EP0124613A1 (en) | 1984-11-14 |
SE8403375L (sv) | 1984-06-25 |
GB8414992D0 (en) | 1984-07-18 |
GB2138824A (en) | 1984-10-31 |
CH660742A5 (de) | 1987-06-15 |
EP0124613B1 (en) | 1992-12-30 |
GB2138824B (en) | 1986-12-31 |
DK307384D0 (da) | 1984-06-22 |
IT8323533A0 (it) | 1983-10-28 |
DE3390272T1 (de) | 1984-11-29 |
NO166314C (no) | 1991-07-03 |
NL191755C (nl) | 1996-07-02 |
FI80597B (fi) | 1990-03-30 |
FI842627A (fi) | 1984-06-29 |
WO1984001714A1 (en) | 1984-05-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Bouma et al. | Thrombin-activatable fibrinolysis inhibitor (TAFI, plasma procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U) | |
Wallén et al. | Purification and identification of two structural variants of porcine tissue plasminogen activator by affinity adsorption on fibrin | |
Van Hinsbergh et al. | Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium | |
Crutchley et al. | Endotoxin induction of an inhibitor of plasminogen activator in bovine pulmonary artery endothelial cells. | |
JPH0378375B2 (fi) | ||
NO164991B (no) | Fremgangsmaate for fremstilling av blodkoaguleringshemmende proteiner. | |
JP2003514790A (ja) | 可逆的に不活性化された酸性化プラスミンの局所送達による血栓溶解の方法 | |
Booth et al. | Plasminogen activator inhibitor from human endothelial cells: purification and partial characterization | |
DK169686B1 (da) | Fremgangsmåde til fremstilling af en plasminogenaktivator afledt fra humannyre | |
US4604285A (en) | Protein C enzyme derivatives | |
JP2000508918A (ja) | 精製されたマルチメラーゼ | |
Hatton et al. | On the interaction of rabbit antithrombin III with the luminal surface of the normal and deendothelialized rabbit thoracic aorta in vitro | |
Berkenpas et al. | Transformation-dependent activation of urokinase-type plasminogen activator by a plasmin-independent mechanism: involvement of cell surface membranes. | |
Knight et al. | Neutral protease inhibitors from human intervertebral disc and femoral head articular cartilage | |
Gurewich et al. | Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator | |
Rao et al. | Serpin inhibitors of urokinase and thrombin in normal rat brain and the 9L brain tumor: evidence for elevated expression of protease nexin I-like inhibitor and a novel sodium dodecyl sulfate-activated tumor antithrombin | |
Winter et al. | Prophylactic antithrombotic therapy with stanozolol in patients with familial antithrombin III deficiency | |
Kwaan et al. | Fibrinolytic system | |
JPH0647555B2 (ja) | フィブリン親和性ウロキナーゼ複合体含有血栓溶解剤 | |
US4957864A (en) | Novel plasminogen activator and its preparation process | |
Toshniwal et al. | Characterization of astrocyte plasminogen activator | |
EP0251806B1 (en) | Plasminogen activator production | |
Gilboa et al. | Inhibition of fibrinolytic enzymes by thrombin inhibitors | |
Podor et al. | The fibrinolytic system of endothelial cells | |
Hirsh et al. | Use of plasminogen activators in venous thrombosis |