DK169521B1 - 3-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne - Google Patents

3-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne Download PDF

Info

Publication number
DK169521B1
DK169521B1 DK035785A DK35785A DK169521B1 DK 169521 B1 DK169521 B1 DK 169521B1 DK 035785 A DK035785 A DK 035785A DK 35785 A DK35785 A DK 35785A DK 169521 B1 DK169521 B1 DK 169521B1
Authority
DK
Denmark
Prior art keywords
methyl
general formula
compound
hydrogen
tetrahydro
Prior art date
Application number
DK035785A
Other languages
Danish (da)
English (en)
Other versions
DK35785A (da
DK35785D0 (da
Inventor
Ian Harold Coates
James Angus Bell
David Cedric Humber
Georges Blanch Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK35785D0 publication Critical patent/DK35785D0/da
Publication of DK35785A publication Critical patent/DK35785A/da
Application granted granted Critical
Publication of DK169521B1 publication Critical patent/DK169521B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK035785A 1984-01-25 1985-01-25 3-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne DK169521B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB8401888 1984-01-25
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds
GB8425959 1984-10-15

Publications (3)

Publication Number Publication Date
DK35785D0 DK35785D0 (da) 1985-01-25
DK35785A DK35785A (da) 1985-07-26
DK169521B1 true DK169521B1 (da) 1994-11-21

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035785A DK169521B1 (da) 1984-01-25 1985-01-25 3-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne

Country Status (29)

Country Link
KR (1) KR920003064B1 (fi)
AT (1) AT392276B (fi)
AU (1) AU579132B2 (fi)
BE (1) BE901576A (fi)
CA (1) CA1252793A (fi)
CH (1) CH664152A5 (fi)
CY (1) CY1479A (fi)
CZ (1) CZ404391A3 (fi)
DE (2) DE3502508A1 (fi)
DK (1) DK169521B1 (fi)
ES (3) ES8609309A1 (fi)
FI (1) FI84349C (fi)
FR (1) FR2561244B1 (fi)
GB (1) GB2153821B (fi)
GR (1) GR850219B (fi)
HK (1) HK33189A (fi)
HU (1) HU193592B (fi)
IE (1) IE57809B1 (fi)
IL (1) IL74165A (fi)
IT (1) IT1182150B (fi)
LU (2) LU88268I2 (fi)
NL (2) NL190373C (fi)
NO (2) NO164025C (fi)
NZ (1) NZ210940A (fi)
PH (1) PH22672A (fi)
PT (1) PT79890B (fi)
SE (1) SE460359B (fi)
SG (1) SG7089G (fi)
SK (1) SK404391A3 (fi)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
EP0191562B1 (en) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolone derivatives
DE201165T1 (de) * 1985-03-14 1989-04-20 Beecham Group P.L.C., Brentford, Gb Arzneimittel zur behandlung von emesis, anxietas und "irritable bowel syndrome".
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
WO1988003801A1 (en) * 1986-11-21 1988-06-02 Glaxo Group Limited Medicaments for treatment or prevention of withdrawal syndrome
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
DE3788057T2 (de) * 1986-12-17 1994-03-03 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen.
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
PH25025A (en) * 1986-12-17 1991-01-28 Glaxo Group Ltd A method of treating dementia and other cognitive disorders using 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US4918080A (en) * 1987-04-14 1990-04-17 Glaxo Group Limited Imidazollyl containing ketone derivatives
EP0295836B1 (en) * 1987-06-16 1992-09-02 Btg International Limited Use of dioxopiperidine derivatives for the manufacture of topical medicaments as analgesics
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (ja) * 1988-04-07 1990-02-20 Glaxo Group Ltd イミダゾール誘導体
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
CA2031214A1 (en) * 1989-04-21 1990-10-22 Alberto Azcona Therapeutic use of 5-ht receptor antagonists
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
EP1022025A3 (en) * 1991-06-26 2002-06-05 Sepracor, Inc. Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
CA2157671A1 (en) * 1993-03-08 1994-09-15 Kiyotaka Katsuta Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325408B (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Chewing gum formulation comprising ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
US6548082B1 (en) 1999-03-01 2003-04-15 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure R(+) ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
EP1499623B1 (en) 2002-04-29 2007-06-13 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-¬(2-methyl-1h-imidazol-1-yl)methyl|-4h-carbazol-4-one
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
US7288660B2 (en) 2004-05-07 2007-10-30 Taro Pharmaceutical Industries Limited Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
WO2010133663A1 (en) 2009-05-20 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
CN115611864A (zh) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 一种昂丹司琼类化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
EP0191562B1 (en) * 1985-01-23 1991-07-10 Glaxo Group Limited Tetrahydrocarbazolone derivatives

Also Published As

Publication number Publication date
CZ404391A3 (en) 1993-04-14
NO1994022I1 (no) 1994-11-09
HU193592B (en) 1987-11-30
LU88268I2 (fi) 1994-02-03
KR850005439A (ko) 1985-08-26
FI84349C (fi) 1991-11-25
FI850323A0 (fi) 1985-01-25
SK277923B6 (en) 1995-08-09
GB2153821B (en) 1988-01-20
ATA20485A (de) 1990-08-15
NL940009I1 (nl) 1994-07-18
AU579132B2 (en) 1988-11-17
BE901576A (fr) 1985-07-25
HK33189A (en) 1989-04-28
ES539852A0 (es) 1986-07-16
AU3809785A (en) 1985-08-01
NZ210940A (en) 1989-08-29
GR850219B (fi) 1985-05-23
DE3502508C2 (fi) 1990-05-03
CH664152A5 (fr) 1988-02-15
ES8609309A1 (es) 1986-07-16
ES8801247A1 (es) 1987-12-16
FI850323L (fi) 1985-07-26
NO850300L (no) 1985-07-26
NL940009I2 (nl) 1999-05-03
DK35785A (da) 1985-07-26
FR2561244B1 (fr) 1988-03-04
DE3502508A1 (de) 1985-08-14
SK404391A3 (en) 1995-08-09
SE8500368L (sv) 1985-07-26
CY1479A (en) 1989-07-21
SE460359B (sv) 1989-10-02
ES556101A0 (es) 1987-12-16
NL8500202A (nl) 1985-08-16
SE8500368D0 (sv) 1985-01-25
IT8547600A0 (it) 1985-01-25
CA1252793A (en) 1989-04-18
SG7089G (en) 1989-06-09
GB2153821A (en) 1985-08-29
PH22672A (en) 1988-11-14
DE19375046I2 (de) 2002-10-10
IE57809B1 (en) 1993-04-21
KR920003064B1 (ko) 1992-04-13
NL190373C (nl) 1994-02-01
LU85743A1 (fr) 1986-08-04
ES8708224A1 (es) 1987-10-01
IL74165A (en) 1988-11-15
FR2561244A1 (fr) 1985-09-20
NO164025B (no) 1990-05-14
AT392276B (de) 1991-02-25
IT1182150B (it) 1987-09-30
IE850187L (en) 1985-07-25
HUT37784A (en) 1986-02-28
ES548430A0 (es) 1987-10-01
GB8501889D0 (en) 1985-02-27
PT79890B (en) 1987-02-03
FI84349B (fi) 1991-08-15
NO164025C (no) 1990-08-22
PT79890A (en) 1985-02-01
NL190373B (nl) 1993-09-01
DK35785D0 (da) 1985-01-25

Similar Documents

Publication Publication Date Title
DK169521B1 (da) 3-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne
US5068234A (en) 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
US4695578A (en) 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DK169675B1 (da) 4-Imidazolylmethyltetrahydrocarbazoloner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende forbindelserne
EP0339978B1 (en) Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents
DK169922B1 (da) Substituerede (imidazol-4-yl)methylpyrido-, og -azepino-, indolonderivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende derivaterne
US5563147A (en) Serotonerbic tetrahydropyridoindoles
NO179612B (no) Analogifremgangsmåte for fremstilling av 3-arylkarbonyl-1-aminoalkyl-1H-indol-forbindelser
PT94070A (pt) Processo para a preparacao de derivados de piperazina
US5849746A (en) Substituted 1,4-piperazine-heteroaryl derivatives as 5-HT1D receptor agonists
DE19707628A1 (de) Oxazolidinone
EP0171037B1 (en) 3-carbonyl-1-aminoalkyl-1h-indoles useful as analgesics and preparation thereof
US5834482A (en) Heterocyclic chemistry
US6211219B1 (en) Aminocyclohexane derivatives as 5-HT receptor agonists
WO1997032848A1 (fr) Composes heterocycliques fusionnes et leurs applications pharmaceutiques
DK170506B1 (da) Pyrido- og azepino-indolforbindelser, fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende dem samt anvendelse af forbindelserne
US6127388A (en) Azetidine, pyrrolidine and piperidine derivatives as 5-HT1D receptor agonists
JP2776984B2 (ja) 新規な縮合チアゾール誘導体，その製造法及びその医薬組成物
US6054469A (en) Substituted tetrahydropyridine derivatives acting on 5-HT receptors
AU707750B2 (en) Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives
US5994374A (en) Substituted 1-indolylpropyl-4-benzyl-tetrahydropyridine derivatives
US5925638A (en) Substituted 1-indolylpropyl-4-benzylpiperazine derivatives
US5998416A (en) Piperazine, piperidine and tetrahydropyridine derivatives as 5-HT receptor agonists
AU631795C (en) Fused polycyclic compounds, compositions, methods of manufacture and their use as PAF antagonists, antihistamines and/or antiinflammatory agents
JPH0378862B2 (fi)

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1995 00001, 950118

CTFG Supplementary protection certificate (spc) issued

Free format text: CA 1995 00001, 950118, EXPIRES: 20050223

PUP Patent expired