FR2561244B1 - Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant - Google Patents

Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant

Info

Publication number
FR2561244B1
FR2561244B1 FR8501056A FR8501056A FR2561244B1 FR 2561244 B1 FR2561244 B1 FR 2561244B1 FR 8501056 A FR8501056 A FR 8501056A FR 8501056 A FR8501056 A FR 8501056A FR 2561244 B1 FR2561244 B1 FR 2561244B1
Authority
FR
France
Prior art keywords
tetrahydrocarbazolone
preparation
pharmaceutical composition
same
heterocyclic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8501056A
Other languages
English (en)
French (fr)
Other versions
FR2561244A1 (fr
Inventor
Ian Harold Coates
James Angus Bell
David Cedric Humber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2561244A1 publication Critical patent/FR2561244A1/fr
Application granted granted Critical
Publication of FR2561244B1 publication Critical patent/FR2561244B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8501056A 1984-01-25 1985-01-25 Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant Expired FR2561244B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
FR2561244A1 FR2561244A1 (fr) 1985-09-20
FR2561244B1 true FR2561244B1 (fr) 1988-03-04

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8501056A Expired FR2561244B1 (fr) 1984-01-25 1985-01-25 Composes heterocycliques du type tetrahydrocarbazolone, procede pour leur preparation et composition pharmaceutique les comprenant

Country Status (29)

Country Link
KR (1) KR920003064B1 (fi)
AT (1) AT392276B (fi)
AU (1) AU579132B2 (fi)
BE (1) BE901576A (fi)
CA (1) CA1252793A (fi)
CH (1) CH664152A5 (fi)
CY (1) CY1479A (fi)
CZ (1) CZ404391A3 (fi)
DE (2) DE3502508A1 (fi)
DK (1) DK169521B1 (fi)
ES (3) ES8609309A1 (fi)
FI (1) FI84349C (fi)
FR (1) FR2561244B1 (fi)
GB (1) GB2153821B (fi)
GR (1) GR850219B (fi)
HK (1) HK33189A (fi)
HU (1) HU193592B (fi)
IE (1) IE57809B1 (fi)
IL (1) IL74165A (fi)
IT (1) IT1182150B (fi)
LU (2) LU88268I2 (fi)
NL (2) NL190373C (fi)
NO (2) NO164025C (fi)
NZ (1) NZ210940A (fi)
PH (1) PH22672A (fi)
PT (1) PT79890B (fi)
SE (1) SE460359B (fi)
SG (1) SG7089G (fi)
SK (1) SK404391A3 (fi)

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AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
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GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (ja) * 1988-04-07 1990-02-20 Glaxo Group Ltd イミダゾール誘導体
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
CA2031214A1 (en) * 1989-04-21 1990-10-22 Alberto Azcona Therapeutic use of 5-ht receptor antagonists
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
EP1022025A3 (en) * 1991-06-26 2002-06-05 Sepracor, Inc. Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
CA2157671A1 (en) * 1993-03-08 1994-09-15 Kiyotaka Katsuta Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325408B (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Chewing gum formulation comprising ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
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US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
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EP1499623B1 (en) 2002-04-29 2007-06-13 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-¬(2-methyl-1h-imidazol-1-yl)methyl|-4h-carbazol-4-one
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
US7288660B2 (en) 2004-05-07 2007-10-30 Taro Pharmaceutical Industries Limited Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
WO2010133663A1 (en) 2009-05-20 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
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Also Published As

Publication number Publication date
CZ404391A3 (en) 1993-04-14
NO1994022I1 (no) 1994-11-09
HU193592B (en) 1987-11-30
LU88268I2 (fi) 1994-02-03
KR850005439A (ko) 1985-08-26
FI84349C (fi) 1991-11-25
FI850323A0 (fi) 1985-01-25
SK277923B6 (en) 1995-08-09
GB2153821B (en) 1988-01-20
ATA20485A (de) 1990-08-15
NL940009I1 (nl) 1994-07-18
AU579132B2 (en) 1988-11-17
BE901576A (fr) 1985-07-25
HK33189A (en) 1989-04-28
ES539852A0 (es) 1986-07-16
AU3809785A (en) 1985-08-01
NZ210940A (en) 1989-08-29
GR850219B (fi) 1985-05-23
DE3502508C2 (fi) 1990-05-03
CH664152A5 (fr) 1988-02-15
ES8609309A1 (es) 1986-07-16
ES8801247A1 (es) 1987-12-16
FI850323L (fi) 1985-07-26
NO850300L (no) 1985-07-26
NL940009I2 (nl) 1999-05-03
DK35785A (da) 1985-07-26
DE3502508A1 (de) 1985-08-14
SK404391A3 (en) 1995-08-09
SE8500368L (sv) 1985-07-26
CY1479A (en) 1989-07-21
SE460359B (sv) 1989-10-02
ES556101A0 (es) 1987-12-16
NL8500202A (nl) 1985-08-16
SE8500368D0 (sv) 1985-01-25
IT8547600A0 (it) 1985-01-25
CA1252793A (en) 1989-04-18
SG7089G (en) 1989-06-09
GB2153821A (en) 1985-08-29
PH22672A (en) 1988-11-14
DK169521B1 (da) 1994-11-21
DE19375046I2 (de) 2002-10-10
IE57809B1 (en) 1993-04-21
KR920003064B1 (ko) 1992-04-13
NL190373C (nl) 1994-02-01
LU85743A1 (fr) 1986-08-04
ES8708224A1 (es) 1987-10-01
IL74165A (en) 1988-11-15
FR2561244A1 (fr) 1985-09-20
NO164025B (no) 1990-05-14
AT392276B (de) 1991-02-25
IT1182150B (it) 1987-09-30
IE850187L (en) 1985-07-25
HUT37784A (en) 1986-02-28
ES548430A0 (es) 1987-10-01
GB8501889D0 (en) 1985-02-27
PT79890B (en) 1987-02-03
FI84349B (fi) 1991-08-15
NO164025C (no) 1990-08-22
PT79890A (en) 1985-02-01
NL190373B (nl) 1993-09-01
DK35785D0 (da) 1985-01-25

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0185, 920511

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0185, 850125

CL Concession to grant licences