DK169505B1 - Fremgangsmåde til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmåden - Google Patents

Fremgangsmåde til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmåden Download PDF

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Publication number
DK169505B1
DK169505B1 DK328187A DK328187A DK169505B1 DK 169505 B1 DK169505 B1 DK 169505B1 DK 328187 A DK328187 A DK 328187A DK 328187 A DK328187 A DK 328187A DK 169505 B1 DK169505 B1 DK 169505B1
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DK
Denmark
Prior art keywords
hydrogen
alkyl
compound
formula
halogen
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DK328187A
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Danish (da)
English (en)
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DK328187A (da
DK328187D0 (da
Inventor
Guy Rossey
David Long
Original Assignee
Synthelabo
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Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of DK328187D0 publication Critical patent/DK328187D0/da
Publication of DK328187A publication Critical patent/DK328187A/da
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Publication of DK169505B1 publication Critical patent/DK169505B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK328187A 1986-06-27 1987-06-26 Fremgangsmåde til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmåden DK169505B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8609330 1986-06-27
FR8609330A FR2600650B1 (fr) 1986-06-27 1986-06-27 Procede de preparation d'imidazopyridines et composes intermediaires

Publications (3)

Publication Number Publication Date
DK328187D0 DK328187D0 (da) 1987-06-26
DK328187A DK328187A (da) 1987-12-28
DK169505B1 true DK169505B1 (da) 1994-11-14

Family

ID=9336785

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328187A DK169505B1 (da) 1986-06-27 1987-06-26 Fremgangsmåde til fremstilling af imidazopyridiner og mellemprodukter til brug ved fremgangsmåden

Country Status (21)

Country Link
US (1) US4794185A (de)
EP (1) EP0251859B1 (de)
JP (1) JPH0653740B2 (de)
KR (1) KR940006594B1 (de)
AR (1) AR243188A1 (de)
AT (1) ATE58537T1 (de)
AU (1) AU7477287A (de)
CA (1) CA1324138C (de)
DE (1) DE3766300D1 (de)
DK (1) DK169505B1 (de)
ES (1) ES2019646B3 (de)
FI (1) FI872850A (de)
FR (1) FR2600650B1 (de)
GR (1) GR3001118T3 (de)
HU (1) HU204826B (de)
IE (1) IE60467B1 (de)
IL (1) IL82982A (de)
NO (1) NO167392C (de)
NZ (1) NZ220853A (de)
PT (1) PT85188B (de)
ZA (1) ZA874643B (de)

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ATE62687T1 (de) * 1986-01-22 1991-05-15 Synthelabo Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung.
FR2615513B1 (fr) * 1987-05-21 1989-07-13 Synthelabo Derives d'acylaminomethyl-3 tetrahydro-5,6,7,8 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
ATE247967T1 (de) 1998-06-09 2003-09-15 Takeda Chemical Industries Ltd Pharmazeutische kombination mit einem trizyclischen komponent und mindestens einem aus zolpidem, zopiclone und brotizolam, zur behandlung von schlafstörungen
ES2151834B1 (es) * 1998-08-06 2001-08-16 Sint Quimica Sa Procedimiento para preparar n,n,6-trimetil-2-(4-metilfenil)-imidazo-(1,2-a)-piridina-3-acetamida y sus sales.
ATE242241T1 (de) 1999-03-25 2003-06-15 Synthon Bv Imidazopyridinderivate und verfahren zu ihrer herstellung
EP1163241B1 (de) * 1999-03-25 2005-06-15 Synthon B.V. Zolpidem salze
US6333345B1 (en) * 1999-05-14 2001-12-25 Sepracor, Inc. Methods of using and compositions comprising N-desmethylzolpidem
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
WO2001078725A2 (en) * 2000-04-13 2001-10-25 Synthon B.V. Modified release formulations containing a hypnotic agent
DE60125429T2 (de) * 2000-04-24 2007-09-27 Teva Pharmaceutical Industries Ltd. Zolpidem hemitartrat solvat
EP1473036B1 (de) * 2000-04-24 2006-08-09 Teva Pharmaceutical Industries Ltd. Zolpidem Hemitartrat Solvat
IT1318624B1 (it) 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
WO2002014306A1 (en) * 2000-08-17 2002-02-21 Cilag Ag Process for the preparation of imidazopyridines
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE10121638A1 (de) * 2001-05-03 2002-11-14 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Imidazopyridinen
US20020183522A1 (en) 2001-05-03 2002-12-05 Markus Sauter Process for preparing zolpidem
AU2003249262B2 (en) * 2002-07-15 2008-08-14 Scinopharm Taiwan, Ltd. Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides
CA2509561A1 (en) * 2002-12-18 2004-07-15 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
US20040241100A1 (en) * 2003-03-17 2004-12-02 Fabre Kramer Pharmaceutical, Inc. Nasally administrable compositions of zolpidem and methods of use
GB0311457D0 (en) * 2003-05-19 2003-06-25 Sciencom Ltd New therapeutic use
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
AU2005262622A1 (en) * 2004-06-22 2006-01-19 Mallinckrodt Inc. Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
EP2275095A3 (de) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
WO2007040995A1 (en) * 2005-10-03 2007-04-12 Mallinckrodt Inc. Process for preparing zolpidem hemitartrate and tartrate polymorphs
CN101291654A (zh) * 2005-10-17 2008-10-22 马林克罗特公司 片剂基质中唑吡坦的多晶型转化
EP2377530A3 (de) 2005-10-21 2012-06-20 Braincells, Inc. Modulation von Neurogenese durch PDE-Hemmung
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
CA2629740A1 (en) 2005-11-18 2007-06-14 Synthon B.V. Zolpidem tablets
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007292848A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN103360387B (zh) * 2012-03-28 2016-12-14 江苏豪森药业集团有限公司 一种制备化合物唑吡坦的方法
KR101704589B1 (ko) * 2016-07-12 2017-02-08 주식회사 뉴트라팜텍 후박 추출물 및 신이 추출물의 혼합물을 유효성분으로 함유하는 치주조직 성장 촉진용 및 치주염 예방 또는 치료용 약학적 조성물
CN107793415A (zh) * 2016-12-01 2018-03-13 湖南省食品药品检验研究院 酒石酸唑吡坦杂质的合成方法
CN106749237A (zh) * 2016-12-28 2017-05-31 江苏豪森药业集团有限公司 酒石酸唑吡坦及其中间体的制备方法
CN114057725B (zh) * 2020-07-31 2024-01-16 株洲千金药业股份有限公司 一种酒石酸唑吡坦的合成方法
CN114057727B (zh) * 2020-07-31 2024-02-27 株洲千金药业股份有限公司 一种唑吡坦中间体的合成方法
CN114057726A (zh) * 2020-07-31 2022-02-18 株洲千金药业股份有限公司 一种唑吡坦盐酸盐的合成方法
CN114249668B (zh) * 2020-09-25 2024-08-23 鲁南制药集团股份有限公司 一种唑吡坦中间体n,n-二甲基-2-氧乙酰胺的制备方法

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
GR68765B (de) * 1979-06-20 1982-02-17 Rohm & Haas
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
AR243188A1 (es) 1993-07-30
KR880000433A (ko) 1988-03-25
HUT44547A (en) 1988-03-28
JPH0653740B2 (ja) 1994-07-20
ATE58537T1 (de) 1990-12-15
AU7477287A (en) 1988-01-07
CA1324138C (en) 1993-11-09
GR3001118T3 (en) 1992-05-12
IE60467B1 (en) 1994-07-13
HU204826B (en) 1992-02-28
DK328187A (da) 1987-12-28
EP0251859B1 (de) 1990-11-22
DK328187D0 (da) 1987-06-26
NO872682D0 (no) 1987-06-26
FI872850A0 (fi) 1987-06-26
US4794185A (en) 1988-12-27
PT85188B (pt) 1990-03-30
FI872850A (fi) 1987-12-28
NO167392B (no) 1991-07-22
IL82982A0 (en) 1987-12-20
FR2600650B1 (fr) 1988-09-09
IL82982A (en) 1992-03-29
ES2019646B3 (es) 1991-07-01
DE3766300D1 (de) 1991-01-03
PT85188A (fr) 1987-07-01
EP0251859A2 (de) 1988-01-07
NZ220853A (en) 1989-09-27
FR2600650A1 (fr) 1987-12-31
NO872682L (no) 1987-12-28
EP0251859A3 (en) 1989-07-19
ZA874643B (en) 1988-02-24
NO167392C (no) 1991-10-30
JPS638384A (ja) 1988-01-14
IE871723L (en) 1987-12-27
KR940006594B1 (ko) 1994-07-23

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B1 Patent granted (law 1993)
PUP Patent expired