DK168691B1 - Fast farmaceutisk præparat indeholdende nifedipin eller derivater deraf og fremgangsmåde til fremstilling af præparatet - Google Patents
Fast farmaceutisk præparat indeholdende nifedipin eller derivater deraf og fremgangsmåde til fremstilling af præparatet Download PDFInfo
- Publication number
- DK168691B1 DK168691B1 DK481186A DK481186A DK168691B1 DK 168691 B1 DK168691 B1 DK 168691B1 DK 481186 A DK481186 A DK 481186A DK 481186 A DK481186 A DK 481186A DK 168691 B1 DK168691 B1 DK 168691B1
- Authority
- DK
- Denmark
- Prior art keywords
- active substance
- polyethylene glycol
- solution
- nifedipine
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Heat Treatment Of Sheet Steel (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22494/85A IT1187751B (it) | 1985-10-15 | 1985-10-15 | Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute |
IT2249485 | 1985-10-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK481186D0 DK481186D0 (da) | 1986-10-08 |
DK481186A DK481186A (da) | 1987-04-16 |
DK168691B1 true DK168691B1 (da) | 1994-05-24 |
Family
ID=11197023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK481186A DK168691B1 (da) | 1985-10-15 | 1986-10-08 | Fast farmaceutisk præparat indeholdende nifedipin eller derivater deraf og fremgangsmåde til fremstilling af præparatet |
Country Status (18)
Country | Link |
---|---|
US (1) | US4880623A (it) |
EP (1) | EP0220760B1 (it) |
JP (1) | JPH0811731B2 (it) |
KR (1) | KR940006320B1 (it) |
AT (1) | ATE66367T1 (it) |
AU (1) | AU590622B2 (it) |
CA (1) | CA1280976C (it) |
DE (1) | DE3680989D1 (it) |
DK (1) | DK168691B1 (it) |
ES (1) | ES2040209T3 (it) |
FI (1) | FI87424C (it) |
GR (1) | GR3003150T3 (it) |
HK (1) | HK12595A (it) |
IT (1) | IT1187751B (it) |
NO (1) | NO172168C (it) |
NZ (1) | NZ217841A (it) |
PT (1) | PT83522B (it) |
ZA (1) | ZA867767B (it) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
US5215752A (en) * | 1988-03-17 | 1993-06-01 | Vectorpharma International S.P.A. | Pharmaceutical tablets and capsule granulates of scleroglucan and active substance |
US5028433A (en) * | 1988-11-30 | 1991-07-02 | Banyu Pharmaceutical Co., Ltd. | Readily absorbable drug formulation of NB-818 |
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
HU203041B (en) * | 1989-03-14 | 1991-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin |
GB9025251D0 (en) * | 1990-11-20 | 1991-01-02 | Solomon Montague C | Nifedipine dosage forms |
US5145859A (en) * | 1991-03-20 | 1992-09-08 | Case Western Reserve University | Methods of treating interstitial cystitis and urethral syndrome |
US5271944A (en) * | 1991-04-05 | 1993-12-21 | Biofor, Ltd. | Pharmacologically enhanced formulations |
US5302397A (en) * | 1991-11-19 | 1994-04-12 | Amsden Brian G | Polymer-based drug delivery system |
DK0557244T3 (da) * | 1992-02-17 | 1996-04-01 | Siegfried Ag Pharma | Dosisformer med forlænget afgivelse af aktivt stof |
IL104192A (en) * | 1992-02-17 | 1998-01-04 | Siegfried Ag Pharma | Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient |
WO1994005262A1 (en) * | 1992-09-10 | 1994-03-17 | F.H. Faulding & Co. Limited | Sustained release matrix composition |
US6726930B1 (en) * | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5773025A (en) * | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5543099A (en) * | 1994-09-29 | 1996-08-06 | Hallmark Pharmaceutical, Inc. | Process to manufacture micronized nifedipine granules for sustained release medicaments |
US5618845A (en) * | 1994-10-06 | 1997-04-08 | Cephalon, Inc. | Acetamide derivative having defined particle size |
IL123505A (en) | 1996-07-08 | 2004-12-15 | Penwest Pharmaceuticals Compan | Sustained release matrix for high-dose insoluble drugs |
IT1284604B1 (it) * | 1996-09-27 | 1998-05-21 | Roberto Valducci | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6485748B1 (en) | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
US8293277B2 (en) | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
CA2352211C (en) * | 1999-09-30 | 2009-03-24 | Edward Mendell Co., Inc. | Sustained release matrix systems for highly soluble drugs |
CA2395331C (en) | 1999-12-23 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions providing enhanced drug concentrations |
IL134701A0 (en) | 2000-02-23 | 2001-04-30 | J P M E D Ltd | Homogeneous solid matrix containing vegetable proteins |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
EP1269994A3 (en) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
MXPA03011935A (es) * | 2001-06-22 | 2004-03-26 | Pfizer Prod Inc | Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco. |
DE10142417A1 (de) * | 2001-08-31 | 2003-03-20 | Molecular And Clinical Drug Re | Arzneimittel |
DE10142416A1 (de) * | 2001-08-31 | 2003-03-20 | Molecular And Clinical Drug Re | Verfahren zur Herstellung von Lösungen |
WO2003033462A2 (en) * | 2001-10-15 | 2003-04-24 | The Regents Of The University Of Michigan | Systems and methods for the generation of crystalline polymorphs |
GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
US20040048931A1 (en) * | 2002-07-12 | 2004-03-11 | Craig Heacock | Modafinil pharmaceutical compositions |
CA2511992A1 (en) * | 2003-02-24 | 2004-09-10 | Mallinckrodt Inc. | Process for preparing benzhydrylthioacetamide |
WO2004087102A2 (en) * | 2003-03-26 | 2004-10-14 | Teva Pharmaceutical Industries Ltd. | A process for preparing a pharmaceutical active ingredient with high specific surface area |
US20040253308A1 (en) * | 2003-04-29 | 2004-12-16 | Barr Laboratories, Inc. | Surface-treated modafinil particles |
CA2644069A1 (en) * | 2006-02-28 | 2007-09-07 | Helicon Therapeutics, Inc. | Therapeutic piperazines as pde4 inhibitors |
US20080181966A1 (en) * | 2006-10-18 | 2008-07-31 | Cephalon, Inc. | Modafinil pharmaceutical compositions |
CN102014918A (zh) * | 2007-04-20 | 2011-04-13 | 太阳医药工业有限公司 | 由微量沉淀产生的药学组合物 |
RU2629843C1 (ru) * | 2016-05-24 | 2017-09-04 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) | Способ получения мази нифедипина (варианты) |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO98434A (it) * | 1959-04-30 | |||
US3920809A (en) * | 1973-11-05 | 1975-11-18 | Lilly Co Eli | Dibenzo(b,d)pyranone dispersions |
US3988439A (en) * | 1973-11-05 | 1976-10-26 | Eli Lilly And Company | Dibenzo[b,d]pyranone dispersions |
DE2400819C2 (de) * | 1974-01-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung |
US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
EP0001247A1 (en) * | 1977-09-14 | 1979-04-04 | Kanebo, Ltd. | Pharmaceutical preparation containing nifedipine and a method for producing the same. |
JPS55129221A (en) * | 1979-03-29 | 1980-10-06 | Kaken Pharmaceut Co Ltd | Preparation of oral preparation containing hardly soluble medicine |
CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
US4311694A (en) * | 1979-12-31 | 1982-01-19 | American Cyanamid Company | Amorphous coprecipitates of 4-(monoalkylamino) benzoic acid and derivatives and certain water-soluble materials |
DE3033919A1 (de) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
JPS58116414A (ja) * | 1981-12-23 | 1983-07-11 | Yamanouchi Pharmaceut Co Ltd | ニカルジピン持続性製剤用球形顆粒およびその製造法 |
DE3318649A1 (de) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | Zweiphasenformulierung |
NL194389C (nl) * | 1984-06-14 | 2002-03-04 | Novartis Ag | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
IT1178511B (it) * | 1984-09-14 | 1987-09-09 | Pharmatec Spa | Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio |
DE3438830A1 (de) * | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
-
1985
- 1985-10-15 IT IT22494/85A patent/IT1187751B/it active
-
1986
- 1986-10-02 AT AT86201704T patent/ATE66367T1/de not_active IP Right Cessation
- 1986-10-02 DE DE8686201704T patent/DE3680989D1/de not_active Expired - Lifetime
- 1986-10-02 EP EP86201704A patent/EP0220760B1/en not_active Expired - Lifetime
- 1986-10-02 ES ES198686201704T patent/ES2040209T3/es not_active Expired - Lifetime
- 1986-10-07 NZ NZ217841A patent/NZ217841A/en unknown
- 1986-10-08 DK DK481186A patent/DK168691B1/da active
- 1986-10-10 PT PT83522A patent/PT83522B/pt not_active IP Right Cessation
- 1986-10-13 AU AU63832/86A patent/AU590622B2/en not_active Ceased
- 1986-10-13 NO NO864060A patent/NO172168C/no unknown
- 1986-10-14 FI FI864151A patent/FI87424C/fi not_active IP Right Cessation
- 1986-10-14 ZA ZA867767A patent/ZA867767B/xx unknown
- 1986-10-14 CA CA000520378A patent/CA1280976C/en not_active Expired - Lifetime
- 1986-10-14 JP JP61242180A patent/JPH0811731B2/ja not_active Expired - Lifetime
- 1986-10-14 US US06/918,382 patent/US4880623A/en not_active Expired - Fee Related
- 1986-10-15 KR KR1019860008647A patent/KR940006320B1/ko not_active IP Right Cessation
-
1991
- 1991-11-19 GR GR91401773T patent/GR3003150T3/el unknown
-
1995
- 1995-01-26 HK HK12595A patent/HK12595A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE66367T1 (de) | 1991-09-15 |
IT1187751B (it) | 1987-12-23 |
KR870003779A (ko) | 1987-05-04 |
NO172168C (no) | 1993-06-16 |
HK12595A (en) | 1995-02-03 |
DK481186A (da) | 1987-04-16 |
GR3003150T3 (en) | 1993-02-17 |
US4880623A (en) | 1989-11-14 |
AU6383286A (en) | 1987-04-16 |
EP0220760A2 (en) | 1987-05-06 |
PT83522A (en) | 1986-11-01 |
NZ217841A (en) | 1990-01-29 |
DK481186D0 (da) | 1986-10-08 |
FI87424C (fi) | 1993-01-11 |
IT8522494A0 (it) | 1985-10-15 |
ZA867767B (en) | 1987-06-24 |
NO172168B (no) | 1993-03-08 |
PT83522B (pt) | 1988-11-30 |
KR940006320B1 (ko) | 1994-07-16 |
DE3680989D1 (de) | 1991-09-26 |
FI864151A0 (fi) | 1986-10-14 |
NO864060D0 (no) | 1986-10-13 |
EP0220760B1 (en) | 1991-08-21 |
EP0220760A3 (en) | 1987-09-23 |
JPS62167727A (ja) | 1987-07-24 |
JPH0811731B2 (ja) | 1996-02-07 |
CA1280976C (en) | 1991-03-05 |
FI87424B (fi) | 1992-09-30 |
ES2040209T3 (es) | 1993-10-16 |
FI864151A (fi) | 1987-04-16 |
NO864060L (no) | 1987-04-21 |
AU590622B2 (en) | 1989-11-09 |
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