IT8522494A0 - Procedimento per la preparazione di formulazioni solide di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute. - Google Patents

Procedimento per la preparazione di formulazioni solide di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute.

Info

Publication number
IT8522494A0
IT8522494A0 IT8522494A IT2249485A IT8522494A0 IT 8522494 A0 IT8522494 A0 IT 8522494A0 IT 8522494 A IT8522494 A IT 8522494A IT 2249485 A IT2249485 A IT 2249485A IT 8522494 A0 IT8522494 A0 IT 8522494A0
Authority
IT
Italy
Prior art keywords
formulations
nifedipine
procedure
preparation
long
Prior art date
Application number
IT8522494A
Other languages
English (en)
Other versions
IT1187751B (it
Inventor
Piergiorgio Rossi
Massimo Calanchi
Original Assignee
Eurand Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Spa filed Critical Eurand Spa
Publication of IT8522494A0 publication Critical patent/IT8522494A0/it
Priority to IT22494/85A priority Critical patent/IT1187751B/it
Priority to AT86201704T priority patent/ATE66367T1/de
Priority to DE8686201704T priority patent/DE3680989D1/de
Priority to EP86201704A priority patent/EP0220760B1/en
Priority to ES198686201704T priority patent/ES2040209T3/es
Priority to NZ217841A priority patent/NZ217841A/en
Priority to DK481186A priority patent/DK168691B1/da
Priority to PT83522A priority patent/PT83522B/pt
Priority to NO864060A priority patent/NO172168C/no
Priority to AU63832/86A priority patent/AU590622B2/en
Priority to JP61242180A priority patent/JPH0811731B2/ja
Priority to FI864151A priority patent/FI87424C/fi
Priority to US06/918,382 priority patent/US4880623A/en
Priority to ZA867767A priority patent/ZA867767B/xx
Priority to CA000520378A priority patent/CA1280976C/en
Priority to KR1019860008647A priority patent/KR940006320B1/ko
Application granted granted Critical
Publication of IT1187751B publication Critical patent/IT1187751B/it
Priority to GR91401773T priority patent/GR3003150T3/el
Priority to HK12595A priority patent/HK12595A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
IT22494/85A 1985-10-15 1985-10-15 Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute IT1187751B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT22494/85A IT1187751B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute
AT86201704T ATE66367T1 (de) 1985-10-15 1986-10-02 Verfahren zur herstellung von festen nifedipinzusammensetzungen mit verzoegerter abgabe und so erhaltene zusammensetzungen.
DE8686201704T DE3680989D1 (de) 1985-10-15 1986-10-02 Verfahren zur herstellung von festen nifedipinzusammensetzungen mit verzoegerter abgabe und so erhaltene zusammensetzungen.
EP86201704A EP0220760B1 (en) 1985-10-15 1986-10-02 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
ES198686201704T ES2040209T3 (es) 1985-10-15 1986-10-02 Procedimiento de preparacion de formulaciones de nifedipina solida de alta disponibilidad biologica y con efecto sostenido, y las formulaciones obtenidas.
NZ217841A NZ217841A (en) 1985-10-15 1986-10-07 Solid pharmaceutical formulations containing nifedipine or a derivative thereof present on very fine particles of carrier with very high total specific surface
DK481186A DK168691B1 (da) 1985-10-15 1986-10-08 Fast farmaceutisk præparat indeholdende nifedipin eller derivater deraf og fremgangsmåde til fremstilling af præparatet
PT83522A PT83522B (pt) 1985-10-15 1986-10-10 Processo para a preparacao de formulacoes de nifedipina solidas de elevada eficacia biologica e com efeito prolongado
NO864060A NO172168C (no) 1985-10-15 1986-10-13 Fremgangsmaate for fremstilling av faste nifedipinpreparater med hoey biotilgjengelighet og med forlenget virkning
AU63832/86A AU590622B2 (en) 1985-10-15 1986-10-13 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
JP61242180A JPH0811731B2 (ja) 1985-10-15 1986-10-14 固形ニフエジピン製剤の製造方法及びそのようにして得られた製剤
FI864151A FI87424C (fi) 1985-10-15 1986-10-14 Foerfarande foer framstaellning av fasta nifedipinpreparat, som biologiskt laett kan tillgodogoeras och som har en foerdroejd effekt
US06/918,382 US4880623A (en) 1985-10-15 1986-10-14 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
ZA867767A ZA867767B (en) 1985-10-15 1986-10-14 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect,and formulations thus obtained
CA000520378A CA1280976C (en) 1985-10-15 1986-10-14 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thusobtained
KR1019860008647A KR940006320B1 (ko) 1985-10-15 1986-10-15 고 생체이용율 및 서방성 효과를 갖는 니페디핀의 고형 제제의 제조방법
GR91401773T GR3003150T3 (en) 1985-10-15 1991-11-19 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
HK12595A HK12595A (en) 1985-10-15 1995-01-26 Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22494/85A IT1187751B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute

Publications (2)

Publication Number Publication Date
IT8522494A0 true IT8522494A0 (it) 1985-10-15
IT1187751B IT1187751B (it) 1987-12-23

Family

ID=11197023

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22494/85A IT1187751B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute

Country Status (18)

Country Link
US (1) US4880623A (it)
EP (1) EP0220760B1 (it)
JP (1) JPH0811731B2 (it)
KR (1) KR940006320B1 (it)
AT (1) ATE66367T1 (it)
AU (1) AU590622B2 (it)
CA (1) CA1280976C (it)
DE (1) DE3680989D1 (it)
DK (1) DK168691B1 (it)
ES (1) ES2040209T3 (it)
FI (1) FI87424C (it)
GR (1) GR3003150T3 (it)
HK (1) HK12595A (it)
IT (1) IT1187751B (it)
NO (1) NO172168C (it)
NZ (1) NZ217841A (it)
PT (1) PT83522B (it)
ZA (1) ZA867767B (it)

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IL104192A (en) * 1992-02-17 1998-01-04 Siegfried Ag Pharma Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient
WO1994005262A1 (en) * 1992-09-10 1994-03-17 F.H. Faulding & Co. Limited Sustained release matrix composition
US6726930B1 (en) * 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5543099A (en) * 1994-09-29 1996-08-06 Hallmark Pharmaceutical, Inc. Process to manufacture micronized nifedipine granules for sustained release medicaments
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
ES2322405T3 (es) 1996-07-08 2009-06-19 Penwest Pharmaceuticals Co. Matriz de liberacion controlada para farmacos insolubles en dosis elevadas.
IT1284604B1 (it) * 1996-09-27 1998-05-21 Roberto Valducci Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US6056977A (en) * 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US8293277B2 (en) 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
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US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
AU762291B2 (en) * 1999-09-30 2003-06-19 Penwest Pharmaceutical Co. Sustained release matrix systems for highly soluble drugs
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IL134701A0 (en) 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
MXPA03011935A (es) * 2001-06-22 2004-03-26 Pfizer Prod Inc Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco.
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
WO2003033462A2 (en) * 2001-10-15 2003-04-24 The Regents Of The University Of Michigan Systems and methods for the generation of crystalline polymorphs
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Also Published As

Publication number Publication date
NO172168B (no) 1993-03-08
IT1187751B (it) 1987-12-23
FI87424B (fi) 1992-09-30
EP0220760B1 (en) 1991-08-21
NO864060L (no) 1987-04-21
EP0220760A2 (en) 1987-05-06
FI87424C (fi) 1993-01-11
DE3680989D1 (de) 1991-09-26
JPS62167727A (ja) 1987-07-24
PT83522B (pt) 1988-11-30
US4880623A (en) 1989-11-14
DK168691B1 (da) 1994-05-24
AU6383286A (en) 1987-04-16
CA1280976C (en) 1991-03-05
FI864151A0 (fi) 1986-10-14
ATE66367T1 (de) 1991-09-15
FI864151A (fi) 1987-04-16
ZA867767B (en) 1987-06-24
PT83522A (en) 1986-11-01
ES2040209T3 (es) 1993-10-16
KR940006320B1 (ko) 1994-07-16
DK481186A (da) 1987-04-16
HK12595A (en) 1995-02-03
AU590622B2 (en) 1989-11-09
NO172168C (no) 1993-06-16
DK481186D0 (da) 1986-10-08
NZ217841A (en) 1990-01-29
EP0220760A3 (en) 1987-09-23
JPH0811731B2 (ja) 1996-02-07
KR870003779A (ko) 1987-05-04
GR3003150T3 (en) 1993-02-17
NO864060D0 (no) 1986-10-13

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