DK166414B1 - Alfa-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)-benzenacetonitriler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne - Google Patents

Alfa-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)-benzenacetonitriler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne Download PDF

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Publication number
DK166414B1
DK166414B1 DK347585A DK347585A DK166414B1 DK 166414 B1 DK166414 B1 DK 166414B1 DK 347585 A DK347585 A DK 347585A DK 347585 A DK347585 A DK 347585A DK 166414 B1 DK166414 B1 DK 166414B1
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DK
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Prior art keywords
alkyl
hydrogen
triazine
dioxo
halogen
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DK347585A
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Danish (da)
English (en)
Other versions
DK347585D0 (da
DK347585A (da
Inventor
Gustaaf Maria Boeckx
Alfons Herman Marg Raeymaekers
Victor Sipido
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK347585D0 publication Critical patent/DK347585D0/da
Publication of DK347585A publication Critical patent/DK347585A/da
Application granted granted Critical
Publication of DK166414B1 publication Critical patent/DK166414B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Lubricants (AREA)
DK347585A 1984-08-01 1985-07-31 Alfa-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)-benzenacetonitriler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne DK166414B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63653884A 1984-08-01 1984-08-01
US63653884 1984-08-01

Publications (3)

Publication Number Publication Date
DK347585D0 DK347585D0 (da) 1985-07-31
DK347585A DK347585A (da) 1986-02-02
DK166414B1 true DK166414B1 (da) 1993-05-17

Family

ID=24552347

Family Applications (1)

Application Number Title Priority Date Filing Date
DK347585A DK166414B1 (da) 1984-08-01 1985-07-31 Alfa-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)-benzenacetonitriler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne

Country Status (36)

Country Link
EP (1) EP0170316B1 (xx)
JP (2) JPS6143176A (xx)
KR (1) KR870000787B1 (xx)
CN (1) CN1016687B (xx)
AT (1) ATE53206T1 (xx)
AU (1) AU579653B2 (xx)
BG (1) BG46599A3 (xx)
CA (2) CA1244024A (xx)
CY (1) CY1656A (xx)
CZ (1) CZ277962B6 (xx)
DE (1) DE3577984D1 (xx)
DK (1) DK166414B1 (xx)
DZ (1) DZ814A1 (xx)
EG (1) EG17589A (xx)
ES (2) ES8609284A1 (xx)
FI (1) FI90235C (xx)
GR (1) GR851837B (xx)
HK (1) HK68092A (xx)
HU (1) HU194191B (xx)
IE (1) IE58076B1 (xx)
IL (1) IL75962A (xx)
LT (1) LT2069B (xx)
LV (2) LV5027A3 (xx)
MA (1) MA20497A1 (xx)
NO (1) NO171634C (xx)
NZ (1) NZ212770A (xx)
PH (1) PH21137A (xx)
PL (1) PL147667B1 (xx)
PT (1) PT80903B (xx)
RO (1) RO92300B (xx)
SG (1) SG65992G (xx)
SK (1) SK278310B6 (xx)
SU (1) SU1443799A3 (xx)
ZA (1) ZA855793B (xx)
ZM (1) ZM5385A1 (xx)
ZW (1) ZW12385A1 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000072A1 (en) * 1984-06-12 1986-01-03 Fmc Corporation Herbicidal 2-aryl-1,2,4-triazine-3,5(2h,4h)-diones and sulfur analogs thereof
DE3531919A1 (de) * 1985-09-07 1987-03-19 Hoechst Ag Substituierte 2-phenyl-hexahydro-1,2,4-triazin-3,5-dione, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
DE3826058A1 (de) * 1988-07-30 1990-02-08 Bayer Ag Mittel gegen fischparasiten
EP0364765A3 (de) * 1988-10-08 1991-07-17 Bayer Ag Substituierte 1,3,5-Triazintrione, Verfahren zu ihrer Herstellung und ihre Verwendung gegen parasitäre Protozoen
EP0377903A3 (de) * 1989-01-09 1991-07-17 Bayer Ag Substituierte Hexahydro-1,2,4-triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE58905324D1 (de) * 1989-01-09 1993-09-23 Bayer Ag Mittel gegen protozoen bei insekten.
CN1044905A (zh) * 1989-02-16 1990-08-29 赫彻斯特股份公司 鱼和昆虫寄生虫对抗剂
DE4030042A1 (de) * 1990-05-17 1991-11-21 Bayer Ag Verwendung von substituierten 1,2,4-triazindionen
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
US5830893A (en) * 1997-04-23 1998-11-03 Mortar & Pestle Veterinary Pharmacy, Inc. Treatment of equine protozoan myeloencephalitis using triazinediones
US6867207B2 (en) 1997-07-10 2005-03-15 Janssen Pharmaceutica N.V. IL-5 inhibiting 6-azauracil derivatives
EE200000016A (et) * 1997-07-10 2000-10-16 Janssen Pharmaceutica N.V. IL-5 inhibeerivad 6-asauratsiili derivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod, retseptori markeerimismeetod ja organi visualiseerimismeetod
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
BR9916366A (pt) 1998-12-18 2001-09-18 Janssen Pharmaceutica Nv Derivados de 6-azauracila, inibidores de il-5
NZ516506A (en) 1999-08-06 2004-02-27 Janssen Pharmaceutica Nv Interleukin-5 inhibiting 6-azauracil derivatives
CN101265238B (zh) * 2007-12-12 2010-06-16 重庆天极旅业有限公司 一种三嗪环衍生物的合成方法
CN101265216B (zh) * 2007-12-18 2012-06-27 重庆华邦胜凯制药有限公司 4-(取代乙氰基)-苯腙衍生物及其合成方法
CN102911080B (zh) * 2012-09-12 2015-01-21 衢州学院 一种制备2,6-二氯-α-(4-氯苯基)-4-硝基苯乙腈的方法
CN107746390B (zh) * 2017-11-21 2021-03-16 连云港市亚晖医药化工有限公司 抗球虫药地克珠利的制备方法
CN113999139A (zh) * 2021-12-03 2022-02-01 杭州臻峰科技有限公司 制备2，6-二氯-α-（4-氯代苯基） -4-硝基苯乙腈的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3905971A (en) * 1971-03-29 1975-09-16 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
GB1448696A (en) * 1973-05-29 1976-09-08 Pfizer 2-phqnyl-astriazine-3,4-2h,4h-diones

Also Published As

Publication number Publication date
AU579653B2 (en) 1988-12-01
FI90235C (fi) 1994-01-10
CY1656A (en) 1993-05-14
IE851911L (en) 1986-02-01
IL75962A0 (en) 1985-12-31
EP0170316B1 (en) 1990-05-30
EP0170316A3 (en) 1986-11-05
IL75962A (en) 1989-09-28
CN85105673A (zh) 1987-01-14
HK68092A (en) 1992-09-18
RO92300A (ro) 1987-11-30
EP0170316A2 (en) 1986-02-05
PL254700A1 (en) 1986-09-23
SK557685A3 (en) 1996-09-04
CA1305479C (en) 1992-07-21
LV5772A4 (lv) 1996-12-20
ZM5385A1 (en) 1987-03-27
NO171634B (no) 1993-01-04
ZW12385A1 (en) 1987-02-25
PH21137A (en) 1987-07-27
IE58076B1 (en) 1993-06-30
FI90235B (fi) 1993-09-30
BG46599A3 (en) 1990-01-15
JPH0420435B2 (xx) 1992-04-02
SK278310B6 (en) 1996-09-04
ES545744A0 (es) 1986-07-16
NZ212770A (en) 1988-10-28
HU194191B (en) 1988-01-28
LV5772B4 (lv) 1997-06-20
SG65992G (en) 1992-09-04
CZ277962B6 (en) 1993-07-14
FI852958A0 (fi) 1985-07-31
MA20497A1 (fr) 1986-04-01
JPH0517454A (ja) 1993-01-26
PT80903B (pt) 1987-11-11
NO853037L (no) 1986-02-03
CA1244024A (en) 1988-11-01
JPS6143176A (ja) 1986-03-01
DE3577984D1 (de) 1990-07-05
PT80903A (en) 1985-09-01
FI852958L (fi) 1986-02-02
HUT39433A (en) 1986-09-29
CZ557685A3 (en) 1993-02-17
JPH0625177B2 (ja) 1994-04-06
DK347585D0 (da) 1985-07-31
EG17589A (en) 1991-12-30
ZA855793B (en) 1987-03-25
LV5027A3 (lv) 1993-06-10
CN1016687B (zh) 1992-05-20
GR851837B (xx) 1985-12-02
ES8609284A1 (es) 1986-07-16
KR860001796A (ko) 1986-03-22
DZ814A1 (en) 2004-09-13
DK347585A (da) 1986-02-02
ES552443A0 (es) 1987-05-01
ES8705403A1 (es) 1987-05-01
AU4566485A (en) 1986-02-06
ATE53206T1 (de) 1990-06-15
SU1443799A3 (ru) 1988-12-07
NO171634C (no) 1993-04-14
PL147667B1 (en) 1989-07-31
KR870000787B1 (ko) 1987-04-18
LT2069B (lt) 1993-06-15
RO92300B (ro) 1987-12-02

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired