DK163988C - 9alfa,11alfa-epoxy-20-spiroxaner og analoge deraf med aaben tetrahydrofuranring e samt deres fremstilling og farmaceutiske praeparater indeholdende dem - Google Patents

9alfa,11alfa-epoxy-20-spiroxaner og analoge deraf med aaben tetrahydrofuranring e samt deres fremstilling og farmaceutiske praeparater indeholdende dem

Info

Publication number
DK163988C
DK163988C DK189484A DK189484A DK163988C DK 163988 C DK163988 C DK 163988C DK 189484 A DK189484 A DK 189484A DK 189484 A DK189484 A DK 189484A DK 163988 C DK163988 C DK 163988C
Authority
DK
Denmark
Prior art keywords
tetrahydrofuranring
9alfa
11alfa
spiroxanes
analogues
Prior art date
Application number
DK189484A
Other languages
Danish (da)
English (en)
Other versions
DK189484D0 (da
DK189484A (da
DK163988B (da
Inventor
Juergen Grob
Jaroslav Kalvoda
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK189484D0 publication Critical patent/DK189484D0/da
Publication of DK189484A publication Critical patent/DK189484A/da
Publication of DK163988B publication Critical patent/DK163988B/da
Application granted granted Critical
Publication of DK163988C publication Critical patent/DK163988C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK189484A 1983-04-13 1984-04-12 9alfa,11alfa-epoxy-20-spiroxaner og analoge deraf med aaben tetrahydrofuranring e samt deres fremstilling og farmaceutiske praeparater indeholdende dem DK163988C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH198183 1983-04-13
CH198183 1983-04-13

Publications (4)

Publication Number Publication Date
DK189484D0 DK189484D0 (da) 1984-04-12
DK189484A DK189484A (da) 1984-10-14
DK163988B DK163988B (da) 1992-04-27
DK163988C true DK163988C (da) 1992-09-21

Family

ID=4223123

Family Applications (1)

Application Number Title Priority Date Filing Date
DK189484A DK163988C (da) 1983-04-13 1984-04-12 9alfa,11alfa-epoxy-20-spiroxaner og analoge deraf med aaben tetrahydrofuranring e samt deres fremstilling og farmaceutiske praeparater indeholdende dem

Country Status (23)

Country Link
US (1) US4559332A (cs)
EP (1) EP0122232B1 (cs)
JP (1) JPS59231100A (cs)
AR (4) AR241918A1 (cs)
AT (1) ATE39256T1 (cs)
AU (1) AU565017B2 (cs)
CA (1) CA1220781A (cs)
DD (2) DD251144A5 (cs)
DE (2) DE3475622D1 (cs)
DK (1) DK163988C (cs)
ES (4) ES531517A0 (cs)
FI (1) FI77669C (cs)
GR (1) GR81834B (cs)
HU (1) HU191406B (cs)
IE (1) IE57541B1 (cs)
IL (1) IL71504A (cs)
LU (1) LU91072I2 (cs)
NL (1) NL300144I1 (cs)
NO (1) NO159800C (cs)
NZ (1) NZ207826A (cs)
PH (1) PH19997A (cs)
PT (1) PT78413B (cs)
ZA (1) ZA842710B (cs)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670551A (en) * 1984-06-21 1987-06-02 Ciba-Geigy Corporation Epoxy steroids
DK0526642T3 (da) * 1991-01-29 1998-10-19 Shionogi & Co Triterpenderivat
US6245755B1 (en) 1992-04-21 2001-06-12 Curators Of The Unversity Of Missouri Use of aldosterone antagonists to inhibit myocardial fibrosis
US6150347A (en) * 1992-04-21 2000-11-21 The Curators Of The University Of Missouri Use of aldosterone antagonists to inhibit myocardial fibrosis
JPH05329410A (ja) * 1992-05-29 1993-12-14 Sekisui Plastics Co Ltd マスキング材
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6262277B1 (en) * 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
PT831910E (pt) * 1995-06-07 2002-05-31 Searle & Co Terapia de combinacao a base de um antagonista epoxi-esteroidal de aldosterona e um antagonista de angiotensina ii para o tratamento de ataque cardiaco congestivo
AU6039296A (en) * 1995-06-07 1996-12-30 G.D. Searle & Co. Method to treat cardiofibrosis with a combination therapy of an angiotensin ii antagonist and an epoxy-steroidal aldoste rone antagonist
US20020038021A1 (en) * 1995-12-11 2002-03-28 Barton Kathleen P. Eplerenone crystalline form exhibiting enhanced dissolution rate
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
US20050159594A1 (en) * 1995-12-11 2005-07-21 Pharmacia Corporation Eplerenone crystal form exhibiting enhanced dissolution rate
US20050267302A1 (en) * 1995-12-11 2005-12-01 G.D. Searle & Co. Eplerenone crystalline form exhibiting enhanced dissolution rate
US20020045746A1 (en) * 1995-12-11 2002-04-18 Barton Kathleen P. Eplerenone crystalline form
AU747959B2 (en) * 1995-12-11 2002-05-30 G.D. Searle & Co. Processes and intermediates for the preparation of 9, 11-epoxy steroids
DK0973791T3 (da) 1995-12-11 2007-09-17 Searle Llc Fremgangsmåde til fremstilling af en epoxyforbindelse
ZA9711038B (en) * 1996-12-11 1999-01-25 Searle & Co Spr process for preparation of 9,11-Epoxy steroids and intermediates useful therein
IL130182A0 (en) 1996-12-11 2000-06-01 Searle & Co Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
EP1223174A3 (en) * 1996-12-11 2005-03-16 G.D. Searle & Co. Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein
JP4334144B2 (ja) * 1998-05-29 2009-09-30 キリン協和フーズ株式会社 糠漬け風味液の製造方法
AU1714000A (en) * 1998-11-06 2000-05-29 G.D. Searle & Co. Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
UA74141C2 (uk) 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
PL348508A1 (en) 1998-12-23 2002-05-20 Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
IL143943A0 (en) 1998-12-23 2002-04-21 Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
CA2356607A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
AU3103800A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acidderivatives for cardiovascular indications
AU2157500A (en) 1998-12-23 2000-07-31 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
EP1140186B1 (en) 1998-12-23 2003-06-04 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
AU2157400A (en) 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
EA200100704A1 (ru) * 1998-12-23 2002-02-28 Джи.Ди.Сирл Ллс Комбинация для применения по сердечно-сосудистым показаниям
US20030203884A1 (en) * 1999-11-09 2003-10-30 Pharmacia Corporation Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist
US20030096798A1 (en) * 1999-11-09 2003-05-22 Williams Gordon H. Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist
EP1177204A2 (en) * 1999-12-08 2002-02-06 Pharmacia Corporation Eplerenone crystalline form exhibiting enhanced dissolution rate
EP1527782A1 (en) * 1999-12-08 2005-05-04 Pharmacia Corporation Nanoparticulate eplerenone compositions
US20030083493A1 (en) * 1999-12-08 2003-05-01 Barton Kathleen P. Eplerenone drug substance having high phase purity
EP1505072A3 (en) * 1999-12-08 2006-06-21 Pharmacia Corporation Eplerenone crystalline form exhiniting enhanced dissolution rate
JP4219105B2 (ja) * 1999-12-08 2009-02-04 ファルマシア コーポレーション エプレレノン結晶形
DE60019741T2 (de) * 1999-12-08 2006-03-02 Pharmacia Corp., Chicago Nanopartikelzusammensetzungen enthaltend eplerenon
WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US20020132001A1 (en) * 2000-05-11 2002-09-19 Garthwaite Susan M. Aldosterone antagonist composition for release during aldosterone acrophase
AU1604001A (en) * 2000-06-13 2001-12-24 Pharmacia Corp Use of an aldosterone antagonist for the treatment or prohpylaxis of aldosterone-mediated pathogenic effects
US20020123485A1 (en) * 2000-07-27 2002-09-05 Alexander John C. Epoxy steroidal aldosterone antagonist and beta-adrenergic antagonist combination therapy for treatment of congestive heart failure
US6716829B2 (en) 2000-07-27 2004-04-06 Pharmacia Corporation Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders
DE60114027T2 (de) * 2000-08-28 2006-07-13 Pharmacia Corp. Verwendung von einem aldosteron-rezeptor-antagonisten zur verbesserung der kognitiven funktion
AU2002241768A1 (en) * 2000-10-30 2002-06-18 Pharmacia Corporation Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase
IL155691A0 (en) * 2000-11-09 2003-11-23 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
US20030220310A1 (en) * 2001-07-27 2003-11-27 Schuh Joseph R. Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
WO2003040127A1 (en) * 2001-11-02 2003-05-15 G.D. Searle Llc Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake
WO2003049745A1 (en) 2001-12-12 2003-06-19 Pharmacia Corporation Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
MXPA04006255A (es) 2002-01-17 2004-09-27 Pharmacia Corp Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato.
CN1642556A (zh) * 2002-03-18 2005-07-20 法玛西雅公司 醛固酮受体拮抗剂与胆汁酸多价螯合剂的联合
KR20040091141A (ko) * 2002-03-18 2004-10-27 파마시아 코포레이션 알도스테론 수용체 길항물질 및 니코틴산 또는 니코틴산유도체의 혼합물
WO2003080181A2 (en) * 2002-03-20 2003-10-02 Pharmacia Corporation Storage stable eplerenone formulation
KR20040097201A (ko) * 2002-03-22 2004-11-17 파마시아 앤드 업존 캄파니 에플레레논의 제조 방법
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
US20070066579A1 (en) * 2002-08-16 2007-03-22 White Michael J 5-androsten-3beta-ol steroid intermediates and processs for their preparation
DE60308388T2 (de) * 2002-08-16 2007-09-20 Pharmacia & Upjohn Co. Llc, Kalamazoo 5-Androsten-3beta-ol-Steroide und Verfahren für ihre Herstellung
CA2504745A1 (en) * 2002-11-06 2004-05-27 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
CN1694896A (zh) * 2002-11-07 2005-11-09 法马西亚和厄普乔恩公司 制备c－7取代的5－雄甾烯的方法
CL2004000545A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul
CL2004000544A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
CL2004000574A1 (es) * 2003-03-21 2005-02-11 Pharmacia Corp Sa Organizada B Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
WO2004100871A2 (en) * 2003-05-09 2004-11-25 Pharmacia Corporation Combination of an aldosterone receptor antagonist and a renin inhibitor
US20040265948A1 (en) * 2003-06-27 2004-12-30 White Michael Jon Microbial method for hydrolysis and oxidation of androst-5-ene and pregn-5-ene steroid esters
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
CN1934126A (zh) * 2004-03-22 2007-03-21 法玛西雅厄普约翰有限责任公司 9,11环氧甾族化合物的改进制备方法
US20070196471A1 (en) * 2004-04-02 2007-08-23 Thosar Shilpa S Micronized Eplerenone Compositions
US20050232957A1 (en) * 2004-04-14 2005-10-20 Katz Kenneth A Compositions and methods for moisturizing skin
CN1321128C (zh) * 2005-07-15 2007-06-13 浙江医药股份有限公司新昌制药厂 孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
EP1842543A1 (en) 2006-04-05 2007-10-10 Speedel Pharma AG Pharmaceutical composition coprising an aldosterone synthase inhibitor and a mineralcorticoid receptor antagonist
US20070248665A1 (en) * 2006-04-24 2007-10-25 Sherman Bernard C Compositions comprising co-precipitate of eplerenone and a water-soluble excipient
DE102006028032A1 (de) * 2006-06-14 2007-12-20 Henkel Kgaa Aufhell- und/oder Färbemittel mit Nitrilen
CA2673419A1 (en) * 2006-12-21 2008-06-26 Alphapharm Pty Ltd Pharmaceutical composition
CA2582496A1 (en) * 2007-03-20 2008-09-20 Apotex Pharmachem Inc. Improved process for the preparation and purification of eplerenone
FR2917975B1 (fr) 2007-06-26 2009-10-16 Ceva Sante Animale Sa Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains
DE102008026793A1 (de) * 2008-06-02 2009-12-03 Bayer Schering Pharma Aktiengesellschaft C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
CN101863951B (zh) * 2009-04-15 2012-06-06 浙江省天台县奥锐特药业有限公司 依普利酮的制备方法
EP3048100A1 (en) 2009-05-28 2016-07-27 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
PT2435409E (pt) 2009-05-28 2014-11-05 Novartis Ag Derivados aminopropiónicos substituídos como inibidores de neprilisina
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
EP3689364A1 (en) * 2010-02-08 2020-08-05 Shenzhen Evergreen Therapeutics Co., Ltd. Methods for the use of progestogen as a glucocorticoid sensitizer
EP2568986B1 (en) 2010-05-10 2016-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for the treatment of fluid accumulation in and/ or under the retina
US9241944B2 (en) 2010-06-16 2016-01-26 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and compositions for stimulating reepithelialisation during wound healing
TR201007653A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Eplerenon içeren farmasötik kompozisyon
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
WO2012107513A1 (en) * 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20121037A1 (it) * 2012-06-14 2013-12-15 Ind Chimica Srl Processo per la preparazione di nitrili utili come intermedi per la sintesi di molecole ad attivita' farmacologica
HRP20180958T1 (hr) 2013-02-14 2018-07-27 Novartis Ag Supstituirani derivati bisfenolbutanfosfonske kiseline kao inhibitori za nep (neutralnu endopeptidazu)
CN104262450A (zh) * 2014-09-19 2015-01-07 江苏嘉逸医药有限公司 依普利酮的制备及精制方法
ES2699923T3 (es) 2014-10-17 2019-02-13 Ind Chimica Srl Proceso para la preparación de 7alfa-(metoxicarbonil)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactona, un intermedio útil para la síntesis de moléculas con actividad farmacológica
WO2017055248A1 (en) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of heart failure
EP3362095B1 (en) 2015-10-13 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
CN105753930A (zh) * 2016-03-30 2016-07-13 北京万全德众医药生物技术有限公司 依普利酮的一种合成方法
ES2973248T3 (es) 2016-07-26 2024-06-19 Inst Nat Sante Rech Med Antagonista del receptor mineralocorticoide para el tratamiento de la osteoartritis
JOP20190086A1 (ar) 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
US20240366632A1 (en) 2021-08-31 2024-11-07 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of ocular rosacea

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
US3729491A (en) * 1970-06-15 1973-04-24 Searle & Co 3,5-dioxo-a-nor-b-homo steroidal spirolactones
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3849404A (en) * 1973-03-09 1974-11-19 Searle & Co Purification of 6,7-dihydro-17-hydroxy-3-oxo-3'h-cyclopropa(6,7)-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactones
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2922500A1 (de) * 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
ES8705461A1 (es) 1987-05-01
ZA842710B (en) 1984-11-28
DK189484D0 (da) 1984-04-12
IE57541B1 (en) 1992-10-07
PH19997A (en) 1986-08-28
ES544769A0 (es) 1987-05-01
LU91072I2 (fr) 2004-04-07
DD233375A5 (de) 1986-02-26
PT78413B (en) 1986-08-22
NL300144I2 (nl) 2004-06-01
ES8705459A1 (es) 1987-05-01
IL71504A (en) 1987-07-31
HU191406B (en) 1987-02-27
AU2685384A (en) 1984-10-18
DD251144A5 (de) 1987-11-04
FI77669C (fi) 1989-04-10
NO841465L (no) 1984-10-15
AR241918A1 (es) 1993-01-29
JPH0212479B2 (cs) 1990-03-20
AR242222A1 (es) 1993-03-31
FI841400L (fi) 1984-10-14
CA1220781A (en) 1987-04-21
ES8705460A1 (es) 1987-05-01
GR81834B (cs) 1984-12-12
EP0122232B1 (de) 1988-12-14
US4559332A (en) 1985-12-17
ATE39256T1 (de) 1988-12-15
NO159800C (no) 1989-02-08
NZ207826A (en) 1986-07-11
ES8602846A1 (es) 1985-12-01
IE840906L (en) 1984-10-13
EP0122232A1 (de) 1984-10-17
DE122004000012I1 (de) 2012-05-16
ES544770A0 (es) 1987-05-01
NO159800B (no) 1988-10-31
FI77669B (fi) 1988-12-30
JPS59231100A (ja) 1984-12-25
ES544768A0 (es) 1987-05-01
DE3475622D1 (en) 1989-01-19
PT78413A (en) 1984-05-01
NL300144I1 (nl) 2004-06-01
AU565017B2 (en) 1987-09-03
DK189484A (da) 1984-10-14
IL71504A0 (en) 1984-07-31
FI841400A0 (fi) 1984-04-09
DK163988B (da) 1992-04-27
AR242221A1 (es) 1993-03-31
ES531517A0 (es) 1985-12-01
AR242223A1 (es) 1993-03-31
DE122004000012I2 (de) 2006-06-08

Similar Documents

Publication Publication Date Title
DK163988C (da) 9alfa,11alfa-epoxy-20-spiroxaner og analoge deraf med aaben tetrahydrofuranring e samt deres fremstilling og farmaceutiske praeparater indeholdende dem
DK316189D0 (da) Heteroaryloxy-n-isopropylanilider, fremgangsmaade til deres fremstilling samt deres anvendelse
DK120188A (da) Aminomethylheterocycler, fremgangsmaader til deres fremstilling samt deres anvendelse
DK477686D0 (da) Heteropolysaccharid, fremgangsmaade til fremstilling deraf og anvendelse deraf i et kompleks samt fremgangsmaade til fremstilling af et saadant kompleks
DK518687A (da) Imidazo-benzoxazinoner, deres fremstilling og laegemidler indholdende forbindelserne
DK40986D0 (da) 4h-1-benzopyran-4-oner og deres svovlholdige analoge, og farmaceutiske kompositioner indeholdende forbindelserne
DK621486D0 (da) 1-benzensulfonyl-2-oxo-5-alkoxypyrrolidinderivater samt deres fremstilling, anvendelse og praeparater med indhold deraf
DK642588D0 (da) Indanderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
NO863895D0 (no) Sementholdige blandinger og fremgangsmaate for deres fremstilling.
DK477685D0 (da) Peptidsubstituerede heterocycliske forbindelser og anvendelse deraf som immunostimulerende eller antiinfektive forbindelser samt farmaceutiske praeparater
DK469189A (da) Substituerede thienopyraner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK361288D0 (da) Hydroxyethylazolylderivater, deres fremstilling og anvendelse samt mellemprodukter til fremstilling og disses fremstilling
DK178589A (da) Triazoloaziner, fremgangsmaade til deres fremstilling samt deres anvendelse
DK581183A (da) 2-azabicyclo(2.2.1)heptan-derivater, fremgangsmaader til deres fremstilling, midler indeholdende disse derivater og deres anvendelse, samt 2-azabicyclo(2.2.1)heptan-derivater som mellemprodukter samt fremgangsmaader til deres fremstilling
DK39486D0 (da) 4,4-diakyl-2-azetidinoner, fremstilling og anvendelse deraf, samt vedfremstillingen anvendelige mellemprodukter og deres fremstilling
DK289287D0 (da) 1-phenylalkylimidazol-4- og/eller -5-carboxamider samt deres fremstiling og anvendelse
DK440688A (da) Sulfonylaminoguanidinoaziner, fremgangsmaade til deres fremstilling samt deres anvendelse
DK402585D0 (da) Pseudooligosaccharider med alfa-glucosidase-inhiberende virkning, deres fremstilling og anvendelse samt farmaceutiske praeparater
DK259089A (da) Aminoguanidinoaziner, fremgangsmaade til deres fremstilling samt deres anvendelse
NO891986L (no) Fremgangsmaate for fremstilling av difenyl-sulfider, difenyl-sulfoksyder og difenylsulfoner.
DK447687A (da) Urdamycin g og derivater deraf samt deres fremstilling og anvendelse
DK511687A (da) Farmaceutisk praeparat, samt fremstilling og anvendelse heraf
DK264788D0 (da) Azolyl-tetrahydrofuran-2-yliden-methaner, fremgangsmaader til deres fremstilling samt deres anvendelse
DK390287D0 (da) Cephalosporiner og derivater deraf samt fremgangsmaader til deres fremstilling
DK208989D0 (da) 3-cyano-4-phenyl-pyrroler, fremgangsmaade til deres fremstilling samt deres anvendelse

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
PUP Patent expired
CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2004 00006

Filing date: 20040407

Expiry date: 20090412

CTFW Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn

Free format text: PRODUCT NAME: EPLERENONE

Spc suppl protection certif: CA 2004 00006

Filing date: 20040407