DK162233C - Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii - Google Patents

Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Info

Publication number
DK162233C
DK162233C DK562189A DK562189A DK162233C DK 162233 C DK162233 C DK 162233C DK 562189 A DK562189 A DK 562189A DK 562189 A DK562189 A DK 562189A DK 162233 C DK162233 C DK 162233C
Authority
DK
Denmark
Prior art keywords
viii
blood plasma
phatar
factor viii
procedure
Prior art date
Application number
DK562189A
Other languages
Danish (da)
English (en)
Other versions
DK562189D0 (da
DK162233B (da
DK562189A (da
Inventor
Per Kaersgaard
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of DK562189D0 publication Critical patent/DK562189D0/da
Priority to DK562189A priority Critical patent/DK162233C/da
Priority to ZA908599A priority patent/ZA908599B/xx
Priority to CS905371A priority patent/CZ537190A3/cs
Priority to SK5371-90A priority patent/SK278640B6/sk
Priority to JP3500067A priority patent/JP2509407B2/ja
Priority to AT90917201T priority patent/ATE118508T1/de
Priority to PCT/DK1990/000279 priority patent/WO1991007438A1/en
Priority to DE69017050T priority patent/DE69017050T2/de
Priority to EP90917201A priority patent/EP0524172B1/en
Priority to SU905052211A priority patent/RU2055593C1/ru
Priority to ES90917201T priority patent/ES2068404T3/es
Priority to UA94020494A priority patent/UA29421C2/ru
Priority to CA002073012A priority patent/CA2073012C/en
Priority to HU9201551A priority patent/HU214905B/hu
Priority to AU67470/90A priority patent/AU631471B2/en
Priority to NZ236004A priority patent/NZ236004A/xx
Priority to US07/610,480 priority patent/US5245014A/en
Priority to YU210590A priority patent/YU47524B/sh
Priority to SI9012105A priority patent/SI9012105A/sl
Priority to IL9627790A priority patent/IL96277A/en
Priority to PT95830A priority patent/PT95830B/pt
Priority to IE402290A priority patent/IE66836B1/en
Priority to PL90287703A priority patent/PL164894B1/pl
Priority to CN90109030A priority patent/CN1044121C/zh
Publication of DK562189A publication Critical patent/DK562189A/da
Publication of DK162233B publication Critical patent/DK162233B/da
Application granted granted Critical
Publication of DK162233C publication Critical patent/DK162233C/da
Priority to NO921839A priority patent/NO180741C/no
Priority to BG96316A priority patent/BG61231B1/bg
Priority to FI922105A priority patent/FI103510B/fi
Priority to HRP-2105/90A priority patent/HRP930277A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Networks Using Active Elements (AREA)
  • Amplifiers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cephalosporin Compounds (AREA)
  • Housing For Livestock And Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Separation By Low-Temperature Treatments (AREA)
DK562189A 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii DK162233C (da)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii
ZA908599A ZA908599B (en) 1989-11-09 1990-10-26 A method for isolating biologically active compounds
CS905371A CZ537190A3 (cs) 1989-11-09 1990-11-01 Způsob izolování faktoru VIII
SK5371-90A SK278640B6 (en) 1989-11-09 1990-11-01 Method of the factor viii isolation
AU67470/90A AU631471B2 (en) 1989-11-09 1990-11-05 A method for isolating factor viii
AT90917201T ATE118508T1 (de) 1989-11-09 1990-11-05 Verfahren zur isolierung von faktor viii.
PCT/DK1990/000279 WO1991007438A1 (en) 1989-11-09 1990-11-05 A method for isolating factor viii
DE69017050T DE69017050T2 (de) 1989-11-09 1990-11-05 Verfahren zur isolierung von faktor viii.
EP90917201A EP0524172B1 (en) 1989-11-09 1990-11-05 A method for isolating factor viii
SU905052211A RU2055593C1 (ru) 1989-11-09 1990-11-05 Способ выделения фактора viii из других белков в плазме крови
ES90917201T ES2068404T3 (es) 1989-11-09 1990-11-05 Un metodo para aislar el factor viii.
UA94020494A UA29421C2 (ru) 1989-11-09 1990-11-05 Способ выделения фактора viii из других белков в плазме крови
CA002073012A CA2073012C (en) 1989-11-09 1990-11-05 Method for isolating factor viii
HU9201551A HU214905B (hu) 1989-11-09 1990-11-05 Eljárás VIII. faktor izolálására
JP3500067A JP2509407B2 (ja) 1989-11-09 1990-11-05 生物学的に活性な化合物の単離方法
YU210590A YU47524B (sh) 1989-11-09 1990-11-07 Postupak za izolovanje faktora viii iz drugih proteina u krvnoj plazmi
US07/610,480 US5245014A (en) 1989-11-09 1990-11-07 Method for isolating factors viii from plasma by gel filtration chromatography under group separation conditions
NZ236004A NZ236004A (en) 1989-11-09 1990-11-07 Isolation of factor viii using gel filtration
SI9012105A SI9012105A (sl) 1989-11-09 1990-11-07 Postopek za izoliranje biološko aktivnih spoji
IL9627790A IL96277A (en) 1989-11-09 1990-11-08 Method for isolating factor IIIV
PT95830A PT95830B (pt) 1989-11-09 1990-11-08 Processo para o isolamento do factor viii sob a forma de uma fraccao pura directamente de plasma mediante filtracao em gel
IE402290A IE66836B1 (en) 1989-11-09 1990-11-08 A method for isolating biologically active compounds
PL90287703A PL164894B1 (pl) 1989-11-09 1990-11-09 Sposób izolowania c zynnika krzepniecia VIII PL PL PL PL PL PL PL PL
CN90109030A CN1044121C (zh) 1989-11-09 1990-11-09 分离凝血因子viii配合物的方法
FI922105A FI103510B (fi) 1989-11-09 1992-05-08 Menetelmä tekijän VIII eristämiseksi
BG96316A BG61231B1 (en) 1989-11-09 1992-05-08 A method for isolating factor viii
NO921839A NO180741C (no) 1989-11-09 1992-05-08 Fremgangsmåte for isolering av Faktor VIII
HRP-2105/90A HRP930277A2 (en) 1989-11-09 1993-03-08 A method for isolating biologically active compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii
DK562189 1989-11-09

Publications (4)

Publication Number Publication Date
DK562189D0 DK562189D0 (da) 1989-11-09
DK562189A DK562189A (da) 1991-05-10
DK162233B DK162233B (da) 1991-09-30
DK162233C true DK162233C (da) 1992-03-16

Family

ID=8144000

Family Applications (1)

Application Number Title Priority Date Filing Date
DK562189A DK162233C (da) 1989-11-09 1989-11-09 Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii

Country Status (26)

Country Link
US (1) US5245014A (ru)
EP (1) EP0524172B1 (ru)
JP (1) JP2509407B2 (ru)
CN (1) CN1044121C (ru)
AT (1) ATE118508T1 (ru)
AU (1) AU631471B2 (ru)
BG (1) BG61231B1 (ru)
CA (1) CA2073012C (ru)
CZ (1) CZ537190A3 (ru)
DE (1) DE69017050T2 (ru)
DK (1) DK162233C (ru)
ES (1) ES2068404T3 (ru)
FI (1) FI103510B (ru)
HU (1) HU214905B (ru)
IE (1) IE66836B1 (ru)
IL (1) IL96277A (ru)
NO (1) NO180741C (ru)
NZ (1) NZ236004A (ru)
PL (1) PL164894B1 (ru)
PT (1) PT95830B (ru)
RU (1) RU2055593C1 (ru)
SK (1) SK278640B6 (ru)
UA (1) UA29421C2 (ru)
WO (1) WO1991007438A1 (ru)
YU (1) YU47524B (ru)
ZA (1) ZA908599B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69002033T2 (de) * 1989-05-24 1993-09-30 Miles Inc Gelfiltration von wärmebehandeltem Faktor VIII.
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6531577B1 (en) * 1997-12-15 2003-03-11 Hemasure Denmark A/S von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations
US6290527B1 (en) * 1998-07-03 2001-09-18 Nippon Telegraph And Telephone Corp. Nippon telegraph and telephone corporation
DK2130554T3 (da) 1999-02-22 2012-12-03 Univ Connecticut Albuminfrie faktor VIII-præparater
JP2002348300A (ja) * 1999-04-12 2002-12-04 Fujimori Kogyo Co Ltd 血液凝固第ｖｉｉｉ因子および血液凝固第ｖｉｉｉ因子／フォン・ビルブラント因子複合体の精製方法
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
SI1750733T1 (sl) 2004-05-03 2014-03-31 Emory University POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B
EP1784415A2 (en) * 2004-08-27 2007-05-16 Novo Nordisk Health Care AG Purification of factor xiii polypeptides from biological materials
US20060226086A1 (en) * 2005-04-08 2006-10-12 Robinson Thomas C Centrifuge for blood processing systems
AU2009313325B2 (en) * 2008-11-07 2014-05-01 Takeda Pharmaceutical Company Limited Factor VIII formulations
WO2011121020A1 (en) * 2010-03-30 2011-10-06 Octapharma Ag A process for purifying vitamin k dependent proteins such as coagulation factor ix
RU2445974C2 (ru) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Способ получения концентрата фактора viii из плазмы крови человека
CA2816575C (en) 2010-11-05 2019-06-11 Baxter Healthcare S.A. A new variant of antihemophilic factor viii having increased specific activity
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
CN103506080A (zh) * 2012-06-19 2014-01-15 汪志友 一种用于分离纯化凝血因子viii的介质及其制备方法
TWI609083B (zh) * 2012-09-28 2017-12-21 Chugai Pharmaceutical Co Ltd Blood coagulation reaction assessment method
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
DK525384D0 (da) * 1984-11-05 1984-11-05 Nordisk Insulinlab Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat
US4847362A (en) * 1985-02-01 1989-07-11 New York University Method for purifying antihemophilic factor
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
EP0321835B1 (en) * 1987-12-21 1994-09-28 Miles Inc. Gel filteration of factor VIII
WO1989009784A1 (en) * 1988-04-08 1989-10-19 Commonwealth Serum Laboratories Commission Production of heat-stable factor viii concentrate
DE69002033T2 (de) * 1989-05-24 1993-09-30 Miles Inc Gelfiltration von wärmebehandeltem Faktor VIII.

Also Published As

Publication number Publication date
FI922105A0 (fi) 1992-05-08
YU210590A (sh) 1993-05-28
CZ537190A3 (cs) 1998-05-13
JP2509407B2 (ja) 1996-06-19
BG96316A (bg) 1993-12-24
DK562189D0 (da) 1989-11-09
CA2073012A1 (en) 1991-05-10
DE69017050T2 (de) 1995-06-14
PL287703A1 (en) 1991-12-02
RU2055593C1 (ru) 1996-03-10
WO1991007438A1 (en) 1991-05-30
FI103510B1 (fi) 1999-07-15
PL164894B1 (pl) 1994-10-31
HUT60511A (en) 1992-09-28
ES2068404T3 (es) 1995-04-16
DE69017050D1 (de) 1995-03-23
NZ236004A (en) 1991-11-26
AU631471B2 (en) 1992-11-26
ATE118508T1 (de) 1995-03-15
UA29421C2 (ru) 2000-11-15
YU47524B (sh) 1995-10-03
DK162233B (da) 1991-09-30
EP0524172A1 (en) 1993-01-27
AU6747090A (en) 1991-06-13
HU214905B (hu) 1998-07-28
JPH05501557A (ja) 1993-03-25
CN1051732A (zh) 1991-05-29
ZA908599B (en) 1991-07-31
BG61231B1 (en) 1997-03-31
PT95830B (pt) 1997-11-28
HU9201551D0 (en) 1992-08-28
NO180741C (no) 1997-06-11
US5245014A (en) 1993-09-14
NO180741B (no) 1997-03-03
PT95830A (pt) 1991-09-30
NO921839D0 (no) 1992-05-08
CN1044121C (zh) 1999-07-14
IL96277A0 (en) 1991-08-16
FI103510B (fi) 1999-07-15
CA2073012C (en) 1996-03-19
IE904022A1 (en) 1991-05-22
DK562189A (da) 1991-05-10
IE66836B1 (en) 1996-02-07
IL96277A (en) 1995-07-31
FI922105A (fi) 1992-05-08
SK537190A3 (en) 1997-12-10
SK278640B6 (en) 1997-12-10
NO921839L (no) 1992-07-08
EP0524172B1 (en) 1995-02-15

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