DK158229C - Analogifremgangsmaade til fremstilling af 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller alkanoyl-derivater deraf eller farmaceutisk acceptable syreadditionssalte deraf og n,n'-dioxidet deraf til anvendelse som udgangsmateriale ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller alkanoyl-derivater deraf eller farmaceutisk acceptable syreadditionssalte deraf og n,n'-dioxidet deraf til anvendelse som udgangsmateriale ved fremgangsmaaden

Info

Publication number
DK158229C
DK158229C DK332583A DK332583A DK158229C DK 158229 C DK158229 C DK 158229C DK 332583 A DK332583 A DK 332583A DK 332583 A DK332583 A DK 332583A DK 158229 C DK158229 C DK 158229C
Authority
DK
Denmark
Prior art keywords
animally
homoerythromycin
deoxo
aza
alkanoyl
Prior art date
Application number
DK332583A
Other languages
Danish (da)
English (en)
Other versions
DK332583D0 (da
DK158229B (da
DK332583A (da
Inventor
Gene Michael Bright
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK332583D0 publication Critical patent/DK332583D0/da
Publication of DK332583A publication Critical patent/DK332583A/da
Publication of DK158229B publication Critical patent/DK158229B/da
Application granted granted Critical
Publication of DK158229C publication Critical patent/DK158229C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK332583A 1982-07-19 1983-07-19 Analogifremgangsmaade til fremstilling af 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller alkanoyl-derivater deraf eller farmaceutisk acceptable syreadditionssalte deraf og n,n'-dioxidet deraf til anvendelse som udgangsmateriale ved fremgangsmaaden DK158229C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39940182A 1982-07-19 1982-07-19
US39940182 1982-07-19
US44198182 1982-11-15
US06/441,981 US4474768A (en) 1982-07-19 1982-11-15 N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor

Publications (4)

Publication Number Publication Date
DK332583D0 DK332583D0 (da) 1983-07-19
DK332583A DK332583A (da) 1984-01-20
DK158229B DK158229B (da) 1990-04-16
DK158229C true DK158229C (da) 1990-09-24

Family

ID=27016614

Family Applications (1)

Application Number Title Priority Date Filing Date
DK332583A DK158229C (da) 1982-07-19 1983-07-19 Analogifremgangsmaade til fremstilling af 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller alkanoyl-derivater deraf eller farmaceutisk acceptable syreadditionssalte deraf og n,n'-dioxidet deraf til anvendelse som udgangsmateriale ved fremgangsmaaden

Country Status (15)

Country Link
US (1) US4474768A (fi)
EP (1) EP0101186B1 (fi)
JP (1) JPH01193292A (fi)
AU (1) AU540056B2 (fi)
CA (1) CA1202963A (fi)
DE (1) DE3367395D1 (fi)
DK (1) DK158229C (fi)
FI (1) FI832606A (fi)
HU (1) HU196426B (fi)
IE (1) IE55365B1 (fi)
IL (1) IL69265A (fi)
NO (1) NO160261C (fi)
NZ (1) NZ204938A (fi)
PH (1) PH18054A (fi)
PT (1) PT77062B (fi)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0132026B1 (en) * 1983-05-23 1986-12-30 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin a and intermediates therefor
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
SI8611592A8 (en) * 1986-09-12 1995-04-30 Pliva Pharm & Chem Works Process for preparing complexes of N-methyl-11-aza-10-deoxo-10-dihydroeritromicine A and 11-aza-10-deoxo-10-dihydroeritromicine A with metals
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
MX13723A (es) * 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a
US5837691A (en) * 1988-08-03 1998-11-17 Schering Corporation Actinomadura vulgaris subsp vulgaris and antimicrobial complex and antimicrobial
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
CA2064634C (en) 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
TW271400B (fi) * 1992-07-30 1996-03-01 Pfizer
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
DE69403963T2 (de) * 1993-05-19 1997-11-20 Pfizer Zwischenprodukt für azithromycin
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
HRP940251B1 (en) * 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
CZ292360B6 (cs) * 1994-05-06 2003-09-17 Pfizer Inc. Dávkovací forma s řízeným uvolňováním obsahující azithromycin a způsob její výroby
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
HN1998000074A (es) * 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
JP2003512290A (ja) * 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての８ａ−アザライド
ATE267835T1 (de) * 1997-10-16 2004-06-15 Pliva Pharm & Chem Works Neue 9a-azalide
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
DK0925789T4 (da) * 1997-12-02 2009-07-13 Pfizer Prod Inc Anvendelse af azithromycin ved topisk behandling af öjeninfektioner
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
WO2000017218A1 (en) 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
JP4043191B2 (ja) * 1998-11-03 2008-02-06 ファイザー・プロダクツ・インク 新規なマクロライド抗生物質
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
EP1152765B1 (en) * 1998-11-30 2004-10-13 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
EP1137654A1 (en) 1998-12-10 2001-10-04 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1147121B1 (en) * 1999-01-27 2003-12-17 Pfizer Products Inc. Ketolide antibiotics
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) * 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
ATE315042T1 (de) * 1999-08-24 2006-02-15 Abbott Lab 9a-azalide mit antibakterieller wirkung
EP1101769A3 (en) 1999-11-18 2001-10-24 Pfizer Products Inc. Nitrogen containing erythromycin derivatives
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
US6586576B2 (en) 2000-01-04 2003-07-01 Teva Pharmaceutical Industries Ltd Preparation method of azithromycin hydrates
IL141438A0 (en) * 2000-02-23 2002-03-10 Pfizer Prod Inc Method of increasing the bioavailability and tissue penetration of azithromycin
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20030213724A1 (en) * 2000-03-20 2003-11-20 Sven Dobler Fragrance sampler insert
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
DE60026718T2 (de) 2000-07-25 2006-11-16 Laboratorio Silanes, S.A. De C.V. Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
EP1313749B1 (en) * 2000-08-23 2005-10-12 Wockhardt Limited Process for preparation of anhydrous azithromycin
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
SK287814B6 (sk) 2000-11-27 2011-11-04 Sandoz Ag Azithromycin in the form of a monohydrate, a process for its preparation and pharmaceutical compositions comprising same
MXPA03009786A (es) 2001-04-27 2004-01-29 Pfizer Prod Inc Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-sustituidos.
EA007618B1 (ru) * 2001-05-22 2006-12-29 Пфайзер Продактс Инк. Кристаллический полуторогидрат азитромицина, содержащая его фармацевтическая композиция и способ лечения на его основе
SI1390377T1 (sl) 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
CZ2004232A3 (cs) * 2001-08-21 2005-10-12 Pfizer Products Inc. Jednorázová dávka azithromycinu
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
US6764997B2 (en) * 2001-10-18 2004-07-20 Teva Pharmaceutical Industries Ltd. Stabilized azithromycin compositions
CN1668282A (zh) * 2001-12-21 2005-09-14 辉瑞产品公司 可直接压制的阿齐霉素配方
CN1606433A (zh) * 2001-12-21 2005-04-13 辉瑞产品公司 阿齐霉素湿法制粒法
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
WO2003063838A1 (en) * 2002-02-01 2003-08-07 Pfizer Products Inc. Dry granulated formulations of azithromycin
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
US20040186063A1 (en) * 2002-02-15 2004-09-23 Hans-Jurgen Gutke Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
AU2003211113B2 (en) * 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
AU2003215245A1 (en) * 2002-02-15 2003-09-09 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003072589A1 (fr) * 2002-02-26 2003-09-04 Meiji Seika Kaisha, Ltd. Nouveau compose azalide cyclique a 15 chainons, nouveau derive diazalide cyclique a 16 chainons et procede de production de ceux-ci
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US20040043073A1 (en) * 2002-06-14 2004-03-04 Chih-Ming Chen Pharmaceutical compositions for drugs having pH-dependent solubility
RS20050006A (en) * 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., Novel compounds,compositions as carriers for steroid/non- steroid anti-inflammatory,antineoplastic and antiviral active molecules
AU2003255849A1 (en) * 2002-07-08 2004-01-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
PL374731A1 (en) * 2002-07-08 2005-10-31 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
ES2552682T3 (es) * 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
CA2520192A1 (en) * 2003-03-25 2004-10-14 Teva Pharmaceutical Industries Ltd. Degradation products of azithromycin, and methods for their identification
ES2220229B1 (es) * 2003-05-29 2005-10-16 Quimica Sintetica, S.A. Sales de adicion de azitromicina y acido citrico y procedimiento para su obtencion.
PL1638529T3 (pl) * 2003-06-16 2017-03-31 Andrx Pharmaceuticals, Llc. Kompozycja doustna o przedłużonym uwalnianiu
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
AU2004258944B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2533178C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533292C (en) 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1653925A1 (en) 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
JPWO2005019238A1 (ja) * 2003-08-22 2006-10-19 明治製菓株式会社 新規アザライド及びアザラクタム誘導体とその製造法
WO2005023184A2 (en) * 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
CN1313476C (zh) * 2003-09-09 2007-05-02 上海新先锋药业有限公司 阿奇霉素的水溶性磷酸盐的注射剂型及其制备方法
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005030227A1 (en) * 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
US20050101547A1 (en) * 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
BRPI0417348A (pt) 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
CN1889931A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
ES2308274T3 (es) 2003-12-04 2008-12-01 Pfizer Products Inc. Procedimiento para fabricar multiparticulados farmaceuticos.
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
WO2006004085A1 (ja) * 2004-07-02 2006-01-12 Wakamoto Pharmaceutical Co., Ltd. アジスロマイシン含有水性医薬組成物及びその調製方法
EP1771158A4 (en) 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp TABLET FOR PULSED DELIVERY
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
CA2576291A1 (en) * 2004-08-12 2006-02-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
BRPI0519135A2 (pt) 2004-12-21 2008-12-23 Pfizer Prod Inc macrolÍdeos
US20100048498A1 (en) * 2004-12-21 2010-02-25 Johnson Barbara A Stable non-dihydrate azithromycin oral suspensions
US20090318375A1 (en) * 2005-06-08 2009-12-24 Hanmi Pharm Co., Ltd Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
RU2008106915A (ru) * 2005-07-26 2009-09-10 Меркле Гмбх (De) Макролидные конъюгаты пирролиновых и индолизиновых соединений
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US7704959B2 (en) 2006-10-03 2010-04-27 Dow Pharmaceutical Sciences Azithromycin for the treatment of nodular acne
US8293715B2 (en) * 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
US8124123B2 (en) * 2007-09-05 2012-02-28 Dow Pharmaceutical Sciences, Inc. Controlled release azithromycin solid dosages forms
WO2009055557A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
WO2010048601A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US20170128481A9 (en) 2009-03-06 2017-05-11 Insite Vision Corporation Ocular treatment with reduced intraocular pressure
EA201101319A1 (ru) 2009-03-13 2012-04-30 Да Волтерра Композиции и способы элиминации грамотрицательных бактерий
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011015219A1 (en) 2009-08-06 2011-02-10 Shifa Pharmed Industrial Group Co. Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
SI2550286T1 (sl) 2010-03-22 2016-04-29 Cempra Pharmaceuticals, Inc. Kristalne oblike makrolida in njihove uporabe
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
RU2658050C2 (ru) 2012-03-27 2018-06-19 Семпра Фармасьютикалз, Инк. Парентеральные составы для введения макролидных антибиотиков
US10987370B2 (en) 2012-12-24 2021-04-27 Ramot At Tel-Aviv University Ltd. Methods of inducing read-through of a nonsense mutation associated with ataxia telangiectasia, Rett syndrome or spinal muscular atrophy by erythromycin or azithromycin
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
US9044508B2 (en) 2013-03-15 2015-06-02 Insite Vision Corporation Concentrated aqueous azalide formulations
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
US20150141328A1 (en) * 2013-11-18 2015-05-21 The Schepens Eye Research Institute Stimulation of human meibomian gland function
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
AU2018225389B2 (en) 2017-02-22 2021-09-02 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating compound
EP3585793B1 (en) 2017-02-22 2021-01-06 ISR Immune System Regulation Holding AB (publ) Novel immune stimulating macrolide
US20230321229A1 (en) 2020-09-03 2023-10-12 ISR Immune System Regulation Holding AB (publ) Vaccine comprising an antigen and a tlr2 agonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3928387A (en) * 1974-02-04 1975-12-23 Hoffmann La Roche Antibiotic 1745A/X and methods for the production thereof
US4036853A (en) * 1976-08-06 1977-07-19 Pfizer Inc. Semi-synthetic oleandomycin derivatives-C8 modifications
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
US4283527A (en) * 1980-04-01 1981-08-11 Pfizer Inc. Erythromycylamine 11,12-carbonate and derivatives thereof
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof

Also Published As

Publication number Publication date
DK332583D0 (da) 1983-07-19
DK158229B (da) 1990-04-16
NO832616L (no) 1984-01-20
JPH01193292A (ja) 1989-08-03
EP0101186B1 (en) 1986-11-05
NZ204938A (en) 1986-04-11
HU196426B (en) 1988-11-28
AU540056B2 (en) 1984-11-01
AU1692383A (en) 1984-01-26
NO160261C (no) 1989-03-29
PH18054A (en) 1985-03-18
DK332583A (da) 1984-01-20
FI832606A0 (fi) 1983-07-18
PT77062A (en) 1983-08-01
IE831667L (en) 1984-01-19
IE55365B1 (en) 1990-08-29
EP0101186A1 (en) 1984-02-22
PT77062B (en) 1986-04-09
IL69265A (en) 1986-08-31
IL69265A0 (en) 1983-11-30
FI832606A (fi) 1984-01-20
US4474768A (en) 1984-10-02
NO160261B (no) 1988-12-19
CA1202963A (en) 1986-04-08
DE3367395D1 (en) 1986-12-11

Similar Documents

Publication Publication Date Title
DK158229C (da) Analogifremgangsmaade til fremstilling af 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a eller alkanoyl-derivater deraf eller farmaceutisk acceptable syreadditionssalte deraf og n,n'-dioxidet deraf til anvendelse som udgangsmateriale ved fremgangsmaaden
DK153399C (da) Analogifremgangsmaade til fremstilling af 2,4-diaminoquinazolin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf og 4-aminoquinazolin-forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden
DK1187A (da) Fremgangsmaade til fremstilling af tvaerbunde reliefformer ved fotopolymerisation
DK157862C (da) Analogifremgangsmaade til fremstilling af imidazolylphenylamidiner eller farmaceutisk acceptable syreadditionssalte deraf
DK163181C (da) Analogifremgangsmaade til fremstilling af n,n'-di(arylalkylen)alkylendiaminer eller farmaceutisk acceptable salte deraf
DK220986A (da) Fremgangsmaade til fremstilling af piperidyliden-dihydrodibenzo(a,d)cycloheptener og aza-derivater deraf, forbindelser vundet ved fremgangsmaaden og disses anvendelse til fremstilling af farmaceutiske kompositioner
DK341281A (da) Fremgangsmaade til fremstilling af 3,3-dialkyldenzodiazepinderivater eller syreadditionssalte deraf samt ved fremgangsmaaden som mellemprodukter anvendelige forbindelrser
DK162166C (da) Analogifremgangsmaade til fremstilling af (2s)-isomere af 2-oe4-(2-hydroxycyclopentan-1-ylmethyl)phenylaapropionsyre eller farmaceutisk acceptable salte deraf
DK154557C (da) Analogifremgangsmaade til fremstilling af 3,4-dihydro-8-((2-hydroxy-3-alkylamino)-propoxy)-2h-1-benzopyranderivater eller et farmaceutisk acceptabelt syreadditionssalt deraf
DK162842C (da) Analogifremgangsmaade til fremstilling af 1-perfluoralkyl-2-(1,2,4-triazol-1-yl)-ethanol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK423189A (da) Fremgangsmaade til fremstilling af 1,3-propandiol ved fermentering
DK154647C (da) Analogifremgangsmaade til fremstilling af n-oe(4-oe3-substitueret 2-pyridylaapiperazino)butylaaazaspirodecanforbindelser eller et farmaceutisk acceptabelt syreadditionssalt deraf
DK641187A (da) Fremgangsmaade til fremstilling af vandfri alkansulfonsyre
DK159853C (da) Analogifremgangsmaade til fremstilling af 9-dihydro-11,12-o-isopropyliden-erythromycin a eller -4ae-epi-erythromycin a eller 2'-o-acylater deraf eller farmaceutisk acceptable syreadditionssalte deraf
DK164551C (da) Analogifremgangsmaade til fremstilling af cyclohexylthienyleddikesyreamider eller fysiologisk taalelige syreadditionssalte deraf
DK93481A (da) Fremgangsmaade til fremstilling af 7-oxo-1-azabicyclo (3.2.0) hept-2-en-carboxylsyre
DK157135C (da) Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK158457C (da) Analogifremgangsmaade til fremstilling af 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaensyre eller salte heraf
DK160875C (da) Analogifremgangsmaade til fremstilling af 3,7-diazabicyklooe3.3.1aa-nonanforbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK151021C (da) Analogifremgangsmaade til fremstilling af 17,18-dehydro-apovincaminol-3',4',5'-trimethoxybenzoat eller farmaceutisk acceptable syreadditionssalte deraf
DK165290C (da) Analogifremgangsmaade til fremstilling af mercaptoacylcarnitiner
DK398283A (da) Fremgangsmaade til fremstilling af 1,4-dihydropyridinderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK70185D0 (da) Fremgangsmaade til fremstilling af carbaminsyrederivater
DK435189A (da) Fremgangsmaade til fremstilling af phosphonoravsyretetramethylester eller phosphonoravsyretetraethylester
DK393685D0 (da) Fremgangsmaade til fremstilling af sulfonyliso-(thio)urinstoffer

Legal Events

Date Code Title Description
PUP Patent expired