DK157997C - 6-fluor-1,4-dihydro-4-oxo-7-substituerede piperazinylquinolin-3-carboxylsyrederivater og deres farmakologisk acceptable salte samt farmaceutiske sammensaetninger til brug ved behandling af bakterielle sygdomme - Google Patents

6-fluor-1,4-dihydro-4-oxo-7-substituerede piperazinylquinolin-3-carboxylsyrederivater og deres farmakologisk acceptable salte samt farmaceutiske sammensaetninger til brug ved behandling af bakterielle sygdomme

Info

Publication number
DK157997C
DK157997C DK445084A DK445084A DK157997C DK 157997 C DK157997 C DK 157997C DK 445084 A DK445084 A DK 445084A DK 445084 A DK445084 A DK 445084A DK 157997 C DK157997 C DK 157997C
Authority
DK
Denmark
Prior art keywords
fluor
dihydro
oxo
treatment
carboxylic acid
Prior art date
Application number
DK445084A
Other languages
Danish (da)
English (en)
Other versions
DK445084A (da
DK157997B (da
DK445084D0 (da
Inventor
Yasuo Itoh
Hideo Kato
Nobuo Ogawa
Eiichi Koshinaka
Tomio Suzuki
Noriyuki Yagi
Original Assignee
Hokuriku Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP17127183A external-priority patent/JPS6064979A/ja
Priority claimed from JP4566484A external-priority patent/JPS60190777A/ja
Priority claimed from JP12378084A external-priority patent/JPS615075A/ja
Application filed by Hokuriku Pharmaceutical filed Critical Hokuriku Pharmaceutical
Publication of DK445084D0 publication Critical patent/DK445084D0/da
Publication of DK445084A publication Critical patent/DK445084A/da
Publication of DK157997B publication Critical patent/DK157997B/da
Application granted granted Critical
Publication of DK157997C publication Critical patent/DK157997C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK445084A 1983-09-19 1984-09-18 6-fluor-1,4-dihydro-4-oxo-7-substituerede piperazinylquinolin-3-carboxylsyrederivater og deres farmakologisk acceptable salte samt farmaceutiske sammensaetninger til brug ved behandling af bakterielle sygdomme DK157997C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP17127183A JPS6064979A (ja) 1983-09-19 1983-09-19 ７−ピペラジン置換−６−フルオロ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
JP17127183 1983-09-19
JP4566484 1984-03-12
JP4566484A JPS60190777A (ja) 1984-03-12 1984-03-12 光学活性な６，８−ジフルオロ−１，４−ジヒドロ−４−オキソ−７−置換ピペラジニルキノリン−３−カルボン酸誘導体
JP12378084A JPS615075A (ja) 1984-06-18 1984-06-18 ６−フルオロ−１，４−ジヒドロ−４−オキソ−７−置換ピペラジニルキノリン−３−カルボン酸誘導体
JP12378084 1984-06-18

Publications (4)

Publication Number Publication Date
DK445084D0 DK445084D0 (da) 1984-09-18
DK445084A DK445084A (da) 1985-03-20
DK157997B DK157997B (da) 1990-03-12
DK157997C true DK157997C (da) 1990-08-06

Family

ID=27292329

Family Applications (1)

Application Number Title Priority Date Filing Date
DK445084A DK157997C (da) 1983-09-19 1984-09-18 6-fluor-1,4-dihydro-4-oxo-7-substituerede piperazinylquinolin-3-carboxylsyrederivater og deres farmakologisk acceptable salte samt farmaceutiske sammensaetninger til brug ved behandling af bakterielle sygdomme

Country Status (13)

Country Link
US (1) US4528287A (de)
EP (1) EP0140116B1 (de)
KR (1) KR870001016B1 (de)
AU (1) AU553415B2 (de)
CA (1) CA1238638A (de)
DE (1) DE3433924A1 (de)
DK (1) DK157997C (de)
ES (2) ES8604565A1 (de)
FI (1) FI80033C (de)
FR (1) FR2555584B1 (de)
HK (1) HK62191A (de)
HU (1) HU193226B (de)
YU (1) YU45204B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
EP0191185B1 (de) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Chinolincarbonsäure-Derivate
US4755513A (en) * 1985-01-30 1988-07-05 Otsuka Pharmaceutical Company, Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
US4578473A (en) * 1985-04-15 1986-03-25 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
NZ217650A (en) * 1985-09-24 1989-09-27 Hoffmann La Roche Quinoline derivatives and pharmaceutical compositions
HU196782B (en) * 1985-12-09 1989-01-30 Chinoin Gyogyszer Es Vegyeszet Process for production of quinoline carbonic acid
CA1306750C (en) * 1985-12-09 1992-08-25 Istvan Hermecz Process for the preparation of quinoline carboxylic acide
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JPH0696533B2 (ja) * 1987-01-14 1994-11-30 北陸製薬株式会社 キノロンカルボン酸の水性組成物
JP2547263B2 (ja) * 1987-12-10 1996-10-23 ラ・ジョラ・キャンサー・リサーチ・ファウンデーション 立体配座的に安定化された細胞付着ペプチド
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
NZ229605A (en) * 1988-07-15 1990-07-26 Abbott Lab Preparation of 1,4-dihydro-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-quinoline (or naphthyridine) carboxylic acid derivatives
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
US6075024A (en) 1991-11-27 2000-06-13 Sepracor Inc. Methods for treating infection using optically pure (S)-lomefloxacin
US5476854A (en) * 1991-11-27 1995-12-19 Sepracor Inc. Methods and compositions for treating bacterial infection using optically pure (R)-lomefloxacin
CA2124443A1 (en) * 1991-11-27 1993-06-10 James W. Young Methods and compositions for treating infection using optically pure (s)-lomefloxacin
JPH07501546A (ja) * 1991-11-27 1995-02-16 セプラコア，インコーポレーテッド 光学的に純粋な（ｒ）−ロメフロキサシンを用いた感染症治療の方法と組成物
US5430152A (en) * 1993-02-16 1995-07-04 Hoechst Celanese Corporation Method for preparing quinoline carboxylic acids and derivatives thereof
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
US5668134A (en) 1994-01-28 1997-09-16 G. D. Searle & Co. Method for preventing or reducing photosensitivity and/or phototoxicity reactions to medications
US6114531A (en) * 1998-07-28 2000-09-05 Pfizer Inc. Process for preparing quinolone and naphthyridone carboxylic acids
JP5138128B2 (ja) * 1998-08-21 2013-02-06 千寿製薬株式会社 水性液剤
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
TW584632B (en) 2000-01-12 2004-04-21 Pharmaceutical Ind Tech & Dev 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions
DE102005006827A1 (de) * 2004-11-04 2006-05-24 Huhtamaki Ronsberg, Zweigniederlassung Der Huhtamaki Deutschland Gmbh & Co. Kg Verfahren zur Herstellung eines flaschen- oder schlauchartigen Behälters, insbesondere Schlauchbeutels, mit einem eingesiegelten Boden sowie entsprechend hergestellter Schlauchbeutel
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
FR2916446B1 (fr) * 2007-05-24 2009-08-21 Biocodex Sa Nouveau procede de synthese de fluoroquinolones

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS5762259A (en) * 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPS57145862A (en) * 1981-03-06 1982-09-09 Kyorin Pharmaceut Co Ltd Quinolinecarboxylic acid derivative
JPS5910580A (ja) * 1982-07-09 1984-01-20 Hokuriku Seiyaku Co Ltd ７−フエニル置換ピペラジノ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
JPS5929685A (ja) * 1982-08-11 1984-02-16 Hokuriku Seiyaku Co Ltd ７−置換フエニルピペラジノ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents

Also Published As

Publication number Publication date
EP0140116A1 (de) 1985-05-08
HK62191A (en) 1991-08-16
DK445084A (da) 1985-03-20
YU45204B (en) 1992-05-28
ES8604565A1 (es) 1986-02-01
HUT35666A (en) 1985-07-29
ES8609303A1 (es) 1986-07-16
DE3433924C2 (de) 1988-07-28
KR870001016B1 (ko) 1987-05-23
ES545756A0 (es) 1986-07-16
EP0140116B1 (de) 1988-05-25
DE3433924A1 (de) 1985-04-04
DK157997B (da) 1990-03-12
US4528287A (en) 1985-07-09
DK445084D0 (da) 1984-09-18
FI843620L (fi) 1985-03-20
CA1238638A (en) 1988-06-28
FR2555584B1 (fr) 1987-10-23
HU193226B (en) 1987-08-28
FI80033B (fi) 1989-12-29
YU160384A (en) 1987-02-28
ES536004A0 (es) 1986-02-01
AU553415B2 (en) 1986-07-17
FI80033C (fi) 1990-04-10
FR2555584A1 (fr) 1985-05-31
AU3298484A (en) 1985-03-28
KR850002481A (ko) 1985-05-13
FI843620A0 (fi) 1984-09-17

Similar Documents

Publication Publication Date Title
DK157997C (da) 6-fluor-1,4-dihydro-4-oxo-7-substituerede piperazinylquinolin-3-carboxylsyrederivater og deres farmakologisk acceptable salte samt farmaceutiske sammensaetninger til brug ved behandling af bakterielle sygdomme
DK164543C (da) Salte af l-carnitin og alkanoyl-l-carnitiner, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
DK410781A (da) N-arylbenzamid-derivater og salte deraf fremgangsmaade til deres fremstilling og deres anvendelse som herbicider
DK208787A (da) Quinolinderivater og farmaceutisk acceptable estere deraf, deres farmaceutisk acceptable salte samt fremstilling og anvendelse deraf
DK164917C (da) Analogifremgangsmaade til fremstilling af bicyklisk substituerede dipeptidderivater og deres farmaceutisk acceptable salte
DK397387D0 (da) Carbostyrilderivater og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK522983D0 (da) Arylphenyletherderivater og syreadditionssalte deraf samt fremgangsmade til fremstilling deraf
DK285685A (da) Farmaceutisk aktive derivater af d,l-glutaminsyre og d,l-asparaginsyre og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse
DK135884A (da) 1,4-dihydropyridin-forbindelser og farmaceutisk acceptable syreadditionssalte deraf og deres anvendelse som anti-ischaemiske og antihypertensive midler
DK567983A (da) 2-hydroxymethyl-3-carbamoyl-1,4-dihydro-pyridin-forbindelser og salte deraf samt deres fremstilling og anvendelse
DK197684D0 (da) Substituerede indeno-pyridazinoner og salte deraf,fremgangsmaade til deres fremstilling samt deres anvendelse
DK423184D0 (da) 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin d og farmaceutisk acceptable salte deraf samt forbindelser til anvendelse som mellemprodukter ved fremstilling deraf
DK256085D0 (da) Cephemforbindelser og salte og estere deraf, samt deres fremstilling og anvendelse
DK160763C (da) Imidazooe1,5-aaapyridiner og salte deraf samt deres 5,6,7,8-tetrahydroderivater, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelse af forbindelserne
DK543084A (da) Substituerede 3-carbamoyl-1,4-dihydropyridin-forbindelser og saltederaf samt deres fremstilling og anvendelse
DK152115C (da) Analogifremgangsmaade til fremstilling af fluorerede 2,5-diamino-3-pentenderivater og farmaceutisk acceptable salte deraf
DK410183D0 (da) 2-(substitueret-phenyl)-benzoesyrederivater, fremgangsmade til deres frenstilling samt deres anvendelse
DK586283D0 (da) Substituerede azabicycloalkaner og salte deraf samt deres fremstilling og anvendelse
DK558283A (da) Spiro-3-heteroazolidindion-forbindelser og farmaceutisk acceptable salte deraf, farmaceutisk praeparat indeholdende saadanne forbindelser og mellemprodukter ved deres fremstilling
DK162449C (da) Fremgangsmaade til fremstilling af den antibiotiske forbindelse cl-1957a eller farmaceutisk acceptable salte deraf, samt et renset actinomycet-isolat til brug ved fremgangsmaaden
DK562686A (da) 2,2 -bi-1h-imidazoler, tautomere og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse som cardiotonika samt mellemprodukter ved fremstillingen
DK94382A (da) Analogifremgangsmaade til fremstilling af 1-(4-amino-7-methoxy-2-quinazolinyl)-4-acyl-piperazin-forbindelser eller deres homopiperazin-analoge eller farmaceutisk acceptable salte deraf
DK507684D0 (da) Thiadiazinderivater, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende disse thiadiazinderivater
DK514085A (da) Fremgangsmaade til fremstilling af corticosteroid-21-phosphorsyrer og deres salte og corticosteroid-21-phosphorsyretriestere
DK325687D0 (da) Hydrogenerede 1-phenoxyalkylpyridin-3-carboxylsyreforbindelser og salte deraf samt deres fremstilling og anvendelse

Legal Events

Date Code Title Description
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1995 00010, 950727

CTFG Supplementary protection certificate (spc) issued

Free format text: CA 1995 00010, 950727, EXPIRES: 20061104

PUP Patent expired