DK154539C - Fremgangsmaade til fremstilling af cyclosporinholdige farmaceutiske praeparater i flydende form - Google Patents

Fremgangsmaade til fremstilling af cyclosporinholdige farmaceutiske praeparater i flydende form

Info

Publication number
DK154539C
DK154539C DK086079A DK86079A DK154539C DK 154539 C DK154539 C DK 154539C DK 086079 A DK086079 A DK 086079A DK 86079 A DK86079 A DK 86079A DK 154539 C DK154539 C DK 154539C
Authority
DK
Denmark
Prior art keywords
cyclospor
preparing
procedure
liquid form
pharmaceutical preparations
Prior art date
Application number
DK086079A
Other languages
English (en)
Other versions
DK154539B (da
DK86079A (da
Inventor
Thomas Cavanak
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25690510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK154539(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH246178A external-priority patent/CH636013A5/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK86079A publication Critical patent/DK86079A/da
Publication of DK154539B publication Critical patent/DK154539B/da
Application granted granted Critical
Publication of DK154539C publication Critical patent/DK154539C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK086079A 1978-03-07 1979-02-28 Fremgangsmaade til fremstilling af cyclosporinholdige farmaceutiske praeparater i flydende form DK154539C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH246178 1978-03-07
CH246178A CH636013A5 (en) 1978-03-07 1978-03-07 More readily absorbable pharmaceutical composition
CH863478 1978-08-14
CH863478 1978-08-14

Publications (3)

Publication Number Publication Date
DK86079A DK86079A (da) 1979-09-08
DK154539B DK154539B (da) 1988-11-28
DK154539C true DK154539C (da) 1989-05-16

Family

ID=25690510

Family Applications (1)

Application Number Title Priority Date Filing Date
DK086079A DK154539C (da) 1978-03-07 1979-02-28 Fremgangsmaade til fremstilling af cyclosporinholdige farmaceutiske praeparater i flydende form

Country Status (27)

Country Link
US (1) US4388307A (da)
JP (1) JPS54132223A (da)
AR (1) AR223667A1 (da)
AT (1) AT375828B (da)
AU (1) AU528714B2 (da)
CA (1) CA1139667A (da)
CY (1) CY1285A (da)
DD (1) DD142149A5 (da)
DE (1) DE2907460A1 (da)
DK (1) DK154539C (da)
ES (1) ES478295A1 (da)
FI (1) FI65914C (da)
FR (1) FR2419072A1 (da)
GB (1) GB2015339B (da)
HK (1) HK48585A (da)
IE (1) IE48016B1 (da)
IL (1) IL56790A (da)
IT (1) IT1115038B (da)
KE (1) KE3516A (da)
MY (1) MY8500134A (da)
NL (2) NL187260C (da)
NO (2) NO152635C (da)
NZ (1) NZ189819A (da)
PH (1) PH15159A (da)
PT (1) PT69309A (da)
SE (1) SE445174B (da)
SG (1) SG14785G (da)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE43335T1 (de) * 1980-02-14 1989-06-15 Sandoz Ag Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
DE3224619A1 (de) * 1981-07-14 1983-05-19 Freund Industrial Co., Ltd., Tokyo Orale pharmazeutische zusammensetzung
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form
EP0127426A1 (en) * 1983-05-23 1984-12-05 Takeda Chemical Industries, Ltd. Percutaneous pharmaceutical compositions for external use
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US5411951A (en) * 1984-10-04 1995-05-02 Monsanto Company Prolonged release of biologically active somatotropin
US5474980A (en) * 1984-10-04 1995-12-12 Monsanto Company Prolonged release of biologically active somatotropins
US4727035A (en) * 1984-11-14 1988-02-23 Mahoney Walter C Immunoassay for cyclosporin
US4576645A (en) * 1984-12-06 1986-03-18 Block Drug Co., Inc. Whipped gel composition
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
US4775659A (en) * 1985-08-19 1988-10-04 Eli Lilly And Company Injectable semi-solid formulations
GB8524421D0 (en) * 1985-10-03 1985-11-06 Boots Co Plc Therapeutic agents
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US5118493A (en) * 1986-05-02 1992-06-02 Brigham And Women's Hospital Composition having reduced nephrotoxocity comprising a fatty acid containing component and cyclosporine
WO1987006463A1 (en) * 1986-05-02 1987-11-05 Brigham And Women's Hospital A composition having reduced nephrotoxicity comprising a fatty acid containing component and cyclosporine
KR880012221A (ko) * 1987-04-13 1988-11-26 사노 가즈오 에스테르 또는 아미드를 활성성분으로 함유하는 약제 조성물
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
AU620048B2 (en) * 1987-09-03 1992-02-13 University Of Georgia Research Foundation, Inc., The Ocular cyclosporin composition
DE3851152T2 (de) * 1987-09-03 1995-01-26 Univ Georgia Cyclosporin-augenmittel.
US5756450A (en) * 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
DE3830494B4 (de) * 1987-09-15 2006-05-18 Novartis Ag Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
DE68900991D1 (de) * 1988-01-29 1992-04-23 Sankyo Co Cyclosporin-zusammensetzungen.
CH679119A5 (da) * 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
BE1003009A5 (fr) * 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
ES2098739T3 (es) 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
EP0570829B1 (de) * 1992-05-18 2001-04-25 CicloMulsion AG Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur intravenösen Applikation sowie Verfahren zu ihrer Herstellung
US5637317A (en) * 1992-05-18 1997-06-10 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
SK278290B6 (en) * 1992-09-07 1996-08-07 Milan Stuchlik Medicaments with n-methylated cyclic undecapeptides
EP0589843B1 (en) 1992-09-25 2001-11-28 Novartis AG Pharmaceutical compositions containing cyclosporins
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
DE69426408T2 (de) 1993-09-28 2001-07-12 Novartis Ag, Basel Herstellung von Weichgelatinekapseln
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
NZ270145A (en) * 1994-03-01 1996-08-27 Lilly Co Eli Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent
SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
JPH10504291A (ja) * 1994-07-22 1998-04-28 ジー．ディー．サール アンド カンパニー 自己乳化性ドラッグデリバリーシステム
RU2158601C2 (ru) 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
KR0167613B1 (ko) * 1994-12-28 1999-01-15 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제 조성물
KR100239799B1 (ko) * 1995-01-21 2000-02-01 손경식 경구투여용 사이클로스포린 에이 고체미셀분산체, 이의 제조 방법 및 고형제제
US6696413B2 (en) * 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
SE504582C2 (sv) * 1995-07-06 1997-03-10 Gs Dev Ab Cyklosporinkomposition baserad på en L2-fas
BR9606603A (pt) * 1995-08-25 1997-09-30 Sangstat Medical Corp Formulação de ciclosporina dispersão aquosa de nanopartículas de ciclosporina kit e processo de preparação de dispersão aquosa de partículas de ciclosporina
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
US5958876A (en) * 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
KR980008239A (ko) * 1996-07-26 1998-04-30 김충환 사이클로스포린-함유 약학적 조성물
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
DE29824679U1 (de) 1997-01-30 2002-03-28 Novartis Ag, Basel Pharmazeutische Zusammensetzungen
WO1998040094A1 (en) * 1997-03-12 1998-09-17 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
AR012627A1 (es) 1997-04-29 2000-11-08 Sherman Bernard Charles Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado
NZ314702A (en) * 1997-04-29 1998-07-28 Bernard Charles Sherman Pharmaceutical composition comprising a cyclosporin in a solvent system of acetylated monoglycerides and a surfactant and optionally a hydrophilic solvent
US6008191A (en) * 1997-09-08 1999-12-28 Panacea Biotec Limited Pharmaceutical compositions containing cyclosporin
IN188719B (da) * 1997-09-08 2002-11-02 Panacea Biotec Ltd
US6187747B1 (en) 1997-09-08 2001-02-13 Panacea Biotech Limited Pharmaceutical composition comprising cyclosporin
US6346511B1 (en) 1997-09-08 2002-02-12 Panacea Biotec Limited Pharmaceutical composition comprising cyclosporin
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
US6028067A (en) * 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
KR19990047897A (ko) * 1997-12-05 1999-07-05 김충환 사이클로스포린 함유 약학적 조성물
PL348193A1 (en) * 1998-12-11 2002-05-06 Pharmasolutions Self-emulsifying compositions for drugs poorly soluble in water
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
DE60023465T2 (de) * 1999-03-24 2006-07-20 R.P. Scherer Technologies, Inc., Las Vegas Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6057289A (en) * 1999-04-30 2000-05-02 Pharmasolutions, Inc. Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
EP1273287A1 (en) * 2000-04-04 2003-01-08 Shionogi & Co., Ltd. Oily compositions containing highly fat-soluble drugs
AU6608701A (en) * 2000-06-21 2002-01-02 Audit Institute For Medical Services And Quality Assurance Gmbh Pharmaceutical preparations containing cyclosporines and neutral oils
AU2001225459B2 (en) 2000-09-18 2005-12-22 Rpg Life Sciences Limited Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities
OA12619A (en) * 2001-06-21 2006-06-12 Pfizer Prod Inc Self-emulsifying formulations of cholesteryl estertransfer protein inhibitors.
KR20040019034A (ko) 2001-07-06 2004-03-04 수캄포 아게 인터루킨 2 억제제 및 항미생물제를 포함하는 국소 투여용조성물
EP1435910B9 (en) * 2001-10-19 2010-02-03 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
WO2003043650A1 (en) * 2001-11-21 2003-05-30 Sucampo Ag Use of fk506 and analogues for treating allergic diseases
EP1455753A1 (en) * 2001-12-20 2004-09-15 Bernard Charles Sherman Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US6828301B2 (en) * 2002-02-07 2004-12-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
GB2391471B (en) * 2002-08-02 2005-05-04 Satishchandra Punambhai Patel Pharmaceutical compositions
GB2391473B (en) * 2002-08-02 2004-07-07 Satishchandra Punambhai Patel Pharmaceutical compositions
GB2391472B (en) * 2002-08-02 2004-12-08 Satishchandra Punambhai Patel Pharmaceutical compositions
KR100507771B1 (ko) * 2002-11-08 2005-08-17 한미약품 주식회사 난용성 감기약 활성 성분의 경구투여용 조성물 및 그의제조 방법
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
US20040150061A1 (en) * 2003-01-30 2004-08-05 Hsin Chung Hsien Package structure of a photosensor
ES2665464T3 (es) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin costuras
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
AU2004292445B2 (en) 2003-11-21 2010-02-04 Zalicus Inc. Methods and reagents for the treatment of inflammatory disorders
DE102004038980A1 (de) * 2004-08-10 2006-02-23 Cognis Deutschland Gmbh & Co. Kg Antibeschlagmittel für Kunststoffe
EP2444071A1 (en) * 2004-09-27 2012-04-25 Sigmoid Pharma Limited Minicapsule formulations
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
ES2573539T3 (es) * 2005-03-21 2016-06-08 Teva Czech Industries S.R.O. Inhibidor de la cristalización y su uso en cápsulas de gelatina
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
EP2066309B1 (en) * 2007-04-04 2012-08-29 Sigmoid Pharma Limited An oral pharmaceutical composition
BRPI0811538A2 (pt) * 2007-05-04 2015-08-11 Allergan Inc Uso de ciclosporinas no tratamento de pacientes com lentes intraoculares.
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
TW200932240A (en) * 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
EP2376102B1 (en) 2009-01-08 2014-04-02 Allergan, Inc. Compositions for enhancing nail growth
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US20110009339A1 (en) 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
CA2762179A1 (en) 2009-05-18 2010-11-25 Sigmoid Pharma Limited Composition comprising oil drops
KR101685941B1 (ko) 2009-07-07 2016-12-13 베링거 인겔하임 인터내셔날 게엠베하 Ｃ형 간염 바이러스 프로테아제 억제제를 위한 약제학적 조성물
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
CA2852056C (en) 2011-03-11 2021-08-10 Beth Israel Deaconess Medical Center, Inc. Anti-cd40 antibodies and uses thereof
WO2013052380A2 (en) 2011-10-05 2013-04-11 Allergan, Inc. Compositions for enhancing nail health
EP2763649A2 (en) 2011-10-05 2014-08-13 Allergan, Inc. Compositions for enhancing nail health
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
AU2015341695B2 (en) 2014-11-07 2021-07-08 Sublimity Therapeutics Limited Compositions comprising cyclosporin
AU2016315873B2 (en) 2015-09-04 2022-08-18 Primatope Therapeutics Inc. Humanized anti-CD40 antibodies and uses thereof
JPWO2017047299A1 (ja) * 2015-09-15 2017-12-21 富士フイルム株式会社 注射用液剤組成物
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1274354A (fr) * 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1110875A (en) * 1964-12-11 1968-04-24 Glaxo Lab Ltd Compositions containing procaine penicillins
FR94740E (fr) * 1967-10-25 1969-10-24 Rhone Poulenc Sa Nouveaux cyclopeptides et leur préparation.
NL167323C (nl) * 1970-09-26 1981-12-16 Organon Nv Werkwijze ter bereiding van een psychofarmacologisch preparaat.
ES396746A1 (es) * 1971-11-06 1974-12-01 Gallardo Antonio Sa Nuevo procedimiento de fabricacion de suspensiones establesidoneas para antibioticos.
CH574247A5 (en) * 1972-02-17 1976-04-15 Ciba Geigy Ag Oily, injectable peptide/aluminium alkanoate compsns - - with prolonged duration of activity
JPS4891218A (da) * 1972-03-06 1973-11-28
AR207116A1 (es) * 1973-03-28 1976-09-15 Ciba Geigy Ag Procedimiento para preparar nuevas dotriacontapeptidoamidas
DE2455859C2 (de) * 1973-12-06 1983-12-15 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung
GB1547164A (en) * 1975-08-14 1979-06-06 Beecham Group Ltd Veterinary compositions
CH614931A5 (da) * 1975-11-04 1979-12-28 Sandoz Ag
DE2555481C3 (de) * 1975-12-10 1985-10-03 Sandoz-Patent-GmbH, 7850 Lörrach Herstellung stabiler Tropflösungen von hydrierten Ergotalkaloiden
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung

Also Published As

Publication number Publication date
KE3516A (en) 1985-04-19
GB2015339A (en) 1979-09-12
DK154539B (da) 1988-11-28
ES478295A1 (es) 1979-05-16
DD142149A5 (de) 1980-06-11
FI65914C (fi) 1984-08-10
NO152635B (no) 1985-07-22
AU528714B2 (en) 1983-05-12
FI790640A (fi) 1979-09-08
IL56790A (en) 1982-01-31
FI65914B (fi) 1984-04-30
PT69309A (fr) 1979-04-01
NO152635C (no) 1985-10-30
DE2907460C2 (da) 1990-09-27
GB2015339B (en) 1982-09-15
CY1285A (en) 1985-07-05
FR2419072B1 (da) 1983-04-22
MY8500134A (en) 1985-12-31
JPS627891B2 (da) 1987-02-19
JPS54132223A (en) 1979-10-15
DK86079A (da) 1979-09-08
DE2907460A1 (de) 1979-09-13
ATA163779A (de) 1984-02-15
US4388307A (en) 1983-06-14
IE48016B1 (en) 1984-09-05
AT375828B (de) 1984-09-10
SE7901683L (sv) 1979-09-08
NL187260C (nl) 1991-08-01
PH15159A (en) 1982-08-24
HK48585A (en) 1985-06-28
FR2419072A1 (fr) 1979-10-05
AU4486279A (en) 1979-09-13
IT1115038B (it) 1986-02-03
NO790661L (no) 1979-09-10
IE790704L (en) 1979-09-07
NO1994028I1 (no) 1994-12-28
SE445174B (sv) 1986-06-09
NL930135I1 (nl) 1993-11-01
IL56790A0 (en) 1979-05-31
NL7901703A (nl) 1979-09-11
AR223667A1 (es) 1981-09-15
IT7948152A0 (it) 1979-02-27
SG14785G (en) 1985-08-16
NZ189819A (en) 1984-05-31
CA1139667A (en) 1983-01-18

Similar Documents

Publication Publication Date Title
DK154539C (da) Fremgangsmaade til fremstilling af cyclosporinholdige farmaceutiske praeparater i flydende form
DK155172C (da) Fremgangsmaade til fremstilling af liposomholdige farmaceutiske praeparater
DK363179A (da) Fremgangsmaade til fremstilling af tetrazolylalkoxycarbostyrilderivater
NO793885L (no) Flytende dentalperparat, samt fremgangsmaate for fremstilling derav.
DK460283D0 (da) Fremgangsmade til fremstilling af topiske farmaceutiske praeparater
DK368579A (da) Fremgangsmaade til fremstilling af et antistofholdigt immunoglobulinpraeparat til intravenoes indgift og deraf fremstillede praeparater
DK488379A (da) Fremgangsmaade til fremstilling af polyetherderivater
DK7579A (da) Fremgangsmaade til fremstilling af (%n-diethylmeta-toluamid
DK19579A (da) Fremgangsmaade til fremstilling af spirothienohydantoinderivater
DK316186D0 (da) Stabilt prostaglandin-indeholdende praeparat til ikke-laegemiddel-anvendelse
DK220380A (da) Vandigt koncentreret stofbloedgoeringsmiddel og fremgangsmaade til fremstilling deraf
DK152138C (da) Fremgangsmaade til fremstilling af urokinase
DK280282A (da) Fremgangsmaade til fremstilling af farmaceutiske praeparater indeholdende ergotalkaloider
DK148879A (da) Fremgangsmaade til fremstilling af mercaptoimidazolderivater
DK225979A (da) Fremgangsmaade til fremstilling af inulaekstrakt
DK393379A (da) Fremgangsmaade til fremstilling af galeniske praeparater
DK283579A (da) Fremgangsmaade i gsmaade til fremstilling af praeparater af disse
DK330279A (da) Fremgangsmaade til fremstilling af soem
DK117479A (da) Fremgangsmaade til fremstilling af trifluormethylphenoler
DK529879A (da) Galeniske praeparater indehldende ergotalkaloider
DK157165C (da) Flydende herbicider indeholdende propachlor og fremgangsmaade til fremstilling deraf
DK154926C (da) Fremgangsmaade til fremstilling af en etomidatholdig infusionsvaeske
DK431479A (da) Fremgagnsmaade til fremstilling af 3-exomethylencepham-sulfoxider
DK47681A (da) Fremgangsmaade til fremstilling af farmaceutiske praeparater
DK73579A (da) Nitrosourinstofderivater isaer n1-glucofurasosid 6-yl-n3nitrosourinsoffer og fremgangsmaade til fremstilling deraf

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1993 00055, 930701

CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1993 00055, 930701

PUP Patent expired