HUP0400263A2 - Koleszteril-észter transzfer protein inhibitort tartalmazó önemulgeáló készítmény - Google Patents
Koleszteril-észter transzfer protein inhibitort tartalmazó önemulgeáló készítményInfo
- Publication number
- HUP0400263A2 HUP0400263A2 HU0400263A HUP0400263A HUP0400263A2 HU P0400263 A2 HUP0400263 A2 HU P0400263A2 HU 0400263 A HU0400263 A HU 0400263A HU P0400263 A HUP0400263 A HU P0400263A HU P0400263 A2 HUP0400263 A2 HU P0400263A2
- Authority
- HU
- Hungary
- Prior art keywords
- self
- transfer protein
- cholesteryl ester
- protein inhibitors
- ester transfer
- Prior art date
Links
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 3
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 abstract 2
- 239000008157 edible vegetable oil Substances 0.000 abstract 2
- 239000006184 cosolvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Abstract
A találmány tárgya javított oldékonyságú és biohasznosulásúkészítmény, amely egy CETP inhibitort és egy alábbiak közül választottlipofil vivőanyagot tartalmaz: ehető olajok, lipofil oldószerek,felületaktív anyagok. A készítmények előnyösen önemulgeáló vagyönmikroemulgeáló készítmények, amelyek tartalmaznak: 1. egy CETPinhibitort, 2. egy segédoldószert, 3. egy 1-8 közötti HLB értékűfelületaktív anyagot, 4. egy 8-20 közötti HLB értékű felületaktívanyagot és 5. adott esetben egy ehető olajat. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30002801P | 2001-06-21 | 2001-06-21 | |
PCT/IB2002/001571 WO2003000295A2 (en) | 2001-06-21 | 2002-05-03 | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0400263A2 true HUP0400263A2 (hu) | 2005-03-29 |
Family
ID=23157363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400263A HUP0400263A2 (hu) | 2001-06-21 | 2002-05-03 | Koleszteril-észter transzfer protein inhibitort tartalmazó önemulgeáló készítmény |
Country Status (33)
Country | Link |
---|---|
US (2) | US6962931B2 (hu) |
EP (1) | EP1453544A2 (hu) |
JP (1) | JP2005500314A (hu) |
KR (1) | KR20040015746A (hu) |
CN (1) | CN1635911A (hu) |
AP (1) | AP2002002559A0 (hu) |
AR (1) | AR034599A1 (hu) |
BG (1) | BG108486A (hu) |
BR (1) | BR0210505A (hu) |
CA (1) | CA2455288A1 (hu) |
CR (1) | CR7163A (hu) |
CZ (1) | CZ20033341A3 (hu) |
EA (1) | EA200301139A1 (hu) |
EC (1) | ECSP034875A (hu) |
EE (1) | EE200400024A (hu) |
GT (1) | GT200200124A (hu) |
HN (1) | HN2002000153A (hu) |
HU (1) | HUP0400263A2 (hu) |
IL (1) | IL158765A0 (hu) |
IS (1) | IS7014A (hu) |
MA (1) | MA27034A1 (hu) |
MX (1) | MXPA04000014A (hu) |
NO (1) | NO20035632L (hu) |
OA (1) | OA12619A (hu) |
PA (1) | PA8548601A1 (hu) |
PE (1) | PE20030128A1 (hu) |
PL (1) | PL368850A1 (hu) |
SK (1) | SK15172003A3 (hu) |
SV (1) | SV2003001103A (hu) |
TN (1) | TNSN03139A1 (hu) |
UY (1) | UY27344A1 (hu) |
WO (1) | WO2003000295A2 (hu) |
ZA (1) | ZA200308561B (hu) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002534370A (ja) * | 1998-12-30 | 2002-10-15 | デクセル リミテッド | サイクロスポリンを送達するための分散可能な濃縮物 |
US7732404B2 (en) * | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
JP4031232B2 (ja) * | 2001-11-09 | 2008-01-09 | カプスゲル・ジャパン株式会社 | 新規カプセル |
CA2474838C (en) | 2002-02-01 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
CA2478433C (en) * | 2002-03-01 | 2009-12-08 | Cesi Chemical, A Flotek Company | Composition and process for well cleaning |
US20040175341A1 (en) * | 2003-03-04 | 2004-09-09 | Manning Monna Marie | Microemulsion for cosmetic or pharmaceutical use containing an active ingredient |
JP5546715B2 (ja) * | 2003-03-17 | 2014-07-09 | 日本たばこ産業株式会社 | Cetp阻害剤の医薬組成物 |
BRPI0408442A (pt) * | 2003-03-17 | 2006-04-04 | Japan Tobacco Inc | método para aumento da biodisponibilidade oral de s-[2-([[1-(2-etilbutil)ciclohexil]carbonil]amino)fenil]2- metilpropanotioato |
CN1761463A (zh) * | 2003-03-17 | 2006-04-19 | 日本烟草产业株式会社 | 提高s-[2-([[1-(2-乙基丁基)环己基]羰基]氨基)苯基]-2-甲基丙硫代酸酯口服生物利用度的方法 |
TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
ATE540671T1 (de) * | 2003-08-04 | 2012-01-15 | Bend Res Inc | Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien |
EP1670765A2 (en) * | 2003-09-30 | 2006-06-21 | Pfizer Products Inc. | Cetp inhibitors and metabolites thereof |
MXPA06003927A (es) * | 2003-10-08 | 2008-02-07 | Lilly Co Eli | Compuestos y metodos para tratar dislipidemia. |
US20050220866A1 (en) * | 2004-04-02 | 2005-10-06 | Dr. Reddy's Laboratories Limited | Novel capsule formulations of etoposide for oral use |
WO2006069162A1 (en) | 2004-12-20 | 2006-06-29 | Reddy Us Therapeutics, Inc. | Novel heterocyclic compounds and their pharmaceutical compositions |
EP1848430B1 (en) | 2004-12-31 | 2017-08-02 | Dr. Reddy's Laboratories Ltd. | Novel benzylamine derivatives as cetp inhibitors |
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
US20090169583A1 (en) * | 2005-02-08 | 2009-07-02 | Pfizer, Inc. | Solid Adsorbates of Hydrophobic Drugs |
US7623458B2 (en) * | 2005-09-30 | 2009-11-24 | The Boeing Company | System and method for providing integrated services across cryptographic boundaries in a network |
ATE516016T1 (de) * | 2005-12-05 | 2011-07-15 | Merck Sharp & Dohme | Selbstemulgierende formulierungen von cetp- hemmern |
MY148473A (en) * | 2005-12-31 | 2013-04-30 | Tasly Pharmaceutical Group Co | Extracts of chenopodium ambrosioides l., the compositions comprising said extracts, the preparing process and application thereof |
US20080026050A1 (en) * | 2006-06-30 | 2008-01-31 | Rajan Gupta | Solid dose formulations of a thrombin receptor antagonist |
EP1961412A1 (en) | 2006-12-27 | 2008-08-27 | LEK Pharmaceuticals D.D. | Self-microemulsifying drug delivery systems |
US9222013B1 (en) | 2008-11-13 | 2015-12-29 | Cesi Chemical, Inc. | Water-in-oil microemulsions for oilfield applications |
JP5538423B2 (ja) * | 2008-12-08 | 2014-07-02 | エフ.ホフマン−ラ ロシュ アーゲー | 薬物の併用投与 |
US20100273730A1 (en) * | 2009-04-27 | 2010-10-28 | Innopharmax, Inc. | Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof |
AU2010260208B2 (en) | 2009-06-16 | 2014-11-13 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | Dosage forms of apixaban |
CA2835912A1 (en) * | 2011-05-20 | 2012-11-29 | Aventis Pharmaceuticals Inc. | Pharmaceutical composition comprising fexofenadine |
MX2014001849A (es) | 2011-08-18 | 2014-10-24 | Reddys Lab Ltd Dr | Compuestos de amina heterociclicos sustituidos como inhibidores de proteina de transferencia de ester colesterilo (cetp). |
CN103958511A (zh) | 2011-09-27 | 2014-07-30 | 雷迪博士实验室有限公司 | 作为胆固醇酯转移蛋白(CETP)抑制剂用于治疗动脉粥样硬化的5-苄基氨基甲基-6-氨基吡唑并[3,4-b]吡啶衍生物 |
US10874635B2 (en) | 2011-10-21 | 2020-12-29 | First Tech International Limited | Tocotrienol compositions |
WO2013158567A1 (en) | 2012-04-15 | 2013-10-24 | Cesi Chemical, Inc. | Surfactant formulations for foam flooding |
US9200192B2 (en) | 2012-05-08 | 2015-12-01 | Cesi Chemical, Inc. | Compositions and methods for enhancement of production of liquid and gaseous hydrocarbons |
US11407930B2 (en) | 2012-05-08 | 2022-08-09 | Flotek Chemistry, Llc | Compositions and methods for enhancement of production of liquid and gaseous hydrocarbons |
WO2014128564A2 (en) * | 2013-02-21 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
US9464223B2 (en) | 2013-03-14 | 2016-10-11 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells |
US10717919B2 (en) | 2013-03-14 | 2020-07-21 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells |
US9068108B2 (en) | 2013-03-14 | 2015-06-30 | Cesi Chemical, Inc. | Methods and compositions for stimulating the production of hydrocarbons from subterranean formations |
US9321955B2 (en) | 2013-06-14 | 2016-04-26 | Flotek Chemistry, Llc | Methods and compositions for stimulating the production of hydrocarbons from subterranean formations |
US11180690B2 (en) | 2013-03-14 | 2021-11-23 | Flotek Chemistry, Llc | Diluted microemulsions with low surface tensions |
US10590332B2 (en) | 2013-03-14 | 2020-03-17 | Flotek Chemistry, Llc | Siloxane surfactant additives for oil and gas applications |
US10941106B2 (en) | 2013-03-14 | 2021-03-09 | Flotek Chemistry, Llc | Methods and compositions incorporating alkyl polyglycoside surfactant for use in oil and/or gas wells |
US10000693B2 (en) | 2013-03-14 | 2018-06-19 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells |
US9884988B2 (en) | 2013-03-14 | 2018-02-06 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells |
US11254856B2 (en) | 2013-03-14 | 2022-02-22 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells |
US10577531B2 (en) | 2013-03-14 | 2020-03-03 | Flotek Chemistry, Llc | Polymers and emulsions for use in oil and/or gas wells |
US9868893B2 (en) | 2013-03-14 | 2018-01-16 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells |
US10421707B2 (en) | 2013-03-14 | 2019-09-24 | Flotek Chemistry, Llc | Methods and compositions incorporating alkyl polyglycoside surfactant for use in oil and/or gas wells |
US10287483B2 (en) | 2013-03-14 | 2019-05-14 | Flotek Chemistry, Llc | Methods and compositions for use in oil and/or gas wells comprising a terpene alcohol |
US9428683B2 (en) | 2013-03-14 | 2016-08-30 | Flotek Chemistry, Llc | Methods and compositions for stimulating the production of hydrocarbons from subterranean formations |
US10053619B2 (en) | 2013-03-14 | 2018-08-21 | Flotek Chemistry, Llc | Siloxane surfactant additives for oil and gas applications |
CN104706689A (zh) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | 一种鸦胆子油脂肪乳浓缩液、其制备方法及用途 |
CN104706586A (zh) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | 一种丁酸氯维地平脂肪乳浓缩液、其制备方法及用途 |
CN104706587A (zh) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | 一种依托咪酯脂肪乳浓缩液、其制备方法及用途 |
US9890624B2 (en) | 2014-02-28 | 2018-02-13 | Eclipse Ior Services, Llc | Systems and methods for the treatment of oil and/or gas wells with a polymeric material |
US9890625B2 (en) | 2014-02-28 | 2018-02-13 | Eclipse Ior Services, Llc | Systems and methods for the treatment of oil and/or gas wells with an obstruction material |
CA2891278C (en) | 2014-05-14 | 2018-11-06 | Cesi Chemical, Inc. | Methods and compositions for use in oil and / or gas wells |
CA2898770C (en) | 2014-07-28 | 2019-05-21 | Cesi Chemical, Inc. | Methods and compositions related to gelled layers in oil and/or gas wells |
MX2017005883A (es) | 2014-11-04 | 2017-11-28 | Innopharmax Inc | Administracion oral de farmacos inestables o deficientemente absorbidos. |
CN104490775A (zh) * | 2014-12-20 | 2015-04-08 | 长沙佰顺生物科技有限公司 | 一种安塞曲匹脂肪乳及其制备方法 |
CN104546710A (zh) * | 2014-12-20 | 2015-04-29 | 长沙佰顺生物科技有限公司 | 一种安塞曲匹纳米乳及其制备方法 |
KR101590072B1 (ko) * | 2014-12-23 | 2016-01-29 | 한미약품 주식회사 | 두타스테라이드를 포함하는 자가유화 약물전달 시스템용 조성물 |
KR101994129B1 (ko) | 2015-05-28 | 2019-06-28 | 닥터 레디스 레보러터리즈 리미티드 | 통증 치료를 위한 셀레콕시브 경구용 조성물 |
EP3442524A2 (en) | 2016-04-15 | 2019-02-20 | Novira Therapeutics Inc. | Combinations and methods comprising a capsid assembly inhibitor |
US10934472B2 (en) | 2017-08-18 | 2021-03-02 | Flotek Chemistry, Llc | Compositions comprising non-halogenated solvents for use in oil and/or gas wells and related methods |
US11053433B2 (en) | 2017-12-01 | 2021-07-06 | Flotek Chemistry, Llc | Methods and compositions for stimulating the production of hydrocarbons from subterranean formations |
US10973801B2 (en) | 2018-03-14 | 2021-04-13 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
BR112021009967A2 (pt) * | 2018-11-26 | 2021-08-17 | Hepion Pharmaceuticals, Inc. | formulações farmacêuticas de análogos de ciclosporina |
CN113784722A (zh) * | 2019-04-11 | 2021-12-10 | R·P·舍勒科技有限责任公司 | 用于有不良渗透性的蛋白质、肽和小分子的口服递送的制剂 |
CN110252395B (zh) | 2019-07-01 | 2020-10-16 | 湖北远大生命科学与技术有限责任公司 | 一种用于制备高纯度牛磺酸的催化剂及其应用 |
US11104843B2 (en) | 2019-10-10 | 2021-08-31 | Flotek Chemistry, Llc | Well treatment compositions and methods comprising certain microemulsions and certain clay control additives exhibiting synergistic effect of enhancing clay swelling protection and persistency |
FR3110852B1 (fr) | 2020-05-27 | 2024-03-15 | Centre Nat Rech Scient | Emulsions pour liberation controlee de medicaments |
US11512243B2 (en) | 2020-10-23 | 2022-11-29 | Flotek Chemistry, Llc | Microemulsions comprising an alkyl propoxylated sulfate surfactant, and related methods |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2907460A1 (de) | 1978-03-07 | 1979-09-13 | Sandoz Ag | Neue resorbierbare galenische kompositionen |
GB9208712D0 (en) | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
WO1995031979A1 (en) | 1994-05-19 | 1995-11-30 | R.P. Scherer International Corporation | Solutions of aryl or heteroaryl substituted alkanoic acids in lipophilic solvents and soft gelatin capsules containing such solutions |
WO1996033697A1 (fr) | 1995-04-24 | 1996-10-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulation auto-emulsionnable formant une emulsion huile dans l'eau |
GB9608719D0 (en) | 1996-04-26 | 1996-07-03 | Scherer Ltd R P | Pharmaceutical compositions |
US5993858A (en) * | 1996-06-14 | 1999-11-30 | Port Systems L.L.C. | Method and formulation for increasing the bioavailability of poorly water-soluble drugs |
ES2227700T3 (es) | 1996-06-19 | 2005-04-01 | Novartis Ag | Preparados de capsulas blandas que contienen ciclosporina. |
US5958876A (en) | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
JP2894445B2 (ja) * | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Cetp活性阻害剤として有効な化合物 |
WO1999014204A1 (en) * | 1997-09-16 | 1999-03-25 | G.D. Searle & Co. | Substituted 1,2,4-triazoles useful for inhibiting cholesteryl ester transfer protein activity |
DE19741399A1 (de) | 1997-09-19 | 1999-03-25 | Bayer Ag | Tetrahydrochinoline |
US6063762A (en) | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
WO1999041237A1 (en) * | 1998-02-13 | 1999-08-19 | G.D. Searle & Co. | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity |
US6140342A (en) * | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
US6147090A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
US6147089A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
JP2002525350A (ja) * | 1998-09-25 | 2002-08-13 | モンサント カンパニー | コレステロールエステル輸送タンパク質活性阻害に有効な置換されたn−脂肪族−n−芳香族第三級ヘテロアルキルアミン |
JP2002534370A (ja) | 1998-12-30 | 2002-10-15 | デクセル リミテッド | サイクロスポリンを送達するための分散可能な濃縮物 |
CO5271716A1 (es) * | 1999-11-30 | 2003-04-30 | Pfizer Prod Inc | Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida |
US6482862B1 (en) * | 1999-12-20 | 2002-11-19 | G.D. Searle & Co. | Method of using substituted N-benzyl-N-phenyl aminoalcohols for inhibiting cholesteryl ester transfer protein activity |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
JP2004534812A (ja) * | 2001-06-22 | 2004-11-18 | ファイザー・プロダクツ・インク | 薬物および中性ポリマーの分散物の医薬組成物 |
EP1401399A2 (en) * | 2001-06-22 | 2004-03-31 | Pfizer Products Inc. | Pharmaceutical compositions containing polymer and drug assemblies |
EP1269994A3 (en) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
AU2002304387A1 (en) * | 2001-06-22 | 2003-01-08 | Pfizer Products Inc. | Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer |
JP2005517690A (ja) * | 2002-02-01 | 2005-06-16 | ファイザー・プロダクツ・インク | 固体薬物分散物を含有する即時放出剤形 |
CA2474838C (en) * | 2002-02-01 | 2009-01-06 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
ES2300628T3 (es) * | 2002-12-20 | 2008-06-16 | Pfizer Products Inc. | Formas de dosificacion que comprenden un inhibidor de cetp y un inhibidor de la hmg-coa reductasa. |
-
2002
- 2002-05-03 OA OA1200300317A patent/OA12619A/en unknown
- 2002-05-03 CN CNA028124820A patent/CN1635911A/zh active Pending
- 2002-05-03 JP JP2003506937A patent/JP2005500314A/ja active Pending
- 2002-05-03 MX MXPA04000014A patent/MXPA04000014A/es active IP Right Grant
- 2002-05-03 SK SK1517-2003A patent/SK15172003A3/sk not_active Application Discontinuation
- 2002-05-03 PL PL02368850A patent/PL368850A1/xx not_active Application Discontinuation
- 2002-05-03 CA CA002455288A patent/CA2455288A1/en not_active Abandoned
- 2002-05-03 EP EP02732994A patent/EP1453544A2/en not_active Withdrawn
- 2002-05-03 HU HU0400263A patent/HUP0400263A2/hu unknown
- 2002-05-03 BR BR0210505-5A patent/BR0210505A/pt not_active IP Right Cessation
- 2002-05-03 CZ CZ20033341A patent/CZ20033341A3/cs unknown
- 2002-05-03 KR KR10-2003-7016651A patent/KR20040015746A/ko not_active Application Discontinuation
- 2002-05-03 TN TNPCT/IB2002/001571A patent/TNSN03139A1/fr unknown
- 2002-05-03 IL IL15876502A patent/IL158765A0/xx unknown
- 2002-05-03 EE EEP200400024A patent/EE200400024A/xx unknown
- 2002-05-03 EA EA200301139A patent/EA200301139A1/ru unknown
- 2002-05-03 WO PCT/IB2002/001571 patent/WO2003000295A2/en active Application Filing
- 2002-06-19 PE PE2002000528A patent/PE20030128A1/es not_active Application Discontinuation
- 2002-06-19 GT GT200200124A patent/GT200200124A/es unknown
- 2002-06-19 AR ARP020102297A patent/AR034599A1/es unknown
- 2002-06-19 US US10/175,643 patent/US6962931B2/en not_active Expired - Fee Related
- 2002-06-20 UY UY27344A patent/UY27344A1/es not_active Application Discontinuation
- 2002-06-20 PA PA20028548601A patent/PA8548601A1/es unknown
- 2002-06-20 AP APAP/P/2002/002559A patent/AP2002002559A0/en unknown
- 2002-06-20 HN HN2002000153A patent/HN2002000153A/es unknown
- 2002-06-20 SV SV2002001103A patent/SV2003001103A/es not_active Application Discontinuation
-
2003
- 2003-10-31 IS IS7014A patent/IS7014A/is unknown
- 2003-11-03 ZA ZA200308561A patent/ZA200308561B/xx unknown
- 2003-11-24 CR CR7163A patent/CR7163A/es not_active Application Discontinuation
- 2003-12-03 EC EC2003004875A patent/ECSP034875A/es unknown
- 2003-12-10 MA MA27430A patent/MA27034A1/fr unknown
- 2003-12-17 NO NO20035632A patent/NO20035632L/no not_active Application Discontinuation
- 2003-12-22 BG BG108486A patent/BG108486A/bg unknown
-
2005
- 2005-09-08 US US11/222,908 patent/US20060014788A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0400263A2 (hu) | Koleszteril-észter transzfer protein inhibitort tartalmazó önemulgeáló készítmény | |
ATE365536T1 (de) | Lösungsmittelsysteme für pharmazeutische mittel | |
EA200400765A1 (ru) | Фармацевтические составы, содержащие соединения активного витамина d | |
CY1109135T1 (el) | Φαρμακευτικο διαλυμα το οποιο περιλαμβανει ριτοναβιρη, εναν διαλυτη (μακριας αλυσιδας λιπαρο οξυ) και νερο | |
TW349867B (en) | Pharmaceutical composition for inducing a cytotoxic T-lymphocyte responses | |
NO20030506L (no) | Farmasöytiske sammensetninger av kolesterylesteroverföringsproteininhibitorer | |
CA2296244A1 (en) | Adjuvants for use in vaccines | |
HUP0202737A2 (hu) | Lipáz inhibítorokat tartalmazó diszperziós készítmények | |
SE9604793D0 (sv) | New polymorphs | |
ATE397602T1 (de) | 9-(piperazinylalkyl)carbazole als bax-modulatoren | |
MY127749A (en) | Liquid formulation | |
NO974104L (no) | Faste diacyl-organiske peroksyd-dispersjoner | |
AU2435101A (en) | Apparatus and methods for high throughput determination and ranking of formulations and solubility | |
BRPI0408466B8 (pt) | composição farmacêutica e uso de inibidor de proteína de transferência de colesteril éster e crospovidona | |
DE69939335D1 (de) | Dispergierbares konzentrat zur verabreichung von cyclosporin | |
ATE267602T1 (de) | 2-methyl-thieno-benzodiazepin-formulierung | |
HUP0402208A2 (hu) | Kit spred készítéséhez | |
FR2806624B1 (fr) | Systeme huile silicone/co-solvant concentre en matiere(s) active(s) cosmetique(s) liposoluble(s), emulsion et formulation cosmetiques correspondantes | |
NO20034581L (no) | Fremgangsmåte for autolog transplantasjon | |
DOP2002000419A (es) | Formulaciones autoemulsionantes de inhibidores de las protenia de transferencia de la colesteril ester. | |
DK0884952T3 (da) | Fremgangsmåde til beskyttelse af fedtbaserede vandige emulsionsprodukter mod metalkatalyseret oxidation og således beskyttet produkt | |
EA200600009A2 (ru) | Фармацевтические композиции, содержащие активные соединения витамина d | |
AU2002337107A1 (en) | 3-`hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7,8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors | |
TH43987A (th) | อิมัลชันทางเภสัชกรรมสำหรับตัวยับยั้งรีโทรไวรอลโปรเทเอส | |
DE60042203D1 (de) | Emulsionszusammensetzungen vom typ oel-in-wasser |