DK1482938T3 - Farmaceutisk præparat af en PDE4 eller en PDE3/4 inhibitor og en histaminreceptorantagonist - Google Patents

Farmaceutisk præparat af en PDE4 eller en PDE3/4 inhibitor og en histaminreceptorantagonist

Info

Publication number
DK1482938T3
DK1482938T3 DK03708130T DK03708130T DK1482938T3 DK 1482938 T3 DK1482938 T3 DK 1482938T3 DK 03708130 T DK03708130 T DK 03708130T DK 03708130 T DK03708130 T DK 03708130T DK 1482938 T3 DK1482938 T3 DK 1482938T3
Authority
DK
Denmark
Prior art keywords
pde3
pde4
inhibitor
receptor antagonist
pharmaceutical preparation
Prior art date
Application number
DK03708130T
Other languages
Danish (da)
English (en)
Inventor
Rolf Beume
Daniela Bundschuh
Christian Weimar
Stefan-Lutz Wollin
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Application granted granted Critical
Publication of DK1482938T3 publication Critical patent/DK1482938T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/423Oxazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK03708130T 2002-03-06 2003-02-25 Farmaceutisk præparat af en PDE4 eller en PDE3/4 inhibitor og en histaminreceptorantagonist DK1482938T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004987 2002-03-06
PCT/EP2003/001876 WO2003074055A1 (en) 2002-03-06 2003-02-25 Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist

Publications (1)

Publication Number Publication Date
DK1482938T3 true DK1482938T3 (da) 2007-12-03

Family

ID=27771841

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03708130T DK1482938T3 (da) 2002-03-06 2003-02-25 Farmaceutisk præparat af en PDE4 eller en PDE3/4 inhibitor og en histaminreceptorantagonist
DK07112823.5T DK1849468T3 (da) 2002-03-06 2003-02-25 Farmaceutisk sammensætning omfattende roflumilast og levocetirizin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK07112823.5T DK1849468T3 (da) 2002-03-06 2003-02-25 Farmaceutisk sammensætning omfattende roflumilast og levocetirizin

Country Status (32)

Country Link
US (1) US20050112069A1 (xx)
EP (2) EP1849468B1 (xx)
JP (1) JP5150034B2 (xx)
KR (1) KR20040095255A (xx)
CN (1) CN101257904A (xx)
AR (1) AR038858A1 (xx)
AT (1) ATE369134T1 (xx)
AU (1) AU2003212268B2 (xx)
BR (1) BR0308220A (xx)
CA (1) CA2478612C (xx)
CO (1) CO5611148A2 (xx)
CY (2) CY1106927T1 (xx)
DE (1) DE60315426T2 (xx)
DK (2) DK1482938T3 (xx)
EA (2) EA007903B1 (xx)
ES (2) ES2291618T3 (xx)
HK (1) HK1071308A1 (xx)
HR (1) HRP20040909B1 (xx)
IL (1) IL163336A (xx)
IS (2) IS2536B (xx)
MX (1) MXPA04008460A (xx)
NO (1) NO335254B1 (xx)
NZ (1) NZ535611A (xx)
PL (1) PL211574B1 (xx)
PT (2) PT1849468E (xx)
RS (1) RS51018B (xx)
SG (1) SG160197A1 (xx)
SI (2) SI1849468T1 (xx)
TW (1) TWI347845B (xx)
UA (1) UA80117C2 (xx)
WO (1) WO2003074055A1 (xx)
ZA (1) ZA200407104B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080065704A (ko) * 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
ES2341813T3 (es) * 2006-12-20 2010-06-28 Glaxo Group Limited 4-bencil-1 (2h)-ftalazinonas como antagonistas del receptor h1.
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
WO2008127975A2 (en) * 2007-04-11 2008-10-23 Alcon Research, Ltd. Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US8877816B2 (en) 2007-11-21 2014-11-04 Decode Genetics Ehf 4-(or 5-) substituted catechol derivatives
KR20090061972A (ko) * 2007-12-12 2009-06-17 한미약품 주식회사 베포타스틴 p-톨루엔술폰산염의 결정형, 이의 제조방법 및이를 포함하는 약학 조성물
PL2672957T3 (pl) 2011-02-07 2017-05-31 Scipharm Sàrl Nowe kompozycje do leczenia mukowiscydozy
KR102226833B1 (ko) * 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
JP2017525721A (ja) * 2014-08-26 2017-09-07 ファンダシオン パラ ラ インベスティガシオン メディカ アプリカダFundacion Para La Investigasion Medica Aplicada 認知欠損または認知障害に伴って進行する神経障害のおよび神経変性疾患の処置および予防のための製品
EP3205652B1 (en) 2014-10-09 2022-03-09 Guangdong Raynovent Biotech Co., Ltd. Hydroxyl purine compounds and applications thereof
CN109956947A (zh) * 2017-12-25 2019-07-02 江苏恒瑞医药股份有限公司 一种cns抑制剂的新晶型、制备方法及用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
KR100331255B1 (ko) * 1993-07-02 2002-10-25 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5990147A (en) * 1997-11-07 1999-11-23 Schering Corporation H3 receptor ligands of the phenyl-alkyl-imidazoles type
BR9804993A (pt) * 1998-11-10 2000-06-06 Panacea Biotec Ltd Composição antialérgica e antiinflamatória
US6174878B1 (en) * 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
PL354979A1 (en) * 1999-10-25 2004-03-22 Altana Pharma Ag Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
GB0115181D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Novel use

Also Published As

Publication number Publication date
JP2005524666A (ja) 2005-08-18
CY1106927T1 (el) 2012-09-26
IS7438A (is) 2004-09-03
TW200306855A (en) 2003-12-01
PL211574B1 (pl) 2012-05-31
DE60315426D1 (de) 2007-09-20
ES2400670T3 (es) 2013-04-11
EA007903B1 (ru) 2007-02-27
EP1482938B1 (en) 2007-08-08
HRP20040909B1 (en) 2012-11-30
CA2478612A1 (en) 2003-09-12
EP1482938A1 (en) 2004-12-08
CA2478612C (en) 2013-12-10
JP5150034B2 (ja) 2013-02-20
AU2003212268B2 (en) 2008-09-11
CO5611148A2 (es) 2006-02-28
NZ535611A (en) 2006-03-31
SI1482938T1 (sl) 2007-12-31
BR0308220A (pt) 2005-01-04
PT1849468E (pt) 2013-02-27
CN101257904A (zh) 2008-09-03
SI1849468T1 (sl) 2013-03-29
ES2291618T3 (es) 2008-03-01
DK1849468T3 (da) 2013-02-04
ZA200407104B (en) 2006-12-27
SG160197A1 (en) 2010-04-29
AR038858A1 (es) 2005-01-26
NO335254B1 (no) 2014-10-27
NO20044230L (no) 2004-12-06
IS8760A (is) 2008-09-04
CY1113894T1 (el) 2016-07-27
EA200601592A1 (ru) 2006-12-29
US20050112069A1 (en) 2005-05-26
EP1849468A2 (en) 2007-10-31
EP1849468A3 (en) 2007-11-07
EA010886B1 (ru) 2008-12-30
PT1482938E (pt) 2007-11-15
HRP20040909A2 (en) 2005-08-31
HK1071308A1 (en) 2005-07-15
UA80117C2 (uk) 2007-08-27
AU2003212268A1 (en) 2003-09-16
IS2536B (is) 2009-08-15
MXPA04008460A (es) 2004-12-06
DE60315426T2 (de) 2008-07-03
PL371056A1 (en) 2005-06-13
RS78004A (xx) 2006-12-15
WO2003074055A1 (en) 2003-09-12
EP1849468B1 (en) 2012-12-05
TWI347845B (en) 2011-09-01
IL163336A (en) 2009-02-11
RS51018B (sr) 2010-10-31
ATE369134T1 (de) 2007-08-15
KR20040095255A (ko) 2004-11-12
EA200401137A1 (ru) 2005-04-28

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