DK1390340T3 - Kobberkatalyseret dannelse af kulstof-heteroatom- og kulstof-kulstofbindinger - Google Patents

Kobberkatalyseret dannelse af kulstof-heteroatom- og kulstof-kulstofbindinger Download PDF

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DK1390340T3
DK1390340T3 DK02728925.5T DK02728925T DK1390340T3 DK 1390340 T3 DK1390340 T3 DK 1390340T3 DK 02728925 T DK02728925 T DK 02728925T DK 1390340 T3 DK1390340 T3 DK 1390340T3
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mmol
diaminocyclohexane
mol
ethyl acetate
trans
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DK02728925.5T
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Stephen L Buchwald
Artis Klapars
Jon C Antilla
Gabriel E Job
Fuk Y Kwong
Edward J Hennessy
Gero Nordmann
Martina Uhlenbrock
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Massachusetts Inst Technology
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Claims (14)

1. Fremgangsmåde repræsenteret ved Scheme 1:
hvori - X repræsenterer I, Br, Cl, alkylsulfonat eller arylsulfonat; - Z repræsenterer aryl, heteroaryl eller alkenyl; - katalysator (catalyst) omfatter et kobberatom eller -ion og en ligand, som er valgt fra gruppen bestående af 1,2-diaminocyclohexan, 2-hydroxyetylamin, 1,2-diaminoetan, 2-fenylfenol, 2,6-dimetylfenol, 2-isopropylfenol, 1-naphtol, 8-hydroxyquinolin, 8-aminoquinolin, DBU, 2-(dimetylamino)etanol, etylenglykol, Ν,Ν-dietylsalicylamid, 2-(dimetylamino)glycin, N, N, Ν', N'-tetrametyl-l,2-diaminoetan og (metylimino)dieddikesyre; - base repræsentereren Bronstedbase; - R repræsenterer alkyl, cycloalkyl, aralkyl, aryl, heteroaryl, formyl, acyl, al-kyl02C-, aryl02C-, heteroaryl02C-, aralkyl02C-, heteroaralkyl02C-, acyKR^N-, alkylOC(0)N(R1)-, arylOQCONCR1)-, aralkylOCCCONCR1)-, heteroaral-kylOC(0)N(R1)-,-N=C(alkyl)2, or -N=C(aryl)2; - R1 repræsenterer H, alkyl, cycloalkyl, aralkyl, heteroaralkyl, aryl, heteroaryl, formyl, acyl, amino, or -C(NR5)N(R5)2; - R5 repræsenterer uafhængigt for hver forekomst H, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl eller heteroaralkyl; - R og R1 taget sammen kan repræsentere =C (alkyl)2 eller =C(aryl)2; og - R og R1 er valgfrit forbundet med en kovalent binding; forudsat at når R er aryl eller heteroaryl, er R1 ikke formyl eller acyl; og yderligere forudsat, at når R er formyl eller acyl, er R1 ikke aryl eller heteroaryl.
2. Fremgangsmåde ifølge krav 1, hvori X repræsenterer I.
3. Fremgangsmåde ifølge krav 1, hvori X repræsenterer Br.
4. Fremgangsmåde ifølge krav 1, hvori X repræsenterer Cl.
5. Fremgangsmåde ifølge krav 1, hvori liganden omfattet af katalysatoren er valgt fra gruppen bestående af 1,2-diaminocyclohexan, 2-hydroxyetylamin, 1,2- diaminoetan, 2-(dimetylamino)etanol, etylenglykol, 2-(dimetylamino)glycin, N, N, Ν', N'-tetrametyl-l,2-diaminoetan, og (metylimino)dieddikesyre.
6. Fremgangsmåde ifølge krav 1, hvori liganden omfattet af katalysatoren er cis- 1.2- diaminocyclohexan, trans-l,2-diaminocyclohexan, en blanding af cis- og trans-l,2-diaminocyclohexan, cis-N, N'-dimetyl-l,2-diaminocydohexan, trans-N,N'-dimetyl-l,2-diaminocyclohexan, en blanding af cis- og trans-N, N'-dimetyl- 1.2- diaminocyclohexan, cis-N-tolyl-l,2-diaminocyclohexan, trans-N-tolyl-1,2-diaminocyclohexan, en blanding af cis- and trans-N-tolyl-l,2-diaminocyclohexan, etanolamin, 1,2-diaminoetan, eller N,N'-dimetyl-l,2-diaminoetan.
7. Fremgangsmåde ifølge krav 6, hvori liganden omfattet af katalysatoren er cis- 1.2- diaminocyclohexan, trans-l,2-diaminocyclohexan, en blanding af cis- and trans-l,2-diaminocyclohexan, cis-N, N'-dimetyl-l,2-diaminocyclohexan, trans- N, N'-dimetyl-l,2-diaminocyclohexan, en blanding af cis- and trans-N,N'-dimetyl- 1.2- diaminocyclohexan, eller N, N'-dimetyl-l,2-diaminoetan.
8. Fremgangsmåde ifølge krav 1, krav 6 eller krav 7, hvori basen er en karbonat, fosfat, oxid, hydroxid, alkoxid, aryloxid, amin, metaamid, fluorid eller guanidin.
9. Fremgangsmåde ifølge krav 8, hvori basen er kaliumfosfat, kaliumkarbonat, cæsiumkarbonat, natriumtertbutoxid eller natriumhydroxid.
10. Fremgangsmåde ifølge krav 1, hvori katalysatoren er tilstede i en mængde i forhold til Z-X på mindre end eller lig med 10 mol%, for eksempel mindre end eller lig med 5 mol%, såsom mindre end 1 mol%, f.eks. mindre end eller lig med O, 1 mol%.
11. Fremgangsmåde ifølge krav 1, hvori fremgangsmåden udføres ved en temperatur mindre end 150°C, f.eks. mindre end 140°C, såsom mindre end 110°C, f.eks. mindre end 100°C, fortrinsvis ved en temperatur mindre end 90°C, f.eks. mindre end 50°C, såsom mindre end 40°C, f.eks. ved omgivelsestemperatur.
12. Fremgangsmåde ifølge krav 1, hvori Z repræsenterer valgfrit substitueret a ryl.
13. Fremgangsmåde ifølge krav 12, hvori Z repræsenterer valgfrit substitueret feny I.
14. Fremgangsmåde ifølge krav 1, hvori R1 repræsenterer H eller alkyl.
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Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1668595A (zh) * 2002-05-31 2005-09-14 罗狄亚化学公司 形成碳－碳或碳－杂原子键的方法
US7202367B2 (en) * 2002-05-31 2007-04-10 Rhodia Chimie Process for arylating or vinylating or alkynating a nucleophilic compound
AU2003257062A1 (en) 2002-08-02 2004-02-23 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
AU2003269399A1 (en) * 2002-11-01 2004-05-25 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination
DE10300126A1 (de) * 2003-01-07 2004-07-15 Bayer Aktiengesellschaft Verfahren zur Herstellung von Aminodiphenylaminen
DE10300125A1 (de) * 2003-01-07 2004-07-15 Bayer Ag Verfahren zur Herstellung von Nitrodiphenylaminen
WO2004080975A1 (ja) * 2003-03-13 2004-09-23 Idemitsu Kosan Co., Ltd. 新規含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
FR2854890B1 (fr) * 2003-05-15 2006-06-30 Rhodia Chimie Sa Procede de formation d'une liaison carbone-heteroatome
DE10326386A1 (de) * 2003-06-12 2004-12-30 Bayer Cropscience Ag N-Heterocyclyl-phenylsubstituierte cyclische Ketoenole
TWI322806B (en) * 2003-06-30 2010-04-01 Mitsubishi Tanabe Pharma Corp Process of preparating 3-acylaminobenzofuran-2-carboxylic acid derivatives
FR2859205B1 (fr) * 2003-08-28 2006-02-03 Rhodia Chimie Sa Procede de formation d'une liaison carbone-carbone ou carbone-heteroatome
US6894191B1 (en) * 2003-12-10 2005-05-17 Council Of Scientific And Industrial Research Process for the preparation of arylamines
US20100048513A1 (en) 2008-08-20 2010-02-25 Hawkins Michael J Novel inhibitors of chymase
CA2562578C (en) * 2004-04-12 2013-04-02 Eisai R&D Management Co., Ltd. Process for production of pyrazole-fused ring derivatives
JP4542831B2 (ja) * 2004-06-11 2010-09-15 富士フイルムファインケミカルズ株式会社 アリールアミンの製造方法
JP4542838B2 (ja) * 2004-06-30 2010-09-15 富士フイルムファインケミカルズ株式会社 アリールアミンの製造方法
EP1765771A4 (en) * 2004-07-08 2008-04-02 Merck & Co Inc FORMATION OF TETRA-SUBSTITUTED ENAMIDS AND STEREOSELECTIVE REDUCTION THEREOF
US20090012300A1 (en) * 2004-07-16 2009-01-08 Mathilda Maria Henrica Lambers Process for the Preparation of an (Hetero) Arylamine
JP4857546B2 (ja) * 2004-11-02 2012-01-18 三菱化学株式会社 トリアリールアミン化合物の製造方法
JP2008526850A (ja) * 2005-01-06 2008-07-24 マリンクロッド・インコーポレイテッド ベンジル化アミン類の製造方法
WO2007010082A1 (en) * 2005-07-15 2007-01-25 Fermion Oy Process for preparing a 3-aryloxy-3-arylpropylamine
JP4894226B2 (ja) * 2005-10-31 2012-03-14 Ｄｉｃ株式会社 ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法
CA2645668A1 (en) 2006-03-14 2007-09-20 Mallinckrodt Inc. Metal complexes of tetraazamacrocycle derivatives
JP4784402B2 (ja) * 2006-06-06 2011-10-05 東ソー株式会社 アリールアミン類製造用触媒およびそれを用いたアリールアミン類の製造方法
DE102006026431A1 (de) * 2006-06-07 2007-12-13 Archimica Gmbh Verfahren zur Herstellung von Alkyl- und Arylethern
KR20110077006A (ko) * 2006-08-15 2011-07-06 노파르티스 아게 증가된 지질 수준과 관련된 질환의 치료에 적합한 헤테로시클릭 화합물
CA2662574A1 (en) * 2006-09-22 2008-03-27 Novartis Ag Heterocyclic organic compounds
US7681741B2 (en) * 2006-12-15 2010-03-23 General Electric Company Functional polyarylethers
US7669720B2 (en) * 2006-12-15 2010-03-02 General Electric Company Functional polyarylethers
TWI415827B (zh) * 2006-12-21 2013-11-21 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
WO2008112280A1 (en) 2007-03-12 2008-09-18 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
FR2915200B1 (fr) 2007-04-20 2009-07-03 Centre Nat Rech Scient Procede de preparation de ligands de type phosphines butadieniques,leurs complexes avec le cuivre,et leurs applications en catalyse
WO2009071997A2 (en) * 2007-12-06 2009-06-11 Centre National De La Recherche Scientifique (C.N.R.S.) Iron and copper catalytic systems for cross-coupling reactions
MY152687A (en) 2008-04-15 2014-10-31 Eisai R&D Man Co Ltd 3-phenylpyrazolo[5,1-b]thiazole compound
WO2010051372A1 (en) * 2008-10-29 2010-05-06 Janssen Pharmaceutica Nv Process for the preparation of chymase modulators
BRPI0923401B1 (pt) * 2008-12-24 2021-11-23 Syngenta Limited Método para o preparo de aril amidas e composto
KR101772234B1 (ko) * 2009-02-09 2017-08-28 호도가야 가가쿠 고교 가부시키가이샤 방향족 아미노 화합물의 제조 방법
JP2010235575A (ja) * 2009-03-09 2010-10-21 Konica Minolta Holdings Inc 含窒素縮合複素環化合物の製造方法
US20110034691A1 (en) * 2009-03-25 2011-02-10 Elan Pharmaceuticals, Inc. Process for the Production of Fused, Tricyclic Sulfonamides
JP2011148751A (ja) * 2010-01-25 2011-08-04 Konica Minolta Holdings Inc 含窒素縮合複素環化合物の製造方法
BR112012020058A2 (pt) * 2010-02-10 2016-11-01 Mapi Pharma Ltd preparação de benzofuranos e uso dos mesmos como intermediários sintéticos.
CN103097360B (zh) 2010-07-16 2016-02-10 艾伯维巴哈马有限公司 用于制备抗病毒化合物的方法
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
EP2593226B1 (en) 2010-07-16 2018-11-14 AbbVie Ireland Unlimited Company Phosphine ligands for catalytic reactions
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
CN102532050A (zh) * 2011-12-20 2012-07-04 中国科学院兰州化学物理研究所 一种2-胺基取代的噁(噻)唑衍生物的制备方法
WO2013134296A1 (en) * 2012-03-05 2013-09-12 The Regents Of The University Of California Difluoromethylation of aryl and vinyl iodides
CN104519886B (zh) 2012-04-14 2017-09-12 细胞内治疗公司 有机化合物
JPWO2013191188A1 (ja) * 2012-06-22 2016-05-26 住友化学株式会社 縮合複素環化合物
WO2014071512A1 (en) * 2012-11-06 2014-05-15 Universite Laval Combination therapy and methods for the treatment of respiratory diseases
CN102976966B (zh) * 2012-11-27 2015-01-28 浙江大学 一种高位阻三级酰胺的合成方法
CN102977017B (zh) * 2012-12-24 2014-11-26 湖南大学 一种由铜化合物催化制备6(5h)-菲啶酮的方法
CN103012126B (zh) * 2012-12-25 2014-12-03 江苏联化科技有限公司 一种苯甲酸衍生物的制备方法
CN103254194B (zh) * 2013-05-17 2015-07-08 浙江师范大学 一种8-硫杂黄嘌呤化合物的制备方法
CN103554002B (zh) * 2013-10-08 2016-04-27 常州大学 1-苯基吲哚及其制备方法
CN104312193B (zh) * 2013-10-14 2016-06-15 大连理工大学 溴氨酸芳胺化合成蒽醌型染料或色基的方法
CN104326947B (zh) * 2013-10-14 2016-08-24 大连理工大学 活性艳蓝k-gr中间体的制备方法
CN104327532B (zh) * 2013-10-14 2016-08-24 大连理工大学 溴氨蓝的制备方法
CN104326953A (zh) * 2013-10-14 2015-02-04 大连理工大学 活性艳蓝kn-r中间体的制备方法
CA3148326A1 (en) 2013-12-03 2015-06-11 Intra-Cellular Therapies, Inc. Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia
CN103694189A (zh) * 2013-12-21 2014-04-02 西北大学 一种2-噁唑或2-噻唑的合成方法
JP7066321B2 (ja) 2014-01-10 2022-05-13 アヴァリン ファーマ インク． エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
EP3125892A4 (en) 2014-04-04 2017-12-27 Intra-Cellular Therapies, Inc. Organic compounds
WO2015154025A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
CN104001553B (zh) * 2014-06-20 2016-02-24 武汉工程大学 N取代的1,2,3-三唑衍生物/Cu(I)复合催化剂及其合成与应用
CA2955071A1 (en) 2014-07-15 2016-01-21 Grunenthal Gmbh Substituted azaspiro(4.5)decane derivatives
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
CN104530040B (zh) * 2015-01-19 2017-01-11 西华大学 1,2,3‑噻二唑‑5‑甲脒类化合物合成新方法
CN105985328B (zh) * 2015-02-03 2019-03-19 中国科学院广州生物医药与健康研究院 多沙唑嗪的合成方法
PT3407888T (pt) 2016-01-26 2021-03-19 Intra Cellular Therapies Inc Compostos de piridopirroloquinoxalina, suas composições e utilizações
MX2018011676A (es) 2016-03-25 2018-12-19 Intra Cellular Therapies Inc Compuestos organicos.
WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2017172784A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
US10906906B2 (en) 2016-12-29 2021-02-02 Intra-Cellular Therapies, Inc. Organic compounds
JP7132939B2 (ja) 2017-03-24 2022-09-07 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規組成物および方法
TWI783993B (zh) 2017-04-24 2022-11-21 美商提薩羅有限公司 尼拉帕尼(niraparib)之製備方法
WO2019023063A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
EP3658145A4 (en) 2017-07-26 2021-04-21 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
WO2019067591A1 (en) 2017-09-26 2019-04-04 Intra-Cellular Therapies, Inc. NEW SALTS AND CRYSTALS
CN107827913B (zh) * 2017-11-23 2020-01-10 天津师范大学 含1,10-菲啰啉状的n-杂环卡宾铜（i）配合物及用途
CA3106447A1 (en) * 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
KR20210052472A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
JP2021536453A (ja) 2018-08-31 2021-12-27 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 新規方法
CN109206333A (zh) * 2018-10-16 2019-01-15 河南师范大学 一种具有抗菌活性的苯佐卡因单取代衍生物的合成方法和应用
CN110194713A (zh) * 2019-02-25 2019-09-03 广东工业大学 一种ɑ, β不饱和酮化合物及其制备方法和应用
JP7041092B2 (ja) 2019-04-05 2022-03-23 日本化学工業株式会社 ビアリールホスフィンの製造方法
FR3099158B1 (fr) * 2019-07-23 2021-07-30 Arianegroup Sas Procede de fabrication de chromenes par catalyse aux sels de cuivre destines a la preparation de resines thermodurcissables
FR3099157B1 (fr) 2019-07-23 2022-07-15 Arianegroup Sas Procede de fabrication de chromenes par catalyse a l’or destines a la preparation de resines thermodurcissables
CN110256290A (zh) * 2019-08-06 2019-09-20 宜春学院 一种4-氰基苄氧基-4′-氰基苯基醚的制备方法
CN110982806B (zh) * 2019-08-30 2022-09-02 浙江工业大学 一种蛋白质芳基衍生物及其制备方法
WO2021113813A1 (en) * 2019-12-06 2021-06-10 University Of Cincinnati Mechanochemical snar reactions
CA3164104A1 (en) 2019-12-18 2021-06-24 Intervet International B.V. Anthelmintic compounds comprising azaindoles structure
CN111686816A (zh) * 2020-07-15 2020-09-22 太原理工大学 一种液体配位化合物催化剂及其制备方法和应用
CN111875555B (zh) * 2020-08-11 2022-07-19 南京合创药业有限公司 一种糖精-6-乙酸酯的合成方法
CN112225361B (zh) * 2020-09-24 2022-07-19 北京金崇光药业有限公司 一种用于清洗三七粉的纯化水及其生产工艺
CN112094201B (zh) * 2020-09-30 2023-03-24 郑州大学 一种带吸电子基团的芳香化合物的胺化方法
CN112341417B (zh) * 2020-10-28 2022-05-27 宁波工程学院 一种光/铜共催化合成多取代呋喃的方法
CN112375105B (zh) * 2020-11-30 2022-08-23 上海应用技术大学 一种n,n-配位的含间位碳硼烷配体的二价镍配合物的应用
CN113861222A (zh) * 2021-11-19 2021-12-31 山东安舜制药有限公司 一种采用新型催化剂合成去氧他唑巴坦二苯甲酯的方法
WO2024011415A1 (zh) * 2022-07-12 2024-01-18 苏州大学 一种邻碘苯基化合物的制备方法
WO2024011414A1 (zh) * 2022-07-12 2024-01-18 苏州大学 一种仲胺与邻二碘苯的反应方法
CN115232127B (zh) * 2022-08-04 2023-05-09 中钢集团南京新材料研究院有限公司 一种α-咔啉的制备方法及α-咔啉
CN116037152A (zh) * 2022-12-02 2023-05-02 深圳大学 一种钯铜-氧化亚铜核壳纳米笼催化剂及其制备方法与应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US47013A (en) * 1865-03-28 Improved machine for cutting sheaf-bands
US10347A (en) * 1853-12-20 Cleansing hair and feathers from insects
US2490813A (en) * 1944-11-29 1949-12-13 Standard Oil Co Continuous process for making aryl amines
GB1420211A (en) * 1972-01-17 1976-01-07 Secr Defence Alkylaromatic compoudns containing fluorine
US4259519A (en) 1975-06-27 1981-03-31 Polymer Sciences Corporation Process for the carbonylation of diolefins
US4764625A (en) * 1980-12-12 1988-08-16 Xerox Corporation Process for preparing arylamines
US4423234A (en) 1982-05-17 1983-12-27 Fmc Corporation Copper-catalyzed biaromatic coupling process
DE3332377A1 (de) 1983-09-08 1985-03-28 Chemische Werke Hüls AG, 4370 Marl Verfahren zur reinigung von polyphenylenoxiden, die nach abstoppung der kupferaminkatalysierten polykondensation von diorthosubstituierten phenolen erhalten werden
GB8412197D0 (en) 1984-05-12 1984-06-20 British Petroleum Co Plc Chemical processes
US4734521A (en) 1985-11-15 1988-03-29 The Dow Chemical Company Process for making beta, gamma-unsaturated ester, carbamates and sulfonamides
JPS6335548A (ja) * 1986-07-30 1988-02-16 Asahi Chem Ind Co Ltd トリアリ−ルアミンの製造方法
US4983774A (en) 1988-12-16 1991-01-08 Societe Nationale Elf Aquitaine Preparation of ketones by the acylation of organo-manganous compounds
US5159115A (en) * 1989-08-18 1992-10-27 Amoco Corporation Catalyzed gas-phase mono N-alkylation of aromatic primary amines
JPH03148235A (ja) * 1989-11-01 1991-06-25 Yoshitomi Pharmaceut Ind Ltd ４―ビフェニル―ｐ―トリルエーテルの製造法
EP0502060A4 (en) 1989-11-13 1993-05-05 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
JPH03215448A (ja) * 1990-01-17 1991-09-20 Yoshitomi Pharmaceut Ind Ltd ４―ビフェニル―ｐ―トリルエーテルの製造法
ATE244065T1 (de) 1990-12-06 2003-07-15 Affymetrix Inc Verfahren und reagenzien für immobilisierten polymersynthese in sehr grossem masstab
DE69233501T2 (de) 1991-11-22 2006-02-23 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Kombinatorische Strategien für die Polymersynthese
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
JP3224412B2 (ja) 1992-03-30 2001-10-29 サントリー株式会社 ４−置換アゼチジノン誘導体の製造方法
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
IL107166A (en) 1992-10-01 2000-10-31 Univ Columbia Complex combinatorial chemical libraries encoded with tags
US5405981A (en) 1993-03-26 1995-04-11 The Regents Of The University Of California Copper catalyzed coupling reactions
US5300675A (en) 1993-06-29 1994-04-05 Hoechst Celanese Corp. Process for synthesizing substituted cinnamic acid derivatives
US5362899A (en) 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
US5648539A (en) * 1996-02-29 1997-07-15 Xerox Corporation Low temperature arylamine processes
US5648542A (en) * 1996-02-29 1997-07-15 Xerox Corporation Arylamine processes
JP3161360B2 (ja) * 1996-04-19 2001-04-25 東ソー株式会社 アリールアミン類の製造方法
US5908939A (en) 1996-11-11 1999-06-01 Roche Vitamins Inc. Method of making D,L-A-tocopherol
US5723669A (en) * 1997-01-30 1998-03-03 Xerox Corporation Arylamine processes
US5723671A (en) * 1997-01-30 1998-03-03 Xerox Corporation Arylamine processes
US5705697A (en) * 1997-01-30 1998-01-06 Xerox Corporation Arylamine processes
JP4098858B2 (ja) * 1997-08-25 2008-06-11 富士フイルムファインケミカルズ株式会社 アリールアミンの製造方法
JP4098866B2 (ja) * 1998-01-09 2008-06-11 富士フイルムファインケミカルズ株式会社 アリールアミンの製造方法
JP4098867B2 (ja) * 1998-01-09 2008-06-11 富士フイルムファインケミカルズ株式会社 アリールアミンの製造方法
JP5035813B2 (ja) * 1998-07-10 2012-09-26 マサチューセッツ インスティテュート オブ テクノロジー 金属用のリガンドおよびそれらに基づいて改善された金属触媒法
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
CA2288851A1 (en) 1998-11-11 2000-05-11 F. Hoffmann-La Roche Ag Process for manufacturing d,i-alpha-tocopherol
US6242648B1 (en) * 1999-01-08 2001-06-05 Orient Chemical Industries, Ltd. Process for preparing triarylamine dimer
JP4313916B2 (ja) * 1999-01-08 2009-08-12 オリヱント化学工業株式会社 トリアリールアミンダイマーの製造方法
RU2148613C1 (ru) * 1999-07-20 2000-05-10 Кардаш Александр Филиппович Способ получения высокооктановых бензинов
DE19938736A1 (de) * 1999-08-16 2001-02-22 Bayer Ag Verfahren zur Herstellung von [Bis-(trifluormethyl)-phenyl]-essigsäuren und deren Alkylestern sowie [Bis-(trifluormethyl)-phenyl]-malonsäure-dialkylester
US6180836B1 (en) 1999-08-17 2001-01-30 National Science Council Of Republic Of China Preparation of phenol via one-step hydroxylation of benzene catalyzed by copper-containing molecular sieve
US20010047013A1 (en) * 2000-03-10 2001-11-29 Fengrui Lang Process for the preparation of arylamines
US6541639B2 (en) * 2000-07-26 2003-04-01 Bristol-Myers Squibb Pharma Company Efficient ligand-mediated Ullmann coupling of anilines and azoles

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CN1266112C (zh) 2006-07-26
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US6867298B2 (en) 2005-03-15
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