BR112012020058A2 - preparação de benzofuranos e uso dos mesmos como intermediários sintéticos. - Google Patents

preparação de benzofuranos e uso dos mesmos como intermediários sintéticos.

Info

Publication number
BR112012020058A2
BR112012020058A2 BR112012020058A BR112012020058A BR112012020058A2 BR 112012020058 A2 BR112012020058 A2 BR 112012020058A2 BR 112012020058 A BR112012020058 A BR 112012020058A BR 112012020058 A BR112012020058 A BR 112012020058A BR 112012020058 A2 BR112012020058 A2 BR 112012020058A2
Authority
BR
Brazil
Prior art keywords
preparation
benzofurans
synthetic intermediates
dronedarone
formula
Prior art date
Application number
BR112012020058A
Other languages
English (en)
Inventor
Ehud Marom
Michael Mizhiritskii
Shai Rubnov
Original Assignee
Mapi Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mapi Pharma Ltd filed Critical Mapi Pharma Ltd
Publication of BR112012020058A2 publication Critical patent/BR112012020058A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

preparação de benzofuranos e uso dos mesmos como intermediários sintéticos. a presente invenção refere-se a diversos métodos sintéticos para preparar n-(2-butilbenzofuran-5-il)-n-(metilsulfonil)metanossulfonamida, um composto de fórmula (3), um intermediário na preparação de dronedarona. a presente invenção adicionalmente provê um processo para preparar dronedarona, compreendendo as etapas de converter 2-butil-5-bis (metanossulfon)-amidobenzofurano de fórmula (3) em dronedarona, em que 2-butil-5-bis (metanossulfon)-amidobenzofurano de fórmula (3) é preparado pelos processos da presente invenção.
BR112012020058A 2010-02-10 2011-02-10 preparação de benzofuranos e uso dos mesmos como intermediários sintéticos. BR112012020058A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30297410P 2010-02-10 2010-02-10
US34512110P 2010-05-16 2010-05-16
PCT/IL2011/000150 WO2011099010A1 (en) 2010-02-10 2011-02-10 Preparation of benzofurans and use thereof as synthetic intermediates

Publications (1)

Publication Number Publication Date
BR112012020058A2 true BR112012020058A2 (pt) 2016-11-01

Family

ID=44367347

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012020058A BR112012020058A2 (pt) 2010-02-10 2011-02-10 preparação de benzofuranos e uso dos mesmos como intermediários sintéticos.

Country Status (9)

Country Link
US (1) US20130046103A1 (pt)
EP (1) EP2533636A4 (pt)
JP (1) JP2013519663A (pt)
CN (1) CN102753018A (pt)
AU (1) AU2011213921A1 (pt)
BR (1) BR112012020058A2 (pt)
CA (1) CA2787551A1 (pt)
MX (1) MX2012009299A (pt)
WO (1) WO2011099010A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2958290B1 (fr) * 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) * 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
HUP1000386A2 (en) * 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
CN102725279A (zh) * 2010-11-08 2012-10-10 山东邹平大展新材料有限公司 一种盐酸决奈达隆的制备方法
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
WO2012171135A1 (zh) * 2011-06-13 2012-12-20 山东邹平大展新材料有限公司 一种苯并呋喃化合物、其制备方法及用途
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN102675267B (zh) * 2012-06-07 2015-05-13 济南富创医药科技有限公司 盐酸决奈达隆及其中间体的制备方法
TW201536763A (zh) * 2013-08-27 2015-10-01 Gilead Sciences Inc 製備決奈達隆或其鹽類之製程
EP3142709A4 (en) * 2014-05-15 2017-12-20 Mayo Foundation for Medical Education and Research Solution target for cyclotron production of radiometals
CN109400507A (zh) * 2018-10-09 2019-03-01 常州工程职业技术学院 艾拉莫德中间体杂质的合成
WO2022207123A1 (de) * 2021-04-03 2022-10-06 Symrise Ag Herstellungsverfahren für polycyclische riechstoffe
CN114539193A (zh) * 2022-01-20 2022-05-27 海南普利制药股份有限公司 一种盐酸胺碘酮中间体的制备方法
CN116924946B (zh) * 2023-09-15 2023-11-21 成都泰和伟业生物科技有限公司 一种化合物及其制备方法和作为氨基保护试剂的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
RU2186062C1 (ru) * 2001-04-09 2002-07-27 Федеральное государственное унитарное предприятие Новокузнецкий научно-исследовательский химико-фармацевтический институт Способ получения 2-бутирилбензофурана
EP1390340B1 (en) * 2001-04-24 2017-03-01 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
KR20040030818A (ko) * 2001-07-20 2004-04-09 카로 바이오 아베 심방 세동의 치료에 있어서의 벤조 퓨란 및 이들의 용도
IL146389A0 (en) * 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
DE10237819A1 (de) * 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
WO2004100945A1 (en) * 2003-05-14 2004-11-25 Dsm Ip Assets B.V. Use of phthalide derivatives for the treatment and prevention of diabetes mellitus

Also Published As

Publication number Publication date
EP2533636A1 (en) 2012-12-19
US20130046103A1 (en) 2013-02-21
WO2011099010A1 (en) 2011-08-18
CA2787551A1 (en) 2011-08-18
EP2533636A4 (en) 2013-06-19
CN102753018A (zh) 2012-10-24
JP2013519663A (ja) 2013-05-30
AU2011213921A1 (en) 2012-08-09
MX2012009299A (es) 2012-09-12

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Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority

Free format text: PERDA DAS PRIORIDADES US 61/302,974 DE 10/02/2010 E US 61/345,121 DE 16/05/2010 REIVINDICADAS NO PCT/IL2011/000150 POR NAO ENVIO DE DOCUMENTO COMPROBATORIO DE CESSAO DA MESMA CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 6O, ITEM 27 DO ATO NORMATIVO 128/97 E NO ART. 28 DA RESOLUCAO INPI-PR 77/2013 UMA VEZ QUE DEPOSITANTE CONSTANTE DA PETICAO DE REQUERIMENTO DO PEDIDO PCT E DISTINTO DAQUELE QUE DEPOSITOU A PRIORIDADE REIVINDICADA. A CESSAO DO PCT ENVIADA NAO VALE COMO CESSAO DAS PRIORIDADES, POIS A EMPRESA NAO E A DETENTORA DOS DIREITOS DAS MESMAS, JA QUE OS DEPOSITANTES CONSTANTES NA BIBLIOTECA DIGITAL DA OMPI SAO OS PROPRIOS INVENTORES.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]