DK1343770T3 - Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse - Google Patents

Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse

Info

Publication number
DK1343770T3
DK1343770T3 DK01991788T DK01991788T DK1343770T3 DK 1343770 T3 DK1343770 T3 DK 1343770T3 DK 01991788 T DK01991788 T DK 01991788T DK 01991788 T DK01991788 T DK 01991788T DK 1343770 T3 DK1343770 T3 DK 1343770T3
Authority
DK
Denmark
Prior art keywords
triscarboxymethyl
tetraazacyclododecane
dihydroxypropyl
hydroxymethyl
preparation
Prior art date
Application number
DK01991788T
Other languages
Danish (da)
English (en)
Inventor
Johannes Platzek
Peter Blaszkiewicz
Orlin Petrov
Holger Hoffmann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of DK1343770T3 publication Critical patent/DK1343770T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK01991788T 2000-12-15 2001-12-05 Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse DK1343770T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (fr) 2000-12-15 2001-12-05 Complexes de lithium du n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, leur fabrication et leur utilisation

Publications (1)

Publication Number Publication Date
DK1343770T3 true DK1343770T3 (da) 2009-08-10

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01991788T DK1343770T3 (da) 2000-12-15 2001-12-05 Lithium-komplekser af N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, fremstilling og anvendelse af disse

Country Status (35)

Country Link
US (1) US6894151B2 (fr)
EP (1) EP1343770B1 (fr)
JP (1) JP4399163B2 (fr)
KR (1) KR100869627B1 (fr)
CN (1) CN1229357C (fr)
AR (1) AR035609A1 (fr)
AT (1) ATE430737T1 (fr)
AU (2) AU3165902A (fr)
BG (1) BG66117B1 (fr)
BR (1) BR0116219A (fr)
CA (1) CA2431976C (fr)
CY (1) CY1109280T1 (fr)
CZ (1) CZ304573B6 (fr)
DE (2) DE10064467C2 (fr)
DK (1) DK1343770T3 (fr)
EC (1) ECSP034676A (fr)
EE (1) EE05245B1 (fr)
ES (1) ES2325982T3 (fr)
HK (1) HK1064098A1 (fr)
HR (1) HRP20030576B1 (fr)
HU (1) HU229657B1 (fr)
IL (1) IL156432A0 (fr)
ME (1) ME00157B (fr)
MX (1) MXPA03005240A (fr)
NO (1) NO324864B1 (fr)
NZ (1) NZ526478A (fr)
PL (1) PL204181B1 (fr)
PT (1) PT1343770E (fr)
RS (1) RS51862B (fr)
RU (1) RU2003120513A (fr)
SK (1) SK287424B6 (fr)
TW (1) TWI302531B (fr)
UY (1) UY27056A1 (fr)
WO (1) WO2002048119A2 (fr)
ZA (1) ZA200305421B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007521254A (ja) * 2003-06-25 2007-08-02 ゲルベ 診断画像用化合物
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
ATE430146T1 (de) * 2004-07-02 2009-05-15 Bracco Imaging Spa Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten
EP1999118B1 (fr) 2006-03-14 2012-10-17 Mallinckrodt LLC Complexes métalliques de dérivés de tétraazamacrocycle
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
WO2011054480A1 (fr) * 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Préparation de gadobutrol au moyen d'une membrane céramique
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
KR20190079682A (ko) 2011-04-21 2019-07-05 바이엘 인텔렉쳐 프로퍼티 게엠베하 고순도 가도부트롤의 제조
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
TWI302531B (en) 2008-11-01
KR100869627B1 (ko) 2008-11-21
US6894151B2 (en) 2005-05-17
WO2002048119A2 (fr) 2002-06-20
RU2003120513A (ru) 2004-12-27
CN1481371A (zh) 2004-03-10
NO20032523D0 (no) 2003-06-04
DE10064467C2 (de) 2002-10-31
HRP20030576A2 (en) 2005-06-30
HRP20030576B1 (en) 2011-09-30
HUP0302563A2 (hu) 2003-12-29
EP1343770A2 (fr) 2003-09-17
UY27056A1 (es) 2002-07-31
WO2002048119A3 (fr) 2002-11-07
MXPA03005240A (es) 2003-09-25
JP4399163B2 (ja) 2010-01-13
EE05245B1 (et) 2009-12-15
ZA200305421B (en) 2004-08-27
HK1064098A1 (en) 2005-01-21
EP1343770B1 (fr) 2009-05-06
SK287424B6 (sk) 2010-09-07
KR20030077555A (ko) 2003-10-01
BR0116219A (pt) 2006-02-21
HUP0302563A3 (en) 2011-04-28
MEP15708A (en) 2010-06-10
IL156432A0 (en) 2004-01-04
CN1229357C (zh) 2005-11-30
BG107901A (bg) 2004-06-30
NZ526478A (en) 2006-04-28
CZ20031641A3 (cs) 2003-09-17
CA2431976C (fr) 2010-04-13
JP2004515545A (ja) 2004-05-27
ATE430737T1 (de) 2009-05-15
CY1109280T1 (el) 2014-07-02
CZ304573B6 (cs) 2014-07-16
DE10064467A1 (de) 2002-07-11
RS51862B (sr) 2012-02-29
NO324864B1 (no) 2007-12-17
EE200300282A (et) 2003-10-15
PT1343770E (pt) 2009-07-20
CA2431976A1 (fr) 2002-06-20
DE50114889D1 (de) 2009-06-18
YU48103A (sh) 2006-05-25
NO20032523L (no) 2003-06-04
ECSP034676A (es) 2003-08-29
BG66117B1 (bg) 2011-05-31
AU2002231659B2 (en) 2007-07-05
ES2325982T3 (es) 2009-09-28
ME00157B (fr) 2010-10-10
HU229657B1 (en) 2014-03-28
PL204181B1 (pl) 2009-12-31
SK7292003A3 (en) 2003-11-04
AR035609A1 (es) 2004-06-16
US20020128472A1 (en) 2002-09-12
PL366141A1 (en) 2005-01-24
AU3165902A (en) 2002-06-24

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