DK1186667T3 - Kappegendeficient virusvektor af Paramyxoviridae - Google Patents

Kappegendeficient virusvektor af Paramyxoviridae

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Publication number
DK1186667T3
DK1186667T3 DK00927807T DK00927807T DK1186667T3 DK 1186667 T3 DK1186667 T3 DK 1186667T3 DK 00927807 T DK00927807 T DK 00927807T DK 00927807 T DK00927807 T DK 00927807T DK 1186667 T3 DK1186667 T3 DK 1186667T3
Authority
DK
Denmark
Prior art keywords
gene
deficient
virus
successfully
paramyxoviridae
Prior art date
Application number
DK00927807T
Other languages
Danish (da)
English (en)
Inventor
Kaio Kitazato
Tsugumine Shu
Hidekazu Kuma
Yasuji Ueda
Makoto Asakawa
Mamoru Hasegawa
Akihiro Iida
Fumino Tokitou
Takahiro Hirata
Tsuyoshi Tokusumi
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Application granted granted Critical
Publication of DK1186667T3 publication Critical patent/DK1186667T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18822—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18845—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18861—Methods of inactivation or attenuation
    • C12N2760/18862—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
    • C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK00927807T 1999-05-18 2000-05-18 Kappegendeficient virusvektor af Paramyxoviridae DK1186667T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20073999 1999-05-18
PCT/JP2000/003195 WO2000070070A1 (fr) 1999-05-18 2000-05-18 Vecteur de virus paramyxoviridae defectueux dans un gene enveloppe

Publications (1)

Publication Number Publication Date
DK1186667T3 true DK1186667T3 (da) 2007-10-22

Family

ID=16429375

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00927807T DK1186667T3 (da) 1999-05-18 2000-05-18 Kappegendeficient virusvektor af Paramyxoviridae

Country Status (12)

Country Link
EP (1) EP1186667B1 (ja)
JP (2) JP3602058B2 (ja)
KR (2) KR100739938B1 (ja)
CN (1) CN1330767C (ja)
AT (1) ATE367445T1 (ja)
AU (1) AU4614600A (ja)
CA (1) CA2368948C (ja)
DE (1) DE60035589T2 (ja)
DK (1) DK1186667T3 (ja)
ES (1) ES2288473T3 (ja)
HK (1) HK1044352A1 (ja)
WO (1) WO2000070070A1 (ja)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3883213B2 (ja) * 1998-07-03 2007-02-21 株式会社ディナベック研究所 神経細胞用（−）鎖ｒｎａウィルスベクター
US7241617B2 (en) 1998-07-03 2007-07-10 Dnavec Research, Inc. Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci
US7226786B2 (en) 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
AU2001225487A1 (en) * 2000-01-19 2001-07-31 Dnavec Research Inc. Use of paramyxovirus vector in gene transfer into blood vessel
CN1248740C (zh) 2000-03-30 2006-04-05 株式会社载体研究所 使用仙台病毒载体的aids病毒疫苗
JP2002142770A (ja) 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
KR100812884B1 (ko) 2000-11-27 2008-03-11 가부시키가이샤 디나벡크 겐큐쇼 혈관신생 유전자를 코드하는 파라믹소바이러스 벡터 및 그 이용
US8715922B2 (en) 2001-01-19 2014-05-06 ViroNovative Virus causing respiratory tract illness in susceptible mammals
JP5503096B2 (ja) 2001-01-19 2014-05-28 ヴィロノヴァティブ，ベスローテン ヴェンノートシャップ 感受性哺乳動物において気道疾患を引き起こすウイルス
FR2826010B1 (fr) * 2001-06-14 2005-02-25 Mahmood Salman Al Oligonucleotides antisens capables d'inhiber la formation des tubes capillaires par les cellules endotheliales
CA2460778A1 (en) * 2001-09-18 2003-03-27 Dnavec Research Inc. Methods for testing and producing (-) strand rna virus vectors with reduced particle formation ability
CA2477235A1 (en) 2002-02-21 2003-09-04 Medimmune Vaccines, Inc. Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus
AU2003234775A1 (en) 2002-04-30 2003-11-17 Dnavec Research Inc. Vector with modified protease-dependent tropism
KR100587388B1 (ko) * 2003-02-14 2006-06-08 주식회사 효성 고강도 폴리비닐알코올 섬유의 제조방법 및 그로부터수득되는 고강도 폴리비닐알코올 섬유
KR20110097971A (ko) * 2003-04-25 2011-08-31 메디뮨 백신즈, 인코포레이티드 메타뉴모바이러스 유래 이종 항원을 포함하는 재조합 파라인플루엔자 바이러스 발현 시스템 및 백신
US7585667B2 (en) * 2003-06-13 2009-09-08 The United States Of America As Represented By The Department Of Health And Human Services Negative strand RNA virus replicon
CN1902312B (zh) * 2003-11-04 2011-02-23 株式会社载体研究所 制备导入了基因的树突细胞的方法
AU2005205441A1 (en) 2004-01-13 2005-07-28 Dnavec Research Inc. Gene therapy for tumor using minus-strand RNA virus vector encoding immunostimulating cytokine
CN1934257A (zh) * 2004-01-22 2007-03-21 株式会社载体研究所 病毒载体的制备方法
CA2553976C (en) 2004-01-22 2013-09-24 Dnavec Research Inc. Method for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken .beta.-actin promoter
JPWO2005097988A1 (ja) * 2004-03-23 2008-02-28 株式会社ディナベック研究所 組織の維持および／または修復に関連する骨髄関連細胞
KR20070028573A (ko) * 2004-06-24 2007-03-12 가부시키가이샤 디나벡크 겐큐쇼 마이너스 가닥 ｒｎａ 바이러스를 포함하는 항암제
JP2008105946A (ja) * 2005-02-08 2008-05-08 Dnavec Corp 遺伝子導入造血細胞から血液細胞を再構築させる方法
DE102005015005A1 (de) * 2005-04-01 2006-10-05 Qiagen Gmbh Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe
US20110162093A1 (en) 2005-06-14 2011-06-30 Yasuji Ueda Methods for producing antibodies
WO2006137517A1 (ja) * 2005-06-24 2006-12-28 Dnavec Corporation 幼少個体への遺伝子導入用ベクター
KR20080068098A (ko) 2005-10-28 2008-07-22 디나벡크 가부시키가이샤 Ｒｎａ 바이러스 또는 ｄｎａ 바이러스의 스파이크단백질로 슈도타입화된 렌티바이러스 벡터를 사용한 기도상피 간세포로의 유전자 도입
JP5102630B2 (ja) * 2005-11-24 2012-12-19 ジェノミディア株式会社 改変パラミクソウイルスおよびその作製方法
JPWO2007083644A1 (ja) * 2006-01-17 2009-06-11 ディナベック株式会社 新規タンパク質発現系
EP2034014A1 (en) 2006-05-31 2009-03-11 Dnavec Corporation Therapeutic agent for alzheimer's disease
EP2048232A4 (en) 2006-07-13 2010-10-13 Dnavec Corp NON-REPLICATIVE PARAMYXOVIRIDAE VIRUS VECTOR
US20100323428A1 (en) 2007-02-07 2010-12-23 Dnavec Corporation Attenuated minus-stranded rna virus
WO2008129971A1 (ja) * 2007-04-13 2008-10-30 National Institute Of Advanced Industrial Science And Technology 改良された持続感染型センダイウイルスベクター
CA2685417A1 (en) 2007-04-27 2008-11-13 Kyushu University, National University Corporation Viral vector for gene therapy
KR20110046472A (ko) 2008-07-16 2011-05-04 디나벡크 가부시키가이샤 염색체 비삽입형 바이러스 벡터를 사용해서 리프로그램된 세포를 제조하는 방법
WO2010050586A1 (ja) 2008-10-31 2010-05-06 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
EP2607476B1 (en) 2009-02-27 2015-04-08 Kyoto University Novel nuclear reprogramming substance
CN102625837B (zh) 2009-08-07 2015-01-14 国立大学法人京都大学 有效建立诱导的多能干细胞的方法
US8993329B2 (en) 2009-09-24 2015-03-31 Kyoto University Method of efficiently establishing induced pluripotent stem cells
BR112012003380A2 (pt) * 2009-11-02 2016-11-16 Biocomo Co Ltd vacina contra tuberculose do tipo spray intranasal usando um vetor de paramyxovírus.
US8945576B2 (en) 2010-01-08 2015-02-03 Kyoto University Vaccine for treatment of tautopathy
JP5827220B2 (ja) 2010-01-22 2015-12-02 国立大学法人京都大学 人工多能性幹細胞の樹立効率改善方法
CA2796599A1 (en) 2010-04-16 2011-10-20 Keio University Method for producing induced pluripotent stem cells
KR20130093624A (ko) * 2010-08-30 2013-08-22 디나벡크 가부시키가이샤 다능성 줄기 세포를 유도하기 위한 조성물 및 그의 사용
US9447408B2 (en) 2010-09-14 2016-09-20 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US20130302367A1 (en) 2010-10-22 2013-11-14 Hisatoshi Shida Virus vector for prime/boost vaccines, which comprises vaccinia virus vector and sendai virus vector
WO2012074106A1 (ja) 2010-12-03 2012-06-07 国立大学法人京都大学 多能性幹細胞からの好酸球の製造方法
WO2012074117A1 (ja) 2010-12-03 2012-06-07 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
CN103403159B (zh) 2011-02-08 2018-09-14 国立大学法人三重大学 用于基因导入的病毒载体的制造方法
EP3636755A1 (en) * 2012-12-26 2020-04-15 BioComo Inc. Vaccine prepared utilizing human parainfluenza virus type 2 vector
JP6543194B2 (ja) 2013-09-24 2019-07-10 株式会社Ｉｄファーマ 多能性幹細胞の誘導効率を改善する方法
WO2016199936A1 (ja) * 2015-06-12 2016-12-15 国立大学法人三重大学 ヒトパラインフルエンザ２型ウイルスベクター及びワクチン
EP3542818A4 (en) 2016-11-17 2020-07-29 Japan as Represented by The Director-General of National Institute of Infectious Diseases VACCINE AGAINST INFECTIOUS DISEASES USING NON-INFECTIOUS PARAMYXOVIRUS PARTICLES
WO2019017438A1 (ja) 2017-07-21 2019-01-24 株式会社Ｉｄファーマ 標的配列を改変するためのポリヌクレオチドおよびその使用
JP7314441B2 (ja) 2018-01-22 2023-07-26 国立感染症研究所長 選択的ｃｄ８陽性ｔ細胞誘導ワクチン抗原
WO2021138447A1 (en) 2019-12-31 2021-07-08 Elixirgen Therapeutics, Inc. Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
CN116018402A (zh) 2020-09-04 2023-04-25 心脏康复株式会社 iPS细胞的品质改善剂、iPS细胞的制备方法、iPS细胞、及iPS细胞制备用组合物
CA3203232A1 (en) 2020-12-25 2022-06-30 Kyoto University Method for producing naive human ips cells from somatic cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512421A (en) * 1991-02-19 1996-04-30 The Regents Of The University Of California Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors
ATE298789T1 (de) * 1995-10-31 2005-07-15 Dnavec Research Inc Negativstrand rna virus mit selbständiger replikationsaktivität
DK0863202T3 (da) * 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
AU7335396A (en) * 1995-11-01 1997-05-22 Dnavec Research Inc. Membrane-fusible liposome with the use of recombinant sendai virus
JP3766596B2 (ja) * 1999-05-18 2006-04-12 株式会社ディナベック研究所 パラミクソウイルスに由来するｒｎｐ

Also Published As

Publication number Publication date
AU4614600A (en) 2000-12-05
EP1186667A1 (en) 2002-03-13
KR20020014786A (ko) 2002-02-25
ATE367445T1 (de) 2007-08-15
HK1044352A1 (en) 2002-10-18
KR20070058607A (ko) 2007-06-08
CN1355851A (zh) 2002-06-26
CA2368948C (en) 2013-12-24
EP1186667B1 (en) 2007-07-18
CA2368948A1 (en) 2000-11-23
KR100739938B1 (ko) 2007-07-16
DE60035589D1 (de) 2007-08-30
ES2288473T3 (es) 2008-01-16
JP3602058B2 (ja) 2004-12-15
CN1330767C (zh) 2007-08-08
WO2000070070A1 (fr) 2000-11-23
DE60035589T2 (de) 2008-04-17
JP2004329222A (ja) 2004-11-25
EP1186667A4 (en) 2004-06-30

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