CY1107431T1 - Σωματιδια για γoνιδιακη θεραπεια - Google Patents

Σωματιδια για γoνιδιακη θεραπεια

Info

Publication number
CY1107431T1
CY1107431T1 CY20081101145T CY081101145T CY1107431T1 CY 1107431 T1 CY1107431 T1 CY 1107431T1 CY 20081101145 T CY20081101145 T CY 20081101145T CY 081101145 T CY081101145 T CY 081101145T CY 1107431 T1 CY1107431 T1 CY 1107431T1
Authority
CY
Cyprus
Prior art keywords
particles
protein
gonal
treatment
virus
Prior art date
Application number
CY20081101145T
Other languages
English (en)
Inventor
Eberhard Hildt
Peter Hofschneider
Original Assignee
Diaferon Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diaferon Gmbh filed Critical Diaferon Gmbh
Publication of CY1107431T1 publication Critical patent/CY1107431T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10141—Use of virus, viral particle or viral elements as a vector
    • C12N2730/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
    • C12N2810/405—Vectors comprising RGD peptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σωματίδια, τα οποία περιλαμβάνουν: (a) ένα πρωτεϊνικό κάλυμμα με μια πρωτεΐνη σύντηξης, η οποία περιλαμβάνει μια ιική πρωτεΐνη, ένα πεπτίδιο που διαμεσολαβεί την κυτταρική διαπερατότητα και μια ετερόλογη ειδική θέση πρόσδεσης, και (b) ένα νουκλεϊνικό οξύ που βρίσκεται στο πρωτεϊνικό κάλυμμα, το οποίο έχει αλληλουχίες για ένα ειδικό στον ιό σήμα συσκευασίας και ένα δομικό γονίδιο. Περαιτέρω η εφεύρεση αφορά μεθόδους για την παρασκευή τέτοιων σωματιδίων και κατάλληλα για το σκοπό αυτό μέσα, καθώς και τη χρήση των σωματιδίων για γονιδιακή θεραπεία.
CY20081101145T 1999-02-05 2008-10-16 Σωματιδια για γoνιδιακη θεραπεια CY1107431T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904800A DE19904800C1 (de) 1999-02-05 1999-02-05 Partikel zur Gentherapie
EP00909000A EP1165797B1 (de) 1999-02-05 2000-02-04 Partikel zur gentherapie

Publications (1)

Publication Number Publication Date
CY1107431T1 true CY1107431T1 (el) 2012-12-19

Family

ID=7896602

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101145T CY1107431T1 (el) 1999-02-05 2008-10-16 Σωματιδια για γoνιδιακη θεραπεια

Country Status (9)

Country Link
US (1) US7018826B1 (el)
EP (1) EP1165797B1 (el)
AT (1) ATE402261T1 (el)
CY (1) CY1107431T1 (el)
DE (2) DE19904800C1 (el)
DK (1) DK1165797T3 (el)
ES (1) ES2310988T3 (el)
PT (1) PT1165797E (el)
WO (1) WO2000046376A2 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19850718C1 (de) 1998-11-03 2000-05-18 Hildt Eberhardt Zellpermeabilität-vermittelndes Polypeptid
JP2003286199A (ja) * 2002-03-29 2003-10-07 Japan Science & Technology Corp タンパク質中空ナノ粒子を用いる肝臓疾患治療用薬剤
DK1523329T3 (da) * 2002-07-05 2013-10-14 Folia Biotech Inc Viruspartikeladjuvant
US8101189B2 (en) 2002-07-05 2012-01-24 Folia Biotech Inc. Vaccines and immunopotentiating compositions and methods for making and using them
DE10240894A1 (de) * 2002-09-04 2004-03-11 Procom Biotechnologische Produktions Gmbh Verstärkung der Resorption von Subtanzen über die Haut und Schleimhaut
KR101253261B1 (ko) * 2011-05-11 2013-04-10 한국과학기술연구원 ｓｉＲＮＡ 의 전달을 위한 재조합 단백질 및 이를 포함하는 조성물
CN108611395A (zh) * 2016-12-12 2018-10-02 中山大学 一种抗人乙肝病毒药物的筛选方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633943A4 (en) * 1992-04-03 1997-05-02 Alexander T Young GENTHERAPY USING TARGETED VIRAL VECTORS.
JP2001519647A (ja) * 1995-12-28 2001-10-23 カイロン コーポレイション 標的細胞中へのウイルスおよび粒子の取り込みおよびインターナリゼーションのためのレセプター特異的キメラウイルス表面ポリペプチド
DE19850718C1 (de) 1998-11-03 2000-05-18 Hildt Eberhardt Zellpermeabilität-vermittelndes Polypeptid

Also Published As

Publication number Publication date
WO2000046376A3 (de) 2000-11-16
DE19904800C1 (de) 2001-02-08
ES2310988T3 (es) 2009-02-01
WO2000046376A2 (de) 2000-08-10
EP1165797A2 (de) 2002-01-02
PT1165797E (pt) 2008-10-30
DE50015272D1 (de) 2008-09-04
ATE402261T1 (de) 2008-08-15
EP1165797B1 (de) 2008-07-23
US7018826B1 (en) 2006-03-28
DK1165797T3 (da) 2008-11-24

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