DK1183243T3 - Korttidsvirkende benzodiazepiner - Google Patents
Korttidsvirkende benzodiazepinerInfo
- Publication number
- DK1183243T3 DK1183243T3 DK00930686T DK00930686T DK1183243T3 DK 1183243 T3 DK1183243 T3 DK 1183243T3 DK 00930686 T DK00930686 T DK 00930686T DK 00930686 T DK00930686 T DK 00930686T DK 1183243 T3 DK1183243 T3 DK 1183243T3
- Authority
- DK
- Denmark
- Prior art keywords
- sedation
- compounds
- present
- purposes
- short
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Paper (AREA)
- Gyroscopes (AREA)
- Surface Treatment Of Glass Fibres Or Filaments (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9911152.8A GB9911152D0 (en) | 1999-05-14 | 1999-05-14 | Short-acting benzodiazepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1183243T3 true DK1183243T3 (da) | 2006-06-12 |
Family
ID=10853415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00930686T DK1183243T3 (da) | 1999-05-14 | 2000-05-12 | Korttidsvirkende benzodiazepiner |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1183243B1 (https=) |
| JP (4) | JP3773792B2 (https=) |
| AT (1) | ATE317390T1 (https=) |
| AU (1) | AU4846300A (https=) |
| DE (1) | DE60025921T2 (https=) |
| DK (1) | DK1183243T3 (https=) |
| ES (1) | ES2258008T3 (https=) |
| GB (1) | GB9911152D0 (https=) |
| HK (1) | HK1042296B (https=) |
| PT (1) | PT1183243E (https=) |
| WO (1) | WO2000069836A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02001340A (es) * | 1999-08-05 | 2004-07-16 | Prescient Neuropharma Inc | Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos. |
| GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| BRPI0714886B8 (pt) | 2006-07-10 | 2021-05-25 | Paion Uk Ltd | sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica |
| EP2305647A1 (en) * | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
| EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| CN102964349A (zh) * | 2011-08-31 | 2013-03-13 | 江苏恒瑞医药股份有限公司 | 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途 |
| PE20150683A1 (es) | 2012-05-22 | 2015-06-03 | Paion Uk Ltd | Composiciones que comprenden benzodiazepinas de accion corta |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
| AU2013309860B2 (en) | 2012-08-31 | 2017-12-21 | Paion Uk Limited | Method for administering hypnotic/sedative agent |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| CN103232454A (zh) * | 2013-05-05 | 2013-08-07 | 王元青 | 治疗精神疾病的药物 |
| CN104146970A (zh) * | 2013-05-05 | 2014-11-19 | 王元青 | 治疗精神疾病的冻干粉针剂 |
| CN103202815B (zh) * | 2013-05-05 | 2014-09-24 | 李友香 | 治疗精神疾病的注射剂 |
| CN103230595B (zh) * | 2013-05-05 | 2014-10-08 | 李友香 | 治疗精神疾病的组合物 |
| PL3157928T3 (pl) | 2014-06-20 | 2019-07-31 | Constellation Pharmaceuticals, Inc. | Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu |
| WO2016011943A1 (zh) * | 2014-07-23 | 2016-01-28 | 李勤耕 | 新的苯并二氮杂䓬类衍生物及其用途 |
| CN106892924B (zh) * | 2015-12-17 | 2021-01-08 | 四川科伦博泰生物医药股份有限公司 | 短效苯并二氮*衍生物、其制备方法及其用途 |
| CN107266452A (zh) * | 2016-04-08 | 2017-10-20 | 四川科伦药物研究院有限公司 | 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途 |
| US20190175613A1 (en) | 2016-04-14 | 2019-06-13 | Paion Uk Limited | Orally inhaled and nasal benzodiazepines |
| CN109790170B (zh) | 2016-08-16 | 2022-08-02 | Uwm研究基金会有限公司 | Gaba(a)受体调节剂和控制哮喘中气道高反应性和炎症的方法 |
| CN108503644B (zh) * | 2016-12-09 | 2019-06-14 | 成都倍特药业有限公司 | 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途 |
| CN108264499B (zh) * | 2017-01-04 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种苯并二氮杂*衍生物的制备方法 |
| CN110418791B (zh) * | 2017-04-28 | 2022-07-01 | 四川科伦博泰生物医药股份有限公司 | 包含苯并二氮䓬类化合物的注射用组合物及其制备方法 |
| CN108948018B (zh) * | 2017-05-17 | 2021-03-30 | 四川科伦博泰生物医药股份有限公司 | 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途 |
| ES2697918A1 (es) | 2017-07-28 | 2019-01-29 | Moehs Iberica Sl | Procedimiento para preparar ester metilico del acido 3-[(3s)-7-bromo-2-oxo-5-(piridin-2-il)-2,3-dihidro-1h-[1,4]-benzodiazepin-3-il] propionico, y compuestos utiles en ese procedimiento |
| ES2709298B2 (es) | 2017-10-13 | 2019-08-21 | Moehs Iberica Sl | Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento |
| RU2701557C2 (ru) * | 2017-11-24 | 2019-09-30 | Общество С Ограниченной Ответственностью "Инновационные Фармакологические Разработки" (Ооо "Ифар") | Производные 1,4-бензодиазепин-2-она и их применение |
| CN108084187A (zh) * | 2017-12-15 | 2018-05-29 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类氢化物 |
| CN108003164A (zh) * | 2017-12-15 | 2018-05-08 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类化合物 |
| CN107868088A (zh) * | 2017-12-15 | 2018-04-03 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类氮氧化物 |
| CN108033964B (zh) * | 2017-12-28 | 2021-02-09 | 杭州奥默医药股份有限公司 | 一种吡啶基咪唑并苯并二氮杂卓丙酸酯化合物及其合成和应用 |
| CN111712501A (zh) | 2018-02-13 | 2020-09-25 | 江苏恩华络康药物研发有限公司 | 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用 |
| EP3992194A4 (en) * | 2019-06-28 | 2023-07-12 | West China Hospital, Sichuan University | BENZODIAZEPIN COMPOUND, METHOD OF MANUFACTURE AND USE THEREOF IN MEDICINE |
| ES2803099B2 (es) | 2019-07-22 | 2021-11-08 | Moehs Iberica Sl | Procedimiento de obtención de besilato de remimazolam amorfo |
| KR102526590B1 (ko) | 2020-06-19 | 2023-04-28 | 하나제약 주식회사 | 3-[(4S)-8-브로모-1-메틸-6-(2-피리디닐)-4H-이미다조[1,2-a][1,4]벤조디아제핀-4-일]프로피온산 메틸 에스테르의 제조방법 |
| CN112358483A (zh) * | 2020-11-09 | 2021-02-12 | 中国药科大学 | 一类新型苯并二氮*类化合物、其制备方法及其用途 |
| CN114644612B (zh) * | 2020-12-17 | 2023-04-28 | 成都苑东生物制药股份有限公司 | 一种苯二氮杂类神经抑制剂中间体化合物的制备方法 |
| WO2023083191A1 (zh) * | 2021-11-09 | 2023-05-19 | 四川大学华西医院 | 苯二氮卓类化合物及其制备方法和在医药上的用途 |
| CN116253761A (zh) * | 2021-12-10 | 2023-06-13 | 宜昌人福药业有限责任公司 | 一种制备瑞马唑仑o-磷酰化中间体的方法 |
| EP4504731A1 (en) | 2022-04-08 | 2025-02-12 | Fresenius Kabi Oncology Ltd | An improved process for the preparation of remimazolam |
| CN115322144B (zh) * | 2022-08-30 | 2024-05-24 | 上海药坦药物研究开发有限公司 | 一种2-(2-氨基-5-溴-苯甲酰基)吡啶的制备方法 |
| CN115385891A (zh) * | 2022-09-06 | 2022-11-25 | 上海药坦药物研究开发有限公司 | 一种瑞马唑仑中间体的制备方法 |
| WO2024251275A1 (zh) * | 2023-06-09 | 2024-12-12 | 成都麻沸散医药科技有限公司 | 一种氮杂*类化合物及其组合物和应用 |
| CN121318975A (zh) * | 2024-07-11 | 2026-01-13 | 宜昌人福药业有限责任公司 | 苯并二氮䓬类化合物、药物组合物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6915069D0 (pt) * | 1969-02-28 | 1973-08-16 | Upjohn Co | Compostos organicos e processo |
| DE2156472A1 (de) * | 1970-11-23 | 1972-05-31 | Ciba-Geigy Ag, Basel (Schweiz) | Verfahren zur Herstellung von neuen Diazepinderivaten |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| IE41197B1 (en) * | 1973-05-29 | 1979-11-07 | Squibb & Sons Inc | 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones |
| CH608234A5 (en) * | 1974-08-30 | 1978-12-29 | Crc Ricerca Chim | Process for the preparation of lithium salts of 1,4-benzodiazepines |
| DE2900017A1 (de) * | 1978-01-10 | 1979-07-12 | Clin Midy | 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| MC1528A1 (fr) * | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | Imidazobenzodiazepines |
| IT1165588B (it) * | 1983-03-23 | 1987-04-22 | Medosan Ind Biochimi | 1,4 benzodiazepine terapeuticamente attive |
| ES2084577T3 (es) * | 1986-10-24 | 1996-05-16 | Abbott Lab | Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas. |
| US5220017A (en) * | 1991-04-10 | 1993-06-15 | Merck & Co., Inc. | Cholecystokinin antagonists |
| JPH07304755A (ja) * | 1994-05-12 | 1995-11-21 | Yamanouchi Pharmaceut Co Ltd | 縮合ジアゼピン誘導体 |
| US5834464A (en) * | 1994-11-18 | 1998-11-10 | Merck & Co., Inc. | Imidazolinobenzodiazepines |
| AU722110B2 (en) * | 1996-06-28 | 2000-07-20 | Merck & Co., Inc. | Pharmaceutical preparation |
| EP0881235A1 (fr) * | 1997-05-26 | 1998-12-02 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles |
-
1999
- 1999-05-14 GB GBGB9911152.8A patent/GB9911152D0/en not_active Ceased
-
2000
- 2000-05-12 PT PT00930686T patent/PT1183243E/pt unknown
- 2000-05-12 DK DK00930686T patent/DK1183243T3/da active
- 2000-05-12 WO PCT/US2000/013134 patent/WO2000069836A1/en not_active Ceased
- 2000-05-12 ES ES00930686T patent/ES2258008T3/es not_active Expired - Lifetime
- 2000-05-12 JP JP2000618253A patent/JP3773792B2/ja not_active Expired - Lifetime
- 2000-05-12 AU AU48463/00A patent/AU4846300A/en not_active Abandoned
- 2000-05-12 DE DE60025921T patent/DE60025921T2/de not_active Expired - Lifetime
- 2000-05-12 AT AT00930686T patent/ATE317390T1/de active
- 2000-05-12 HK HK02103523.8A patent/HK1042296B/en not_active IP Right Cessation
- 2000-05-12 EP EP00930686A patent/EP1183243B1/en not_active Expired - Lifetime
-
2005
- 2005-12-07 JP JP2005353914A patent/JP4769562B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-11 JP JP2007127264A patent/JP4769760B2/ja not_active Expired - Lifetime
- 2007-05-11 JP JP2007127245A patent/JP4769759B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1042296A1 (en) | 2002-08-09 |
| EP1183243A1 (en) | 2002-03-06 |
| JP2007197468A (ja) | 2007-08-09 |
| DE60025921D1 (de) | 2006-04-20 |
| JP3773792B2 (ja) | 2006-05-10 |
| JP2007197469A (ja) | 2007-08-09 |
| WO2000069836A1 (en) | 2000-11-23 |
| ATE317390T1 (de) | 2006-02-15 |
| GB9911152D0 (en) | 1999-07-14 |
| HK1042296B (en) | 2006-08-25 |
| JP4769760B2 (ja) | 2011-09-07 |
| JP4769759B2 (ja) | 2011-09-07 |
| JP4769562B2 (ja) | 2011-09-07 |
| AU4846300A (en) | 2000-12-05 |
| DE60025921T2 (de) | 2006-10-26 |
| PT1183243E (pt) | 2006-06-30 |
| ES2258008T3 (es) | 2006-08-16 |
| EP1183243B1 (en) | 2006-02-08 |
| JP2006151984A (ja) | 2006-06-15 |
| JP2002544266A (ja) | 2002-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1183243T3 (da) | Korttidsvirkende benzodiazepiner | |
| KR940014328A (ko) | 인돌린 화합물 | |
| RU2559888C2 (ru) | Аналоги этомидата, которые не ингибируют синтез адренокортикостероидов | |
| KR970701183A (ko) | 4-헤테로사이클릴-치환된 퀴나졸릴 유도체, 이들의 제조 방법 및 항암제로서의 용도(4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents) | |
| AU4818000A (en) | Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands | |
| TW200621249A (en) | Substituted amide beta secretase inhibitors | |
| GC0000375A (en) | Benzodiazepine derivatives as gaba a receptor modulators | |
| IL176107A0 (en) | Azabicyclic heterocycles as cannabinoid receptor modulators | |
| RU96119255A (ru) | 4-гетероциклил-замещенные производные хиназолина, способ их получения и их применение в качестве противоракового средства | |
| TWI265029B (en) | Formulations for pharmaceutical agents ionizable as free acids or free bases | |
| DE69331190D1 (de) | Überbrückte azabicyclische derivate als substanz p antagonisten | |
| TNSN08027A1 (en) | Combination of a long-acting hypnotic agent and a short-acting hypnotic agent and therapeutic use of same | |
| ES2120070T3 (es) | Esteres nitricos dotados de una actividad anti-inflamatoria y/o analgesica y su procedimiento de preparacion. | |
| EP1510221A4 (en) | MEANS FOR THE PREVENTION AND / OR TREATMENT OF PERSONS EXPRESSING OR ACTIVATING HER2 AND / OR EGFR | |
| JP2004511512A (ja) | 認識障害の治療のためのアセチルコリンエステラーゼ阻害薬およびｇａｂａａ反作用薬の組合せ使用 | |
| AU5835194A (en) | Thiazolidine derivatives, preparation thereof and drugs containing same | |
| UA93393C2 (uk) | 1,3-діоксанкарбонові кислоти | |
| ES2751627T3 (es) | Nuevo derivado de benzodiazepina y uso del mismo | |
| WO2006016689A1 (ja) | Ｅｐ４アゴニストを含有してなる下部尿路系疾患の予防および／または治療剤 | |
| JP2019535680A (ja) | キナーゼを阻害する組成物及び方法 | |
| BR0111767A (pt) | Composições analgésicas e anti-inflamatórias contendo inibidores de cox-2, seu uso e método para potencializar um composto analgésico | |
| JP2005511623A (ja) | 情動および注意障害、神経因性疼痛の処置用医薬の製造において使用するためのモノヒドロキシカルバマゼピン | |
| AU2003276514A1 (en) | 4-imidazol-1-ylmethyl-pyrimidine derivatives_as ligands for gabaa receptors | |
| BRPI0415966A (pt) | combinações compreendendo antagonistas do receptor ampa para tratamento de esquizofrenia | |
| ATE303148T1 (de) | Chinolin-harnstoff-derivate zur behandlung von entzugssyndrom und durch entzugssyndrom verursachten gehirnschaden |