CN111712501A - 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用 - Google Patents

苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用 Download PDF

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Publication number
CN111712501A
CN111712501A CN201980012858.0A CN201980012858A CN111712501A CN 111712501 A CN111712501 A CN 111712501A CN 201980012858 A CN201980012858 A CN 201980012858A CN 111712501 A CN111712501 A CN 111712501A
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China
Prior art keywords
crystalline form
ray powder
powder diffraction
hcl
diffraction spectrum
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Pending
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CN201980012858.0A
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English (en)
Inventor
李勤耕
段衬
王涛
廖建
李长文
郝超
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Jiangsu Nhwaluokang Pharmceutical Research And Development Co ltd
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Jiangsu Nhwaluokang Pharmceutical Research And Development Co ltd
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Application filed by Jiangsu Nhwaluokang Pharmceutical Research And Development Co ltd filed Critical Jiangsu Nhwaluokang Pharmceutical Research And Development Co ltd
Publication of CN111712501A publication Critical patent/CN111712501A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

本发明提供具有如下式I的苯二氮卓类衍生物盐酸盐或其乙醇合物的晶体结构，

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201980012858.0A 2018-02-13 2019-02-13 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用 Pending CN111712501A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018101519790 2018-02-13
CN201810151979 2018-02-13
PCT/CN2019/074935 WO2019158075A1 (zh) 2018-02-13 2019-02-13 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用

Publications (1)

Publication Number Publication Date
CN111712501A true CN111712501A (zh) 2020-09-25

Family

ID=67618826

Family Applications (1)

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CN201980012858.0A Pending CN111712501A (zh) 2018-02-13 2019-02-13 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用

Country Status (13)

Country Link
US (1) US11708368B2 (zh)
EP (1) EP3753940A4 (zh)
JP (1) JP7410036B2 (zh)
KR (1) KR102647713B1 (zh)
CN (1) CN111712501A (zh)
AU (1) AU2019222052B2 (zh)
BR (1) BR112020016323A2 (zh)
CA (1) CA3090913C (zh)
EA (1) EA202091927A1 (zh)
IL (1) IL276611A (zh)
MX (1) MX2020008465A (zh)
SG (1) SG11202007733SA (zh)
WO (1) WO2019158075A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478535A (zh) * 2020-10-23 2022-05-13 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103347519A (zh) * 2010-11-08 2013-10-09 Paion英国有限公司 使用cns 7056(雷米马唑仑)镇静的给药方案
WO2016011943A1 (zh) * 2014-07-23 2016-01-28 李勤耕 新的苯并二氮杂䓬类衍生物及其用途
CN107266452A (zh) * 2016-04-08 2017-10-20 四川科伦药物研究院有限公司 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911152D0 (en) 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
KR20150081370A (ko) 2006-07-10 2015-07-13 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
CN102964349A (zh) 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
ES2916845T3 (es) * 2017-02-09 2022-07-06 Assia Chem Ind Ltd Proceso para la preparación de remimazolam y formas en estado sólido de sales de remimazolam

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103347519A (zh) * 2010-11-08 2013-10-09 Paion英国有限公司 使用cns 7056(雷米马唑仑)镇静的给药方案
WO2016011943A1 (zh) * 2014-07-23 2016-01-28 李勤耕 新的苯并二氮杂䓬类衍生物及其用途
CN107266452A (zh) * 2016-04-08 2017-10-20 四川科伦药物研究院有限公司 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114478535A (zh) * 2020-10-23 2022-05-13 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法
CN114478535B (zh) * 2020-10-23 2024-02-09 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法

Also Published As

Publication number Publication date
SG11202007733SA (en) 2020-09-29
MX2020008465A (es) 2020-12-07
BR112020016323A2 (pt) 2020-12-15
JP2021514353A (ja) 2021-06-10
CA3090913C (en) 2024-01-02
CA3090913A1 (en) 2019-08-22
KR102647713B1 (ko) 2024-03-13
WO2019158075A1 (zh) 2019-08-22
EP3753940A4 (en) 2021-12-22
US11708368B2 (en) 2023-07-25
AU2019222052B2 (en) 2022-05-12
EA202091927A1 (ru) 2020-12-07
US20210002283A1 (en) 2021-01-07
IL276611A (en) 2020-09-30
AU2019222052A1 (en) 2020-09-17
KR20200120935A (ko) 2020-10-22
JP7410036B2 (ja) 2024-01-09
EP3753940A1 (en) 2020-12-23

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