PT3580219T - Processo para a preparação de remimazolam e formas de estado sólido de sais de remimazolam - Google Patents

Processo para a preparação de remimazolam e formas de estado sólido de sais de remimazolam

Info

Publication number
PT3580219T
PT3580219T PT187061478T PT18706147T PT3580219T PT 3580219 T PT3580219 T PT 3580219T PT 187061478 T PT187061478 T PT 187061478T PT 18706147 T PT18706147 T PT 18706147T PT 3580219 T PT3580219 T PT 3580219T
Authority
PT
Portugal
Prior art keywords
remimazolam
preparation
solid state
salts
state forms
Prior art date
Application number
PT187061478T
Other languages
English (en)
Original Assignee
Assia Chem Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assia Chem Ind Ltd filed Critical Assia Chem Ind Ltd
Publication of PT3580219T publication Critical patent/PT3580219T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
PT187061478T 2017-02-09 2018-02-08 Processo para a preparação de remimazolam e formas de estado sólido de sais de remimazolam PT3580219T (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201711004706 2017-02-09
IN201711033273 2017-09-20
IN201711046934 2017-12-27
IN201811002128 2018-01-18

Publications (1)

Publication Number Publication Date
PT3580219T true PT3580219T (pt) 2022-06-02

Family

ID=61244816

Family Applications (1)

Application Number Title Priority Date Filing Date
PT187061478T PT3580219T (pt) 2017-02-09 2018-02-08 Processo para a preparação de remimazolam e formas de estado sólido de sais de remimazolam

Country Status (5)

Country Link
US (2) US11034697B2 (pt)
EP (2) EP4086260A1 (pt)
ES (1) ES2916845T3 (pt)
PT (1) PT3580219T (pt)
WO (1) WO2018148361A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2697918A1 (es) * 2017-07-28 2019-01-29 Moehs Iberica Sl Procedimiento para preparar ester metilico del acido 3-[(3s)-7-bromo-2-oxo-5-(piridin-2-il)-2,3-dihidro-1h-[1,4]-benzodiazepin-3-il] propionico, y compuestos utiles en ese procedimiento
ES2709298B2 (es) 2017-10-13 2019-08-21 Moehs Iberica Sl Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento
AU2019222052B2 (en) * 2018-02-13 2022-05-12 Jiangsu Nhwaluokang Pharmaceutical Research And Development Co., Ltd. Benzodiazepine derivative hydrochloride and crystal form, preparation method, and application thereof
JP2022539126A (ja) * 2019-06-28 2022-09-07 ウェストチャイナホスピタル、スーチョワンユニバーシティ ベンゾジアゼピン系化合物及びその製造方法並びに医薬における作用
CN112209932B (zh) * 2019-07-12 2023-03-24 成都倍特药业股份有限公司 一种化合物氢溴酸盐的新固体形态及其制备方法和用途
KR102526590B1 (ko) 2020-06-19 2023-04-28 하나제약 주식회사 3-[(4S)-8-브로모-1-메틸-6-(2-피리디닐)-4H-이미다조[1,2-a][1,4]벤조디아제핀-4-일]프로피온산 메틸 에스테르의 제조방법
CN112462015B (zh) * 2020-11-18 2022-07-12 海南倍特药业有限公司 一种氢溴酸瑞马唑仑细菌内毒素的检测方法
CN112321594B (zh) * 2020-12-07 2022-05-20 扬子江药业集团有限公司 一种苯并二氮杂䓬类药物的制备方法
CN114644612B (zh) * 2020-12-17 2023-04-28 成都苑东生物制药股份有限公司 一种苯二氮杂类神经抑制剂中间体化合物的制备方法
WO2023037237A1 (en) * 2021-09-09 2023-03-16 Wavelength Enterprises Ltd Process for the preparation of remimazolam
WO2023083191A1 (zh) * 2021-11-09 2023-05-19 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的用途
WO2023194945A1 (en) 2022-04-08 2023-10-12 Fresenius Kabi Oncology Ltd. An improved process for the preparation of remimazolam

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
PT2081921E (pt) 2006-07-10 2010-12-10 Paion Uk Ltd Sais de benzodiazepina de acção curta e suas formas polimórficas
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
US9994578B2 (en) * 2014-07-23 2018-06-12 Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd Benzodiazepine derivative and use thereof
CN105130996B (zh) * 2015-08-07 2017-05-03 成都倍特药业有限公司 苯并二氮杂*衍生物的1,5‑萘二磺酸盐及晶型和它们的制备方法
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
ES2709298B2 (es) 2017-10-13 2019-08-21 Moehs Iberica Sl Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento

Also Published As

Publication number Publication date
EP3580219A1 (en) 2019-12-18
EP4086260A1 (en) 2022-11-09
WO2018148361A1 (en) 2018-08-16
US11034697B2 (en) 2021-06-15
EP3580219B1 (en) 2022-04-13
ES2916845T3 (es) 2022-07-06
US20190359619A1 (en) 2019-11-28
US11820776B2 (en) 2023-11-21
US20210277013A1 (en) 2021-09-09

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